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31. 发明申请

US20140322767A1 DROPLET MICROREACTOR 审中-公开
公开(公告)号：US20140322767A1
公开(公告)日：2014-10-30
申请号：US14270799
申请日：2014-05-06
申请人： Gilles MARCHAND , Françoise VINET , Guillaume DE LAPIERRE , Fatima HASSINE , Saïd GMOUH , Michel VAULTIER
发明人： Gilles MARCHAND , Françoise VINET , Guillaume DE LAPIERRE , Fatima HASSINE , Saïd GMOUH , Michel VAULTIER
IPC分类号： C07D221/18 , B01L3/00 , C07C227/16 , C07C41/14 , C12P17/12
CPC分类号： C07D221/18 , B01F13/0071 , B01F13/0076 , B01J14/00 , B01J19/0093 , B01L3/502792 , B01L2300/0816 , B01L2300/089 , B01L2400/0406 , B01L2400/0415 , B01L2400/0427 , B01L2400/0433 , B01L2400/0442 , B01L2400/0487 , C07C41/14 , C07C227/16 , C12P17/12 , G01N2035/1046
摘要： The present invention relates to a droplet microreactor, i.e. a microreactor consisting of a droplet of a specific liquid, the microreactor being wall-less, wherein the interface of the specific liquid with the ambient environment and with the support on which the droplet is deposited defines the limits of the microreactor. The microreactor is characterized in that it consists of a droplet comprising at least one ionic liquid. The present invention also relates to methods for carrying out chemical or biochemical reactions and/or mixes using said droplet microreactor, and also to a lab-on-chip comprising a microreactor according to the invention.
摘要翻译：液滴微反应器本发明涉及液滴微反应器，即由特定液体的液滴组成的微反应器，微反应器是无壁的，其中特定液体与周围环境的界面和其上沉积有液滴的载体界定微反应器的极限。微反应器的特征在于其由包含至少一种离子液体的液滴组成。本发明还涉及使用所述液滴微反应器进行化学或生物化学反应和/或混合的方法，还涉及包括根据本发明的微反应器的片上实验室。

32. 发明授权

US08617853B2 Ketoreductase polypeptides for the production of (S,E)-methyl 2-(3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-hydroxypropyl)benzoate 有权
公开(公告)号：US08617853B2
公开(公告)日：2013-12-31
申请号：US13329986
申请日：2011-12-19
申请人： Jack Liang , Birthe Borup , Vesna Mitchell , Emily Mundorff , James Lalonde , Gjalt Huisman
发明人： Jack Liang , Birthe Borup , Vesna Mitchell , Emily Mundorff , James Lalonde , Gjalt Huisman
IPC分类号： C12P17/12 , C12N9/00 , C12N9/04 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12N9/0006 , C12P17/12
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.

33. 发明授权

US08551732B2 Increased production of a target product via stabilization of mRNA 有权
标题翻译：通过稳定mRNA增加目标产品的产量
公开(公告)号：US08551732B2
公开(公告)日：2013-10-08
申请号：US12601614
申请日：2008-06-09
申请人： Martin Lehmann , Zoltan Pragai , Michéle Schaber
发明人： Martin Lehmann , Zoltan Pragai , Michéle Schaber
IPC分类号： C12P25/00 , C12P17/16 , C12P13/04 , C12P17/12 , C12P17/18 , C12N15/74 , C12N15/75
CPC分类号： C12N15/75 , C12P1/04 , C12P13/02 , C12P17/12 , C12P17/167 , C12P17/182 , C12P17/186 , C12P21/02 , C12P25/00
摘要： The present invention relates to newly identified mRNA stabilizing elements useful for the production of a target fermentation product, such as e.g. vitamins or enzymes, in particular riboflavin (vitamin B2), biotin, pantothenic acid (vitamin B5), folic acid, thiamin, pyridoxine (vitamin B6), vitamin B12, xylanase, amylase, protease, glucanase, amylomaltase or maltogenic amylase.
摘要翻译：本发明涉及用于生产靶发酵产物的新鉴定的mRNA稳定化元件，例如，维生素或酶，特别是核黄素（维生素B2），生物素，泛酸（维生素B5），叶酸，硫胺素，吡哆醇（维生素B6），维生素B12，木聚糖酶，淀粉酶，蛋白酶，葡聚糖酶，淀粉芽孢杆菌或麦芽糖淀粉酶。

