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31. 发明授权

US4518608A Watersoluble derivatives of non-steroidal anti-inflammatory agents and a process for the production thereof 失效
标题翻译：非甾体抗炎药的水溶性衍生物及其制备方法
公开(公告)号：US4518608A
公开(公告)日：1985-05-21
申请号：US486861
申请日：1983-04-20
申请人： Agostne Kahan
发明人： Agostne Kahan
IPC分类号： A61K31/13 , A61K9/00 , A61K9/66 , A61K31/00 , A61K31/19 , A61K31/195 , A61K31/205 , A61K31/255 , A61K31/40 , A61K31/405 , A61K31/455 , A61K31/54 , A61K31/60 , A61K31/616 , A61K47/18 , A61P29/00 , C07C57/30 , C07C59/64 , C07C59/68 , C07C59/84
CPC分类号： A61K9/0014 , A61K31/19 , A61K31/195 , A61K31/405 , A61K31/455 , A61K31/54 , A61K31/60 , A61K47/18 , A61K47/183 , A61K9/0019 , C07C57/30 , C07C59/64 , C07C59/68 , C07C59/84
摘要： The invention relates to watersoluble derivatives of non-steroidal anti-inflammatory drugs and also to therapeutic compositions containing these derivatives.
摘要翻译：本发明涉及非甾体抗炎药的水溶性衍生物，还涉及含有这些衍生物的治疗组合物。

32. 发明授权

US4421927A New cinnamoyl-cinnamic acid derivative, and its use as pharmaceutical 失效
标题翻译：新型肉桂酰 - 肉桂酸衍生物及其用作药物
公开(公告)号：US4421927A
公开(公告)日：1983-12-20
申请号：US314041
申请日：1981-10-22
申请人： Francois Picart
发明人： Francois Picart
IPC分类号： C07D295/18 , A61K31/135 , A61K31/165 , A61K31/19 , A61K31/195 , A61K31/215 , A61K31/495 , A61K31/54 , A61P17/00 , A61P43/00 , C07C51/00 , C07C59/76 , C07C59/84 , C07C59/88 , C07C59/90 , C07C67/00 , C07C69/003 , C07D295/08 , C07D295/088 , C07D295/185 , C07D317/30 , C07C69/76
CPC分类号： C07D295/185 , C07C59/84 , C07C59/88 , C07C59/90 , C07D295/088 , C07D317/30 , Y10S514/859 , Y10S514/861 , Y10S514/863
摘要： The present invention relates to a new cinnamoyl-cinnamic acid derivative selected from the group constituted by:(i) the m-cinnamoyl-cinnamic acid derivatives of formula ##STR1## in which: X.sub.o,X.sub.1,X.sub.2,X.sub.3,X.sub.4, which are identical or different, each represent an atom of hydrogen, a halogen, a lower alkyl group, a lower alkoxy group, the group NRR' (where R and R' identical or different, each represent an atom of hydrogen or a lower alkyl group), the group NO.sub.2, CF.sub.3 or OH;R.sub.1 represents an atom of hydrogen or a lower alkyl group;R.sub.2 represents an atom of hydrogen or the methyl group;Y represents a group OH, OR.sub.3 (where R.sub.3 is a lower alkyl group), NRR' (where R and R' are defined as hereinabove) or the group O(CH.sub.2).sub.n NR.sub.4 R.sub.5 (where n is an integer of value 1 to 5--and preferably 2 or 3)--; and R.sub.4 and R.sub.5, identical or different, each represent an atom of hydrogen, a lower alkyl group and may form with the nitrogen atom to which they are bonded a heterocyclic group of 5 to 7 vertices capable of being substituted and of comprising one or more other heteroatoms such as N and O);(ii) their geometrical isomers; and(iii) their salts.It also relates to its method of preparation and its use as pharmaceutical.
摘要翻译：本发明涉及一种新的肉桂酰 - 肉桂酸衍生物，其选自由以下组成的组：（i）式（I）的间肉桂酰 - 肉桂酸衍生物，其中：Xo，X1，X2，X3，X4 相同或不同，各自表示氢原子，卤素，低级烷基，低级烷氧基，NRR'基团（其中R和R'相同或不同，各自表示氢原子或低级烷基），基团NO 2，CF 3或OH; R1表示氢原子或低级烷基; R2表示氢或甲基的原子; Y表示OH，OR 3（其中R 3是低级烷基），NRR'（其中R和R'如上定义）或O（CH 2）n NR 4 R 5基团（其中n是1至5的整数）优选2或3） - ; 并且R 4和R 5相同或不同，各自表示氢原子，低级烷基，并且可以与它们所连接的氮原子形成5至7个能够被取代的顶点的杂环基并且包含一个或多个其它杂原子如N和O）; （ii）它们的几何异构体; 和（iii）它们的盐。它还涉及其制备方法及其作为药物的用途。

