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31. 发明授权

US5776702A Process for the determination of an immunologically detectable substance and a suitable reaction vessel therefor 失效
标题翻译：用于测定免疫学可检测物质及其合适的反应容器的方法
公开(公告)号：US5776702A
公开(公告)日：1998-07-07
申请号：US271855
申请日：1994-07-07
申请人： Urban Schmitt , Eberhard Maurer , Wolfgang Rudinger , Rolf Deeg
发明人： Urban Schmitt , Eberhard Maurer , Wolfgang Rudinger , Rolf Deeg
IPC分类号： G01N33/531 , G01N33/543 , G01N33/569 , G01N33/574 , G01N33/58 , G01N33/547
CPC分类号： G01N33/57473 , G01N33/531 , G01N33/54366 , G01N33/56988 , G01N33/58 , Y10S435/82 , Y10S436/811
摘要： For the determination of an immunologically detectable substance based on a heterogeneous immunoassay by use of a solid phase on which one of the immunologically active reaction components is bound, a reaction vessel is used as the solid phase on the inner surface of which streptavidin or avidin is bound in such an amount that 0.1 to 2.5 .mu.g are present per ml reaction volume. A suitable reaction vessel for this has optically transparent wall areas which face one another and has avidin or streptavidin coated walls which are at least partially within the inner wall region intended as a receptacle for liquid, wherein the inner space of the container intended as a receptacle for liquid and the respective streptavidin or avidin content of the coating are so matched that 0.1 to 2.5 .mu.g streptavidin or avidin are present per ml reaction volume.
摘要翻译：为了通过使用其上结合有免疫活性的反应组分的固相来测定基于非均相免疫测定的免疫学可检测物质，使用反应容器作为其内表面上的固相，其中链霉亲和素或抗生物素蛋白为结合量为每ml反应体积存在0.1至2.5μg。合适的反应容器具有相互面对的光学透明壁区域，并且具有至少部分位于旨在作为液体容器的内壁区域内的抗生物素蛋白或链霉抗生物素蛋白包被的壁，其中容器的内部空间用作容器对于液体，并且涂层的各自的链霉抗生物素蛋白或抗生物素蛋白含量如此匹配，每ml反应体积存在0.1至2.5μg链霉亲和素或抗生物素蛋白。

32. 发明授权

US5380647A Simple test for detecting carcinoembryonic antigen in stool 失效
标题翻译：在粪便中检测癌胚抗原的简单检测
公开(公告)号：US5380647A
公开(公告)日：1995-01-10
申请号：US53024
申请日：1993-04-26
申请人： Kamal Bahar
发明人： Kamal Bahar
IPC分类号： G01N33/53 , C12Q1/02 , G01N33/574 , G01N1/18
CPC分类号： G01N33/57473 , Y10S435/803 , Y10S435/961 , Y10T436/25375 , Y10T436/255
摘要： A rapid, simple, sensitive and reliable method for detecting fecal carcinoembryonic antigens in stool, indicative of the presence of the colorectal cancer is described. The invention is based on the discovery that previous methods of removing coarse and gelatinous materials from a stool and liquid mixture resulted in removing a significant amount of total CEA and CEA-like substances. By not removing or destroying or altering molecules smaller than 500,000 MW, in the process of preparing the stool sample to be examined, a significant portion of CEA and CEA-like substances will remain in the filtered liquid for detection.
摘要翻译：描述了用于检测粪便中的粪便癌胚抗原的快速，简单，灵敏和可靠的方法，指示结肠直肠癌的存在。本发明基于以下发现：先前从粪便和液体混合物中去除粗糙和凝胶状材料的方法导致大量除去总CEA和CEA类物质。在制备要检查的粪便样品的过程中，通过不去除或破坏或改变小于500,000MW的分子，大部分CEA和CEA样物质将保留在经过过滤的液体中进行检测。

33. 发明授权

US4631254A Carcinoembryonic antigen determination 失效
标题翻译：癌胚抗原测定
公开(公告)号：US4631254A
公开(公告)日：1986-12-23
申请号：US773263
申请日：1985-09-06
申请人： Nicholas A. Giorgio , John Krupey , Leonard T. Wilson
发明人： Nicholas A. Giorgio , John Krupey , Leonard T. Wilson
IPC分类号： G01N33/574 , G01N33/53 , G01N33/539 , G01N33/541
CPC分类号： G01N33/57473 , Y10S435/962 , Y10S435/967 , Y10S435/971 , Y10S436/804 , Y10S436/813 , Y10S436/825 , Y10S436/826 , Y10T436/25125 , Y10T436/25375
摘要： Process for the determination of carcinoembryonic antigen (CEA) in a sample of serum or plasma. The process comprises contacting a slightly acidic buffered sample of the serum or plasma with hydrophilic silica at room temperature, separating the silica from the sample and carrying out a radioimmunoassay for carcinoembryonic antigen on said sample.
摘要翻译：用于测定血清或血浆样品中癌胚抗原（CEA）的方法。该方法包括在室温下将血清或血浆的微酸性缓冲样品与亲水性二氧化硅接触，将二氧化硅与样品分离，并对所述样品上的癌胚抗原进行放射免疫测定。

