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31. 发明授权

US09177777B2 Orthogonal acceleration system for time-of-flight mass spectrometer 有权
公开(公告)号：US09177777B2
公开(公告)日：2015-11-03
申请号：US14610003
申请日：2015-01-30
申请人： PerkinElmer Health Sciences, Inc.
发明人： David G. Welkie
IPC分类号： H01J49/40 , H01J49/00
CPC分类号： H01J49/401 , H01J49/0031 , H01J49/40 , H01J49/403 , H05H5/02 , H05H5/047
摘要： An orthogonal pulse accelerator for a Time-of-Flight mass analyzer includes an electrically-conductive first plate extending in a first plane, and a second plate spaced from the first plate. The second plate includes a grid that defines a plurality of apertures each having a first dimension extending in a first direction and a second dimension orthogonal to the first dimension, the first and second dimensions lying in the second plane and the second dimension begin larger than the first dimension. The first and second plates are positioned in the Time-of-Flight mass analyzer to receive, during operation of the mass analyzer, an ion beam propagating in the first direction in a region between the first and second plates, and the orthogonal pulse accelerator directs ions in the ion beam through the apertures.

32. 发明授权

US08772708B2 Time-of-flight mass spectrometer 有权
标题翻译：飞行时间质谱仪
公开(公告)号：US08772708B2
公开(公告)日：2014-07-08
申请号：US13996372
申请日：2011-12-20
申请人： Tohru Kinugawa , Osamu Furuhashi
发明人： Tohru Kinugawa , Osamu Furuhashi
IPC分类号： H01J49/00
CPC分类号： H01J49/405 , G01N27/62 , H01J49/403
摘要： An embodiment with a dual-stage reflectron is as follows: (1) On the assumption that a reflector has a base potential XA(U) created by uniform electric fields, its design parameters are adjusted so as to cancel the first and second order derivatives at energy E=E0 of a total time of flight T(E), and a second-order focusing position on a central axis at which the potential value becomes zero is determined (Mamyrin solution). (2) A correcting potential XC(U) to be superposed on XA(U), beginning from the second-order focusing position, is calculated so that T(E) of ions reflected in a region deeper than the second-order focusing position will be constant. (3) Voltage values of the reflector electrodes are determined so that a real potential XR(U)=XA(U)+XC(U) is created on the central axis.
摘要翻译：具有双级反射器的实施例如下：（1）假设反射器具有由均匀电场产生的基极电位XA（U），其设计参数被调整以抵消第一和第二阶导数在总时间T（E）的能量E = E0和电位值变为零的中心轴上的二次聚焦位置被确定（Mamyrin溶液）。（2）计算从二次聚焦位置开始叠加在XA（U）上的校正电位XC（U），使得在比二次聚焦位置更深的区域中反射的离子的T（E）将不变（3）确定反射器电极的电压值，使得在中心轴上产生实际电位XR（U）= XA（U）+ XC（U））。

33. 发明申请

US20140054454A1 Electrostatic Gimbal for Correction of Errors in Time of Flight Mass Spectrometers 有权
标题翻译：用于校正飞行时间质谱误差的静电万向节
公开(公告)号：US20140054454A1
公开(公告)日：2014-02-27
申请号：US14004946
申请日：2012-03-13
申请人： John Brian Hoyes , David J. Langridge , Jason Wildgoose
发明人： John Brian Hoyes , David J. Langridge , Jason Wildgoose
IPC分类号： H01J49/40
CPC分类号： H01J49/403 , H01J49/40
摘要： A Time of Flight mass analyser is disclosed comprising one or more devices arranged and adapted to correct for tilt in an isochronous plane of ions and to adjust the isochronous plane of the ions so as to be parallel with the plane of detection in an ion detector.
摘要翻译：公开了一种飞行时间质量分析器，其包括一个或多个设备，其被配置并适于校正离子的等时平面中的倾斜，并且在离子检测器中调整离子的等时平面以与检测平面平行。

34. 发明授权

US08653452B2 Triple switch topology for delivery ultrafast pulser polarity switching for mass spectrometry 有权
标题翻译：用于质谱的交换超快脉冲器极性切换的三重开关拓扑
公开(公告)号：US08653452B2
公开(公告)日：2014-02-18
申请号：US13695535
申请日：2011-05-06
申请人： Nicolae Albeanu , Martian Dima
发明人： Nicolae Albeanu , Martian Dima
IPC分类号： H01J49/16
CPC分类号： H01J49/16 , H01J49/0031 , H01J49/0095 , H01J49/06 , H01J49/401 , H01J49/403
摘要： There is provided a pulser, a time of flight mass spectrometer system comprising the same, and a method of analyzing the ions using the pulser. The pulser comprises a first positive switch for coupling and decoupling a first electrode of the accelerator assembly to a first positive voltage; a first negative switch for coupling and decoupling the first electrode to a first negative voltage; and, a first bipolar switch for alternately coupling and decoupling the first electrode to a third voltage.
摘要翻译：提供了一种脉冲发生器，包括该脉冲发生器的飞行时间质谱仪系统和使用脉冲发生器分析离子的方法。脉冲发生器包括用于将加速器组件的第一电极耦合和解耦到第一正电压的第一正开关; 用于将第一电极耦合和去耦合到第一负电压的第一负开关; 以及用于将第一电极交替耦合和去耦合到第三电压的第一双极开关。