33. 发明授权

US4369206A Ammonium salts of .alpha.-ketocarboxylic acids 失效
标题翻译： α-酮羧酸的铵盐
公开(公告)号：US4369206A
公开(公告)日：1983-01-18
申请号：US54315
申请日：1979-07-02
申请人： Wofram Mayer , Hans Rudolph , Eckhard de Cleur , Manfred Schonfelder
发明人： Wofram Mayer , Hans Rudolph , Eckhard de Cleur , Manfred Schonfelder
IPC分类号： C07C69/716 , C07C51/00 , C07C55/07 , C07C59/153 , C07C59/185 , C07C59/347 , C07C59/76 , C07C59/84 , C07C59/90 , C07C67/00 , C07C201/00 , C07C205/61 , C07C209/00 , C07C211/62 , C07C211/63 , C07C211/64 , C07C253/00 , C07C255/57 , C07C313/00 , C07C323/62 , C08G18/18 , C08G59/68 , C09K3/10 , B05D3/06
CPC分类号： C08G18/1875 , C07C59/185 , C07C59/84 , C07C59/90 , C08G59/686
摘要： This invention relates to new ammonium salts of .alpha.-ketocarboxylic acids, to their use for the production of amines in situ by photochemical decomposition and to photochemically hardenable coating compositions containing these ammonium salts.
摘要翻译：本发明涉及α-酮羧酸的新型铵盐，其用于通过光化学分解原位生产胺和用于含有这些铵盐的光化学硬化涂料组合物。

34. 发明授权

US4337353A Novel carboxylic acids, benzoyl phenyl alkanoic acids and use thereof 失效
标题翻译：新型羧酸，苯甲酰基苯基链烷酸及其应用
公开(公告)号：US4337353A
公开(公告)日：1982-06-29
申请号：US875323
申请日：1978-02-06
申请人： Andre Allais , Francois Clemence , Jean Meier , Roger Deraedt
发明人： Andre Allais , Francois Clemence , Jean Meier , Roger Deraedt
IPC分类号： C07C59/76 , C07C45/41 , C07C51/00 , C07C51/08 , C07C51/09 , C07C59/84 , C07C59/88 , C07C59/90 , C07C67/00
CPC分类号： C07C59/90 , C07C45/41 , C07C59/84 , C07C59/88
摘要： Novel carboxylic acids of the formula ##STR1## wherein Z is an aliphatic hydrocarbon chain selected from the group consisting of --(CH.sub.2).sub.n -- and --CH.dbd.CH--(CH.sub.2).sub.n-2 -- where the double bond may be at any point in the chain, n is an integer from 5 to 10 and X, X.sub.1, X.sub.2 and X.sub.3 are individually selected from the group consisting of hydrogen, halogen, alkyl of 1 to 5 carbon atoms, alkoxy of 1 to 5 carbon atoms, alkylthio of 1 to 5 carbon atoms, CF.sub.3 --, CF.sub.3 O-- and CF.sub.3 S-- and their non-toxic, pharmaceutically acceptable organic and inorganic salts and esters having analgesic and anti-inflammatory activity and their preparation.
摘要翻译：式（Ⅰ）的新型羧酸，其中Z是选自 - （CH 2）n - 和-CH = CH-（CH 2）n-2-的脂族烃链，其中双键可以是任何 n为5至10的整数，X，X 1，X 2和X 3分别选自氢，卤素，1至5个碳原子的烷基，1至5个碳原子的烷氧基，烷硫基 1至5个碳原子，CF 3 - ，CF 3 O-和CF 3 S-及其无毒的药学上可接受的有镇痛和抗炎活性的有机和无机盐和酯及其制备。