34. 发明申请

US20130116282A1 BUCKWHEAT EXTRACT ENRICHED IN D-FAGOMINE 审中-公开
标题翻译： BUCKWHEAT提取物在D-FAGOMINE中增强
公开(公告)号：US20130116282A1
公开(公告)日：2013-05-09
申请号：US13808378
申请日：2011-07-15
申请人： Josep Lluis Torres Simón , Susana Amézqueta Pérez , Sergio Pumarola Segura , Pere Clapés Saborit
发明人： Josep Lluis Torres Simón , Susana Amézqueta Pérez , Sergio Pumarola Segura , Pere Clapés Saborit
IPC分类号： A61K31/445 , A23L1/30
CPC分类号： A61K31/445 , A23L7/104 , A23L33/105 , A23V2002/00 , A61K36/70 , C12P7/06 , C12P17/12 , Y02E50/17 , A23V2200/328
摘要： The buckwheat extract comprises a extract of buckwheat which are enriched in D-fagomine and including 3,4-di-epifagomine, a process for their preparation, pharmaceutical or veterinary compositions, dietary supplements or functional foods containing them, their use alone or in combination with saccharide, an iminocyclitol or probiotics, as a blood glucose levels controlling agent reducing the post-prandial glucose levels, as well as the buckwheat extract for use in the prevention and/or coadjuvant treatment of microbiota imbalance, that reduces the adhesion of some potentially harmful microorganism in the microbiota and therefore increasing the resistance to disease.
摘要翻译：荞麦提取物包含富含D-fagomine的荞麦提取物，包括3,4-二表糠胺，其制备方法，药物或兽药组合物，膳食补充剂或含有它们的功能性食品，其单独使用或组合使用作为减少餐后葡萄糖水平的血糖水平控制剂，以及用于预防和/或辅助治疗微生物群不平衡的荞麦提取物，其降低了一些潜在的粘附性，其中糖，亚氨基环醇或益生菌微生物中的有害微生物因而增加了对疾病的抵抗力。

35. 发明申请

US20130109719A1 METHOD OF TREATING ATTENTION DEFICIT DISORDERS WITH D-THREO METHYLPHENIDATE 审中-公开
标题翻译：用D-甲基苯甲酸酯治疗缺陷性疾病的方法
公开(公告)号：US20130109719A1
公开(公告)日：2013-05-02
申请号：US13721224
申请日：2012-12-20
申请人： Andrew L. Zeitlin , Maghsoud M. Dariani , David L. Stirling
发明人： Andrew L. Zeitlin , Maghsoud M. Dariani , David L. Stirling
IPC分类号： A61K31/445
CPC分类号： A61K31/445 , A61K9/1676 , A61K9/2886 , A61K9/5078 , A61K9/5084 , A61K31/4458 , C07D211/34 , C12P17/12 , C12P41/006
摘要： Methods for treating Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder, AIDS Dementia Complex and cognitive decline in HIV-AIDS while minimizing drug hypersensitivity, toxicity, side effects, euphoric effect, and drug abuse potential by administration of d-threo-methylphenidate or pharmaceutically acceptable salts thereof.
摘要翻译：治疗注意力缺陷障碍，注意力缺陷多动障碍，艾滋病痴呆综合征和艾滋病毒/艾滋病认知衰退的方法，同时通过施用二硫代哌甲酯或药学上可接受的方式尽量减少药物过敏反应，毒性，副作用，欣欣乐效和药物滥用潜力的盐。

36. 发明授权

US08361759B2 Process for producing farnesylated dibenzodiazepinone by fermentation 有权
标题翻译：通过发酵生产法呢基化二苯并二氮杂酮的方法
公开(公告)号：US08361759B2
公开(公告)日：2013-01-29
申请号：US12764537
申请日：2010-04-21
申请人： Faustinus Yeboah , Mahmood Piraee
发明人： Faustinus Yeboah , Mahmood Piraee
IPC分类号： C12P17/10
CPC分类号： C12P17/10 , B01D15/00 , B01D61/145 , C07D243/38 , C12N1/20 , C12P17/12 , C12R1/29
摘要： The present invention provides a scalable process for producing a concentrate containing a mass of a farnesylated dibenzodiazepinone by fermenting in an aqueous culture medium a strain of a microorganism that is capable of producing the farnesylated dibenzodiazepinone, upon completion of fermentation harvesting the fermentation broth and extracting the fermentation broth to provide an extract, and thereafter treating the extract to form the concentrate. The concentrate so produced may be utilized in downstream processes for producing pharmaceutical compounds. A strain of a Micromonospora species capable of producing a farnesylated dibenzodiazepinone at a high yield rate is provided, together with culture media for culturing microorganisms, and fermentation conditions for production of the farnesylated dibenzodiazepinone of the concentrate.
摘要翻译：本发明提供了一种可扩展的方法，用于生产含有大量法呢基化二苯并二氮杂酮的浓缩物，其通过在水性培养基中发酵能够产生法呢基化二苯并二氮杂酮的微生物菌株，在完成发酵收获发酵液并提取发酵液提供提取物，然后处理提取物以形成浓缩物。如此生产的浓缩物可用于生产药物化合物的下游方法。提供能够以高产率生产法呢基化二苯并二氮杂酮的小单孢菌属菌株，以及用于培养微生物的培养基和用于生产浓缩物的法呢基化二苯并二氮杂酮的发酵条件。

