专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明授权

US08467040B2 Method and apparatus for sorting cells 有权
标题翻译：用于分选细胞的方法和装置
公开(公告)号：US08467040B2
公开(公告)日：2013-06-18
申请号：US13214699
申请日：2011-08-22
申请人： Mark Luscher
发明人： Mark Luscher
IPC分类号： G01N21/64 , C12M1/34 , C12M1/42
CPC分类号： G01N33/5005 , C12M47/04 , G01N15/1404 , G01N2015/1409 , G01N2015/149
摘要： A method, apparatus, and system for a sorting flow cytometer include an objective lens having an optical axis coaxially aligned with the flow path at the focal point. A controllable energy source selectively alters an analyte according to a determination of whether the analyte is in a desired sub-population. In various embodiments, one or both of the emission from the controllable energy source and/or the emission from an illumination energy source passes through the objective lens. In some embodiments in which the emission from the controllable energy source passes through the objective lens, the objective lens may focus the emission from the controllable energy source at a different point than the focal point of a signal detected from the analyte and, in particular, at a point closer to the objective lens.
摘要翻译：用于分选流式细胞仪的方法，装置和系统包括具有与焦点处的流动路径同轴对准的光轴的物镜。可控能量源根据分析物是否在期望的子群体的确定来选择性地改变分析物。在各种实施例中，来自可控能源的发射和/或来自照明能量源的发射中的一个或两个通过物镜。在可控能量源的发射通过物镜的一些实施例中，物镜可将来自可控能量源的发射聚焦在与从分析物检测的信号的焦点不同的点上，在更靠近物镜的位置。

32. 发明申请

US20130079240A1 PARTICLE QUANTIFYING SYSTEMS AND METHODS USING ACOUSTIC RADIATION PRESSURE 有权
标题翻译：颗粒定量系统和使用声辐射压力的方法
公开(公告)号：US20130079240A1
公开(公告)日：2013-03-28
申请号：US13614956
申请日：2012-09-13
申请人： Michael D. WARD , Gregory Kaduchak
发明人： Michael D. WARD , Gregory Kaduchak
IPC分类号： G01N21/64
CPC分类号： G01N15/1404 , A61M1/3678 , G01N15/12 , G01N15/147 , G01N21/1702 , G01N21/64 , G01N21/6428 , G01N21/645 , G01N27/447 , G01N29/222 , G01N33/56966 , G01N2015/1409 , G01N2015/1415 , G01N2015/142 , G01N2291/02416 , G01N2291/02809 , G01N2291/02836 , Y10T436/101666 , Y10T436/25 , Y10T436/25375 , Y10T436/25625 , Y10T436/2575
摘要： The present invention comprises methods and systems that use acoustic radiation pressure.
摘要翻译：本发明包括使用声辐射压力的方法和系统。

33. 发明授权

US08394326B2 Flow cytometer and fluidic line assembly with multiple injection needles 有权
标题翻译：流式细胞仪和具有多个注射针的流体线组件
公开(公告)号：US08394326B2
公开(公告)日：2013-03-12
申请号：US13271569
申请日：2011-10-12
申请人： Jarden E. Krager , William R. Deicher , Adam Richard Schilffarth , Paul Pempsell , Wayne D. Roth
发明人： Jarden E. Krager , William R. Deicher , Adam Richard Schilffarth , Paul Pempsell , Wayne D. Roth
IPC分类号： G01N21/01
CPC分类号： G01N15/1404 , G01N21/6428 , G01N21/76 , G01N2015/1409 , Y10T137/0352 , Y10T137/85986 , Y10T436/2575
摘要： A flow cytometer is provided which includes an interrogation flow cell and a plurality of assay fluidic lines extending into the interrogation flow cell. A method of operating such a flow cytometer includes priming the interrogation flow cell with a sheath fluid and injecting different assay fluids into a flow of the sheath fluid through the plurality of fluidic lines. A fluidic line assembly is provided which includes a plurality of capillary tubes coupled to a base section configured for coupling to an interrogation flow cell assembly of a flow cytometer. The capillary tubes are dimensionally configured such that when the fluidic line assembly is arranged within the flow cytometer and fluid is dispensed from one or more of the capillary tubes at a given pressure differential with respect to an encompassing sheath fluid within the interrogation flow cell the fluid is substantially centrally aligned within the interrogation flow cell.
摘要翻译：提供了流式细胞仪，其包括询问流动池和延伸到询问流动池中的多个测定流体线。操作这种流式细胞计数器的方法包括用鞘液灌注询问流动池，并将不同的分析流体注入穿过多条流体管线的鞘液流。提供流体线组件，其包括多个毛细管，所述多个毛细管耦合到构造成耦合到流式细胞仪的询问流动池组件的基部。毛细管的尺寸构造使得当流体线组件布置在流式细胞计数器内并且流体从一个或多个毛细管以相对于询问流动池内的包围护套流体的给定压力差分配时，流体在询问流动池内基本集中对齐。

