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41. 发明申请

US20100142410A1 SYSTEM AND METHOD FOR PROVIDING VIRTUAL PRIVATE NETWORKS 有权
标题翻译：用于提供虚拟私有网络的系统和方法
公开(公告)号：US20100142410A1
公开(公告)日：2010-06-10
申请号：US12634536
申请日：2009-12-09
申请人： Olivier HUYNH VAN , Jeff Gray
发明人： Olivier HUYNH VAN , Jeff Gray
IPC分类号： H04L12/28
CPC分类号： H04L41/0806 , H04L12/4633 , H04L12/4641 , H04L41/14 , H04L45/00 , H04L63/0823 , H04L63/164
摘要： A computerized system and method for automatically determining customized configurations for each of a plurality of endpoints of a virtual private network (VPN) and deploying the configurations to the endpoints, comprising: accepting, using an interface, parameters required for building the configurations from a user, the configurations enabling the endpoints to process a mixture of time sensitive and non-time sensitive data, and the parameters comprising: endpoint IP addressing scheme information and network design information; automatically generating, using at least one configuration engine, complete customized endpoint configurations for the parameters, and instantiating the configurations based on endpoint hardware-specific information, with no further input required from the user; and deploying, using a scheduler, the configurations to the endpoints of the at least one VPN, wherein the VPN is an mGRE VPN using NHRP protocol.
摘要翻译：一种用于自动确定虚拟专用网络（VPN）的多个端点中的每个终端的定制配置并将配置部署到端点的计算机化系统和方法，包括：使用接口来接收从用户构建配置所需的参数，使得端点能够处理时间敏感数据和非时间敏感数据的混合的配置，以及包括：端点IP寻址方案信息和网络设计信息的参数; 使用至少一个配置引擎自动生成参数的完整的定制端点配置，以及基于端点硬件特定信息来实例化配置，而不需要用户进一步的输入; 以及使用调度器将配置部署到所述至少一个VPN的端点，其中所述VPN是使用NHRP协议的mGRE VPN。

42. 发明申请

US20100076302A1 Invisible Power Port ID Tattoo 审中-公开
标题翻译：隐形电源端口ID纹身
公开(公告)号：US20100076302A1
公开(公告)日：2010-03-25
申请号：US12238094
申请日：2008-09-25
申请人： Jeff Gray , Stephanie Dubay , Paul DiCarlo
发明人： Jeff Gray , Stephanie Dubay , Paul DiCarlo
IPC分类号： A61B6/12 , A61B8/00
CPC分类号： A61K49/0089 , A61K49/0006 , A61K49/006 , C09D11/50
摘要： A solution for use in medical procedures, comprises including a plurality of microspheres holding a fluorescent dye reactive to ultraviolet light and a base dye which, under white light, has one of a color substantially matching a color of a target portion of skin into which it is to be injected and which has, under UV light, a color slightly darker than a color of the target portion of skin. A method comprises identifying a target area of the skin to be accessed in a medical procedure and injecting into at least a portion of the target area a solution including a plurality of microspheres holding a colored dye and a fluorescent dye reactive to ultraviolet light in combination with locating the target area by illuminating the skin with ultraviolet light.
摘要翻译：用于医疗程序的解决方案包括包含多个保持与紫外线反应的荧光染料的微球体和基础染料，所述基质染料在白光下具有与皮肤目标部分的颜色基本匹配的颜色之一被注入，并且在UV光下具有比目标皮肤部分的颜色稍暗的颜色。一种方法包括在医疗过程中识别要接近的皮肤的目标区域，并且向目标区域的至少一部分注入包含多个保持着色染料的微球和与紫外线反应的荧光染料的溶液，通过用紫外线照射皮肤来定位目标区域。

43. 发明授权

US07189515B2 Human antibodies as detection reagents 有权
标题翻译：人抗体作为检测试剂
公开(公告)号：US07189515B2
公开(公告)日：2007-03-13
申请号：US10149737
申请日：2000-12-06
申请人： Joe Buechler , Gunars Valkirs , Jeff Gray , Nils Lonberg
发明人： Joe Buechler , Gunars Valkirs , Jeff Gray , Nils Lonberg
IPC分类号： G01N33/543
CPC分类号： C07K16/18 , C07K16/244 , C07K2317/21 , C07K2317/55 , G01N33/543 , Y02A50/55 , Y02A50/58 , Y10S435/962 , Y10S435/973 , Y10S436/809
摘要： The invention provides in vitro methods of detection using human antibodies. The methods are particularly useful for analyzing human samples containing HAMA or heterophilic antibodies. A human antibody can bind to an analyte in such samples without binding to HAMA or heterophilic antibodies present in the samples. The methods can be effected using a sandwich format among others.
摘要翻译：本发明提供使用人抗体的体外检测方法。该方法对于分析含有HAMA或异嗜性抗体的人类样品特别有用。人抗体可以结合这样的样品中的分析物而不与样品中存在的HAMA或异嗜性抗体结合。这些方法可以使用夹心形式等来实现。

