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31. 发明申请

US20150330886A1 APPARATUS AND METHOD FOR MIXING SOLUTION AND SYSTEM AND METHOD FOR MONITORING PARTICLES IN SOLUTION 有权
标题翻译：用于混合溶液和方法的装置和方法以及用于监测溶液中颗粒的方法
公开(公告)号：US20150330886A1
公开(公告)日：2015-11-19
申请号：US14631861
申请日：2015-02-26
申请人： Industrial Technology Research Institute
发明人： Hsin-Chia Ho , Guo-Dung Chen , Wei-En Fu , Yen-Liang Lin
IPC分类号： G01N15/10 , G01N15/02 , B01F3/04
CPC分类号： G01N15/0266 , B01F3/04056 , B01F3/0861 , B01F5/0609 , B01F11/0071 , B01F15/00019 , B01F15/0238 , B01F2003/0896 , B01F2215/0037 , G01N1/28 , G01N1/38 , G01N15/0205 , G01N15/10 , G01N2015/0038 , G01N2015/1081 , G01N2015/1087
摘要： An apparatus for mixing a solution includes first and second tanks, a sampling element, a flow control element, a mixing assembly, first and second air-intake systems, and first and second air-exhaust systems. The first tank has a first chamber. The second tank has a second chamber. The sampling element has an extraction port located in the first chamber. The flow control element connects and communicates with the first chamber. Two opposite ends of the mixing assembly connect and communicate with the first chamber and the second chamber, respectively. The first air-intake system and the first air-exhaust system connect and communicate with the first chamber. The second air-intake system and the second air-exhaust system connect and communicate with the second chamber.
摘要翻译：用于混合溶液的装置包括第一和第二罐，取样元件，流量控制元件，混合组件，第一和第二进气系统以及第一和第二排气系统。第一个坦克有一个第一个房间。第二个坦克有一个第二个舱。采样元件具有位于第一室中的抽出口。流量控制元件与第一室连接并连通。混合组件的两个相对端分别与第一腔室和第二腔室连接并连通。第一进气系统和第一排气系统与第一室连接并连通。第二进气系统和第二排气系统与第二室连接并连通。

32. 发明申请

US20150299791A1 DNA METHYLATION BIOMARKERS OF POST-PARTUM DEPRESSION RISK 审中-公开
标题翻译： DNA甲基化生物标志物的后遗症风险
公开(公告)号：US20150299791A1
公开(公告)日：2015-10-22
申请号：US14439468
申请日：2013-11-04
申请人： THE JOHNS HOPKINS UNIVERSITY , UNIVERSITY OF MARYLAND
发明人： Zachary Kaminsky , Jennifer L. Payne , Todd Gould
IPC分类号： C12Q1/68 , G06F19/00 , G01N15/10
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16 , G01N15/10 , G01N2015/008 , G01N2015/1062 , G16H50/30
摘要： The present invention relates to the field of post-partum depression. More specifically, the present invention relates to the use of biomarkers to diagnose post-partum depression or predict a risk thereof. In a specific embodiment, a method for identifying a likelihood of PPD in a patient comprises the steps of (a) providing a sample from the patient; (b) measuring white blood cell type counts and DNA methylation levels of a panel of biomarkers in the sample collected from the patient, wherein the panel of biomarkers comprises HP1BP3 and TTC9B and the white blood cell type counts comprise monocytes and non-monocytes; and (c) identifying the patient as likely to develop PPD based on the relative DNA methylation levels at the biomarker loci relative to the ratio of monocytes:non-monocytes.
摘要翻译：本发明涉及产后抑郁症领域。更具体地，本发明涉及生物标志物诊断产后抑郁症或预测其风险的用途。在具体实施方案中，用于鉴定患者中PPD可能性的方法包括以下步骤：（a）从患者提供样品; （b）测量从患者收集的样品中的一组生物标志物的白细胞类型计数和DNA甲基化水平，其中生物标志物组包括HP1BP3和TTC9B，白细胞类型计数包括单核细胞和非单核细胞; 基于相对于单核细胞比例的生物标记基因座的相对DNA甲基化水平，鉴定患者可能开发PPD：非单核细胞。

