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31. 发明申请

US20160111271A1 TIME-OF-FLIGHT MASS SPECTROMETER WITH SPATIAL FOCUSING OF A BROAD MASS RANGE 有权
标题翻译：时空飞行质谱仪，具有宽阔的大范围空间聚焦
公开(公告)号：US20160111271A1
公开(公告)日：2016-04-21
申请号：US14883127
申请日：2015-10-14
申请人： Bruker Daltonik GmbH
发明人： Sebastian BÖHM
IPC分类号： H01J49/16 , H01J49/40
CPC分类号： H01J49/164 , H01J49/067 , H01J49/403
摘要： The invention relates to time-of-flight mass spectrometers which operate with pulsed ionization of superficially adsorbed analyte substances and with an improvement in the mass resolution by means of a time-delayed start of the ion acceleration; in particular with ion-accelerating voltages which change over time after a delayed start in order to obtain a constant mass resolution over broad mass ranges. Since the varying acceleration produces a broadening of the ion beam at right angles to the direction of flight, and this broadening increases with the ion mass, the invention proposes to compensate, to the desired extent, for the broadening of the ion beam with the aid of an additional ion-optical lens whose voltage is also varied over time. The invention also relates to measurement methods therefor.
摘要翻译：本发明涉及通过表面吸附的分析物质的脉冲电离操作并通过离子加速的时间延迟启动来提高质量分辨率的飞行时间质谱仪; 特别是在延迟启动之后随时间变化的离子加速电压，以便在宽质量范围内获得恒定的质量分辨率。由于变化的加速度导致与飞行方向成直角的离子束的加宽，并且该拓宽随着离子质量的增加而增加，本发明提出了在所需的程度上补偿离子束的扩大，借助于的附加离子光学透镜，其电压也随时间变化。本发明还涉及其测量方法。

32. 发明授权

US09318309B2 Mass spectrometers comprising accelerator devices 有权
标题翻译：包括加速器装置的质谱仪
公开(公告)号：US09318309B2
公开(公告)日：2016-04-19
申请号：US14355884
申请日：2012-11-05
申请人： Micromass UK Limited
发明人： Jeffery Mark Brown , Martin Raymond Green , David J. Langridge
IPC分类号： H01J49/40 , H01J49/06
CPC分类号： H01J49/403 , H01J49/0031 , H01J49/06 , H01J49/40
摘要： A method of mass spectrometry is disclosed comprising providing a flight region for ions to travel through and a detector or fragmentation device. A potential profile is maintained along the flight region such that ions travel towards the detector or fragmentation device. The potential at which a first length of the flight region is maintained is then changed from a first potential to a second potential while at least some ions are travelling within the first length of flight region. The changed potential provides a first potential difference at an exit of the length of flight region, through which the ions are accelerated as they leave the length of flight region. This increases the kinetic energy of the ions prior to them reaching the detector or fragmentation cell.
摘要翻译：公开了一种质谱方法，其包括提供用于离子行进的飞行区域和检测器或碎裂装置。沿着飞行区域保持电位分布，使得离子朝向检测器或碎裂装置行进。然后，维持飞行区域的第一长度的电位然后从第一电位改变到第二电位，而至少一些离子在第一飞行区域内行进。变化的电位在飞行区域的长度的出口处提供第一潜在差异，离子在离开飞行区域的长度时被加速。这增加了离子在它们到达检测器或破碎电池之前的动能。

33. 发明申请

US20160071717A1 ORTHOGONAL ACCELERATION SYSTEM FOR TIME-OF-FLIGHT MASS SPECTROMETER 有权
公开(公告)号：US20160071717A1
公开(公告)日：2016-03-10
申请号：US14928793
申请日：2015-10-30
申请人： PerkinElmer Health Sciences, Inc.
发明人： David G. Welkie
IPC分类号： H01J49/40 , H01J49/00
CPC分类号： H01J49/401 , H01J49/0031 , H01J49/40 , H01J49/403 , H05H5/02 , H05H5/047
摘要： An orthogonal pulse accelerator for a Time-of-Flight mass analyzer includes an electrically-conductive first plate extending in a first plane, and a second plate spaced from the first plate. The second plate includes a grid that defines a plurality of apertures each having a first dimension extending in a first direction and a second dimension orthogonal to the first dimension, the first and second dimensions lying in the second plane and the second dimension begin larger than the first dimension. The first and second plates are positioned in the Time-of-Flight mass analyzer to receive, during operation of the mass analyzer, an ion beam propagating in the first direction in a region between the first and second plates, and the orthogonal pulse accelerator directs ions in the ion beam through the apertures.

