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31. 发明授权

US09685312B2 Removal of ions from survey scans using variable window band-pass filtering to improve intrascan dynamic range 有权
公开(公告)号：US09685312B2
公开(公告)日：2017-06-20
申请号：US14887215
申请日：2015-10-19
申请人： DH Technologies Development PTE. LTD.
发明人： Stephen A. Tate , Nic G. Bloomfield
IPC分类号： H01J49/06 , H01J49/00 , H01J49/42
CPC分类号： H01J49/06 , H01J49/0031 , H01J49/004 , H01J49/429
摘要： Systems and methods are used to band-pass filter ions from a mass range. A full spectrum is received for a full scan of a mass range using a tandem mass spectrometer. A mass selection window of the full spectrum is selected and a set of tuning parameter values is selected. The tandem mass spectrometer is instructed to perform a scan of the mass selection window using the set of tuning parameter values. A spectrum is received for the scan from the tandem mass spectrometer. A band-pass filtered spectrum is created for the mass range that includes values from the spectrum for the mass selection window of the mass range. Systems and methods are also used to band-pass filter ions from two or more mass selection windows across the mass range and to filter out ions from a mass selection window between two band-pass mass selection windows.

32. 发明授权

US09679752B2 Mass spectrometer 有权
公开(公告)号：US09679752B2
公开(公告)日：2017-06-13
申请号：US11996236
申请日：2006-07-21
申请人： John Hoyes
发明人： John Hoyes
IPC分类号： H01J49/24 , H01J49/00 , C08L23/04 , H01J49/42
CPC分类号： H01J49/004 , C08L23/04 , H01J49/4215 , H01J49/422 , H01J49/429 , C08L2666/02
摘要： A mass spectrometer is disclosed comprising a mass selective ion trap (12) and a quadrupole rod set mass filter (14) arranged downstream of the mass selective ion trap (12). Ions are mass selectively ejected from the ion trap (12) in a substantially synchronized manner with the scanning of the mass filter (14) in order to increase the duty cycle of the mass filter (14).

33. 发明授权

US09672330B2 Mass spectrometer 有权
公开(公告)号：US09672330B2
公开(公告)日：2017-06-06
申请号：US12739335
申请日：2007-10-23
申请人： Shinichi Yamaguchi
发明人： Shinichi Yamaguchi
IPC分类号： G01N33/48 , G06F19/00 , G01N33/68 , H01J49/00 , G06G7/58
CPC分类号： G06F19/703 , G01N33/6848 , H01J49/0027 , H01J49/004
摘要： A product ion spectrum is created on the basis of MS2 analysis data respectively obtained for a parent compound and a metabolite (S1 and S2). Additionally, a neutral loss spectrum, in which the mass of each product ion is replaced with a mass difference between the mass of the product ion and that of a precursor ion, is created (S3). Then, a common peak having the same mass on the neutral loss spectrums of both the parent compound and the metabolite is extracted (S4), and a complementary peak appearing on the product ion spectrum of the metabolite is extracted (S5); this peak appears at a position corresponding to the difference between the mass of the common peak and that of the precursor ion. The ion corresponding to the complementary peak is designated as a precursor ion for the next MS3 analysis (S6), and this MS3 analysis is performed (S7). By a dissociation operation, if a portion common to the parent compound and the metabolite is desorbed in the form of a neutral molecule while a different portion remains in the form of an ion, an MS3 analysis in which the ion of the different portion is used as the precursor ion is performed to obtain structural information of a site of metabolism.

34. 发明授权

US09646813B2 Mass spectrometer 有权
公开(公告)号：US09646813B2
公开(公告)日：2017-05-09
申请号：US14689161
申请日：2015-04-17
申请人： Micromass UK Limited
发明人： Robert Harold Bateman , Kevin Giles
IPC分类号： H01J49/26 , H01J49/06 , H01J49/00 , G01N27/62 , H01J49/02
CPC分类号： H01J49/0045 , G01N27/622 , H01J49/004 , H01J49/022 , H01J49/062
摘要： A mass spectrometer is disclosed comprising a first quadrupole rod set mass filter, a collision cell, an ion mobility spectrometer or separator, an ion guide or collision cell arranged downstream of the ion mobility spectrometer or separator, a second quadrupole rod set mass filter and an ion detector.