35. 发明授权

US08648296B2 Spectrometer apparatus 有权
标题翻译：光谱仪器
公开(公告)号：US08648296B2
公开(公告)日：2014-02-11
申请号：US13850123
申请日：2013-03-25
申请人： Smiths Detection-Watford Limited
发明人： William Angus Munro
IPC分类号： H01J49/10 , H01J49/40
CPC分类号： H01J49/10 , G01N27/622 , H01J49/26 , H01J49/40 , H01J49/403
摘要： An ion mobility spectrometer has several electrodes spaced along its ion source region. Voltages are applied to the electrodes to produce a voltage gradient along the length of the ion source region. By varying the voltage gradient, the residence time of ions in the ion source region can be selectively varied. Typically, the spectrometer is arranged to reduce the residence time in response to a decrease in the amplitude of an ion peak detected at the far end of the drift region.
摘要翻译：离子迁移谱仪具有沿其离子源区域间隔开的多个电极。电压被施加到电极以沿着离子源区域的长度产生电压梯度。通过改变电压梯度，可以选择性地改变离子在离子源区域中的停留时间。通常，光谱仪布置成响应于在漂移区域的远端检测到的离子峰值的振幅的减小而减少停留时间。

36. 发明申请

US20130187041A1 CHARGED PARTICLE SPECTRUM ANALYSIS APPARATUS 有权
标题翻译：充电颗粒光谱分析装置
公开(公告)号：US20130187041A1
公开(公告)日：2013-07-25
申请号：US13811117
申请日：2011-07-20
申请人： Mark Brouard , Claire Vallance , Andrei Nomerotski
发明人： Mark Brouard , Claire Vallance , Andrei Nomerotski
IPC分类号： H01J49/40 , H01J49/00 , H01J49/34
CPC分类号： H01J49/403 , H01J49/0004 , H01J49/0031 , H01J49/061 , H01J49/34 , H01J49/40
摘要： A charged particle spectrum analysis apparatus comprising an electric field generator arranged to subject charged particles to a time-varying electric field, a detector to record charged particle time spectrum data of charged particles which have passed through the electric field, the detector comprising a position-sensitive detection portion, and the time-varying electric field arranged to be activated in synchrony with activation of detector, and the time-varying electric field arranged to subject a predetermined region of said detection portion to consecutive charged particle deflection cycles.
摘要翻译：一种带电粒子谱分析装置，包括：电场发生器，被布置成使带电粒子受到时变电场;检测器，记录已经通过电场的带电粒子的带电粒子时间谱数据;检测器，灵敏检测部分，以及被布置成与检测器的激活同步地激活的时变电场，以及布置成使所述检测部分的预定区域经受连续带电粒子偏转周期的时变电场。

37. 发明授权

US08222595B2 Spectrometer apparatus 有权
标题翻译：光谱仪器
公开(公告)号：US08222595B2
公开(公告)日：2012-07-17
申请号：US12444950
申请日：2007-10-22
申请人： William Angus Munro
发明人： William Angus Munro
IPC分类号： H01J49/10 , H01J49/40
CPC分类号： H01J49/10 , G01N27/622 , H01J49/26 , H01J49/40 , H01J49/403
摘要： An ion mobility spectrometer has several electrodes spaced along its ion source region. Voltages are applied to the electrodes to produce a voltage gradient along the length of the ion source region. By varying the voltage gradient, the residence time of ions in the ion source region can be selectively varied. Typically, the spectrometer is arranged to reduce the residence time in response to a decrease in the amplitude, of an ion peak detected at the far end of the drift region.
摘要翻译：离子迁移谱仪具有沿其离子源区域间隔开的多个电极。电压被施加到电极以沿着离子源区域的长度产生电压梯度。通过改变电压梯度，可以选择性地改变离子在离子源区域中的停留时间。通常，光谱仪布置成响应于在漂移区域的远端检测到的离子峰值的幅度的减小而减少停留时间。