33. 发明申请

US20150293009A1 PARTICLE COUNTER AND CLASSIFICATION SYSTEM 有权
标题翻译：颗粒计数器和分类系统
公开(公告)号：US20150293009A1
公开(公告)日：2015-10-15
申请号：US14253354
申请日：2014-04-15
申请人： Spectro Scientific, Inc.
发明人： Patrick F. Henning , Eric J. Olson , John Glaberson
IPC分类号： G01N15/10 , G01N15/06
CPC分类号： G01N15/10 , G01N15/02 , G01N15/0656 , G01N15/1031 , G01N15/1459 , G01N15/1463 , G01N33/2858 , G01N2015/0053 , G01N2015/0294 , G01N2015/0693 , G01N2015/1087 , G01N2015/1093 , G01N2015/1493 , G01N2015/1497
摘要： A particle counter and classification system including an imaging subsystem configured to determine the size and morphology of particles above a predetermined size in a fluid in a sample cell. A first stage magnetometer sensor subsystem is tuned to detect and determine the size of ferrous and/or conducting particles. An optional second stage magnetometer sensor subsystem is tuned to detect the overall ferrous particle content of the fluid. A processor subsystem is configured to calculate and report the number of particles in the fluid in a plurality of size ranges, their morphology, their classification as a particular particle type according to their characteristic morphology, the number of ferrous and/or conducting particles, and the overall ferrous content of the fluid.
摘要翻译：一种粒子计数器和分类系统，包括成像子系统，该成像子系统构造成在样品池中的流体中确定高于预定尺寸的颗粒的尺寸和形态。调整第一级磁力计传感器子系统以检测和确定亚铁和/或导电颗粒的尺寸。调整可选的第二级磁力计传感器子系统以检测流体的总铁含量。处理器子系统被配置为根据其特征形态，亚铁和/或导电粒子的数量来计算和报告多个尺寸范围内的流体中的颗粒数，其形态，其作为特定颗粒类型的分类，以及流体的总铁含量。

34. 发明申请

US20150276593A1 PARTICLE DETECTORS 有权
标题翻译：颗粒检测器
公开(公告)号：US20150276593A1
公开(公告)日：2015-10-01
申请号：US14738371
申请日：2015-06-12
申请人： Xtralis Technologies Ltd
发明人： Ron Knox , Karl Boettger , Kemal Ajay
IPC分类号： G01N21/53 , G01N15/14
CPC分类号： G01N21/53 , F21K9/00 , G01N15/0205 , G01N15/10 , G01N15/1434 , G01N15/1459 , G01N21/538 , G01N2201/061 , G01N2201/062 , G01N2201/0621 , G01N2201/0627 , G01N2201/0633 , G01N2201/0696
摘要： A beam detector including a light source, a receiver, and a target, acting in cooperation to detect particles in a monitored area. The target reflects incident light, resulting in reflected light being returned to receiver. The receiver is capable of recording and reporting light intensity at a plurality of points across its field of view. In the preferred form the detector emits a first light beam in a first wavelength band; a second light beam in a second wavelength band; and a third light beam in a third wavelength band, wherein the first and second wavelengths bands are substantially equal and are different to the third wavelength band.
摘要翻译：一种包括光源，接收器和目标的光束检测器，其协同作用以检测被监视区域中的微粒。目标反射入射光，导致反射光返回到接收器。接收机能够在整个视场的多个点上记录和报告光强度。在优选形式中，检测器发射第一波长带中的第一光束; 在第二波长带中的第二光束; 以及第三波长带中的第三光束，其中所述第一和第二波长带基本相等并且与所述第三波长带不同。

