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31. 发明申请

US20150247785A1 MODIFIED CARBOCYANINE DYES AND THEIR CONJUGATES 审中-公开
公开(公告)号：US20150247785A1
公开(公告)日：2015-09-03
申请号：US14656992
申请日：2015-03-13
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Wai-Yee LEUNG , Ching-Ying CHEUNG , Stephen YUE
IPC分类号： G01N1/30 , C09B23/10 , C07D403/14 , G01N33/535 , G01N33/58 , C12Q1/68 , G01N33/533 , C07D209/24 , C09B23/06
CPC分类号： G01N1/30 , A61K41/0057 , C07C66/02 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/16 , C07D209/18 , C07D209/24 , C07D209/54 , C07D209/60 , C07D209/96 , C07D401/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D417/06 , C07D417/14 , C07D471/04 , C07D498/04 , C07K1/13 , C09B23/02 , C09B23/06 , C09B23/083 , C09B23/107 , C12Q1/6825 , C40B70/00 , G01N31/22 , G01N33/533 , G01N33/535 , G01N33/58 , G01N33/581 , G01N33/582 , G01N2001/302 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.

32. 发明申请

US20150233905A1 METHODS AND ARRAYS FOR TARGET ANALYTE DETECTION AND DETERMINATION OF TARGET ANALYTE CONCENTRATION IN SOLUTION 有权
标题翻译：方法和阵列目标分析仪检测和测定目标分析仪浓度在溶液中
公开(公告)号：US20150233905A1
公开(公告)日：2015-08-20
申请号：US14638245
申请日：2015-03-04
申请人： Trustees of Tufts College
发明人： David R. Walt , David M. Rissin
IPC分类号： G01N33/543
CPC分类号： G01N33/581 , C12Q1/6837 , G01N33/543 , G01N33/54346 , G01N33/54366 , G01N33/54386 , G01N2333/938 , C12Q2527/143
摘要： Arrays of single molecules and methods of producing an array of single molecules are described. Arrays with defined volumes between 10 attoliters and 50 picoliters enable single molecule detection and quantitation.
摘要翻译：描述单分子阵列和产生单分子阵列的方法。在10个载体和50个皮升之间具有定义体积的数组使得能够进行单分子检测和定量。

33. 发明申请

US20150218616A1 Methods and Systems for Rapid Detection of Microorganisms using Infectious Agents 审中-公开
标题翻译：使用传染剂快速检测微生物的方法和系统
公开(公告)号：US20150218616A1
公开(公告)日：2015-08-06
申请号：US14625481
申请日：2015-02-18
申请人： Laboratory Corporation of America Holdings
发明人： Dwight Lyman Anderson , Jose S. Gil , Ben Barrett Hopkins , Stephen Erickson
IPC分类号： C12Q1/66
CPC分类号： C12Q1/66 , C12N15/86 , C12N2795/10121 , C12N2795/10131 , C12N2795/10143 , C12N2795/10221 , C12N2795/10231 , C12N2795/10243 , G01N33/569 , G01N33/56911 , G01N33/581
摘要： Disclosed herein are methods and systems for rapid detection of microorganisms in a sample, without culturing for enrichment of the microorganism. A modified bacteriophage is also disclosed which comprises a non-native indicator gene in the late gene region. The indicator product is not a fusion protein. The specificity of infectious agents allows a specific microorganism to be targeted, and an indicator signal may be amplified to optimize assay sensitivity.
摘要翻译：本文公开了用于快速检测样品中微生物的方法和系统，而不培养用于富集微生物。还公开了一种修饰的噬菌体，其包含晚期基因区域中的非天然指示基因。指示剂不是融合蛋白。感染剂的特异性允许特异性微生物被靶向，并且可以扩增指示信号以优化测定灵敏度。

34. 发明申请

US20150218615A1 METHODS FOR DETECTING ORGANISMS AND ENZYMATIC REACTIONS USING RAMAN SPECTROSCOPY AND AROMATIC COMPOUNDS COMPRISING PHOSPHATE 审中-公开
标题翻译：使用拉曼光谱和包含磷酸盐的芳香化合物检测有机物和酶促反应的方法
公开(公告)号：US20150218615A1
公开(公告)日：2015-08-06
申请号：US14636513
申请日：2015-03-03
申请人： Neal Arthur SIEGEL , Samar Kumar KUNDU , Charles Lester Ginsburgh
发明人： Neal Arthur SIEGEL , Samar Kumar KUNDU , Charles Lester GINSBURGH
IPC分类号： C12Q1/42 , G01N33/569 , G01N33/58
CPC分类号： C12Q1/42 , C12Q1/28 , G01N21/65 , G01N33/56911 , G01N33/56916 , G01N33/56938 , G01N33/56983 , G01N33/58 , G01N33/581 , G01N2333/55
摘要： The present disclosure provides systems for the rapid and sensitive detection of organisms and molecules in samples. Reactants that produce Raman-active products are used in combination with Raman light scattering. Such compounds may comprise phosphates permitting the detection of phosphatases. The present disclosure can also be used to measure enzyme-kinetics.
摘要翻译：本公开提供了用于在样品中快速和灵敏地检测生物体和分子的系统。产生拉曼活性物质的反应物与拉曼光散射结合使用。这样的化合物可以包括允许检测磷酸酶的磷酸盐。本公开还可以用于测量酶动力学。