35. 发明授权

US4336397A 2,4-Dioxo-4-substituted-1-butanoic acid derivatives useful in treating urinary tract calcium oxalate lithiasis 失效
标题翻译：可用于治疗尿路草酸钙结石症的2,4-二氧代-4-取代-1-丁酸衍生物
公开(公告)号：US4336397A
公开(公告)日：1982-06-22
申请号：US221159
申请日：1980-12-29
申请人： Edward J. Cragoe, Jr. , Arthur A. Patchett , Clarence S. Rooney , Haydn W. R. Williams
发明人： Edward J. Cragoe, Jr. , Arthur A. Patchett , Clarence S. Rooney , Haydn W. R. Williams
IPC分类号： C07C45/46 , C07C49/792 , C07C49/813 , C07C59/84 , C07C59/86 , C07C59/88 , C07C69/76
CPC分类号： C07C59/88 , C07C45/46 , C07C49/792 , C07C49/813 , C07C59/84 , C07C59/86 , Y10S514/891
摘要： 2,4-Dioxo-4-substituted-1-butanoic acid derivatives of the formula: ##STR1## where R is hydrogen or C.sub.1-4 alkyl; andL is a lipophilic group consisting essentially of: ##STR2## where R.sup.1 and R.sup.2 are each independently selected from the group consisting of (a) hydrogen; (b) C.sub.4-12 straight or branched chain alkyl; (c) C.sub.4-7 cycloalkyl; and (d) tetrahydronaphthyl; provided that R.sup.1 and R.sup.2 may not both be hydrogen; and when one of R.sup.1 or R.sup.2 is tetrahydronaphthyl, the other must be some other substituent; and that positions 2 and 6 of the substituted phenyl moiety may not be substituted; and ##STR3## where R.sup.1, and R.sup.2 have the same meaning as above except tetrahydronaphthyl;R.sup.3 is bromine, chlorine, or fluorine;m is 0 to 3;or a pharmaceutically acceptable salt thereof.
摘要翻译：下式的2,4-二氧代-4-取代-1-丁酸衍生物：其中R是氢或C 1-4烷基; 并且L是基本上由以下组成的亲脂基团：其中R 1和R 2各自独立地选自（a）氢; （b）C4-12直链或支链烷基; （c）C 4-7环烷基; 和（d）四氢萘基; 条件是R1和R2不能都是氢; 并且当R 1或R 2中的一个为四氢萘基时，另一个必须是一些其它取代基; 并且取代的苯基部分的位置2和6可以不被取代; 和（2）其中R1和R2具有与上述相同的含义，除了四氢萘基; R3是溴，氯或氟; m为0〜3; 或其药学上可接受的盐。

36. 发明授权

US4334089A Substituted oxocarboxylic acids, processes for their preparation, their use and medicaments containing them 失效
标题翻译：取代的氧代羧酸，其制备方法，其用途和含有它们的药物
公开(公告)号：US4334089A
公开(公告)日：1982-06-08
申请号：US279961
申请日：1981-06-29
申请人： Ekkehard Krass , Horst Wolf
发明人： Ekkehard Krass , Horst Wolf
IPC分类号： A61K31/19 , A61P3/08 , C07C27/02 , C07C29/36 , C07C51/02 , C07C51/09 , C07C51/38 , C07C51/41 , C07C59/84 , C07C59/88 , C07C59/90 , C07C67/00 , C07C67/08 , C07C67/317 , C07C67/333 , C07C67/343 , C07C69/65 , C07C69/738 , C07F3/02 , C07F3/08 , C07C62/32
CPC分类号： C07F3/08 , C07C29/36 , C07C59/84 , C07C59/88 , C07C59/90 , C07F3/02 , Y10S514/866
摘要： Substituted oxocarboxylic acids of the formula I ##STR1## wherein R.sup.1 denotes a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group or a trifluoromethyl group,R.sup.2 denotes a hydrogen atom or a halogen atom and n denotes an integer from 3 to 8,and their salts display a hypoglycaemic action in warm-blooded animals. Processes for the preparation of the new compounds and of the intermediate products required for their preparation, as well as of the corresponding medicaments are described.
摘要翻译： PCT No.PCT / EP80 / 00123 Sec。 371日期1981年6月29日第 102（e）日期1981年6月29日PCT提交1980年10月31日PCT公布。出版物WO81 / 01285 日期：1981年5月14日。式I的取代的氧代羧酸（I）其中R1表示氢原子，卤素原子，羟基，低级烷基，低级烷氧基或三氟甲基，R2表示氢原子或卤素原子，n表示3〜8的整数，它们的盐在温血动物中显示低血糖作用。描述了制备新化合物及其制备所需的中间产物以及相应药物的方法。

37. 发明授权

US4287206A Halogen derivatives of 8-hydroxycarboxylic acids; the processes for their preparation and medicaments in which they are present 失效
标题翻译： 8-羟基羧酸的卤素衍生物; 其制备过程及其存在的药物
公开(公告)号：US4287206A
公开(公告)日：1981-09-01
申请号：US72411
申请日：1979-09-04
申请人： Pierre Simon , Jacques Dreux
发明人： Pierre Simon , Jacques Dreux
IPC分类号： C07C59/56 , C07C59/84 , C07C255/56 , C07D309/10 , C07D309/30 , A61K31/335 , C07C59/11
CPC分类号： C07C255/00 , C07C59/56 , C07C59/84 , C07D309/30
摘要： Halogen derivatives of 8-hydroxycarboxylic acids, which correspond to the formula ##STR1## (open form, in a basic medium) or to the formula ##STR2## (cyclized form, in an acid medium) in which formulae: X.sub.1 and X.sub.2 are halogen atoms, n.sub.1 and n.sub.2 are integers between 0 and 5, but, if n.sub.1 =0, n.sub.2 is different from 0, and vice versa, R is a hydrogen atom or an alkyl or aryl group, and Cation represents an ion originating from a base, or a metal ion, which is pharmaceutically compatible are suitable as antidepressants having a psychostimulant action.
摘要翻译： 8-羟基羧酸的卤素衍生物，其对应于下式（图1a）（开放形式，在碱性介质中）或式（IMAGR）（环状化合物，在酸性介质中），式中X 1和X 2为卤素原子，n1和n2是0和5之间的整数，但如果n1 = 0，n2不为0，反之亦然，R为氢原子或烷基或芳基，阳离子表示源自碱的离子或药学上相容的金属离子适合作为具有精神兴奋作用的抗抑郁药。

