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41. 发明授权

US06903485B2 Claw-pole alternator with non-uniform air gap 失效
标题翻译：爪式交流发电机具有不均匀的气隙
公开(公告)号：US06903485B2
公开(公告)日：2005-06-07
申请号：US10442332
申请日：2003-05-21
申请人： Hanyang B. Chen , Steven J. Yockey , Michael T. York
发明人： Hanyang B. Chen , Steven J. Yockey , Michael T. York
IPC分类号： H02K1/22 , H02K19/22 , H02K21/00
CPC分类号： H02K21/044 , H02K2201/03
摘要： An alternator of the present invention includes a housing, a stator assembly mounted stationary within the housing, and a rotor assembly mounted rotatably within the housing in functional engagement with the stator assembly. An air gap extends annularly around the alternator between the rotor assembly and the stator assembly. The rotor assembly has a first end and a second end, and the air gap has a non-uniform thickness that varies along the axial length of the rotor assembly between the first and second ends of the rotor assembly. This non-uniform thickness is designed to avoid interference between rotor outer surface and stator inner surface at high rotor spin speed, but minimize the averaged air gap thickness for high alternator performance.
摘要翻译：本发明的交流发电机包括壳体，固定在壳体内的定子组件，以及可旋转地安装在壳体内的与定子组件功能接合的转子组件。气隙在转子组件和定子组件之间的交流发电机周围环形地延伸。转子组件具有第一端和第二端，并且气隙具有沿转子组件的轴向长度在转子组件的第一和第二端之间变化的不均匀厚度。这种不均匀的厚度被设计为避免转子外表面和定子内表面之间在高转子旋转速度下的干扰，但是对于高交流发电机性能来说，最小化平均气隙厚度。

42. 发明授权

US06773674B2 Thermal analysis for detection and identification of explosives and other controlled substances 失效
标题翻译：用于检测和识别爆炸物和其他受控物质的热分析
公开(公告)号：US06773674B2
公开(公告)日：2004-08-10
申请号：US10066253
申请日：2002-01-31
申请人： William W. Bannister , Chien-Chung Chen , William A. Curby , Eric B. Chen , Paul L. Damour , Antonio Morales
发明人： William W. Bannister , Chien-Chung Chen , William A. Curby , Eric B. Chen , Paul L. Damour , Antonio Morales
IPC分类号： G01N700
CPC分类号： G01N25/4866 , G01N33/0057 , Y10T436/11
摘要： The invention features methods and systems for detecting the presence of an energetic material in a sample in which the presence of the energetic material is unknown. The method includes the steps of: heating the sample; measuring heat flow between the sample and its surrounding environment, e.g., by using differential scanning calorimetry (DSC); and analyzing the measured heat flow between the sample and its surrounding environment. An exothermal peak in the measured heat flow indicates the presence of the energetic material in the sample. The system includes a thermal measuring apparatus for performing the heating and measuring steps, and an analyzer for detecting the presence of the energetic material based on the measured heat flow. The invention also features methods and systems for identifying contraband materials (e.g., explosives and drugs) by measuring the thermogram (e.g., by DSC) of a sample to be identified and comparing it to reference thermograms for known contraband materials.
摘要翻译：本发明的特征在于用于检测在能量材料的存在是未知的样品中能量材料的存在的方法和系统。该方法包括以下步骤：加热样品; 测量样品和其周围环境之间的热流，例如通过使用差示扫描量热法（DSC）; 并分析样品与其周围环境之间的测量热流。测量热流中的放热峰表明样品中存在高能材料。该系统包括用于执行加热和测量步骤的热测量装置，以及用于基于测量的热流检测能量材料的存在的分析器。本发明还具有用于通过测量要鉴定的样品的温谱图（例如通过DSC）来鉴定违禁物质（例如爆炸物和药物）的方法和系统，并将其与已知违禁物质的参考热分析图进行比较。