34. 发明授权

US09177777B2 Orthogonal acceleration system for time-of-flight mass spectrometer 有权
公开(公告)号：US09177777B2
公开(公告)日：2015-11-03
申请号：US14610003
申请日：2015-01-30
申请人： PerkinElmer Health Sciences, Inc.
发明人： David G. Welkie
IPC分类号： H01J49/40 , H01J49/00
CPC分类号： H01J49/401 , H01J49/0031 , H01J49/40 , H01J49/403 , H05H5/02 , H05H5/047
摘要： An orthogonal pulse accelerator for a Time-of-Flight mass analyzer includes an electrically-conductive first plate extending in a first plane, and a second plate spaced from the first plate. The second plate includes a grid that defines a plurality of apertures each having a first dimension extending in a first direction and a second dimension orthogonal to the first dimension, the first and second dimensions lying in the second plane and the second dimension begin larger than the first dimension. The first and second plates are positioned in the Time-of-Flight mass analyzer to receive, during operation of the mass analyzer, an ion beam propagating in the first direction in a region between the first and second plates, and the orthogonal pulse accelerator directs ions in the ion beam through the apertures.

35. 发明授权

US08772708B2 Time-of-flight mass spectrometer 有权
标题翻译：飞行时间质谱仪
公开(公告)号：US08772708B2
公开(公告)日：2014-07-08
申请号：US13996372
申请日：2011-12-20
申请人： Tohru Kinugawa , Osamu Furuhashi
发明人： Tohru Kinugawa , Osamu Furuhashi
IPC分类号： H01J49/00
CPC分类号： H01J49/405 , G01N27/62 , H01J49/403
摘要： An embodiment with a dual-stage reflectron is as follows: (1) On the assumption that a reflector has a base potential XA(U) created by uniform electric fields, its design parameters are adjusted so as to cancel the first and second order derivatives at energy E=E0 of a total time of flight T(E), and a second-order focusing position on a central axis at which the potential value becomes zero is determined (Mamyrin solution). (2) A correcting potential XC(U) to be superposed on XA(U), beginning from the second-order focusing position, is calculated so that T(E) of ions reflected in a region deeper than the second-order focusing position will be constant. (3) Voltage values of the reflector electrodes are determined so that a real potential XR(U)=XA(U)+XC(U) is created on the central axis.
摘要翻译：具有双级反射器的实施例如下：（1）假设反射器具有由均匀电场产生的基极电位XA（U），其设计参数被调整以抵消第一和第二阶导数在总时间T（E）的能量E = E0和电位值变为零的中心轴上的二次聚焦位置被确定（Mamyrin溶液）。（2）计算从二次聚焦位置开始叠加在XA（U）上的校正电位XC（U），使得在比二次聚焦位置更深的区域中反射的离子的T（E）将不变（3）确定反射器电极的电压值，使得在中心轴上产生实际电位XR（U）= XA（U）+ XC（U））。

36. 发明申请

US20140054454A1 Electrostatic Gimbal for Correction of Errors in Time of Flight Mass Spectrometers 有权
标题翻译：用于校正飞行时间质谱误差的静电万向节
公开(公告)号：US20140054454A1
公开(公告)日：2014-02-27
申请号：US14004946
申请日：2012-03-13
申请人： John Brian Hoyes , David J. Langridge , Jason Wildgoose
发明人： John Brian Hoyes , David J. Langridge , Jason Wildgoose
IPC分类号： H01J49/40
CPC分类号： H01J49/403 , H01J49/40
摘要： A Time of Flight mass analyser is disclosed comprising one or more devices arranged and adapted to correct for tilt in an isochronous plane of ions and to adjust the isochronous plane of the ions so as to be parallel with the plane of detection in an ion detector.
摘要翻译：公开了一种飞行时间质量分析器，其包括一个或多个设备，其被配置并适于校正离子的等时平面中的倾斜，并且在离子检测器中调整离子的等时平面以与检测平面平行。

