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31. 发明申请

US20120282661A1 MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF ADIPATE, HEXAMETHYLENEDIAMINE AND 6-AMINOCAPROIC ACID 审中-公开
标题翻译：丙二酸，十六烷二胺和6-氨基酸的生物合成的微生物和方法
公开(公告)号：US20120282661A1
公开(公告)日：2012-11-08
申请号：US13549239
申请日：2012-07-13
申请人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Priti Pharkya
发明人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Priti Pharkya
IPC分类号： C12P13/00 , C12N15/52 , C12N1/15 , C12N1/21 , C12P17/10 , C12N1/19
CPC分类号： C12P17/10 , C12N1/38 , C12N15/52 , C12P7/40 , C12P7/44 , C12P13/001 , C12P13/005 , C12P13/02 , C12P17/12
摘要： The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The invention additionally provides a method for producing 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid. The method can include culturing a 6-aminocaproic acid, caprolactam or hexametheylenediamine producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid.
摘要翻译：本发明提供了具有6-氨基己酸，己内酰胺，六亚甲基二胺或乙酰丙酸途径的非天然存在的微生物生物。微生物生物体含有至少一种编码各自的6-氨基己酸，己内酰胺，六亚甲基二胺或乙酰丙酸途径中的酶的外源核酸。本发明另外提供了制备6-氨基己酸，己内酰胺，己二胺或乙酰丙酸的方法。该方法可以包括培养6-氨基己酸，己内酰胺或六亚甲基二胺生产微生物，其中微生物生物体表达至少一种编码6-氨基己酸，己内酰胺，六亚甲基二胺或乙酰丙酸途径酶的外源核酸，其量足以产生各自的产物在条件下和足够的时间内产生6-氨基己酸，己内酰胺，六亚甲基二胺或乙酰丙酸。

32. 发明授权

US08227617B2 Process for preparing 2-hydroxy-4-substituted pyridines 有权
标题翻译：制备2-羟基-4-取代的吡啶的方法
公开(公告)号：US08227617B2
公开(公告)日：2012-07-24
申请号：US12854273
申请日：2010-08-11
申请人： Mie Sasaki , Seiichiro Matsumoto
发明人： Mie Sasaki , Seiichiro Matsumoto
IPC分类号： C07D213/56 , C12P17/12
CPC分类号： C12R1/01 , C07D213/64 , C07D213/78 , C07D213/803 , C12N1/20 , C12P17/12
摘要： A process for preparing a 2-hydroxy-4-substituted pyridine compound using a microbiological method, a novel microorganism, and a novel compound are provided.
摘要翻译：提供了使用微生物学方法制备2-羟基-4-取代的吡啶化合物的方法，新的微生物和新的化合物。

33. 发明申请

US20120135476A1 PROCESS FOR PREPARING N-HETEROCYCLIC OPTICALLY ACTIVE ALCOHOLS 审中-公开
标题翻译：制备N-杂环光学活性醇的方法
公开(公告)号：US20120135476A1
公开(公告)日：2012-05-31
申请号：US13303559
申请日：2011-11-23
申请人： NINA SCHNEIDER , MELANIE BONNEKESSEL , MICHAEL BREUER , JÜRGEN DÄUWEL , KLAUS DITRICH , ULRICH KARL , TOBIAS STÄB
发明人： NINA SCHNEIDER , MELANIE BONNEKESSEL , MICHAEL BREUER , JÜRGEN DÄUWEL , KLAUS DITRICH , ULRICH KARL , TOBIAS STÄB
IPC分类号： C12P17/00
CPC分类号： C12P41/002 , C12P17/10 , C12P17/12
摘要： Process for preparing N-heterocyclic optically active alcohols of the formula I by reduction of the corresponding ketone, where the reduction is carried out using a dehydrogenase having the polypeptide sequence SEQ ID NO:2 or NO:4, or using a polypeptide sequence where, compared to SEQ ID NO:2 or NO:4, up to 25% of the amino acid residues are modified by deletion; insertion, substitution or a combination thereof.
摘要翻译：通过还原相应的酮制备式I的N-杂环光学活性醇的方法，其中使用具有多肽序列SEQ ID NO：2或NO：4的脱氢酶进行还原，或使用多肽序列，与SEQ ID NO：2或NO：4相比，通过缺失修饰高达25％的氨基酸残基; 插入，取代或其组合。