43. 发明授权

US06251944B1 Para-substituted phenylene derivatives 失效
标题翻译：对位取代亚苯衍生物
公开(公告)号：US06251944B1
公开(公告)日：2001-06-26
申请号：US09288742
申请日：1999-04-08
申请人： Barbara B. Chen , Helen Y. Chen , Glen J. Gesicki , Richard A. Haack , James W. Malecha , Thomas D. Penning , Joseph G. Rico , Thomas E. Rogers , Peter G. Ruminski , Mark A. Russell , Stella S. Yu
发明人： Barbara B. Chen , Helen Y. Chen , Glen J. Gesicki , Richard A. Haack , James W. Malecha , Thomas D. Penning , Joseph G. Rico , Thomas E. Rogers , Peter G. Ruminski , Mark A. Russell , Stella S. Yu
IPC分类号： A61K3119
CPC分类号： C07D271/07 , A61K31/155 , C07C275/42 , C07C279/18 , C07C279/22 , C07C279/24 , C07C279/28 , C07C311/06 , C07C311/13 , C07C311/19 , C07C311/64 , C07C317/44 , C07C323/52 , C07D223/12 , C07D231/12 , C07D233/50 , C07D233/56 , C07D233/88 , C07D239/14 , C07D249/08 , C07D249/14 , C07D295/215
摘要： The present invention relates to a class of compounds represented by Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical composition comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the &agr;v&bgr;3 integrin.
摘要翻译：本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物，以及选择性抑制或拮抗α-角蛋白3整联蛋白的方法。

44. 发明授权

US5618831A Composition and method for treating cancer 失效
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：US5618831A
公开(公告)日：1997-04-08
申请号：US242834
申请日：1994-05-16
申请人： Tadao Shishido , Masayuki Kawakami , Akihiko Ikegawa , Toshinao Ukai , Keizo Koya , Lan B. Chen
发明人： Tadao Shishido , Masayuki Kawakami , Akihiko Ikegawa , Toshinao Ukai , Keizo Koya , Lan B. Chen
IPC分类号： A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/506 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/505
CPC分类号： A61K31/541 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/506
摘要： A pharmaceutical composition for treatment of cancer in an animal comprising:(A) a therapeutically effective amount of at least one compound selected from the group consisting of compounds represented by the General Formula (I). ##STR1## wherein Z.sub.1 and Z.sub.2, which may be the same or different, each represents an atomic group necessary to form a 5- or 6-membered ring;R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, each represents an alkyl group or an aryl group;L.sub.1 and L.sub.2 each represents a methine group or a substituted methine group;X represents a pharmaceutically acceptable anion;k represents a number necessary for electrical charge balance;n represents 0 or 1; and(B) a pharmaceutically acceptable carrier or diluent.
摘要翻译：一种用于治疗动物癌症的药物组合物，其包含：（A）治疗有效量的至少一种选自由通式（I）表示的化合物的化合物。（I）其中Z1和Z2可以相同或不同，分别代表形成5-或6-元环所必需的原子团; R 1，R 2和R 3可以相同或不同，表示烷基或芳基; L1和L2各自表示次甲基或取代的次甲基; X表示药学上可接受的阴离子; k表示电荷平衡所需的数字; n表示0或1; 和（B）药学上可接受的载体或稀释剂。

