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31. 发明授权

US08932485B2 Fluorescent nanoparticle composites themselves, process for the preparation of such composites, and use in rapid diagnosis systems with affinity to biological molecules 有权
标题翻译：荧光纳米颗粒复合材料本身，制备这种复合材料的方法，并用于对生物分子具有亲和力的快速诊断系统
公开(公告)号：US08932485B2
公开(公告)日：2015-01-13
申请号：US12934216
申请日：2009-03-23
申请人： Celso Pinto De Melo , César Augusto Souza De Andrade , Clécio Gomes Dos Santos
发明人： Celso Pinto De Melo , César Augusto Souza De Andrade , Clécio Gomes Dos Santos
IPC分类号： C09K11/06 , A61B5/055 , A21D6/00 , A23C3/00 , C12Q1/68 , C12M1/34 , G01N33/58 , G01N33/533
CPC分类号： C12Q1/6834 , C08G73/0266 , C09K11/06 , C09K2211/14 , C12Q1/701 , C12Q1/708 , G01N33/533 , G01N33/582 , G01N33/587 , Y10S977/704 , Y10S977/773 , Y10S977/84 , Y10S977/902
摘要： The present invention provides fluorescent nanoparticle composites themselves, the process of preparing such composites, to systems for rapid diagnosis (as “kits”) containing such composites, and to the use of such composites. In a preferential embodiment, the composites of the present invention have an affinity for biological molecules, such as DNA. The present invention also comprises the preparation of probes containing biological material, upon which are added fluorescent nanoparticle composites, making viable a rapid and economic biological diagnosis of, for example, diseases and genetic traits, notably in the medical and veterinarian fields. There is yet the fact that the absorption of radiation in the ultraviolet and visible regions, with the emission of light in the near ultraviolet and visible range, including in the colors of deep blue and/or green, provides advantageous use of its fluorescent properties in photovoltaic or electroluminescent devices, such as organic LEDs, or for the increase in luminous gain of fluorescent lamps, which represents another characteristic of the invention.
摘要翻译：本发明本身提供荧光纳米颗粒复合材料本身，制备这种复合材料的方法，用于快速诊断的系统（作为“试剂盒”），以及这些复合材料的使用。在优选的实施方案中，本发明的复合材料对生物分子如DNA具有亲和力。本发明还包括制备包含生物材料的探针，在其上添加荧光纳米颗粒复合材料，使其成为例如疾病和遗传性状的快速和经济的生物学诊断，特别是在医学和兽医领域。还有一个事实是，紫外线和可见光区域的辐射吸收在近紫外和可见光范围内的发射，包括深蓝色和/或绿色的颜色，有利于其荧光性质的使用光电或电致发光器件，例如有机LED，或用于增加荧光灯的发光增益，这代表了本发明的另一个特征。

32. 发明申请

US20140357509A1 DIFFERENTIATION BETWEEN TRANSIENT AND PERSISTENT HIGH-RISK HPV INFECTION BY IN SITU HYBRIDIZATION 审中-公开
标题翻译：通过原位杂交的瞬时和高敏感HPV感染之间的差异
公开(公告)号：US20140357509A1
公开(公告)日：2014-12-04
申请号：US14229604
申请日：2014-03-28
申请人： Advanced Cell Diagnostics, Inc.
发明人： Xiao-Jun MA , Hongwei WANG , Xingyong WU , Yuling LUO
IPC分类号： C12Q1/70
CPC分类号： C12Q1/708 , C12Q2600/112 , C12Q2600/118 , G01N2333/025
摘要： The invention relates to methods of categorizing a cervical tissue or cytology sample by performing an in situ hybridization assay using an antisense E6 or E7 probe on a cervical tissue sample, wherein the antisense E6 or E7 probe can simultaneously detect HPV DNA and HPV RNA; detecting the presence of HPV nucleic acid; and categorizing the cervical tissue sample based on HPV nucleic acid expression.
摘要翻译：本发明涉及通过使用宫颈组织样品上的反义E6或E7探针进行原位杂交测定来对宫颈组织或细胞学样品进行分类的方法，其中反义E6或E7探针可以同时检测HPV DNA和HPV RNA; 检测HPV核酸的存在; 并根据HPV核酸表达对宫颈组织样品进行分类。