35. 发明申请

US20150218380A1 MODIFIED CARBOCYANINE DYES AND THEIR CONJUGATES 有权
公开(公告)号：US20150218380A1
公开(公告)日：2015-08-06
申请号：US14687584
申请日：2015-04-15
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Wai-Yee LEUNG , Ching-Ying CHEUNG , Stephen YUE
IPC分类号： C09B23/10 , C07D403/14 , C07D209/12 , C07D209/14 , C07D471/04 , C09B23/08 , C07D209/60 , C07D498/04 , C09B23/06 , C07D209/18 , C07D417/06
CPC分类号： G01N1/30 , A61K41/0057 , C07C66/02 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/16 , C07D209/18 , C07D209/24 , C07D209/54 , C07D209/60 , C07D209/96 , C07D401/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D417/06 , C07D417/14 , C07D471/04 , C07D498/04 , C07K1/13 , C09B23/02 , C09B23/06 , C09B23/083 , C09B23/107 , C12Q1/6825 , C40B70/00 , G01N31/22 , G01N33/533 , G01N33/535 , G01N33/58 , G01N33/581 , G01N33/582 , G01N2001/302 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.

36. 发明授权

US09091691B2 Immunochemical detection of single target entities 有权
标题翻译：单一目标实体的免疫化学检测
公开(公告)号：US09091691B2
公开(公告)日：2015-07-28
申请号：US13502727
申请日：2010-10-15
申请人： Jesper Lohse
发明人： Jesper Lohse
IPC分类号： G01N33/535 , C12Q1/28 , G01N33/53 , G01N33/58 , G01N33/543
CPC分类号： G01N33/581 , G01N33/54306
摘要： The present invention relates to immunochemical visualization and quantification of single target entities, such as single molecules, single molecular structures, single particles, etc. in samples wherein said single entities are immobilized. In particular, the invention relates to methods for visualization and quantification of single units of biological or chemical targets, in particular to immunochemical visualization of single molecules of biological targets in histological samples. The methods of the invention comprise a step of forming discrete deposits of detectable molecules at single target sites of sample mediated by an enzyme with oxydoreductase activity, wherein a single target site comprises a single unit of a target. The invention also relates to assays comprising the present visualization and quantification methods and diagnostic applications of said methods.
摘要翻译：本发明涉及在其中所述单个实体被固定的样品中的单一目标实体（例如单分子，单分子结构，单个颗粒等）的免疫化学可视化和定量。特别地，本发明涉及用于可视化和定量生物或化学靶单个单位的方法，特别是组织学样品中单分子生物靶标的免疫化学可视化。本发明的方法包括在具有氧化还原酶活性的酶介导的样品的单个靶位点处形成可检测分子的离散沉积物的步骤，其中单个靶位点包含单个靶标单位。本发明还涉及包括本发明的可视化和定量方法以及所述方法的诊断应用的测定。

37. 发明授权

US09079963B2 Monoclonal antibody for the detection of SNAP/CLIP tag 有权
标题翻译：用于检测SNAP / CLIP标签的单克隆抗体
公开(公告)号：US09079963B2
公开(公告)日：2015-07-14
申请号：US14358628
申请日：2012-11-26
申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
发明人： Stefan Barth , Katharina Kolberg , Christiane Püttmann , Severin Schmies
IPC分类号： C07K16/40 , C12N15/13 , G01N33/573 , G01N33/58
CPC分类号： C07K16/40 , C07K2317/565 , G01N33/573 , G01N33/581 , G01N2333/91011
摘要： A monoclonal antibody that binds specifically to the SNAP motif and to the CLIP tag comprising CDRs with the amino acid sequences SEQ ID Nos. 3, 4, 5, and 8, 9, 10.
摘要翻译：特异性结合SNAP基序和CLIP标签的单克隆抗体，其包含具有氨基酸序列SEQ ID No.3,4,5和8,9,10的CDR。

