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    • 41. 发明授权
    • Methods for detecting lung cancer and monitoring treatment response
    • 检测肺癌的方法和监测治疗反应
    • US08728823B2
    • 2014-05-20
    • US12743042
    • 2008-11-24
    • Stephen LamJohn YeeMichael KuzykDon SinMarianne Dorthy SadarCarl Martin Tammemagi
    • Stephen LamJohn YeeMichael KuzykDon SinMarianne Dorthy SadarCarl Martin Tammemagi
    • G01N33/00G01N33/566
    • G01N33/57423G01N2800/50G01N2800/52
    • A method is described for detecting lung cancer comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject at risk for developing lung cancer. Further, a method is described for predicting risk of developing lung cancer in a subject comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject. Additionally, a method of monitoring the success of lung cancer treatment is described comprising detecting levels of a CTAP III-related biomarker in a biological sample from a subject undergoing treatment for lung cancer for comparison with a previous level obtained from the subject. Multivariate analysis may be incorporated into these methods, evaluating such clinical, or demographic risk factors as age, sex, smoking history, smoking status, smoking family history, education level, COPD, socio-economic status, body mass index and lung function. Kits for conducting such methods are described.
    • 描述了一种用于检测肺癌的方法,包括检测来自患有发展为肺癌风险的受试者的生物样品中CTAP III相关生物标志物的升高水平。 此外,描述了用于预测受试者中发展肺癌的风险的方法,包括检测来自受试者的生物样品中CTAP III相关生物标志物的升高水平。 此外,描述了监测肺癌治疗成功的方法,其包括检测来自接受肺癌治疗的受试者的生物样品中的CTAP III相关生物标志物的水平,以与从受试者获得的先前水平进行比较。 多变量分析可纳入这些方法,评估年龄,性别,吸烟史,吸烟状况,吸烟家族史,教育水平,COPD,社会经济状况,体重指数和肺功能等临床或人口学危险因素。 描述了用于进行这种方法的套件。