38. 发明申请

US20100072362A1 TIME-OF-FLIGHT MASS SPECTROMETER AND A METHOD OF ANALYSING IONS IN A TIME-OF-FLIGHT MASS SPECTROMETER 有权
标题翻译：飞行时间质谱仪和在飞行时间质谱仪中分析离子的方法
公开(公告)号：US20100072362A1
公开(公告)日：2010-03-25
申请号：US12518236
申请日：2007-12-07
申请人： Roger Giles , Michael Sudakov , Hermann Wollnik
发明人： Roger Giles , Michael Sudakov , Hermann Wollnik
IPC分类号： H01J49/40 , H01J3/40
CPC分类号： H01J49/403 , H01J49/4295
摘要： A time-of-flight mass spectrometer (1) comprises an ion source a segmented linear ion device (10) for receiving sample ions supplied by the ion source and a time-of-flight mass analyser for analysing ions ejected from the segmented device. A trapping voltage is applied to the segmented device to trap ions initially into a group of two or more adjacent segments and subsequently to trap them in a region of the segmented device shorter than the group of segments. The trapping voltage may also be effective to provide a uniform trapping field along the length of the device (10).
摘要翻译：飞行时间质谱仪（1）包括离子源，用于接收由离子源提供的样品离子的分段线性离子装置（10）和用于分析从分段装置喷射的离子的飞行时间质量分析器。捕获电压被施加到分段器件，以将离子初始化为两个或更多个相邻段的一组，并且随后将它们捕获在分段器件的比段组短的区域中。捕获电压也可以有效地沿着装置（10）的长度提供均匀的捕获场。

39. 发明申请

US20060214103A1 Single-particle mass spectrometer 失效
标题翻译：单粒子质谱仪
公开(公告)号：US20060214103A1
公开(公告)日：2006-09-28
申请号：US11377364
申请日：2006-03-17
申请人： Dong-Geun Lee , Seong-Woo Cho
发明人： Dong-Geun Lee , Seong-Woo Cho
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/0445 , H01J49/067 , H01J49/403
摘要： Disclosed is a single-particle mass spectrometer, which includes a chamber keeping an inside in a vacuum state by a vacuum pump, a cylindrical flying tube installed to communicate with the chamber, an aerodynamic lens installed to the chamber to focus aerosol particles input from outside, a laser generating means for irradiating a laser beam to the particles focused by the aerodynamic lens to emit ions, an extraction acceleration means for extracting the emitted ions and accelerating the ions to fly along the flying tube, and an ion detector installed to an end of the flying tube to detect the ions flying along the flying tube. The extraction acceleration means includes a reflector made of a conductive material with a semispherical shape and to which a relatively high voltage is applied; at least one mesh-shaped grid arranged from the reflector toward the ion detector at regular intervals, and to which a relatively low voltage is applied in comparison to the reflector; a cylindrical electrode; and an Einzel lens. Thus, the ions are biased due to a voltage difference between the reflector and the grid to fly toward the ion detector along the flying tube, and also refracted toward a central axis of the flying tube by means of the cylindrical electrode and the Einzel lens.
摘要翻译：公开了一种单粒子质谱仪，其包括通过真空泵将真空状态保持在内部的腔室，安装成与腔室连通的圆柱形飞管，安装在腔室上以将从外部输入的气溶胶颗粒聚焦的空气动力学透镜激光发生装置，用于将激光束照射到由空气动力学透镜聚焦的颗粒以发射离子;提取加速装置，用于提取所发射的离子并加速离子沿着飞行管飞行;以及离子检测器，安装在末端的飞管，以检测沿着飞管飞行的离子。提取加速装置包括由半球形状的导电材料制成并且施加相对高的电压的反射器; 至少一个从反射器以规则的间隔布置成离子检测器的网状网格，与反射器相比施加相对较低的电压; 圆柱形电极; 和Einzel镜头。因此，由于反射器和栅格之间的电压差，离子被偏置，从而沿着飞行管向离子检测器飞行，并且还通过圆柱形电极和Einzel透镜朝向飞行管的中心轴线折射。

40. 发明申请

US20040079878A1 Time-of-flight mass spectrometry analysis of biomolecules 审中-公开
标题翻译：飞行时间质谱分析生物分子
公开(公告)号：US20040079878A1
公开(公告)日：2004-04-29
申请号：US10308889
申请日：2002-12-03
申请人： PerSeptive Biosystems, Inc.
发明人： Marvin L. Vestal , Peter Juhasz
IPC分类号： H01J049/40
CPC分类号： H01J49/164 , H01J49/403
摘要： A time-of-flight mass spectrometer for measuring the mass-to-charge ratio of a sample molecule is described. The spectrometer provides independent control of the electric field experienced by the sample before and during ion extraction. Methods of mass spectrometry utilizing the principles of this invention reduce matrix background, induce fast fragmentation, and control the transfer of energy prior to ion extraction.
摘要翻译：描述了用于测量样品分子的质荷比的飞行时间质谱仪。离子提取之前和期间，光谱仪可以独立控制样品经历的电场。使用本发明原理的质谱法降低了基质背景，诱导快速碎裂，并控制离子提取前的能量转移。

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