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41. 发明申请

US20080124805A1 CYTOMETER HAVING FLUID CORE STREAM POSITION CONTROL 有权
标题翻译：具有流体核心流动位置控制的流量计
公开(公告)号：US20080124805A1
公开(公告)日：2008-05-29
申请号：US11744685
申请日：2007-05-04
申请人： James A. Cox , Bernard S. Fritz
发明人： James A. Cox , Bernard S. Fritz
IPC分类号： G01N35/08 , G01N1/10
CPC分类号： G01N15/1404 , Y10T436/118339
摘要： A cytometer having two or more chambers or regions in a containment structure of sheathing fluid that may be used to provide hydrodynamic focusing of another fluid having particles to be observed. The latter fluid may be a core stream which may have its lateral position in a flow or measurement channel affected by control of at least one of the parameters of the several segments of the sheathing fluid. The lateral position of the core stream may be aligned with a light source and detector for a count and observation of the particles. Electrical signals from the detector may be fed back to a processor which may control one or more parameters of the sheathing fluid in the various chambers or regions via pumps, valves, and flow and pressure sensors. This control of parameters may provide for the positioning of the core stream. This cytometer may be miniaturized.
摘要翻译：具有在护套液体的容纳结构中的两个或更多个腔室或区域的细胞计数器，其可用于提供具有待观察颗粒的另一种流体的流体动力聚焦。后一流体可以是芯流，其可以在流动或测量通道中具有其横向位置，该流动或测量通道受到护套流体的几个段的参数中的至少一个参数的控制的影响。核心流的横向位置可以与光源和检测器对准，用于计数和观察颗粒。来自检测器的电信号可以被反馈到处理器，处理器可以通过泵，阀和流量和压力传感器来控制各个室或区域中的护套流体的一个或多个参数。参数的这种控制可以提供核心流的定位。该细胞仪可能会小型化。

42. 发明授权

US07283223B2 Cytometer having telecentric optics 有权
标题翻译：血细胞计数器具有远心光学
公开(公告)号：US07283223B2
公开(公告)日：2007-10-16
申请号：US10953197
申请日：2004-09-28
申请人： Bernard S. Fritz
发明人： Bernard S. Fritz
IPC分类号： G01J1/42 , G01J3/30 , G01N21/00
CPC分类号： G01N15/1459 , G01N2015/1452
摘要： A mechanism for moving and positioning a light source so that its light impinges a target as it moves on or off axis of an optical system. A detector may receive scattered light at a same position whether the light impinging the target is on or off axis due to, for example, a telecentric optical system. Further, the light may be positioned so that the detector is maximally impinged with scattered light. An output may go to a processor that sends a signal to the light source to move the emitted light so as to continually impinge the target as it moves on or off axis. An array of light sources may used in lieu of the moving light source. To move the light beam, another light at another position in the array may be selected to replace a previously selected light source.
摘要翻译：一种用于移动和定位光源的机构，使得当光线在光学系统的移动或离开轴线时它的光线撞击目标。由于例如远心光学系统，检测器可以在相同位置处接收散射光，不论射入目标的光是否在轴上。此外，光可以被定位成使得检测器被最大程度地与散射光撞击。输出可以转到处理器，该处理器向光源发送信号以移动发射的光，以便当目标在轴上移动时不断地撞击目标。可以使用光源阵列代替移动光源。为了移动光束，可以选择阵列中另一位置处的另一个光以替代先前选择的光源。