33. 发明授权

US08895719B2 Markers for pre-cancer and cancer cells and the method to interfere with cell proliferation therein 有权
标题翻译：癌前病变和癌细胞的标志物以及干扰细胞增殖的方法
公开(公告)号：US08895719B2
公开(公告)日：2014-11-25
申请号：US13627965
申请日：2012-09-26
申请人： Andes Biotechnoligies S.A.
发明人： Luis Burzio , Jaime E. Villegas , Veronica A. Burzio
IPC分类号： C07H21/04 , C07H21/02 , A61K48/00
CPC分类号： C12Q1/6886 , C07F9/65616 , C12N5/0693 , C12N15/11 , C12N15/113 , C12N2310/11 , C12N2310/53 , C12N2330/10 , C12N2501/06 , C12Q1/6804 , C12Q1/701 , C12Q1/708 , C12Q2600/112 , C12Q2600/158
摘要： A novel family of human mitochondrial RNAs, referred to as chimeric RNAs, which are differentially expressed in normal, pre-cancer and cancer cells, are described. Oligonucleotides targeted to the chimeric RNAs are provided. The described oligonucleotides or their analogs can be used for cancer diagnostics and cancer therapy as well as for research. In one embodiment of this invention, these oligonucleotides hybridize with the sense or with the antisense mitochondrial chimeric RNAs, and the result of the hybridization is useful to differentiate between normal proliferating cells, pre-cancer cells and cancer cells. In another embodiment of the invention, the compositions comprise oligonucleotides that hybridize with the human chimeric RNAs resulting in cancer cell and pre-cancer cell death, while there is no effect in normal cells, constituting therefore, a novel approach for cancer therapy.
摘要翻译：描述了在正常，癌前和癌细胞中差异表达的人线粒体RNA的新家族，被称为嵌合RNA。提供靶向嵌合RNA的寡核苷酸。所描述的寡核苷酸或其类似物可用于癌症诊断和癌症治疗以及研究。在本发明的一个实施方案中，这些寡核苷酸与有义或与反义线粒体嵌合RNA杂交，并且杂交结果可用于区分正常增殖细胞，癌前细胞和癌细胞。在本发明的另一个实施方案中，组合物包含与导致癌细胞和癌前细胞死亡的人嵌合RNA杂交的寡核苷酸，而在正常细胞中没有作用，因此构成了用于癌症治疗的新方法。

34. 发明申请

US20140199686A1 COMPOSITIONS AND METHODS FOR RECOVERY OF NUCLEIC ACIDS OR PROTEINS FROM TISSUE SAMPLES FIXED IN CYTOLOGY MEDIA 审中-公开
标题翻译：用于从细胞培养基中固定的组织样品中恢复核酸或蛋白质的组合物和方法
公开(公告)号：US20140199686A1
公开(公告)日：2014-07-17
申请号：US14216046
申请日：2014-03-17
申请人： QIAGEN GAITHERSBURG, INC.
发明人： Shubing LIU , Suganthi RAMACHANDRAN
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12N15/1003 , C12N1/06 , C12N15/1013 , C12Q1/6806 , C12Q1/708 , C12Q2565/519 , C12Q2565/531
摘要： The present invention provides compositions and methods for improving nucleic acid or protein recovery from fixed biological samples.
摘要翻译：本发明提供了用于从固定生物样品中提高核酸或蛋白回收率的组合物和方法。

