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41. 发明授权

US10981983B2 Antibody targeting interleukin 17A and preparation method and application thereof 有权
公开(公告)号：US10981983B2
公开(公告)日：2021-04-20
申请号：US16461128
申请日：2018-01-19
申请人： Huabo Biopharm (Shanghai) Co., Ltd.
发明人： Xiangyang Zhu , Mingqing Cai , Haijia Yu , Huifeng Jia , Ling Yu
IPC分类号： C07K16/24 , C07K14/725 , C07K14/54 , A61K39/00
摘要： The present invention provides an antibody targeted to interleukin 17A (IL-17A), preparation method and the use thereof. In particular, the invention provides a novel anti-IL-17A monoclonal antibody. The antibody of the present invention is capable of binding IL-17A antigen with high specificity, has high affinity and low immunogenicity, and is used for preparing a medicament for preventing or treating an IL-17A-related disease such as various inflammatory or autoimmune diseases.

42. 发明授权

US10977766B2 Line-based image registration and cross-image annotation devices, systems and methods 有权
公开(公告)号：US10977766B2
公开(公告)日：2021-04-13
申请号：US16706630
申请日：2019-12-06
申请人： Ventana Medical Systems, Inc.
发明人： Srinivas Chukka , Anindya Sarkar , Quan Yuan
IPC分类号： G06T7/33 , G06T3/00 , G06K9/00 , G16H30/20 , G16H30/40
摘要： The disclosure relates to devices, systems and methods for image registration and annotation. The devices include computer software products for aligning whole slide digital images on a common grid and transferring annotations from one aligned image to another aligned image on the basis of matching tissue structure. The systems include computer-implemented systems such as work stations and networked computers for accomplishing the tissue-structure based image registration and cross-image annotation. The methods include processes for aligning digital images corresponding to adjacent tissue sections on a common grid based on tissue structure, and transferring annotations from one of the adjacent tissue images to another of the adjacent tissue images. The basis for alignment may be a line-based registration process, wherein sets of lines are computed on the boundary regions computed for the two images, where the boundary regions are obtained using information from two domains—soft-weighted foreground images and gradient magnitude images. The binary mask image, based on whose boundary the line features are computed, may be generated by combining two binary masks—a first binary mask is obtained on thresholding a soft-weighted (continuous valued) foreground image, which is computed based on the stain content in an image, while a second binary mask is obtained after thresholding a gradient magnitude domain image, where the gradient is computed from the grayscale image obtained from the color image.

43. 发明授权

US10954495B2 Nucleic acid modifying enzymes 有权
公开(公告)号：US10954495B2
公开(公告)日：2021-03-23
申请号：US16101895
申请日：2018-08-13
申请人： Bio-Rad Laboratories, Inc.
发明人： Yan Wang
IPC分类号： C12N9/12 , C07K14/00 , C07K19/00 , C12P19/34 , C12N9/96
摘要： This invention provides for an improved generation of novel nucleic acid modifying enzymes. The improvement is the fusion of a sequence-non-specific nucleic-acid-binding domain to the enzyme in a manner that enhances the ability of the enzyme to bind and catalytically modify the nucleic acid.

44. 发明授权

US10948403B2 Protein quantitation device 有权
公开(公告)号：US10948403B2
公开(公告)日：2021-03-16
申请号：US16151732
申请日：2018-10-04
申请人： Bio-Rad Laboratories, Inc.
发明人： Evan Thrush , Steven Swihart , William Strong , Trey Marlowe , Li Lu
IPC分类号： G01N21/31 , G01N21/3577 , G01N21/3563
摘要： Systems for protein quantitation using a Fabry-Perot interferometer. In one arrangement, a quantitation device includes an infrared source, a sample holder, and a Fabry-Perot interferometer positioned to receive infrared radiation from the source passing through a sample on the sample holder. A band pass optical filter sets the working range of the interferometer, and radiation exiting the interferometer falls on a detector that produces a signal indicating the intensity of the received radiation. A controller causes the interferometer to be tuned to a number of different resonance wavelengths and receives the intensity signals, for determination of an absorbance spectrum.

45. 发明授权

US10919038B2 Modification of surface properties of microfluidic devices 有权
公开(公告)号：US10919038B2
公开(公告)日：2021-02-16
申请号：US15855913
申请日：2017-12-27
申请人： Bio-Rad Laboratories, Inc.
发明人： Joshua Ritchey , Yi Xue , Robert Meltzer
IPC分类号： C09D183/04 , B01L3/00 , C09D183/00 , B81C1/00 , C12Q1/686
摘要： Compositions, devices, and methods are disclosed for the modification of polymer surfaces with coatings having a dispersion of silicone polymer and hydrophobic silica. The surface coatings provide the polymer surface with high hydrophobicity, as well as increased resistance to biofouling with proteinaceous material. The polymer surfaces can be particularly useful in microfluidic devices and methods that involve the contacting of the covalently modified polymer surfaces with emulsions of aqueous droplets containing biological macromolecules within an oil carrier phase.