43. 发明授权

US07277166B2 Cytometer analysis cartridge optical configuration 有权
标题翻译： Cytometer分析盒光学配置
公开(公告)号：US07277166B2
公开(公告)日：2007-10-02
申请号：US10908543
申请日：2005-05-16
申请人： Aravind Padmanabhan , Jay G. Schwichtenberg , Bernard S. Fritz , Cleopatra Cabuz , Ernest A. Satren
发明人： Aravind Padmanabhan , Jay G. Schwichtenberg , Bernard S. Fritz , Cleopatra Cabuz , Ernest A. Satren
IPC分类号： G01N21/01 , G01N33/48 , G01N1/10 , G01N15/02
CPC分类号： G01N15/1459 , B01L3/502715 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0636 , B01L2200/0689 , B01L2300/0645 , B01L2300/0654 , B01L2400/0487 , B01L2400/0633 , G01N15/1456 , G01N15/1484 , G01N2015/008 , G01N2015/1452 , G01N2015/1486
摘要： A medium having microfluidic circuitry for sampling and analyses. The medium may be a cartridge having a window countersunk into it and containing a flow channel. The flow channel may have items of interest flowing through it. Analyses of these items may be optical involving one or more light sources emanating light to and one or more light detectors receiving light from the channel. There are various configurations so that source and detector light cones may reach the flow channel without obscuration or interference of the light to and from the flow channel in the window.
摘要翻译：具有用于取样和分析的微流体电路的介质。该介质可以是具有一个窗口沉入其中并包含流动通道的盒。流动通道可以具有流过其的兴趣物品。这些项目的分析可以是光学的，涉及发射光的一个或多个光源和从该通道接收光的一个或多个光检测器。存在各种配置，使得源和检测器光锥可以到达流动通道而不会使光在窗口中的流动通道的光线不受干扰或干扰。

44. 发明授权

US07262838B2 Optical detection system for flow cytometry 有权
标题翻译：流式细胞仪光学检测系统
公开(公告)号：US07262838B2
公开(公告)日：2007-08-28
申请号：US10759875
申请日：2004-01-16
申请人： Bernard S. Fritz
发明人： Bernard S. Fritz
IPC分类号： G01N21/00
CPC分类号： G01N15/1459 , A61B5/150022 , A61B5/150213 , A61B5/150221 , A61B5/150343 , G01N15/1456 , G01N15/1484 , G01N2015/1452 , G01N2015/1486 , G01N2015/1497
摘要： An optical detection system for flow cytometry that uses two or more light sources positioned laterally at different distances from a central axis of a flow stream for providing light through different parts of the flow stream. One or more lenses are used to focus the light from the two or more light sources through the flow stream and onto a common focal point or region on the opposite side of the flow stream. One or more light detectors are then placed at, near or around the common focal point or region. A processor or the like receives at least one output signal from the one or more light detectors to analyze and determine selected characteristics of the flow stream.
摘要翻译：一种用于流式细胞术的光学检测系统，其使用两个或更多个光源，所述两个或多个光源位于与流动流的中心轴线不同的距离处，用于通过流动流的不同部分提供光。一个或多个透镜用于将来自两个或更多个光源的光聚焦通过流动流并且聚焦在流动流的相对侧上的公共焦点或区域上。然后将一个或多个光检测器放置在公共焦点或区域附近或周围。处理器等从一个或多个光检测器接收至少一个输出信号，以分析和确定流流的选定特性。

45. 发明授权

US07130046B2 Data frame selection for cytometer analysis 有权
标题翻译：数据帧选择用于细胞仪分析
公开(公告)号：US07130046B2
公开(公告)日：2006-10-31
申请号：US10950898
申请日：2004-09-27
申请人： Bernard S. Fritz , Aravind Padmanabhan , Peter Reutiman
发明人： Bernard S. Fritz , Aravind Padmanabhan , Peter Reutiman
IPC分类号： G01N21/00
CPC分类号： G01N15/1404 , G01N15/1459 , G01N15/1484 , G01N2015/1075 , G01N2015/1413 , G01N2015/1477 , G01N2015/1486 , G01N2015/1493
摘要： A system for detecting when a core stream in a channel of a flow device is adequate for sufficient data accession. The system may determine the time period from the beginning of a sample run in a channel of a flow device to when the core stream is adequate. Data of detected FALS versus SALS light scattered by particles of the core stream may be plotted in data frames during a series of time intervals. The quality of the grouping and count rate of the data may indicate which frame and corresponding time interval reveal an adequate core stream.
摘要翻译：一种用于检测流量装置的通道中的核心流何时足以进行足够的数据登录的系统。系统可以确定从流动装置的通道中的样品运行开始到核心流足够时的时间段。在一系列时间间隔内，可以在数据帧中绘制检测到的FALS与由核心流的粒子散射的SALS光的数据。数据的分组和计数率的质量可以指示哪个帧和相应的时间间隔显示出足够的核心流。