45. 发明授权

US5585492A LTA.sub.4 Hydrolase inhibitors 失效
标题翻译： LTA4水解酶抑制剂
公开(公告)号：US5585492A
公开(公告)日：1996-12-17
申请号：US321183
申请日：1994-10-11
申请人： Nizal S. Chandrakumar , Barbara B. Chen , Michael Clare , Bipinchandra N. Desai , Stevan W. Djuric , Stephen H. Docter , Alan F. Gasiecki , Richard A. Haack , Chi-Dean Liang , Julie M. Miyashiro , Thomas D. Penning , Mark A,. Russell , Stella S. Yu
发明人： Nizal S. Chandrakumar , Barbara B. Chen , Michael Clare , Bipinchandra N. Desai , Stevan W. Djuric , Stephen H. Docter , Alan F. Gasiecki , Richard A. Haack , Chi-Dean Liang , Julie M. Miyashiro , Thomas D. Penning , Mark A,. Russell , Stella S. Yu
IPC分类号： C07D295/08 , A61K31/09 , A61K31/135 , A61K31/165 , A61K31/19 , A61K31/195 , A61K31/215 , A61K31/27 , A61K31/336 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/35 , A61K31/352 , A61K31/357 , A61K31/36 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/415 , A61K31/4184 , A61K31/425 , A61K31/426 , A61K31/435 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/46 , A61K31/495 , A61K31/535 , A61K31/55 , A61K31/695 , A61P17/00 , A61P29/00 , A61P43/00 , C07C217/16 , C07C217/18 , C07C229/08 , C07C229/12 , C07C237/06 , C07C271/44 , C07D207/06 , C07D207/08 , C07D207/12 , C07D207/16 , C07D209/12 , C07D209/52 , C07D211/34 , C07D211/58 , C07D211/60 , C07D211/62 , C07D211/74 , C07D213/30 , C07D213/55 , C07D213/56 , C07D213/61 , C07D213/69 , C07D213/73 , C07D213/74 , C07D213/75 , C07D215/12 , C07D223/02 , C07D225/02 , C07D235/08 , C07D277/20 , C07D277/24 , C07D277/34 , C07D295/092 , C07D295/12 , C07D295/14 , C07D295/18 , C07D295/185 , C07D295/215 , C07D295/22 , C07D295/26 , C07D303/02 , C07D307/42 , C07D307/81 , C07D311/58 , C07D317/54 , C07D333/16 , C07D333/32 , C07D401/04 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D417/12 , C07D451/02 , C07D471/04 , C07D471/08 , C07D473/00 , C07D473/28 , C07D491/048 , C07D491/107 , C07D207/10 , C07D207/14
CPC分类号： C07D295/185 , C07C217/16 , C07C229/12 , C07C237/06 , C07D277/24 , C07D295/088 , C07D295/215 , C07D295/26
摘要： The present invention provides compounds of the formula Ar.sup.1 --Q--Ar.sup.2 --Y--R--Z and pharmaceutically acceptable salts thereof wherein Ar.sup.1 and Ar.sup.2 are optionally substituted aryl moieties, Z is an optionally substituted nitrogen-containing moiety which may be an acyclic, cyclic or bicyclic amine or an optionally substituted monocyclic or bicyclic nitrogen-containing heteroaromatic moiety; Q is a linking group capable of linking two aryl groups; R is an alkylene moiety; Y is a linking moiety capable of linking an aryl group to an alkylene moiety and wherein Z is bonded to R through a nitrogen atom. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of inflammatory diseases which are mediated by LTB.sub.4 production, such as psoriasis, ulcerative colitis, IBD and asthma.
摘要翻译：本发明提供式Ar1-Q-Ar2-YRZ的化合物及其药学上可接受的盐，其中Ar1和Ar2是任选取代的芳基部分，Z是任选取代的含氮部分，其可以是无环的，环状的或双环的胺，或任选取代的单环或双环含氮杂芳基部分; Q是能够连接两个芳基的连接基团; R是亚烷基部分; Y是能够将芳基连接到亚烷基部分并且其中Z通过氮原子与R键合的连接部分。本发明的化合物和药物组合物可用于治疗由LTB4产生介导的炎性疾病，例如牛皮癣，溃疡性结肠炎，IBD和哮喘。