35. 发明申请

US20170122908A1 Contamination Filter for Mass Spectrometer 审中-公开
公开(公告)号：US20170122908A1
公开(公告)日：2017-05-04
申请号：US15378957
申请日：2016-12-14
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： Thomas R. Covey , Bradley B. Schneider
IPC分类号： G01N27/62 , H01J49/14 , H01J49/16 , H01J49/04 , H01J49/00
CPC分类号： G01N27/624 , H01J49/0031 , H01J49/004 , H01J49/0422 , H01J49/145 , H01J49/165
摘要： Methods and systems for performing mass spectrometry are provided herein. In accordance with various aspects of the applicants' teachings, the methods and systems can utilize an ion mobility spectrometer operating at atmospheric or low-vacuum pressure to remove the major contributors to the contamination and degradation of critical downstream components of a mass spectrometer located within a high-vacuum system (e.g., ion optics, mass filters, detectors), with limited signal loss.

36. 发明申请

US20170115312A1 MASS SPECTROMETRY ASSAY FOR CONGENITAL ADRENAL HYPERPLASIA 有权
公开(公告)号：US20170115312A1
公开(公告)日：2017-04-27
申请号：US15401797
申请日：2017-01-09
申请人： Quest Diagnostics Investments Incorporated
发明人： Amit Ghoshal , Nigel J. Clarke , Mildred M. Goldman
IPC分类号： G01N33/74 , G01N30/72 , H01J49/16 , H01J49/00
CPC分类号： G01N33/743 , C12Q1/6872 , G01N30/7233 , G01N33/6848 , G01N33/6851 , G01N33/689 , G01N2800/04 , H01J49/0031 , H01J49/004 , H01J49/165
摘要： Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.

37. 发明申请

US20170097321A1 PRACTICAL ION MOBILITY SPECTROMETER APPARATUS AND METHODS FOR CHEMICAL AND/OR BIOLOGICAL DETECTION 审中-公开
公开(公告)号：US20170097321A1
公开(公告)日：2017-04-06
申请号：US15383736
申请日：2016-12-19
申请人： Ching Wu
发明人： Ching Wu
IPC分类号： G01N27/62 , H01J49/04 , H01J49/06
CPC分类号： G01N27/622 , H01J49/0031 , H01J49/004 , H01J49/0468 , H01J49/062
摘要： The present invention relates to ion mobility spectrometers. In one embodiment, the ion mobility spectrometer of the present invention uses a simplified ion mobility spectrometer design having helical resistive material to form substantially constant electric fields that guide ion movements. The drift tube for ion mobility spectrometers described herein is constructed with a non-conductive structure. This configuration provides a robust ion mobility spectrometer that is simple to build. One feature of the present invention is that the drift tube design described herein enables the ion mobility spectrometer to be built with a lower weight, lower power consumption, lower manufacturing cost, and free of sealants.

38. 发明申请

US20170076926A1 De-Convolution of Overlapping Ion Mobility Spectrometer or Separator Data 审中-公开
标题翻译：重叠离子迁移率光谱仪或分离器数据的去卷积
公开(公告)号：US20170076926A1
公开(公告)日：2017-03-16
申请号：US15310714
申请日：2015-05-14
申请人： MICROMASS UK LIMITED
发明人： Martin Raymond GREEN
IPC分类号： H01J49/00 , H01J49/40
CPC分类号： H01J49/0027 , H01J49/004 , H01J49/40
摘要： A method of mass spectrometry is disclosed comprising separating first ions according to a first physico-chemical property in a first separator wherein at least some of the first ions undergo a different number of cycles or passes within the separator and separating the first ions which emerge from the first separator according to a second physico-chemical property wherein the second physico-chemical property is correlated with the first physico-chemical property. The method further comprises determining the second physico-chemical property of the first ions and determining, assigning or de-convolving the first physico-chemical property of the first ions based upon the determined second physico-chemical property of the first ions.
摘要翻译：公开了一种质谱法，其包括根据第一分离器中的第一物理化学性质分离第一离子，其中至少一些第一离子在分离器内经历不同数量的循环或通过，并分离出从根据第二物理化学性质的第一分离器，其中第二物理化学性质与第一物理化学性质相关。该方法还包括确定第一离子的第二物理化学性质，并基于所确定的第一离子的第二物理化学性质来确定，分配或去卷积第一离子的第一物理化学性质。