46. 发明授权

US06909554B2 Wafer integration of micro-optics 有权
标题翻译：晶圆整合微光学
公开(公告)号：US06909554B2
公开(公告)日：2005-06-21
申请号：US10351710
申请日：2003-01-27
申请人： Yue Liu , Klein L. Johnson , James A. Cox , Bernard S. Fritz
发明人： Yue Liu , Klein L. Johnson , James A. Cox , Bernard S. Fritz
IPC分类号： G02B3/00 , G02B6/12 , G02B6/138 , G02B6/42 , G02B7/04 , G02B27/00 , H01L27/14 , H01L27/146 , H01L31/0232 , H01L33/00 , H04N5/335 , G02B27/10 , G03B13/24 , H01L27/00 , H01L27/148 , H04N5/225
CPC分类号： G02B3/0043 , F21Y2107/10 , F21Y2107/50 , F21Y2115/10 , G02B3/0012 , G02B3/0018 , G02B3/005 , G02B6/12002 , G02B6/138 , G02B6/4201 , G02B6/4206 , G02B6/4214 , G02B6/4249 , G02B7/04 , G02B27/0025 , H01L27/14627 , H01L31/02325 , H01L31/02327
摘要： The present invention provides an optical system that includes an array of opto-electronic devices, an array of micro lenses, and a fore optic. The array of opto-electronic devices lie substantially along a plane, but the fore optic has a non-planar focal field. To compensate for the non-planar focal field of the fore optic, each opto-electronic device has a corresponding micro lens. Each micro lens has a focal length and/or separation distance between it and it respective opto-electronic device, which compensates for the non-planar focal field of the fore optic. The focal lengths of these lenses may differ relative to one another. As a result, light that is provided by the fore optic is reconfigured by the micro lenses having various focal lengths to be substantially focused along the plane of the array of opto-electronic devices. Various arrangements of microlenses, placing lenses on standoffs or posts, forming of optical waveguides, lens fabrication, wafer integration of micro-optics, and optical coupling are noted.
摘要翻译：本发明提供了一种光学系统，其包括光电子器件阵列，微透镜阵列和前视镜。光电子器件的阵列基本上沿着平面放置，但前视镜具有非平面焦点。为了补偿前视镜的非平面焦点，每个光电器件具有相应的微透镜。每个微透镜在其与其相应的光电器件之间具有焦距和/或间隔距离，其补偿前光学器件的非平面焦点。这些透镜的焦距可以彼此不同。结果，由前光学器件提供的光由具有各种焦距的微透镜重新配置，以便沿着光电器件阵列的平面基本聚焦。注意到微透镜的各种布置，将透镜放置在支座或柱上，形成光波导，透镜制造，微光学器件的晶片集成以及光耦合。

47. 发明授权

US06718049B2 Near-infrared disguise detection 有权
标题翻译：近红外伪装检测
公开(公告)号：US06718049B2
公开(公告)日：2004-04-06
申请号：US10308465
申请日：2002-12-03
申请人： Ioannis Pavlidis , Peter F. Symosek , Bernard S. Fritz
发明人： Ioannis Pavlidis , Peter F. Symosek , Bernard S. Fritz
IPC分类号： G06K900
CPC分类号： G06K9/00362 , G06K9/00228 , G06K9/2018
摘要： Detection of a person disguised with one or more artificial materials includes detecting reflection from at least one portion of a head of a human body in at least a portion of an upper band of the near infrared spectrum. The presence of an artificial material associated with the head of the human body is determined based on the detected reflection.
摘要翻译：用一种或多种人造材料伪装的人的检测包括在近红外光谱的上部带的至少一部分中检测来自人体的头部的至少一部分的反射。基于检测到的反射来确定与人体头部相关联的人造材料的存在。