38. 发明授权

US09052275B2 Systems and methods for detection and quantification of analytes 有权
公开(公告)号：US09052275B2
公开(公告)日：2015-06-09
申请号：US14543842
申请日：2014-11-17
申请人： CUE INC.
发明人： Ayub Khattak , Clinton Sever
IPC分类号： G01N27/28 , G01N35/08 , G01N33/543 , H04M1/725 , B01L3/00 , G01N35/00 , G01N27/327
CPC分类号： B01L3/502715 , B01L3/5027 , B01L3/502723 , B01L3/502738 , B01L3/5029 , B01L2200/025 , B01L2200/026 , B01L2200/027 , B01L2200/028 , B01L2200/04 , B01L2200/0668 , B01L2200/0684 , B01L2200/0689 , B01L2200/087 , B01L2200/10 , B01L2200/16 , B01L2300/023 , B01L2300/025 , B01L2300/04 , B01L2300/044 , B01L2300/06 , B01L2300/0627 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/12 , B01L2300/161 , B01L2300/1827 , B01L2400/0406 , B01L2400/0487 , B01L2400/0677 , B01L2400/0683 , B05D3/002 , B05D2518/00 , C12Q1/6825 , F16K99/0032 , F16K99/0036 , F16K2099/0084 , G01N1/02 , G01N21/78 , G01N27/28 , G01N27/3271 , G01N27/3272 , G01N27/3273 , G01N33/54306 , G01N33/54326 , G01N33/54333 , G01N33/54366 , G01N33/54373 , G01N33/5438 , G01N33/581 , G01N35/00029 , G01N35/0098 , G01N35/08 , G01N35/1095 , G01N2001/027 , G01N2001/028 , G01N2035/00277 , G01N2035/00564 , G01N2458/30 , H04M1/72527 , H04M1/7253 , Y10T137/1797
摘要： Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. In some embodiments, the reader component communicates with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

39. 发明申请

US20150136599A1 SYSTEMS AND METHODS FOR DETECTION AND QUANTIFICATION OF ANALYTES 有权
公开(公告)号：US20150136599A1
公开(公告)日：2015-05-21
申请号：US14599375
申请日：2015-01-16
申请人： CUE INC.
发明人： Ayub Khattak , Clinton Sever
IPC分类号： G01N27/327
CPC分类号： B01L3/502715 , B01L3/5027 , B01L3/502723 , B01L3/502738 , B01L3/5029 , B01L2200/025 , B01L2200/026 , B01L2200/027 , B01L2200/028 , B01L2200/04 , B01L2200/0668 , B01L2200/0684 , B01L2200/0689 , B01L2200/087 , B01L2200/10 , B01L2200/16 , B01L2300/023 , B01L2300/025 , B01L2300/04 , B01L2300/044 , B01L2300/06 , B01L2300/0627 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/12 , B01L2300/161 , B01L2300/1827 , B01L2400/0406 , B01L2400/0487 , B01L2400/0677 , B01L2400/0683 , B05D3/002 , B05D2518/00 , C12Q1/6825 , F16K99/0032 , F16K99/0036 , F16K2099/0084 , G01N1/02 , G01N21/78 , G01N27/28 , G01N27/3271 , G01N27/3272 , G01N27/3273 , G01N33/54306 , G01N33/54326 , G01N33/54333 , G01N33/54366 , G01N33/54373 , G01N33/5438 , G01N33/581 , G01N35/00029 , G01N35/0098 , G01N35/08 , G01N35/1095 , G01N2001/027 , G01N2001/028 , G01N2035/00277 , G01N2035/00564 , G01N2458/30 , H04M1/72527 , H04M1/7253 , Y10T137/1797
摘要： Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. In some embodiments, the reader component communicates with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

40. 发明授权

US09034168B2 Systems and methods for detection and quantification of analytes 有权
公开(公告)号：US09034168B2
公开(公告)日：2015-05-19
申请号：US14479149
申请日：2014-09-05
申请人： CUE, INC.
发明人： Ayub Khattak , Clinton Sever
IPC分类号： G01N35/00 , G01N33/543 , G01N27/327
CPC分类号： B01L3/502715 , B01L3/5027 , B01L3/502723 , B01L3/502738 , B01L3/5029 , B01L2200/025 , B01L2200/026 , B01L2200/027 , B01L2200/028 , B01L2200/04 , B01L2200/0668 , B01L2200/0684 , B01L2200/0689 , B01L2200/087 , B01L2200/10 , B01L2200/16 , B01L2300/023 , B01L2300/025 , B01L2300/04 , B01L2300/044 , B01L2300/06 , B01L2300/0627 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/12 , B01L2300/161 , B01L2300/1827 , B01L2400/0406 , B01L2400/0487 , B01L2400/0677 , B01L2400/0683 , B05D3/002 , B05D2518/00 , C12Q1/6825 , F16K99/0032 , F16K99/0036 , F16K2099/0084 , G01N1/02 , G01N21/78 , G01N27/28 , G01N27/3271 , G01N27/3272 , G01N27/3273 , G01N33/54306 , G01N33/54326 , G01N33/54333 , G01N33/54366 , G01N33/54373 , G01N33/5438 , G01N33/581 , G01N35/00029 , G01N35/0098 , G01N35/08 , G01N35/1095 , G01N2001/027 , G01N2001/028 , G01N2035/00277 , G01N2035/00564 , G01N2458/30 , H04M1/72527 , H04M1/7253 , Y10T137/1797
摘要： Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. In some embodiments, the reader component communicates with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

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