39. 发明授权

US09583321B2 Method for mass spectrometer with enhanced sensitivity to product ions 有权
标题翻译：对产品离子具有增强敏感性的质谱仪的方法
公开(公告)号：US09583321B2
公开(公告)日：2017-02-28
申请号：US14138589
申请日：2013-12-23
申请人： Thermo Finnigan LLC
发明人： Oleg Silivra , Harald Oser , Terry N. Olney
IPC分类号： H01J49/26 , H01J49/00
CPC分类号： H01J49/0031 , H01J49/0036 , H01J49/004
摘要： A mass spectrometry method comprises: introducing a first portion of a sample of ions including precursor ions comprising a first precursor-ion mass-to-charge (m/z) ratio into a first mass analyzer; transmitting the precursor ions from the first mass analyzer to a reaction or fragmentation cell such that a first population of product ions are continuously accumulated therein over a first accumulation time duration; initiating release of the accumulated first population of product ions from the reaction or fragmentation cell; continuously transmitting the released first population of product ions from the reaction cell to a second mass analyzer; transmitting a portion of the released first population of product ions comprising a first product-ion m/z ratio from the second mass analyzer to a detector; and detecting a varying quantity of the product ions having the first product-ion m/z ratio for a predetermined data-acquisition time period after the initiation of the release.
摘要翻译：一种质谱法包括：将包含第一前体 - 离子质量 - 电荷（m / z）比率的前体离子的离子样品的第一部分引入第一质量分析器; 将所述前体离子从所述第一质量分析器传输到反应或破碎单元，使得第一种产物离子在第一累积持续时间内连续地累积在其中; 开始从反应或碎裂细胞释放累积的第一批产物离子; 将释放的第一批产物离子从反应池连续传输到第二质量分析器; 将包含第一产物离子m / z比率的所述释放的第一产物离子群的一部分从所述第二质量分析器传输到检测器; 以及在释放开始之后，在预定的数据采集时间段内检测具有第一乘积离子m / z比的产物离子的变化量。

40. 发明授权

US09578718B2 Method for manufacturing light-emitting element and deposition apparatus 有权
标题翻译：发光元件和沉积设备的制造方法
公开(公告)号：US09578718B2
公开(公告)日：2017-02-21
申请号：US13870246
申请日：2013-04-25
申请人： Semiconductor Energy Laboratory Co., Ltd.
发明人： Kohei Yokoyama , Hisao Ikeda , Shinichi Hirasa , Yasuhiro Jinbo , Natsuko Takase
IPC分类号： H05B33/10 , C23C14/24 , C23C14/54 , C23C14/56 , H01L51/00 , H01L51/56
CPC分类号： C23C14/24 , A63F13/327 , C23C14/54 , C23C14/564 , F21S6/002 , F21Y2115/20 , H01J49/004 , H01J49/42 , H01L51/001 , H01L51/56 , H05B33/10
摘要： In order to provide a highly reliable organic EL element, a first step in which a deposition material is heated and vaporized in a deposition chamber in which the pressure is reduced and a second step in which a layer included in an EL layer is deposited in the deposition chamber are performed while exhaustion is performed and the partial pressure of water in the deposition chamber is measured with a mass spectrometer. Alternatively, the deposition chamber in the deposition apparatus includes a deposition material chamber and is connected to an exhaust mechanism. The deposition material chamber is separated from the deposition chamber by a sluice valve, includes a deposition material holding portion including a heating mechanism, and is connected to a mass spectrometer and an exhaust mechanism.
摘要翻译：为了提供高可靠性的有机EL元件，在沉积材料在压力降低的沉积室中被加热和蒸发的第一步骤和其中包含在EL层中的层沉积在第二步骤中的第二步骤在进行耗尽的同时进行沉积室，并且用质谱仪测量沉积室中的水分压。或者，沉积设备中的沉积室包括沉积材料室并连接到排气机构。沉积材料室通过闸阀与沉积室分离，包括具有加热机构的沉积材料保持部分，并连接到质谱仪和排气机构。

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