34. 发明申请

US20120100622A1 PICHIA PASTORIS LOCI ENCODING ENZYMES IN THE URACIL BIOSYNTHETIC PATHWAY 审中-公开
标题翻译： PICHIA PASTORIS LOCI ENCODING ENZYMES IN URACIL BIOSYNEE PATHWAY
公开(公告)号：US20120100622A1
公开(公告)日：2012-04-26
申请号：US13272661
申请日：2011-10-13
申请人： Juergen Nett
发明人： Juergen Nett
IPC分类号： C12N15/81 , C12N15/53 , C12N1/19
CPC分类号： C12N15/52 , C12N15/815 , C12P17/12
摘要： Disclosed are the URA1, URA2, URA4, and URA6 genes encoding various enzymes in the uracil biosynthesis pathway of Pichia pastoris. The loci in the Pichia pastoris genome encoding these enzymes are useful sites for stable integration of heterologous nucleic acid molecules into the Pichia pastoris genome. The genes or gene fragments encoding the particular enzymes may be used as selection markers for constructing recombinant Pichia pastoris.
摘要翻译：公开了编码巴斯德毕赤酵母尿嘧啶生物合成途径中各种酶的URA1，URA2，URA4和URA6基因。编码这些酶的巴斯德毕赤酵母基因组中的基因座是将异源核酸分子稳定整合到巴斯德毕赤酵母基因组中的有用位点。可以将编码特定酶的基因或基因片段用作构建重组巴斯德毕赤酵母的选择标记。

35. 发明授权

US08067212B2 Bacillus pumilus strain for high yield of tetramethylpyrazine 有权
标题翻译：短小芽孢杆菌菌株用于高产量的四甲基吡嗪
公开(公告)号：US08067212B2
公开(公告)日：2011-11-29
申请号：US12302275
申请日：2007-05-25
申请人： Ping Xu , Zijun Xiao , Zhonghao Wei , Yi Du
发明人： Ping Xu , Zijun Xiao , Zhonghao Wei , Yi Du
IPC分类号： C12P17/00 , C12N1/20
CPC分类号： C12R1/07 , C12P17/12 , Y10S435/832
摘要： This invention provides a high-yield bacterial strain for producing tetramethylpyrazine named Bacillus pumilus RX3-17. The strain has been deposited in China Center for Type Culture Collection on Apr. 19, 2006. The deposit number is CCTCC M 206043. The bacterial strain, isolated from soil, is rod-shaped, 1.5 μm to 3.0 μm in length and 0.6 μm to 0.7 μm in diameter. The colony color of the strain is milky-white. The strain has typical physiological and biochemical characteristics of Bacillus pumilus. The 16s rDNA sequence of this strain shares a similarity of 99% with other Bacillus pumilus strains. This invention belongs to the domain of biotechnology. The strain can be applied to the production of tetramethylpyrazine with glucose as the substrate, solving the bottleneck of low yield in bacterial tetramethylpyrazine fermentation.
摘要翻译：本发明提供了用于生产称为短小芽孢杆菌RX3-17的四甲基吡嗪的高产菌株。该菌株已于2006年4月19日保藏在中国型号培养物中心中心。沉积物编号为CCTCC M 206043.从土壤中分离的细菌菌株为棒状，长度为1.5〜3.0μm，0.6μm 直径为0.7μm。菌株的菌落颜色是乳白色的。该菌株具有典型的生物和生化特性的短小芽孢杆菌。该菌株的16s rDNA序列与其他短小芽孢杆菌菌株具有99％的相似性。本发明属于生物科技领域。该菌株可用于以葡萄糖为底物生产四甲基吡嗪，解决细菌四甲基吡嗪发酵中低产量的瓶颈。