37. 发明授权

US08653452B2 Triple switch topology for delivery ultrafast pulser polarity switching for mass spectrometry 有权
标题翻译：用于质谱的交换超快脉冲器极性切换的三重开关拓扑
公开(公告)号：US08653452B2
公开(公告)日：2014-02-18
申请号：US13695535
申请日：2011-05-06
申请人： Nicolae Albeanu , Martian Dima
发明人： Nicolae Albeanu , Martian Dima
IPC分类号： H01J49/16
CPC分类号： H01J49/16 , H01J49/0031 , H01J49/0095 , H01J49/06 , H01J49/401 , H01J49/403
摘要： There is provided a pulser, a time of flight mass spectrometer system comprising the same, and a method of analyzing the ions using the pulser. The pulser comprises a first positive switch for coupling and decoupling a first electrode of the accelerator assembly to a first positive voltage; a first negative switch for coupling and decoupling the first electrode to a first negative voltage; and, a first bipolar switch for alternately coupling and decoupling the first electrode to a third voltage.
摘要翻译：提供了一种脉冲发生器，包括该脉冲发生器的飞行时间质谱仪系统和使用脉冲发生器分析离子的方法。脉冲发生器包括用于将加速器组件的第一电极耦合和解耦到第一正电压的第一正开关; 用于将第一电极耦合和去耦合到第一负电压的第一负开关; 以及用于将第一电极交替耦合和去耦合到第三电压的第一双极开关。

38. 发明授权

US08648296B2 Spectrometer apparatus 有权
标题翻译：光谱仪器
公开(公告)号：US08648296B2
公开(公告)日：2014-02-11
申请号：US13850123
申请日：2013-03-25
申请人： Smiths Detection-Watford Limited
发明人： William Angus Munro
IPC分类号： H01J49/10 , H01J49/40
CPC分类号： H01J49/10 , G01N27/622 , H01J49/26 , H01J49/40 , H01J49/403
摘要： An ion mobility spectrometer has several electrodes spaced along its ion source region. Voltages are applied to the electrodes to produce a voltage gradient along the length of the ion source region. By varying the voltage gradient, the residence time of ions in the ion source region can be selectively varied. Typically, the spectrometer is arranged to reduce the residence time in response to a decrease in the amplitude of an ion peak detected at the far end of the drift region.
摘要翻译：离子迁移谱仪具有沿其离子源区域间隔开的多个电极。电压被施加到电极以沿着离子源区域的长度产生电压梯度。通过改变电压梯度，可以选择性地改变离子在离子源区域中的停留时间。通常，光谱仪布置成响应于在漂移区域的远端检测到的离子峰值的振幅的减小而减少停留时间。

39. 发明申请

US20130187041A1 CHARGED PARTICLE SPECTRUM ANALYSIS APPARATUS 有权
标题翻译：充电颗粒光谱分析装置
公开(公告)号：US20130187041A1
公开(公告)日：2013-07-25
申请号：US13811117
申请日：2011-07-20
申请人： Mark Brouard , Claire Vallance , Andrei Nomerotski
发明人： Mark Brouard , Claire Vallance , Andrei Nomerotski
IPC分类号： H01J49/40 , H01J49/00 , H01J49/34
CPC分类号： H01J49/403 , H01J49/0004 , H01J49/0031 , H01J49/061 , H01J49/34 , H01J49/40
摘要： A charged particle spectrum analysis apparatus comprising an electric field generator arranged to subject charged particles to a time-varying electric field, a detector to record charged particle time spectrum data of charged particles which have passed through the electric field, the detector comprising a position-sensitive detection portion, and the time-varying electric field arranged to be activated in synchrony with activation of detector, and the time-varying electric field arranged to subject a predetermined region of said detection portion to consecutive charged particle deflection cycles.
摘要翻译：一种带电粒子谱分析装置，包括：电场发生器，被布置成使带电粒子受到时变电场;检测器，记录已经通过电场的带电粒子的带电粒子时间谱数据;检测器，灵敏检测部分，以及被布置成与检测器的激活同步地激活的时变电场，以及布置成使所述检测部分的预定区域经受连续带电粒子偏转周期的时变电场。

40. 发明授权

US08222595B2 Spectrometer apparatus 有权
标题翻译：光谱仪器
公开(公告)号：US08222595B2
公开(公告)日：2012-07-17
申请号：US12444950
申请日：2007-10-22
申请人： William Angus Munro
发明人： William Angus Munro
IPC分类号： H01J49/10 , H01J49/40
CPC分类号： H01J49/10 , G01N27/622 , H01J49/26 , H01J49/40 , H01J49/403
摘要： An ion mobility spectrometer has several electrodes spaced along its ion source region. Voltages are applied to the electrodes to produce a voltage gradient along the length of the ion source region. By varying the voltage gradient, the residence time of ions in the ion source region can be selectively varied. Typically, the spectrometer is arranged to reduce the residence time in response to a decrease in the amplitude, of an ion peak detected at the far end of the drift region.
摘要翻译：离子迁移谱仪具有沿其离子源区域间隔开的多个电极。电压被施加到电极以沿着离子源区域的长度产生电压梯度。通过改变电压梯度，可以选择性地改变离子在离子源区域中的停留时间。通常，光谱仪布置成响应于在漂移区域的远端检测到的离子峰值的幅度的减小而减少停留时间。

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