34. 发明授权

US08309408B2 Particle quantifying systems and methods using acoustic radiation pressure 有权
标题翻译：使用声辐射压力的粒子量化系统和方法
公开(公告)号：US08309408B2
公开(公告)日：2012-11-13
申请号：US12239513
申请日：2008-09-26
申请人： Michael D. Ward , Gregory Kaduchak
发明人： Michael D. Ward , Gregory Kaduchak
IPC分类号： C02F1/00 , G01N1/22
CPC分类号： G01N15/1404 , A61M1/3678 , G01N15/12 , G01N15/147 , G01N21/1702 , G01N21/64 , G01N21/6428 , G01N21/645 , G01N27/447 , G01N29/222 , G01N33/56966 , G01N2015/1409 , G01N2015/1415 , G01N2015/142 , G01N2291/02416 , G01N2291/02809 , G01N2291/02836 , Y10T436/101666 , Y10T436/25 , Y10T436/25375 , Y10T436/25625 , Y10T436/2575
摘要： A method for fractionating particles includes flowing a fluid having particles therein along a first channel, applying acoustic radiation pressure to the fluid, focusing the particles within the fluid into a single file line, moving the particles in a flow rate, applying acoustic radiation pressure to the fluid for a second time, focusing the particles based on size and acoustic contrast, producing at least two fluid fractions of the particles, and collecting at least one of the fractions.
摘要翻译：分级颗粒的方法包括沿着第一通道流动具有颗粒的流体，向流体施加声辐射压力，将流体内的颗粒聚焦成单个文件管线，以流速移动颗粒，将声辐射压力施加到流体第二次聚焦基于尺寸和声学对比度的颗粒，产生颗粒的至少两个流体部分，并收集至少一个馏分。

35. 发明授权

US08227257B2 Medium switching systems and methods using acoustic radiation pressure 有权
标题翻译：中等开关系统和使用声辐射压力的方法
公开(公告)号：US08227257B2
公开(公告)日：2012-07-24
申请号：US12239390
申请日：2008-09-26
申请人： Michael D. Ward , Carleton C. Stewart , Gregory Kaduchak
发明人： Michael D. Ward , Carleton C. Stewart , Gregory Kaduchak
IPC分类号： G01N37/00
CPC分类号： G01N15/1404 , A61M1/3678 , G01N15/12 , G01N15/147 , G01N21/1702 , G01N21/64 , G01N21/6428 , G01N21/645 , G01N27/447 , G01N29/222 , G01N33/56966 , G01N2015/1409 , G01N2015/1415 , G01N2015/142 , G01N2291/02416 , G01N2291/02809 , G01N2291/02836 , Y10T436/101666 , Y10T436/25 , Y10T436/25375 , Y10T436/25625 , Y10T436/2575
摘要： A method for acoustically reorienting a fluid in a channel includes introducing into a channel a first fluid having a first acoustic contrast, introducing into the channel a second fluid having a second acoustic contrast that is different from the first acoustic contrast, applying acoustic radiation pressure to the channel, and acoustically reorienting the second fluid based upon the difference between the first acoustic contrast and the second acoustic contrast.
摘要翻译：用于声道重新定向通道中的流体的方法包括将具有第一声对比度的第一流体引入通道中，将具有不同于第一声对比度的第二声学对比度的第二流体引入通道中，将声辐射压力施加到基于所述第一声对比度和所述第二声对比度之间的差，对所述通道进行声学重新定向所述第二流体。

36. 发明授权

US08004661B2 Method and apparatus for sorting cells 有权
标题翻译：用于分选细胞的方法和装置
公开(公告)号：US08004661B2
公开(公告)日：2011-08-23
申请号：US12495406
申请日：2009-06-30
申请人： Mark Luscher
发明人： Mark Luscher
IPC分类号： G01N21/64 , C12M1/34 , C12M1/42
CPC分类号： G01N33/5005 , C12M47/04 , G01N15/1404 , G01N2015/1409 , G01N2015/149
摘要： A method, apparatus, and system for a sorting flow cytometer include an objective lens having an optical axis coaxially aligned with the flow path at the focal point. A controllable energy source selectively alters an analyte according to a determination of whether the analyte is in a desired sub-population. In various embodiments, one or both of the emission from the controllable energy source and/or the emission from an illumination energy source passes through the objective lens. In some embodiments in which the emission from the controllable energy source passes through the objective lens, the objective lens may focus the emission from the controllable energy source at a different point than the focal point of a signal detected from the analyte and, in particular, at a point closer to the objective lens.
摘要翻译：用于分选流式细胞仪的方法，装置和系统包括具有与焦点处的流动路径同轴对准的光轴的物镜。可控能量源根据分析物是否在期望的子群体的确定来选择性地改变分析物。在各种实施例中，来自可控能源的发射和/或来自照明能量源的发射中的一个或两个通过物镜。在可控能量源的发射通过物镜的一些实施例中，物镜可将来自可控能量源的发射聚焦在与从分析物检测的信号的焦点不同的点上，在更靠近物镜的位置。