46. 发明授权

US5446232A Removing oxygen from hydrocarbon gases 失效
标题翻译：从碳氢化合物气体中除去氧气
公开(公告)号：US5446232A
公开(公告)日：1995-08-29
申请号：US195310
申请日：1994-02-14
申请人： Hang-Chang B. Chen , Deborah J. Olsen
发明人： Hang-Chang B. Chen , Deborah J. Olsen
IPC分类号： C01B3/58 , C07C7/148 , C07C17/38 , C01B13/00 , C07C7/152
CPC分类号： C07C7/148 , C01B3/58 , C07C17/38 , C01B2203/0435 , C01B2203/0465
摘要： Disclosed is a method and apparatus for removing oxygen from hydrogen, hydrocarbon, or halogenated hydrocarbon gas which contains about 0.01 to about 10 mole % oxygen. The oxygen removal is accomplished by contacting the gas with a Hopcalite catalyst at a temperature of about 100.degree. to about 300.degree. C. The invention can be part of a process for making 1,2-dichloroethane where, in a first reaction, ethane and chlorine are reacted to make ethylene and hydrogen chloride and, in a second reaction, the ethylene and hydrogen chloride are reacted with excess oxygen to make the 1,2-dichloroethane. The unreacted ethane can be recycled to the first step after the method of the invention is applied to remove the oxygen.
摘要翻译：公开了一种从含有约0.01至约10摩尔％氧气的氢，烃或卤代烃气体中除去氧气的方法和装置。除氧是通过在约100℃至约300℃的温度下将气体与Hopcalite催化剂接触来实现的。本发明可以是制备1,2-二氯乙烷的方法的一部分，其中在第一反应中，乙烷和使氯气反应生成乙烯和氯化氢，在第二个反应中，乙烯和氯化氢与过量的氧气反应生成1,2-二氯乙烷。在应用本发明的方法去除氧气之后，未反应的乙烷可以再循环到第一步。

47. 发明授权

US5360803A Composition and method for treating cancer 失效
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：US5360803A
公开(公告)日：1994-11-01
申请号：US972935
申请日：1992-11-06
申请人： Tadao Shishido , Lan B. Chen
发明人： Tadao Shishido , Lan B. Chen
IPC分类号： A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/4427 , A61K31/47 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/555 , A61P35/00 , C07D277/20 , C07D277/34 , C07D277/66 , C07D277/84 , C07D401/14 , C07D413/14 , C07D417/04 , C07D417/14 , C07D421/14 , C07D471/04 , C07D513/04
CPC分类号： A61K31/44 , A61K31/42 , A61K31/425 , A61K31/47 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/555
摘要： A pharmaceutical composition for treatment of cancer comprises:(A) a therapeutically effective amount of at least one compound selected from the group consisting of compounds represented by the General Formula (I) ##STR1## wherein X.sub.1 and X.sub.2, which may be the same or different, each represents O, S, Se, --CH.dbd.CH--, ##STR2## Y.sub.1 represents O, S, Se, or ##STR3## R.sub.1 and R.sub.3, which may be the same or different, each represents an alkyl group;R.sub.2 represents an alkyl group, an aryl group or a heterocyclic group;Z.sub.1 and Z.sub.2, which may be the same or different, each represents an atomic group necessary to form a 5- or 6-membered ring;L.sub.1 represents a methine group or L.sub.1 and R.sub.3 may combine and form a 5- or 6-membered ring;R.sub.4 and R.sub.5, which may be the same or different, each represents a alkyl group;R.sub.6 and R.sub.7, which may be the same or different, each represents an alkyl group or an aryl group;Q represents a pharmaceutically acceptable anion;l represents 1 or 2;m and n, which may be the same or different, each represents 0 or 1; and(B) a pharmaceutically acceptable carrier or diluent.
摘要翻译：用于治疗癌症的药物组合物包括：（A）治疗有效量的至少一种选自由通式（I）表示的化合物的化合物，其中X1和X2可以是相同或不同，各自表示O，S，Se，-CH = CH-， Y1表示O，S，Se或者可以相同或不同的R 1和R 3各自表示烷基组; R2表示烷基，芳基或杂环基; Z 1和Z 2可以相同或不同，表示形成5-或6-元环所必需的原子团; L1表示次甲基或L1和R3可以结合形成5-或6-元环; R 4和R 5可以相同或不同，各自表示烷基; R 6和R 7可以相同或不同，各自表示烷基或芳基; Q表示药学上可接受的阴离子; l表示1或2; m和n可以相同或不同，各自表示0或1; 和（B）药学上可接受的载体或稀释剂。