35. 发明申请

US20150276572A1 STATION AND METHOD FOR MEASURING PARTICLE CONTAMINATION OF A TRANSPORT CARRIER FOR CONVEYING AND STORING SEMICONDUCTOR SUBSTRATES AT ATMOSPHERIC PRESSURE 有权
标题翻译：用于测量运输运载体在大气压力下输送和储存半导体基板的颗粒污染的站和方法
公开(公告)号：US20150276572A1
公开(公告)日：2015-10-01
申请号：US14441669
申请日：2013-11-29
申请人： ADIXEN VACUUM PRODUCTS
发明人： Cindy Thovex , Julien Bounouar , Arnaud Favre
IPC分类号： G01N15/10 , H01L21/673
CPC分类号： G01N15/10 , G01N2015/1062 , H01L21/67389
摘要： The present invention relates to a station for measuring particle contamination of a transport carrier for conveying and storing semiconductor substrates at atmospheric pressure, said transport carrier comprising a rigid casing (2) containing an aperture and a removable door (3) allowing the aperture to be closed, the measuring station comprising: a controlled environment chamber (4) comprising at least one load port (8) capable of coupling, on the one hand, to the rigid casing (2), and on the other hand, to the door (3) of the transport carrier, in order to move the door (3) into the controlled environment chamber (4) and bring the interior of the rigid casing (2) into communication with the interior of the controlled environment chamber (4); and a measuring module (5) comprising a particle measuring unit (14) and a casing-measuring interface (16) configured to couple to the rigid transport carrier casing (2) coupled to the controlled environment chamber (4) in the place of the door (3), characterized in that said casing-measuring interface (16) comprises a measuring head protruding from a base of the casing-measuring interface, bearing a first sampling orifice (12) connected to the particle measuring unit (14), and at least two injecting nozzles (20) configured to direct a gas jet onto at least two separate locations on the rigid casing (2) coupled to the controlled environment chamber (4), the respective orientations of the injecting nozzles (20) being fixed relative to the coupled rigid casing (2). The invention also relates to a method for measuring particle contamination of a transport carrier for conveying and storing semiconductor substrates at atmospheric pressure
摘要翻译：本发明涉及一种用于测量用于在大气压下输送和存储半导体衬底的运输载体的颗粒污染的站，所述运输载体包括容纳孔的刚性壳体（2）和允许孔径为关闭的测量站包括：受控环境室（4），其包括至少一个负载端口（8），所述负载端口能够一方面联接到刚性壳体（2），另一方面与所述门为了将门（3）移动到受控环境室（4）中并使刚性壳体（2）的内部与受控环境室（4）的内部连通; 以及包括粒子测量单元（14）和壳体测量接口（16）的测量模块（5），所述测量接口（16）被配置为耦合到耦合到所述受控环境室（4）的所述刚性输送载体壳体（2）门（3），其特征在于，所述壳体测量接口（16）包括从壳体测量接口的底部突出的测量头，承载连接到颗粒测量单元（14）的第一采样孔（12），以及至少两个注射喷嘴（20），其构造成将气体射流引导到耦合到受控环境室（4）的刚性壳体（2）上的至少两个分开的位置，注射喷嘴（20）的相应定向相对固定耦合到刚性壳体（2）。本发明还涉及用于测量在大气压下输送和存储半导体衬底的运输载体的颗粒污染的方法

36. 发明申请

US20150226657A1 MICROFLUIDIC SYSTEM WITH VISCOELASTIC FLUID 审中-公开
标题翻译：具有粘弹性流体的微流体系统
公开(公告)号：US20150226657A1
公开(公告)日：2015-08-13
申请号：US14620237
申请日：2015-02-12
申请人： Owl biomedical, Inc.
发明人： John S. Foster , John Francis Dunne , Daryl W. GRUMMITT , Mehran R. Hoonejani
IPC分类号： G01N15/10 , G01N15/14
CPC分类号： G01N15/10 , B01L3/502715 , B01L3/502738 , B01L3/502761 , B01L2200/0652 , B01L2300/0816 , B01L2400/0622 , B01L2400/0644 , G01N15/14 , G01N2015/1081
摘要： A system and a method are described for separating particles suspended in a fluid stream according to their weight, size or density, based on their viscoelastic interaction with a suspending fluid. The system may include a particle manipulation stage for manipulating the particles in the sample fluid, an input channel for inputting a sample fluid containing target particles and non-target material, a viscoelastic region that separates particles according to their viscoelastic behavior in the sample fluid upstream of the particle manipulation stage and at least one pickoff channel that removes a subset of the separated particles.
摘要翻译：基于它们与悬浮液的粘弹性相互作用，描述了根据其重量，尺寸或密度来分离悬浮在流体流中的颗粒的系统和方法。该系统可以包括用于操纵样品流体中的颗粒的颗粒操纵阶段，用于输入含有目标颗粒和非目标材料的样品流体的输入通道，根据其在样品流体上游的粘弹性行为分离颗粒的粘弹性区域的粒子处理阶段和至少一个去除通道，其去除分离的颗粒的子集。