46. 发明授权

US10883987B2 Lateral flow device 有权
公开(公告)号：US10883987B2
公开(公告)日：2021-01-05
申请号：US15877658
申请日：2018-01-23
申请人： Bio-Rad Laboratories, Inc.
发明人： William Strong , Clayton T. McKee
IPC分类号： G01N33/558 , G01N33/543 , B01L3/00
摘要： Lateral flow devices, methods and kits for performing lateral flow assays are provided.

47. 发明授权

US10876112B2 Second strand direct 有权
公开(公告)号：US10876112B2
公开(公告)日：2020-12-29
申请号：US16687411
申请日：2019-11-18
申请人： Bio-Rad Laboratories, Inc. , Bio-Rad Europe GmbH
发明人： Ronald Lebofsky , Jeremy Agresti
IPC分类号： C12N15/10
CPC分类号： C12N15/1096 , C12N15/1065
摘要： Methods and compositions are provided herein for preparing high-throughput cDNA sequencing libraries.

48. 发明授权

US10852273B2 Dip-stick western blot 有权
公开(公告)号：US10852273B2
公开(公告)日：2020-12-01
申请号：US16138860
申请日：2018-09-21
申请人： Bio-Rad Laboratories, Inc.
发明人： William Strong
IPC分类号： G01N27/447 , G01N33/543 , G01N30/90
摘要： Methods, kits, and systems are provided for separating, immobilizing, and/or detecting analytes of one or more samples using dipsticks. A ‘dipstick’ is an object that can be embedded and subsequently removed from a separation medium, and to which analytes can be immobilized while the object is embedded in the separation medium. Examples of separation media include an electrophoresis gel of any format and a stationary phase for column chromatography. Embodiments of the present methods include applying a sample to a separation medium; separating analytes of the sample in the separation medium along a separation axis; immobilizing the analytes on a dipstick embedded in the separation medium; removing the dipstick from the separation medium; and detecting the analytes immobilized on the removed dipstick.

49. 发明授权

US10827273B2 Dual loudspeaker enabled cooling 有权
公开(公告)号：US10827273B2
公开(公告)日：2020-11-03
申请号：US16698136
申请日：2019-11-27
申请人： Apple Inc.
发明人： Michael B. Nussbaum , Jason C. Della Rosa , Glenn K. Trainer
IPC分类号： H04R9/02 , H04R1/02 , H05K7/20
摘要： Electronics devices according to embodiments of the present technology may include a first loudspeaker and a second loudspeaker disposed in a housing. The housing may define a first internal volume between a first end of the housing and a backside of the first loudspeaker. The housing may define a second internal volume between a second end of the housing and a backside of the second loudspeaker. The first loudspeaker and the second loudspeaker may be positioned within the housing so a front side of the first loudspeaker faces a front side of the second loudspeaker. A duct may be defined by the housing, which may access the first internal volume at a first end and may access the second internal volume at a second end. The electronic device may also include a processor configured to deliver signals to the first loudspeaker and the second loudspeaker.

50. 发明授权

US10824536B1 Clustering techniques for third party application data 有权
公开(公告)号：US10824536B1
公开(公告)日：2020-11-03
申请号：US16671128
申请日：2019-10-31
申请人： Apple Inc.
发明人： Amit K. Vyas , Abhinav Pathak , Anthony R. Newnam , Anshul Dawra , Vincent B. Yeh , Steve Brashear , Andreas C. Bergen , Yue Li , Rohit Mundra , Ritika Kalia , Anca A. Chandra , Sanket Bedare
IPC分类号： G06F15/173 , G06F11/34 , G06F9/54 , G06F16/906
摘要： Embodiments of the present disclosure present devices, methods, and computer readable medium for techniques for measuring operational performance metrics, and presenting these metrics through an application programming interface (API) for developers to access for optimizing their applications. Exemplary metrics can include central processing unit or graphics processing unit time, foreground/background time, networking bytes (per application), location activity, display average picture luminance, cellular networking condition, peak memory, number of logical writes, launch and resume time, frame rates, and hang time. Regional markers can also be used to measure specific metrics for in application tasks. The techniques provide multiple user interfaces to help developers recognize the important metrics to optimize the performance of their applications. The data can be normalized over various different devices having different battery size, screen size, and processing requirements. The user interfaces can provide an intelligent method for visualizing performance changes for significant changes in application versions.

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