48. 发明授权

US5113028A Process for mixing ethane and chlorine gases 失效
标题翻译：混合乙烷和氯气的方法
公开(公告)号：US5113028A
公开(公告)日：1992-05-12
申请号：US739042
申请日：1991-08-01
申请人： Hang-Chang B. Chen , Gerald F. Achee
发明人： Hang-Chang B. Chen , Gerald F. Achee
IPC分类号： B01F5/00
CPC分类号： B01F5/0057
摘要： A process for mixing hot ethane with chlorine gas using a mixer consisting of a main pipe through which ethane is conducted, and four or more jets through which chlorine gas is introduced into the main pipe. The angle between the axis of each jet and the line from the center point to the point where the axis of each jet makes contact with the inside surface of the main pipe ranges between about 30.degree. to 45.degree..
摘要翻译：使用由引入乙烷的主管构成的混合器以及将氯气引入主管中的四个或更多个喷射器将热乙烷与氯气混合的方法。每个射流的轴线与从中心点到每个射流的轴线与主管内表面接触的点之间的夹角在30°至45°之间。

49. 发明授权

US4596723A Immunoassay substrate 失效
标题翻译：免疫测定底物
公开(公告)号：US4596723A
公开(公告)日：1986-06-24
申请号：US606387
申请日：1984-05-02
申请人： Nancy K. Kaufman , Richard A. Harte , Anthony B. Chen
发明人： Nancy K. Kaufman , Richard A. Harte , Anthony B. Chen
IPC分类号： G01N33/543 , B05D3/02
CPC分类号： G01N33/543 , Y10T428/254
摘要： Preparation of an immunoassay gel substrate which includes the steps of depositing on an immobilizing support structure a liquid mass of a gel-forming emulsion which coalesces into a thick gel-like matrix film characterized by substantial non-agglomerated matrix homogeneity, treating the resulting film to alter matrix homogeneity by agglomerating particles which form part of the gel, and as a consequence of the treating step establishing the object gel. Treating may be performed either by subjecting the gel to multiple time-vigorous water-wash and dry cycles, by emersing the gel in water for a relatively long period of time, or by wetting the gel and then subjecting it to one or more freeze/thaw cycles.
摘要翻译：制备免疫测定凝胶基质，其包括以下步骤：在固定的支持结构上沉积凝胶形成乳液的液体物质，所述液体物质凝结成厚的凝胶状基质膜，其特征在于基本上非团聚的基质均匀性，将所得膜处理通过凝聚形成凝胶的一部分的颗粒来改变基质的均匀性，并且作为建立目标凝胶的处理步骤的结果。处理可以通过使凝胶经受多次时间强烈的水洗和干燥循环，通过在水中照射较长时间的凝胶，或通过润湿凝胶，然后使其经受一次或多次冷冻/ 解冻周期。

50. 发明授权

US4468371A Immunoassay test slide 失效
标题翻译：免疫测定试片
公开(公告)号：US4468371A
公开(公告)日：1984-08-28
申请号：US399920
申请日：1982-07-19
申请人： Anthony B. Chen , Richard A. Harte , Nancy K. Kaufman
发明人： Anthony B. Chen , Richard A. Harte , Nancy K. Kaufman
IPC分类号： G01N33/53 , G01N33/54 , G01N35/00 , G01N35/02
CPC分类号： G01N33/5304 , Y10S436/809
摘要： A test slide for the performance of a series of immunoassay tests having: a substantially elongated and thin body of solid material; a plurality of individual test wells formed in said body; alignment means formed in said body in association with each of said wells; and movement facilitating means formed in said body; said slide being suitable for insertion into an automated testing device, said slide moving by said movement facilitating means, and said wells being aligned for detection by said alignment means.
摘要翻译：用于执行一系列免疫测定试验的测试载玻片，其具有：基本上细长且薄的固体材料; 在所述主体中形成的多个单独测试井; 与每个所述孔相关联地在所述主体中形成对准装置; 以及形成在所述主体中的运动促进装置; 所述滑动件适于插入到自动化测试装置中，所述滑块由所述移动促动装置移动，并且所述孔对准以便由所述对准装置检测。

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