36. 发明授权

US07723068B2 Gene cluster involved in safracin biosynthesis and its uses for genetic engineering 失效
$Gene cluster involved in safracin biosynthesis and its uses for genetic engineering$
标题翻译：涉及safracin生物合成的基因簇及其在遗传工程中的应用
公开(公告)号：US07723068B2
公开(公告)日：2010-05-25
申请号：US10540092
申请日：2003-12-19
申请人： Ana Velasco Iglesias , Fernando de la Calle , Tomás Aparicio Pérez , Carmen Schleissner Sánchez , Paloma Acebo Páis , Pilar Rodríguez Ramos , Fernando Reyes Benítez , Rubén Henrìquez Peláez
发明人： Ana Velasco Iglesias , Fernando de la Calle , Tomás Aparicio Pérez , Carmen Schleissner Sánchez , Paloma Acebo Páis , Pilar Rodríguez Ramos , Fernando Reyes Benítez , Rubén Henrìquez Peláez
IPC分类号： C12P21/06
CPC分类号： C12N9/0004 , A61K31/4995 , C07D401/12 , C07D403/12 , C07D413/14 , C07D471/04 , C07D471/14 , C07K14/21 , C12N9/00 , C12N9/10 , C12N15/52 , C12P17/12 , C12P17/182
摘要： A gene cluster is disclosed having open reading frames which encode polypeptides sufficient to direct the synthesis of a safracin molecule. In addition, the present disclosure is directed to a nucleic acid sequence, suitably an isolated nucleic acid sequence, which includes or comprises at least SEQ ID NO:1, variants or portions thereof, or at least one of the sacA, sacB, sacC, sacC, sacD, sacE, sacF, sacG, sacH, sacH, saI, sacJ, orf1, orf2, orf3 or orf4 genes, including variants or portions.
摘要翻译：公开了一种具有开放阅读框的基因簇，其编码足以引导safracin分子合成的多肽。此外，本公开涉及核酸序列，合适地是分离的核酸序列，其包含或至少包含SEQ ID NO：1，其变体或部分，或至少一种sacA，sacB，sacC， sacC，sacD，sacE，sacF，sacG，sacH，sacH，saI，sacJ，orf1，orf2，orf3或orf4基因，包括变体或部分。

37. 发明申请

US20100081571A1 Novel Euglenoid Derived Alkaloid 有权
标题翻译：新型Euglenoid衍生生物碱
公开(公告)号：US20100081571A1
公开(公告)日：2010-04-01
申请号：US12566884
申请日：2009-09-25
申请人： Paul V. Zimba , Kevin R. Beauchesne , Peter D. Moeller , Richard E. Triemer
发明人： Paul V. Zimba , Kevin R. Beauchesne , Peter D. Moeller , Richard E. Triemer
IPC分类号： A01N43/40 , C07D211/22 , C12P17/12 , A01P13/00
CPC分类号： C12P17/12 , A01N43/40 , A01N65/03 , C07D211/22 , C12R1/90
摘要： Disclosed herein is a novel purified toxin isolated from Euglena sanguinea. More specifically the toxin, termed euglenophycin, is an alkaloid having herbicidal and cytotoxicity against plant and mammalian cells.
摘要翻译：本文公开了从金球菌分离的新型纯化毒素。更具体地说，称为白念珠菌的毒素是对植物和哺乳动物细胞具有除草和细胞毒性的生物碱。

38. 发明申请

US20090088455A1 Chronic, Bolus Adminstration Of D-Threo Methylphenidate 审中-公开
标题翻译：慢性，螺旋管理D-Threo哌甲酯
公开(公告)号：US20090088455A1
公开(公告)日：2009-04-02
申请号：US12331127
申请日：2008-12-09
申请人： Maghsoud M. Dariani , Andrew L. Zeitlin , Jerome B. Zeldis
发明人： Maghsoud M. Dariani , Andrew L. Zeitlin , Jerome B. Zeldis
IPC分类号： A61K31/4458 , A61P25/00
CPC分类号： A61K31/445 , A61K9/1676 , A61K9/2886 , A61K9/5078 , A61K9/5084 , A61K31/4458 , C07D211/34 , C12P17/12 , C12P41/006
摘要： Chronic bolus administration of D-threo methylphenidate is provided. The administration of the D-threo isomer eliminates adverse side effects associated with the DL racemate, and provides improved effectiveness. The compositions and methods of the invention are useful in treating nervous system disorders including attention deficit disorder, attention deficit hyperactivity disorder, and cognitive decline associated with systemic diseases such as acquired immunodeficiency syndrome.
摘要翻译：提供了D-三苯哌甲酯的慢性推注。 D-苏糖异构体的给药消除了与DL外消旋相关的不利副作用，并提供了改善的效果。本发明的组合物和方法可用于治疗神经系统疾病，包括注意力缺陷障碍，注意缺陷多动障碍以及与系统性疾病如获得性免疫缺陷综合征相关的认知衰退。