44. 发明授权

US06908739B2 Diagnostic assays for detection of Giardia lamblia 失效
标题翻译：用于检测贾第鞭毛虫的诊断试验
公开(公告)号：US06908739B2
公开(公告)日：2005-06-21
申请号：US10155163
申请日：2002-05-23
申请人： Joe Buechler , Shanthi Govindaraj , Jeff Gray , Gunars E. Valkirs
发明人： Joe Buechler , Shanthi Govindaraj , Jeff Gray , Gunars E. Valkirs
IPC分类号： G01N33/569 , G01N33/53 , A61K39/02 , A61K39/395 , G01N33/567
CPC分类号： G01N33/56905
摘要： This invention provides methods, reagents, and kits that are useful for diagnosing infection by Giardia lamblia. The methods are based on the discovery of binding agents, including recombinant polyclonal antibodies, that bind to the α-1-giardin antigen of G. lamblia.
摘要翻译：本发明提供了可用于诊断贾第鞭毛虫感染的方法，试剂和试剂盒。所述方法基于结合羊链球菌的α-1-吉达尔抗原的结合剂（包括重组多克隆抗体）的发现。

45. 发明授权

US06810405B1 System and methods for synchronizing data between multiple datasets 有权
标题翻译：用于在多个数据集之间同步数据的系统和方法
公开(公告)号：US06810405B1
公开(公告)日：2004-10-26
申请号：US09679944
申请日：2000-10-04
申请人： Chris LaRue , Jeff Gray , Roy W. Feague
发明人： Chris LaRue , Jeff Gray , Roy W. Feague
IPC分类号： G06F1730
CPC分类号： G06F17/30575 , A61M19/00 , A61M2202/048 , Y10S707/922 , Y10S707/959 , Y10S707/99952
摘要： Methods for synchronizing PIM data between a wireless telephone and a synchronization server. A communication in interface is established between the telephone and the server, using a wireless network and the Internet. The telephone initiates the synchronization by placing a data call to the server and logging on to the server. A sync client within the telephone sends recent changes to its dataset to the server and requests an acknowledgement of these changes. In an acknowledgement message, the server specifies which changes were actually received. Based on this acknowledgment, the client continues resending changes until it receives confirmation that the server has received all of its changes. The server performs conflict and duplicate resolution between the changes received from the client and other changes of which the server is aware, and enters into its dataset those changes that survive the resolutions. The client also requests that the server send changes that have been made to the server's dataset. The server identifies all changes that should be sent to the client and that have survived the conflict and duplicate resolutions. The server then sends its changes to the client, requests acknowledgement, and resends changes until it confirms that the client has received all of the changes. The client enters the changes from the server into its dataset without any further conflict or duplicate resolution. The client then logs off of the server and ends the data call.
摘要翻译：用于在无线电话和同步服务器之间同步PIM数据的方法。使用无线网络和互联网在电话和服务器之间建立接口中的通信。电话通过向服务器发送数据呼叫并登录到服务器来启动同步。电话中的同步客户端将最近对其数据集的更改发送到服务器，并请求确认这些更改。在确认消息中，服务器指定实际接收到哪些更改。基于此确认，客户端继续重新发送更改，直到收到服务器已收到其所有更改的确认。服务器在从客户端接收到的更改和服务器知道的其他更改之间执行冲突和重复解析，并将其转换为其数据集，以便在解决方案之后生效。客户端还要求服务器发送已对服务器的数据集进行的更改。服务器识别应发送给客户端的所有更改，并在冲突和重复的解决方案中幸免。然后，服务器将其更改发送给客户端，请求确认，并重新发送更改，直到确认客户端已收到所有更改。客户端将更改从服务器输入到其数据集中，而不会产生任何进一步的冲突或重复解决。然后，客户端注销服务器并结束数据调用。

46. 发明授权

US11150250B2 Methods for diagnosing acute kidney injury or renal failure 有权
公开(公告)号：US11150250B2
公开(公告)日：2021-10-19
申请号：US13061413
申请日：2009-08-28
申请人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura
发明人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura
IPC分类号： G01N33/53 , G01N33/68
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of soluble p-selectin, protein NOV homolog, soluble epidermal growth factor receptor, netrin-4, haptoglobin, heat shock protein beta-1, alpha-1-antitrypsin, leukocyte elastase, soluble tumor necrosis factor receptor superfamily member 6, soluble tumor necrosis factor ligand superfamily member 6, soluble intercellular adhesion molecule 2, active caspase-3, and soluble platelet endothelial cell adhesion molecule as diagnostic and prognostic biomarkers in renal injuries.