48. 发明授权

US5838490A Head mounted display system using mangin mirror combiner 失效
标题翻译：头戴式显示系统采用美制镜组合
公开(公告)号：US5838490A
公开(公告)日：1998-11-17
申请号：US740741
申请日：1996-11-04
申请人： Bernard S. Fritz
发明人： Bernard S. Fritz
IPC分类号： G02B27/00 , G02B27/01 , G02B27/14
CPC分类号： G02B27/0172 , G02B2027/011
摘要： A head mounted display which utilizes a flat image source, an optical system including a reflecting filter and a Mangin mirror having at least one curved surface, operable to make the flat image compatible with the flat image source, and provide an undistorted image to be viewed by the eye of a viewer.
摘要翻译：一种头戴式显示器，其利用平面图像源，包括反射滤光器的光学系统和具有至少一个曲面的漫反射镜，可操作以使平面图像与平面图像源兼容，并提供待观看的未失真图像通过观众的眼睛。

49. 发明授权

US09104011B2 Light collector devices 有权
标题翻译：集光器件
公开(公告)号：US09104011B2
公开(公告)日：2015-08-11
申请号：US13219242
申请日：2011-08-26
申请人： Matthew S. Marcus , Bernard S. Fritz
发明人： Matthew S. Marcus , Bernard S. Fritz
IPC分类号： G02B19/00
CPC分类号： G02B19/0019 , G02B19/0038 , G02B19/0076
摘要： Light collector devices and methods of operating light collector devices are described herein. One or more embodiments include a plurality of apertures, and a detector coupled to each of the plurality of apertures.
摘要翻译：本文描述了集光器件和操作集光器件的方法。一个或多个实施例包括多个孔，以及耦合到多个孔中的每一个的检测器。

50. 发明授权

US08981296B2 Terahertz dispersive spectrometer system 有权
标题翻译：太赫兹色散光谱仪系统
公开(公告)号：US08981296B2
公开(公告)日：2015-03-17
申请号：US13367209
申请日：2012-02-06
申请人： James A. Cox , Bernard S. Fritz , Fouad Nusseibeh
发明人： James A. Cox , Bernard S. Fritz , Fouad Nusseibeh
IPC分类号： G01J5/00 , G01J5/02 , G01J5/08 , G01J5/10 , G01J3/42 , G01N21/3581 , G01N21/3563 , G01N21/3577
CPC分类号： G01J3/42 , G01J5/0837 , G01N21/3563 , G01N21/3577 , G01N21/3581
摘要： A spectrometer system for providing information about a target with terahertz radiation. The system may receive incident radiation from the target through fore optics, a slit aperture, secondary optics and a dispersive element which images a slit on an array of terahertz sensitive detectors. The detectors may include uncooled sensors. Each sensor may be connected to its own micro antenna. The array of detectors may be situated proximate to the dispersive element so that radiation from the element may be dispersed according to wavelength to the respective detectors optimally sensitive to the various respective wavelengths. Detector signals indicating the impingement of terahertz radiation may provide information for identifying a material of the target.
摘要翻译：用于提供有关太赫兹辐射的目标信息的光谱仪系统。该系统可以通过前光学器件，狭缝孔，次光学器件和对在太赫兹敏感探测器阵列上的狭缝进行成像的色散元件来接收来自靶的入射辐射。检测器可以包括非制冷传感器。每个传感器可以连接到其自己的微天线。检测器阵列可以位于分散元件附近，使得来自元件的辐射可以根据波长分散到对各种相应波长最佳敏感的各个检测器。指示太赫兹辐射冲击的检测器信号可以提供用于识别目标材料的信息。

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