35. 发明申请

US20140193805A1 HPV E6, E7 MRNA Assay and Methods of Use Thereof 有权
标题翻译： HPV E6，E7 MRNA测定及其使用方法
公开(公告)号：US20140193805A1
公开(公告)日：2014-07-10
申请号：US14149747
申请日：2014-01-07
申请人： IncellDx, Inc.
发明人： Bruce K. Patterson
IPC分类号： C12Q1/70
CPC分类号： C12Q1/708 , C12Q1/6841 , C12Q2600/158 , G06F19/00
摘要： Provided is an HPV E6, E7 mRNA assay, referenced herein as the “In Cell HPV Assay,” that is capable of sensitive and specific detection of normal cervical cells undergoing malignant transformation as well as abnormal cervical cells with pre-malignant or malignant lesions. The In Cell HPV Assay identifies HPV E6, E7 mRNA via in situ hybridization with oligonucleotides specific for HPV E6, E7 mRNA and quantitates the HPV E6, E7 mRNA via flow cytometry. The In Cell HPV Assay can be carried out in less than three hours directly from liquid-based cervical (“LBC”) cytology specimens. The In Cell HPV Assay provides an efficient and highly sensitive alternative to the Pap smear for determining abnormal cervical cytology.
摘要翻译：提供了HPV E6，E7mRNA测定法，其在本文中被称为“In Cell HPV Assay”，其能够敏感和特异性检测经历恶性转化的正常宫颈细胞以及具有恶性前或恶性病变的异常宫颈细胞。 In Cell HPV Assay通过与HPV E6，E7 mRNA特异性寡核苷酸的原位杂交鉴定HPV E6，E7 mRNA，并通过流式细胞术定量HPV E6，E7 mRNA。 In Cell HPV Assay可以在不到三个小时的时间内直接从液体宫颈（“LBC”）细胞学标本中进行。 In Cell HPV Assay提供了一种有效和高度敏感的替代方法，用于确定宫颈细胞学异常的Pap涂片。

36. 发明申请

US20140065600A1 METHOD OF EVALUATING ORAL CANCER RISK IN HUMAN 审中-公开
标题翻译：评估人类口腔癌风险的方法
公开(公告)号：US20140065600A1
公开(公告)日：2014-03-06
申请号：US13975256
申请日：2013-08-23
申请人： Institut Clinident
发明人： Franck CHAUBRON
IPC分类号： C12Q1/70
CPC分类号： C12Q1/708 , C12Q1/6886 , C12Q1/689 , C12Q2600/158 , G01N33/57407
摘要： A method of providing a risk evaluation and diagnosis of human oral cancer, by examining at the presence in human saliva sample of a combination of particulate nucleic acids from bacteria, virus, as well as human, and/or the presence of particulate biochemical volatile organic compounds, which are indicative of an increased risk of oral cancer.
摘要翻译：通过在人唾液样品中存在来自细菌，病毒以及人类的颗粒核酸的组合和/或颗粒生物化学挥发性有机物的存在来提供对人类口腔癌的风险评估和诊断的方法化合物，其指示口服癌症的风险增加。

37. 发明申请

US20140065598A1 SELF-CONTAINED BIOLOGICAL ASSAY APPARATUS, METHODS, AND APPLICATIONS 有权
公开(公告)号：US20140065598A1
公开(公告)日：2014-03-06
申请号：US13770521
申请日：2013-02-19
申请人： RHEONIX, INC.
发明人： Peng Zhou , Lincoln C. Young , Benjamin Thomas , Zongyuan Chen , Greg Mouchka , Todd Roswech , Gwendolyn Spizz , Rubina Yasmin
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/6806 , B01L3/022 , B01L3/5027 , B01L3/502753 , B01L7/52 , B01L2200/0647 , B01L2200/0689 , B01L2200/141 , B01L2200/142 , B01L2300/044 , B01L2300/0681 , B01L2300/0829 , B01L2300/0838 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2300/088 , B01L2300/0887 , B01L2400/043 , B01L2400/0481 , B01L2400/0666 , C12Q1/6846 , C12Q1/686 , C12Q1/6883 , C12Q1/708 , G01N35/1002 , C12Q2565/629
摘要： A self-contained, fully automated, biological assay-performing apparatus includes a housing; a dispensing platform including a controllably-movable reagent dispensing system, disposed in the housing; a reagent supply component disposed in the housing; a pneumatic manifold removably disposed in the housing in a space shared by the dispensing platform, removably coupled to a fluidic transport layer and a plurality of reservoirs, wherein the fluidic transport layer, the reservoirs, and a test sample to be introduced therein are disposed in the housing in the space separate from the dispensing platform; a pneumatic supply system removably coupled to the pneumatic manifold in the housing in a space separate from the dispensing platform; and a control system coupled to at least one of the dispensing platform and the pneumatic supply system, disposed in the housing.