47. 发明授权

US09057735B2 Methods and compositions for diagnosis and prognosis of renal injury and renal failure 有权
标题翻译：肾损伤和肾衰竭的诊断和预后的方法和组成
公开(公告)号：US09057735B2
公开(公告)日：2015-06-16
申请号：US13061446
申请日：2009-08-28
申请人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura
发明人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura
IPC分类号： G01N33/53 , G01N33/68
CPC分类号： G01N33/6893 , G01N2333/4745 , G01N2333/65 , G01N2333/80 , G01N2800/347 , G01N2800/56
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of cytochrome c and insulin-like growth factor IA as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译：本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及使用检测一种或多种选自细胞色素c和胰岛素样生长因子IA的标志物作为肾损伤诊断和预后生物标志物的测定法。

48. 发明申请

US20140171522A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
标题翻译：用于诊断和预防肾损伤和肾功能衰竭的方法和组合
公开(公告)号：US20140171522A1
公开(公告)日：2014-06-19
申请号：US14131678
申请日：2012-07-05
申请人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura , James Patrick Kampf
发明人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura , James Patrick Kampf
IPC分类号： G01N33/543
CPC分类号： G01N33/6893 , G01N33/54306 , G01N2333/475 , G01N2333/59 , G01N2333/8107 , G01N2800/347 , G01N2800/52 , G01N2800/56
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Heat shock protein beta-1, WAP four-disulfide core domain protein 2, Choriogonadotropin subunit beta, Placenta growth factor, and Mitochondrial 60 kDa heat shock protein as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译：本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及使用一种或多种测定法，其配置用于检测选自热休克蛋白β-1，WAP四硫化物核域结构域蛋白2，绒毛膜促性腺激素亚基β，胎盘生长因子，和线粒体60 kDa热休克蛋白作为肾损伤的诊断和预后生物标志物。

49. 发明申请

US20130316370A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
标题翻译：用于诊断和预防肾损伤和肾功能衰竭的方法和组合
公开(公告)号：US20130316370A1
公开(公告)日：2013-11-28
申请号：US13878124
申请日：2011-10-06
申请人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura , James Patrick Kampf
发明人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura , James Patrick Kampf
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2800/347 , G01N2800/52 , G01N2800/56
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more biomarkers selected from the group consisting of Beta-nerve growth factor, Interleukin-17A, Follitropin subunit beta, Collagenase 3, Follistatin, Vitamin D Binding Protein, Islet amyloid polypeptide, Insulin C-peptide, Complement Factor H, Gastric inhibitory polypeptide, Glucagon-like peptide 1, Glucagon, Involucrin, Type II cytoskeletal Keratin-1/Keratin-10, Type II cytoskeletal Keratin-6A/6B/6C, Osteocalcin, Lipopolysaccharide, Pancreatic prohormone, Peptide YY, Agouti-related protein, Ciliary neurotrophic factor, Appetite-regulating hormone, Transthyretin, Insulin receptor substrate 1, and NF-kappa-B inhibitor alpha as diagnostic and prognostic biomarker assays in renal injuries.
摘要翻译：本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及使用检测一种或多种生物标志物的测定法，所述生物标志物选自β-神经生长因子，白细胞介素-177，富立替丁亚基β，胶原酶3，胶质蛋白，维生素D结合蛋白，胰岛淀粉样蛋白多肽，胰岛素 C肽，补体因子H，胃抑制性多肽，胰高血糖素样肽1，胰高血糖素，Involucrin，II型细胞骨架角蛋白-1 /角蛋白-10，II型细胞骨架角蛋白-6A / 6B / 6C，骨钙素，脂多糖，胰腺激素，肽YY，Agouti相关蛋白，睫状神经营养因子，食欲调节激素，Transthyretin，胰岛素受体底物1和NF-κB抑制剂α作为肾损伤中的诊断和预后生物标志物测定。

50. 发明申请

US20130252264A1 METHODS AND COMPOSITIONS FOR THE EVALUATION OF RENAL INJURY USING HYALURONIC ACID 审中-公开
标题翻译：使用羟丙酸评估肾损伤的方法和组合
公开(公告)号：US20130252264A1
公开(公告)日：2013-09-26
申请号：US13825675
申请日：2011-09-23
申请人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura , James Patrick Kampf , Kai Singbartl , John A. Kellum
发明人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura , James Patrick Kampf , Kai Singbartl , John A. Kellum
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , G01N33/50 , G01N2400/40 , G01N2800/347 , G01N2800/52 , G01N2800/56
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more of hyaluronic acid (HA) as diagnostic and prognostic biomarker assays in renal injuries.
摘要翻译：本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及使用检测透明质酸（HA）中的一种或多种作为肾损伤中的诊断和预后生物标志物测定的测定法。

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