37. 发明申请

US20150219543A1 CELL EVALUATION METHOD 审中-公开
标题翻译：细胞评估方法
公开(公告)号：US20150219543A1
公开(公告)日：2015-08-06
申请号：US14613672
申请日：2015-02-04
申请人： HAMAMATSU PHOTONICS K.K. , Kyoto University
发明人： Toyohiko YAMAUCHI , Tadashi FUKAMI , Norikazu SUGIYAMA , Hidenao IWAI , Yumi KAKUNO , Kentaro GOTO , Norio NAKATSUJI , Kazuhiro AIBA
IPC分类号： G01N15/10 , G01N15/00
CPC分类号： G01N15/10 , G01N15/00 , G01N15/1475 , G01N2015/0065 , G01N2015/1087 , G06K9/00127 , G06T7/0012 , G06T2207/10056 , G06T2207/30024
摘要： The present invention relates to a cell evaluation method comprising evaluating a cell differentiation degree based on a cell thickness.
摘要翻译：本发明涉及一种细胞评估方法，其包括基于细胞厚度评估细胞分化程度。

38. 发明申请

US20150219542A1 DEVICE FOR HOME MONITORING OF HAEMATOLOGICAL PARAMETERS OF PATIENTS 审中-公开
标题翻译：用于家庭监测患者的血液参数的装置
公开(公告)号：US20150219542A1
公开(公告)日：2015-08-06
申请号：US14419618
申请日：2013-08-10
申请人： KONINKLIJKE PHILIPS N.V.
发明人： Nicholas Young Kent
IPC分类号： G01N15/10 , A61B5/00 , G06F19/00 , A61B5/01
CPC分类号： G01N15/10 , A61B5/0008 , A61B5/0015 , A61B5/0022 , A61B5/01 , A61B5/14546 , A61B5/742 , A61B5/7445 , A61B5/747 , A61B2505/07 , G01N2015/008 , G01N2015/1062 , G06F19/3418 , G16H10/20 , G16H40/63
摘要： The present invention relates to a device for home monitoring of haematological parameters of patients. In particular, the device may be configured for home monitoring of patients undergoing chemotherapy. A white blood cell counter is presented in combination with a physically separated user device. The user interface and the white blood cell counter are configured to exchange data with each other. The present invention allows the white blood cell counter to be produced at lower costs, since no display is integrated into it directly. The patients may use the user interface device anywhere in their home or even on the go, allowing the maximum in freedom to fill in patient-reported outcomes or health assessment questionnaires. Also taking temperature readings is facilitated. In the home, a white blood cell test can be performed if required. The user interface guides the patient through the correct process and may therefore be brought to the cell counter.
摘要翻译：本发明涉及用于家庭监测患者血液学参数的装置。特别地，该装置可以被配置为用于家庭监测接受化疗的患者。白细胞计数器与物理分离的用户设备结合呈现。用户界面和白细胞计数器被配置为彼此交换数据。本发明允许以更低的成本生产白细胞计数器，因为不直接将其显示在其中。患者可以在家中任何地方甚至随时随地使用用户界面装置，从而最大限度地自动填写患者报告的结果或健康评估问卷。同时采取温度读数更容易。在家中，如果需要，可以进行白细胞测试。用户界面引导患者通过正确的过程，并且因此可以被带到细胞计数器。