39. 发明申请

US20080286843A1 Process for Preparing 2-Hydroxy-Substituted Pyridines 有权
标题翻译： 2-羟基取代的吡啶的制备方法
公开(公告)号：US20080286843A1
公开(公告)日：2008-11-20
申请号：US11575455
申请日：2005-09-16
申请人： Mie Sasaki , Seiichiro Matsumoto
发明人： Mie Sasaki , Seiichiro Matsumoto
IPC分类号： C12P17/12 , C12N1/20 , C07D211/72
CPC分类号： C12R1/01 , C07D213/64 , C07D213/78 , C07D213/803 , C12N1/20 , C12P17/12
摘要： A process for preparing a 2-hydroxy-4-substituted pyridine compound using a microbiological method, a novel microorganism, and a novel compound are provided.According to the process, a function of a microorganism or a product obtained therefrom is exerted on a 4-substituted pyridine of the general formula (1): wherein R is a methyl group, a carboxyl group, a carbamoyl group, a hydroxyiminomethyl group or a cyano group, to obtain the corresponding 2-hydroxy-4-substituted pyridine compound. The novel microorganisms are the Delftia species YGK-A649 (FERM BP-10389), Delftia species YGK-C217 (FERM BP-10388), or Acidovorax species YGK-A854 (FERM BP-10387) and the novel compound is a 2-hydroxy-4-pyridinaldoxime.
摘要翻译：提供了使用微生物学方法制备2-羟基-4-取代的吡啶化合物的方法，新的微生物和新的化合物。根据该方法，由通式（1）的4-取代吡啶施加微生物或其产物的功能：其中R是甲基，羧基，氨基甲酰基，羟基亚氨基甲基或氰基，得到相应的2-羟基-4-取代的吡啶化合物。新型微生物是Delftia物种YGK-A649（FERM BP-10389），Delftia物种YGK-C217（FERM BP-10388）或Acidovorax物种YGK-A854（FERM BP-10387），新化合物是2-羟基 -4-吡啶酮肟。

40. 发明授权

US07442798B2 Autoinducer molecules and uses therefor 有权
标题翻译：自动生物分子及其用途
公开(公告)号：US07442798B2
公开(公告)日：2008-10-28
申请号：US10844037
申请日：2004-05-11
申请人： Everett C. Pesci , Barbara H. Iglewski , Jared B. J. Milbank , James P. Pearson , Andrew S. Kende , Everett P. Greenberg
发明人： Everett C. Pesci , Barbara H. Iglewski , Jared B. J. Milbank , James P. Pearson , Andrew S. Kende , Everett P. Greenberg
IPC分类号： C07D215/38
CPC分类号： C07D215/233 , C12N1/20 , C12P17/12 , C12Q1/025 , C12Q1/045
摘要： Novel bacterial quinolone signal molecules and, more particularly, pseudomonas quinolone signal (“PQS”) molecules, e.g., 2-heptyl-3-hydroxy-4-quinolone, and analogs and derivatives thereof are described. Therapeutic compositions containing the molecules, and therapeutic methods, methods of for regulating gene expression, methods for identifying modulators of the autoinducer molecules, and methods of modulating quorum sensing signaling in bacteria using the compounds of the invention are also described.
摘要翻译：描述了新的细菌喹诺酮信号分子，更特别地，假单胞菌喹诺酮信号（“PQS”）分子，例如2-庚基-3-羟基-4-喹诺酮及其类似物和衍生物。还描述了含有分子的治疗组合物，治疗方法，调节基因表达的方法，用于鉴定自身诱导剂分子的调节剂的方法，以及使用本发明的化合物调节细菌群体感应信号传导的方法。

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