37. 发明授权

US07997831B2 Multilayer hydrodynamic sheath flow structure 有权
标题翻译：多层流体动力鞘流动结构
公开(公告)号：US07997831B2
公开(公告)日：2011-08-16
申请号：US12610753
申请日：2009-11-02
申请人： John R. Gilbert , Manish Deshpande , Bernard Bunner
发明人： John R. Gilbert , Manish Deshpande , Bernard Bunner
IPC分类号： B65G51/00
CPC分类号： B65G51/08 , B01F13/0062 , B01F13/0064 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00891 , B01L3/502776 , B01L2200/0636 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0487 , B65G51/00 , G01N15/1404 , G01N15/1484 , G01N2015/1409
摘要： A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.
摘要翻译：用于产生鞘流的微细鞘层流动结构包括用于输送护套流体的初级鞘流动通道，用于将样品注入主鞘流道中的鞘液中的样品入口，用于将样品聚焦在护套流体和辅助聚焦区域，用于提供样品在护套液体内的附加聚焦。次要聚焦区域可以由与主鞘流道相交的流动通道形成，以从选定的方向将另外的鞘流体注入主鞘流动通道。护套流动系统可以包括在微流体芯片上并行操作的多个护套流动结构。

38. 发明授权

US07611309B2 Multilayer hydrodynamic sheath flow structure 有权
标题翻译：多层流体动力鞘流动结构
公开(公告)号：US07611309B2
公开(公告)日：2009-11-03
申请号：US11998557
申请日：2007-11-30
申请人： John R. Gilbert , Manish Deshpande , Bernard Bunner
发明人： John R. Gilbert , Manish Deshpande , Bernard Bunner
IPC分类号： B65G51/00
CPC分类号： B65G51/08 , B01F13/0062 , B01F13/0064 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00891 , B01L3/502776 , B01L2200/0636 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0487 , B65G51/00 , G01N15/1404 , G01N15/1484 , G01N2015/1409
摘要： A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.
摘要翻译：用于产生鞘流的微细鞘层流动结构包括用于输送护套流体的初级鞘流动通道，用于将样品注入主鞘流道中的鞘液中的样品入口，用于将样品聚焦在护套流体和辅助聚焦区域，用于提供样品在护套液体内的附加聚焦。次要聚焦区域可以由与主鞘流道相交的流动通道形成，以从选定的方向将另外的鞘流体注入主鞘流动通道。护套流动系统可以包括在微流体芯片上并行操作的多个护套流动结构。

39. 发明申请

US20090050573A1 Medium Switching Systems and Methods Using Acoustic Radiation Pressure 有权
标题翻译：中等开关系统和方法使用声辐射压力
公开(公告)号：US20090050573A1
公开(公告)日：2009-02-26
申请号：US12239390
申请日：2008-09-26
申请人： Michael D. Ward , Carleton C. Stewart , Gregory Kaduchak
发明人： Michael D. Ward , Carleton C. Stewart , Gregory Kaduchak
IPC分类号： B03D3/04
CPC分类号： G01N15/1404 , A61M1/3678 , G01N15/12 , G01N15/147 , G01N21/1702 , G01N21/64 , G01N21/6428 , G01N21/645 , G01N27/447 , G01N29/222 , G01N33/56966 , G01N2015/1409 , G01N2015/1415 , G01N2015/142 , G01N2291/02416 , G01N2291/02809 , G01N2291/02836 , Y10T436/101666 , Y10T436/25 , Y10T436/25375 , Y10T436/25625 , Y10T436/2575
摘要： The present invention comprises methods and systems that use acoustic radiation pressure.
摘要翻译：本发明包括使用声辐射压力的方法和系统。

40. 发明申请

US20090045107A1 Kits for Systems and Methods Using Acoustic Radiation Pressure 有权
标题翻译：使用声辐射压力的系统和方法套件
公开(公告)号：US20090045107A1
公开(公告)日：2009-02-19
申请号：US12239501
申请日：2008-09-26
申请人： Michael D. Ward , John W. Elling , Gregory Kaduchak
发明人： Michael D. Ward , John W. Elling , Gregory Kaduchak
IPC分类号： B01D21/28
CPC分类号： G01N15/1404 , A61M1/3678 , G01N15/12 , G01N15/147 , G01N21/1702 , G01N21/64 , G01N21/6428 , G01N21/645 , G01N27/447 , G01N29/222 , G01N33/56966 , G01N2015/1409 , G01N2015/1415 , G01N2015/142 , G01N2291/02416 , G01N2291/02809 , G01N2291/02836 , Y10T436/101666 , Y10T436/25 , Y10T436/25375 , Y10T436/25625 , Y10T436/2575
摘要： The present invention comprises methods and systems that use acoustic radiation pressure.
摘要翻译：本发明包括使用声辐射压力的方法和系统。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式