39. 发明授权

US09091623B2 System to determine product characteristics, counts, and per unit weight details 有权
标题翻译：确定产品特性，计数和每单位重量细节的系统
公开(公告)号：US09091623B2
公开(公告)日：2015-07-28
申请号：US14173056
申请日：2014-02-05
申请人： Satake USA, Inc.
发明人： William Keith Beaty , Patric Carey Pike , Calvin G. Gray
IPC分类号： G01N15/10 , G06T7/40 , G01N33/02 , G06T7/00 , G01N33/00
CPC分类号： G01N15/10 , G01N33/02 , G01N2033/0077 , G01N2223/643 , G06K2209/17 , G06K2209/19 , G06T7/0004 , G06T7/40 , G06T2207/10024 , G06T2207/20036 , G06T2207/30242
摘要： A system for determining the characteristics of a volume of preferable small fungible products within an acceptable size range. The system differentiates among products even if in close contact to identify acceptable product. The system may store data for later review or for dispensing of product in real time. The system may include a scale to determine a sample's weight, a camera to image the sample, an imaging table to permit viewing of the sample, a processor to determine the number of products in the sample, and a processor to determine the density of desired product. The system may also determine product count-per-weight, product volume-per-weight, and/or product surface-area-per-weight. These determinations may be useful, including in determining product processing and packaging options.
摘要翻译：一种用于在可接受的尺寸范围内确定体积优选的小型可替代产品的特性的系统。即使与产品密切接触以确定可接受的产品，该系统区分产品。该系统可以存储数据以供以后审查或实时分发产品。系统可以包括用于确定样本重量的比例，用于对样本进行成像的照相机，成像台以允许观察样品，处理器确定样品中的产品数量，以及处理器，以确定所需样品的密度产品。该系统还可以确定每重量产品数量，产品每重量体积和/或产品表面积/重量。这些确定可能是有用的，包括确定产品加工和包装选项。

40. 发明授权

US09090865B2 Systems and methods for particle classification and sorting 有权
标题翻译：用于粒子分类和分选的系统和方法
公开(公告)号：US09090865B2
公开(公告)日：2015-07-28
申请号：US13284781
申请日：2011-10-28
申请人： Dino Di Carlo , Soojung Hur
发明人： Dino Di Carlo , Soojung Hur
IPC分类号： C12M1/00 , G01N15/10 , B01L3/00
CPC分类号： G01N15/14 , B01L3/502746 , B01L3/502761 , B01L3/502776 , B01L2200/0652 , B01L2300/0864 , B01L2400/0487 , C12M47/04 , G01N15/10 , G01N2015/0065 , G01N2015/1006 , G01N2015/105 , G01N2015/1081 , G01N2015/1087 , G01N2015/1495
摘要： A particle analysis system includes an inlet; an inertial focusing microchannel disposed in a substrate and having a downstream expanding region at a distal end, where the inlet is connected to a proximal end of the microchannel; a plurality of outlets connected to the microchannel at the downstream expanding region; a plurality of fluidic resistors, where each fluidic resistor is connected to a respective outlet; and a particle analyzer configured to measure a size and a position of particles in the microchannel. A particle sorting system includes an inlet; an inertial focusing microchannel disposed in a substrate and having a downstream expanding region at a distal end, where the inlet is connected to a proximal end of the microchannel; a plurality of outlets connected to the microchannel at the downstream expanding region; and a plurality of fluidic resistors, where each fluidic resistor is connected to a respective outlet.
摘要翻译：粒子分析系统包括入口; 惯性聚焦微通道，其设置在基底中并且在远端具有下游扩张区域，其中所述入口连接到所述微通道的近端; 在下游扩展区域连接到微通道的多个出口; 多个流体电阻器，其中每个流体电阻器连接到相应的出口; 以及粒子分析器，被配置为测量微通道中颗粒的尺寸和位置。颗粒分选系统包括入口; 惯性聚焦微通道，其设置在基底中并且在远端具有下游扩张区域，其中所述入口连接到所述微通道的近端; 在下游扩展区域连接到微通道的多个出口; 和多个流体电阻器，其中每个流体电阻器连接到相应的出口。

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