38. 发明授权

US4275229A Polymers having improved water resistance and monomers for same 失效
标题翻译：具有改善耐水性的聚合物和相同的单体
公开(公告)号：US4275229A
公开(公告)日：1981-06-23
申请号：US11701
申请日：1979-02-12
申请人： Stamatios G. Mylonakis , Anthony J. Tortorello
发明人： Stamatios G. Mylonakis , Anthony J. Tortorello
IPC分类号： C07C59/84 , C08F12/22 , C09D125/18 , C07C59/86 , C07C57/34 , C08F116/36
CPC分类号： C08F12/22 , C07C59/84 , C09D125/18
摘要： Monoethylenically unsaturated beta-carbonyl-containing carboxyl functional monomers and addition polymers containing them and other monoethylenically unsaturated monomers are disclosed, as are methods of coating substrates with the polymers to provide films of improved water resistance. The monomers are especially stable in the form of a salt with a volatile base, and the removal of the base when a polymer containing the monomer is cured causes decarboxylation, and the removal of the carboxyl groups improves the water resistance.
摘要翻译：公开了含有单烯属不饱和β-羰基的羧基官能单体和含有它们的加成聚合物和其它单烯属不饱和单体，以及用聚合物涂覆基材以提供改善的耐水性的膜的方法。单体是以挥发性碱形式的盐的形式特别稳定的，当含有单体的聚合物固化时，除去碱会导致脱羧，并且除去羧基可提高耐水性。

39. 发明授权

US4257858A Photochemical method for producing biocidal 2-aryl-1,3-cyclohexanedione compounds 失效
标题翻译：生产杀生物2-芳基-1,3-环己二酮化合物的光化学方法
公开(公告)号：US4257858A
公开(公告)日：1981-03-24
申请号：US114348
申请日：1980-01-22
申请人： Thomas N. Wheeler
发明人： Thomas N. Wheeler
IPC分类号： A01N35/06 , A01N37/02 , A01N37/06 , A01N37/08 , A01N37/10 , A01N37/22 , A01N37/24 , A01N37/34 , A01N39/04 , A01N41/10 , A01N53/00 , C07C45/45 , C07C49/665 , C07C59/84 , B01J19/12
CPC分类号： C07C59/84 , A01N35/06 , A01N37/02 , A01N37/06 , A01N37/08 , A01N37/10 , A01N37/22 , A01N37/24 , A01N37/34 , A01N39/04 , A01N41/10 , A01N53/00 , C07C201/12 , C07C221/00 , C07C253/30 , C07C45/455 , C07C45/65 , C07C45/68 , C07C51/08 , C07C2101/16 , C07C2102/50
摘要： 2-Aryl-1,3-cyclohexanedione compounds and their alkali metal and ammonium salts exhibit outstanding herbicidal, miticidal and mite ovicidal activity.
摘要翻译： 2-芳基-1,3-环己二酮化合物及其碱金属和铵盐表现出优异的除草，杀螨和杀螨活性。

40. 发明授权

US4256658A Method of preparing 2-aryl-1,3-cyclohexanedione compounds 失效
公开(公告)号：US4256658A
公开(公告)日：1981-03-17
申请号：US114347
申请日：1980-01-22
申请人： Thomas N. Wheeler
发明人： Thomas N. Wheeler
IPC分类号： A01N35/06 , A01N37/02 , A01N37/06 , A01N37/08 , A01N37/10 , A01N37/22 , A01N37/24 , A01N37/34 , A01N39/04 , A01N41/10 , A01N53/00 , C07C45/45 , C07C49/665 , C07C59/84 , C07C49/713 , C07C121/80 , C07C147/10
CPC分类号： C07C59/84 , A01N35/06 , A01N37/02 , A01N37/06 , A01N37/08 , A01N37/10 , A01N37/22 , A01N37/24 , A01N37/34 , A01N39/04 , A01N41/10 , A01N53/00 , C07C201/12 , C07C221/00 , C07C253/30 , C07C45/455 , C07C45/65 , C07C45/68 , C07C2101/16 , C07C2102/50
摘要： 2-Aryl-1,3-cyclohexanedione compounds and their alkali metal and ammonium salts exhibit outstanding herbicidal, miticidal and mite ovicidal activity.

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