38. 发明申请

US20140038173A1 COMPOSITIONS, REACTION MIXTURES AND METHODS FOR DETECTING NUCLEIC ACIDS FROM MULTIPLE TYPES HUMAN PAPILLOMAVIRUS 有权
标题翻译：组合物，反应混合物和用于从多种类型人类斑马鱼检测核酸的方法
公开(公告)号：US20140038173A1
公开(公告)日：2014-02-06
申请号：US14041970
申请日：2013-09-30
申请人： Gen-Probe Incorporated
发明人： Sylvia A. NORMAN , Jennifer J. BUNGO , William L. HANNA , Neeraj P. RAO
IPC分类号： C12Q1/70
CPC分类号： C12Q1/708 , C07K14/005 , C12N2710/20022 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
摘要： Nucleic acid oligonucleotide sequences are disclosed which include amplification oligomers and probe oligomers which are useful for detecting multiple types of human papillomaviruses (HPV) associated with cervical cancer. Methods for detecting multiple HPV types in biological specimens by amplifying HPV nucleic acid sequences in vitro and detecting the amplified products are disclosed.
摘要翻译：公开了核酸寡核苷酸序列，其包括可用于检测与宫颈癌相关的多种类型的人乳头状瘤病毒（HPV）的扩增寡聚体和探针寡聚体。公开了通过体外扩增HPV核酸序列并检测扩增产物来检测生物标本中多种HPV类型的方法。

39. 发明申请

US20140037622A1 HUMAN PAPILLOMA VIRUS AS PREDICTOR OF CANCER PROGNOSIS 有权
标题翻译：人乳头瘤病毒作为癌症预防的预防者
公开(公告)号：US20140037622A1
公开(公告)日：2014-02-06
申请号：US13958502
申请日：2013-08-02
申请人： UCL Business PLC , FOUNDATION MEDICINE, INC.
发明人： Chris Hendrik Boshoff , Timothy Robert Fenton , Matthias Alexander Lechner , Philip James Stephens , Matthew J. Hawryluk , Roman Yelensky , Garrett Michael Frampton
IPC分类号： C12Q1/70 , A61K31/519 , A61K31/454 , A61K31/52 , A61K31/404 , A61K31/4196 , A61K33/24 , A61K31/282 , A61K31/337 , A61K31/513 , A61K39/395 , A61K31/436 , A61K31/05 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/352 , A61N5/00 , A61K31/506
CPC分类号： A61K31/519 , A61K31/05 , A61K31/282 , A61K31/337 , A61K31/352 , A61K31/366 , A61K31/404 , A61K31/4196 , A61K31/436 , A61K31/439 , A61K31/454 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/52 , A61K31/5377 , A61K31/555 , A61K33/24 , A61K39/39558 , A61K2039/505 , A61N5/00 , A61N5/10 , C07K16/2863 , C12Q1/6883 , C12Q1/6886 , C12Q1/708 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/571 , A61K2300/00
摘要： Methods of treating a head and neck cancer are disclosed.
摘要翻译：公开了治疗头颈癌的方法。

40. 发明申请

US20140030701A1 COMPOSITIONS, REACTION MIXTURES AND METHODS FOR DETECTING NUCLEIC ACIDS FROM TYPE A1 AND/OR TYPE C1 HUMAN PAPILLOMAVIRUS 有权
标题翻译：用于检测来自A1型和/或C1型人类斑马鱼的核酸的组合物，反应混合物和方法
公开(公告)号：US20140030701A1
公开(公告)日：2014-01-30
申请号：US14040399
申请日：2013-09-27
申请人： Gen-Probe Incorporated
发明人： Sylvia A. NORMAN , Jennifer J. BUNGO , William L. HANNA , Neeraj P. RAO
IPC分类号： C12Q1/70
CPC分类号： C12Q1/708 , C07K14/005 , C12N2710/20022 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
摘要： Nucleic acid oligonucleotide sequences are disclosed which include amplification oligomers and probe oligomers which are useful for detecting multiple types of human papillomaviruses (HPV) associated with cervical cancer. Methods for detecting multiple HPV types in biological specimens by amplifying HPV nucleic acid sequences in vitro and detecting the amplified products are disclosed.
摘要翻译：公开了核酸寡核苷酸序列，其包括可用于检测与宫颈癌相关的多种类型的人乳头状瘤病毒（HPV）的扩增寡聚体和探针寡聚体。公开了通过体外扩增HPV核酸序列并检测扩增产物来检测生物标本中多种HPV类型的方法。

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