34. 发明授权

US4467031A Enzyme-immunoassay for carcinoembryonic antigen 失效
标题翻译：癌胚抗原的酶免疫测定
公开(公告)号：US4467031A
公开(公告)日：1984-08-21
申请号：US408388
申请日：1982-08-16
申请人： Harald Gallati , Hans Brodbeck
发明人： Harald Gallati , Hans Brodbeck
IPC分类号： G01N33/574 , G01N33/54
CPC分类号： G01N33/57473 , Y10S435/81 , Y10S435/962 , Y10S435/963 , Y10S435/975 , Y10S436/813 , Y10S436/826
摘要： A solid phase-sandwich enzyme-immunoassay method for the rapid determination of carcinoembryonic antigen (CEA). The sample to be investigated is incubated with a first CEA antibody, which is bound to a water-insoluble carrier, and a second CEA antibody, to which peroxidase is bound directly or via a biotin/avidin bridge. The immunological reaction can be carried out in one or two steps. By the presence of 0.4-1.0 mol/l of phosphate ions, 0.3-0.4 mol/l of sulfate ions or 0.2-0.4 mol/l of tartrate ions in the immunological reaction or in the second step thereof (insofar as it is carried out in two steps) the incubation time period is shortened considerably. After the immunological reaction, the phases are separated, whereupon the peroxidase activity is measured either in the solid or in the liquid phase as the amount of CEA present in the sample.
摘要翻译：一种用于快速测定癌胚抗原（CEA）的固相夹层酶免疫测定方法。将待研究的样品与结合于水不溶性载体的第一CEA抗体和第二CEA抗体一起孵育，过氧化物酶直接或通过生物素/抗生物素蛋白桥结合到其上。免疫反应可以在一个或两个步骤中进行。通过在免疫反应或第二步中存在0.4-1.0mol / l的磷酸根离子，0.3-0.4mol / l的硫酸根离子或0.2-0.4mol / l的酒石酸根离子（只要它被执行）在两个步骤中，孵育时间大大缩短。免疫反应后，分离各相，由此在固体或液相中测量过氧化物酶活性，作为样品中存在的CEA的量。

35. 发明授权

US4228236A Process of producing carcinoembryonic antigen 失效
标题翻译：产生癌胚抗原的方法
公开(公告)号：US4228236A
公开(公告)日：1980-10-14
申请号：US906036
申请日：1978-05-15
申请人： Milda M. Jakstys , Baldwin H. Tom , Barry D. Kahan
发明人： Milda M. Jakstys , Baldwin H. Tom , Barry D. Kahan
IPC分类号： A61K39/00 , G01N33/574 , C12K9/00
CPC分类号： G01N33/57473 , A61K39/00
摘要： Carcinoembryonic antigen (CEA) is produced in vitro from the cell lines LS-180 (ATCC No. CL-187), LS-174T (ATCC No. CL-188), and cells derived therefrom. The CEA thus produced can be used as a standard source for radioimmunoassay procedures to determine CEA plasma levels.
摘要翻译：从细胞系LS-180（ATCC号CL-187），LS-174T（ATCC号CL-188）和从其衍生的细胞体外产生癌胚抗原（CEA）。因此产生的CEA可用作放射免疫测定程序的标准来源，以确定CEA血浆水平。

36. 发明授权

US11820821B2 Anti-CEACAM6 antibodies and methods of use 有权
公开(公告)号：US11820821B2
公开(公告)日：2023-11-21
申请号：US17560232
申请日：2021-12-22
申请人： Singapore Health Services PTE LTD , AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： Hau Wan Leung , Andre Boon Hwa Choo , Mei Yee Vanessa Ding , Shao Weng Daniel Tan , Narayanan Gopalakrishna Iyer
IPC分类号： C07K16/28 , A61P35/00 , G01N33/574 , A61K47/64 , A61K47/68 , C07K16/44 , A61K51/10 , C07K16/30 , A61K39/00
CPC分类号： C07K16/2803 , A61K47/6415 , A61K47/6857 , A61K51/1048 , A61P35/00 , C07K16/30 , C07K16/44 , G01N33/57473 , A61K2039/505 , A61K2039/55 , C07K2317/732
摘要： The present invention relates to an antigen-binding protein, or an antigen-binding fragment thereof which binding to CEACAM6, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GNTFTSYVMH; a VHCDR2 having the amino acid sequence YINPYNDGTKYNEKFKG; and a VHCDR3 having the amino acid sequence STARATPYFYAMDY and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KSSQSLLWSVNQNSYLS, a VLCDR2 having the amino acid sequence GASIRES, and a VLCDR3 having the amino acid sequence QHNHGSFLPYT. The present invention also relates to compositions comprising the antigen-binding protein, or antigen-binding fragment thereof, methods of use of the antigen-binding protein, or antigen-binding fragment thereof for cancer treatment, prevention or detection and a kit comprising the antigen-binding protein, or antigen-binding fragment thereof.

37. 发明申请

US20180016338A1 ANTI CEACAM1 ANTIBODIES AND METHODS OF USING SAME 审中-公开
公开(公告)号：US20180016338A1
公开(公告)日：2018-01-18
申请号：US15715386
申请日：2017-09-26
申请人： TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. , RAMOT AT TEL AVIV UNIVERSITY LTD.
发明人： Gal MARKEL , Rona ORTENBERG , Jacob SCHACHTER
IPC分类号： C07K16/28 , G01N33/574 , A61K39/395 , A61K45/06 , A61K39/00
CPC分类号： C07K16/2803 , A61K35/17 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/14 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57473 , G01N33/57492 , G01N2333/70503
摘要： A hybridoma cell which has been deposited under ATCC Accession Number PTA-9974 is disclosed. Also provided are Antibodies and methods of using same.

38. 发明授权

US09632082B2 Motor protein device 有权
公开(公告)号：US09632082B2
公开(公告)日：2017-04-25
申请号：US14359727
申请日：2012-11-29
申请人： TAIYO YUDEN CO., LTD. , NAGAOKA UNIVERSITY OF TECHNOLOGY
发明人： Takashi Ishiguro , Hajime Honda
IPC分类号： G01N33/558 , G01N33/574 , G01N33/537
CPC分类号： G01N33/558 , G01N33/537 , G01N33/57473
摘要： [Problem] To provide a motor protein device capable of efficiently transporting and detecting a target antibody.[Solution] A motor protein device of the present invention includes a collection region where a carrier molecule collects a target molecule using antigen-antibody reaction, and an unloading region where the target molecule is unloaded from the carrier molecule using chemical equilibrium. Further, the motor protein device includes a transport path provided between the collection region and the unloading region through which the carrier molecule can transport the target molecule, and an analysis portion which detects a change in concentration of the target molecule in the unloading region. The unloading region includes certain antibody having capture force higher than predetermined antibody being modified to the carrier molecule and the target molecule is concentrated in the unloading region. The carrier molecule includes actin obtained by modifying the predetermined antibody, and the transport path includes immobilized myosin.

39. 发明申请

US20170089907A1 METHODS FOR MEASURING CARCINOEMBRYONIC ANTIGEN 审中-公开
公开(公告)号：US20170089907A1
公开(公告)日：2017-03-30
申请号：US15147960
申请日：2016-05-06
申请人： Interpace Diagnostics Corporation
发明人： Sydney David Finkelstein , Sara Ann Jackson , Jamie Michelle Bleicher , Eric Matthew Gayle Ellsworth , Dennis Morgan Smith, JR.
IPC分类号： G01N33/574
CPC分类号： G01N33/57473
摘要： Disclosed herein are methods of accurately measuring carcinoembryonic antigen in a biological sample and methods of identifying and treating a mucinous cyst in a subject.

40. 发明授权

US09557329B2 Quantitative analyte assay device and method 有权
标题翻译：定量分析物测定装置及方法
公开(公告)号：US09557329B2
公开(公告)日：2017-01-31
申请号：US14541093
申请日：2014-11-13
申请人： Assurance LLC
发明人： Jin Po Lee
IPC分类号： G01N33/558 , G01N33/543 , G01N21/78 , G01N33/74 , G01N21/64 , G01N21/77
CPC分类号： G01N33/54373 , G01N21/78 , G01N33/54366 , G01N33/558 , G01N33/57434 , G01N33/57473 , G01N33/74 , G01N33/78 , G01N2021/6439 , G01N2021/7786 , G01N2021/7793 , G01N2021/7796 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/81 , Y10S436/811 , Y10S436/813 , Y10S436/814 , Y10S436/818
摘要： The present invention related to a quantitative assay device and a method for the determination of an analyte, based on a test strip, which contains a porous test membrane allowing for capillary flow of the analyte and complexes of the analyte, a porous upstream membrane in fluid connection with the test membrane and a porous downstream membrane in fluid connection with the test membrane, wherein the test membrane contains two bands having deposited on there high and low concentrations of different calibrator agents and a test band capable of reacting with conjugated analyte complexes giving rise to a measurable signal.
摘要翻译：本发明涉及一种定量测定装置和一种基于测试条测定分析物的方法，该测试条包含允许分析物和分析物复合物毛细管流动的多孔测试膜，流体中的多孔上游膜与测试膜的连接和与测试膜流体连接的多孔下游膜，其中测试膜包含沉积有高浓度和低浓度的不同校准剂的两个带和能够与共轭分析物复合物反应的测试带到可测量的信号。

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