37. 发明授权

US08227234B2 Process for preparing 2-hydroxy-4-substituted pyridines 有权
公开(公告)号：US08227234B2
公开(公告)日：2012-07-24
申请号：US12854261
申请日：2010-08-11
申请人： Mie Sasaki , Seiichiro Matsumoto
发明人： Mie Sasaki , Seiichiro Matsumoto
IPC分类号： C12N1/12
CPC分类号： C12R1/01 , C07D213/64 , C07D213/78 , C07D213/803 , C12N1/20 , C12P17/12
摘要： A process for preparing a 2-hydroxy-4-substituted pyridine compound using a microbiological method, a novel microorganism, and a novel compound are provided.

38. 发明申请

US20120184000A1 KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF (S,E)-METHYL 2-(3-(3-(2-(7-CHLOROQUINOLIN-2-YL)VINYL)PHENYL)-3-HYDROXYPROPYL)BENZOATE 有权
标题翻译：（S，E） - 甲基2-（3-（3-（2-（7-氯代环戊烯-2-基）乙烯基）苯基）-3-羟基丙基）苯甲酸酯的甜菜碱多糖
公开(公告)号：US20120184000A1
公开(公告)日：2012-07-19
申请号：US13329986
申请日：2011-12-19
申请人： Jack Liang , Birthe Borup , Vesna Mitchell , Emily Mundorff , James Lalonde , Gjalt Huisman
发明人： Jack Liang , Birthe Borup , Vesna Mitchell , Emily Mundorff , James Lalonde , Gjalt Huisman
IPC分类号： C12P17/12
CPC分类号： C12N9/0006 , C12P17/12
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
摘要翻译：本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。

39. 发明申请

US20110207183A1 Production Process for Fine Chemicals Using Microorganisms with Reduced Isocitrate Dehydrogenase Activity 审中-公开
标题翻译：使用具有降低的异柠檬酸脱氢酶活性的微生物的精细化学品的生产方法
公开(公告)号：US20110207183A1
公开(公告)日：2011-08-25
申请号：US12990240
申请日：2009-04-28
申请人： Andrea Herold , Hartwig Schröder , Weol Kyu Jeong , Corinna Klopprogge , Oskar Zelder , Stefan Haefner , Ulrike Richter , Judith Becker , Christoph Wittmann
发明人： Andrea Herold , Hartwig Schröder , Weol Kyu Jeong , Corinna Klopprogge , Oskar Zelder , Stefan Haefner , Ulrike Richter , Judith Becker , Christoph Wittmann
IPC分类号： C12P13/20 , C12P1/00 , C12P1/04 , C12P13/04 , C12P13/00 , C12P13/08 , C12N1/00 , C12N1/21 , C12P13/02 , C12P17/12 , C12P17/10 , C12P13/12 , C12P7/40
CPC分类号： C12P13/001 , C12N9/0006 , C12P13/04 , C12P13/08 , C12P17/12 , C12Y101/01041
摘要： The present invention is directed to a method utilizing a microorganism with reduced isocitrate dehydrogenase activity for the production of fine chemicals. Said fine chemicals may be amino acids, monomers for polymer synthesis, sugars, lipids, oils, fatty acids or vitamins and are preferably amino acids of the aspartate family, especially methionine or lysine, or derivatives of said amino acids, especially cadaverine. Furthermore, the present invention relates to a recombinant microorganism having a reduced isocitrate dehydrogenase activity in comparison to the initial microorganism and the use of such microorganisms in producing fine chemicals such as aspartate family amino acids and their derivatives.
摘要翻译：本发明涉及利用具有降低的异柠檬酸脱氢酶活性的微生物来生产精细化学品的方法。所述精细化学品可以是氨基酸，用于聚合物合成的单体，糖，脂质，油，脂肪酸或维生素，并且优选天冬氨酸家族的氨基酸，特别是甲硫氨酸或赖氨酸，或所述氨基酸的衍生物，特别是尸胺。此外，本发明涉及与初始微生物相比具有降低的异柠檬酸脱氢酶活性的重组微生物，以及这些微生物在生产精细化学品如天冬氨酸家族氨基酸及其衍生物中的用途。

40. 发明授权

US07943142B2 Euglenoid derived alkaloid 有权
标题翻译：洋葱衍生生物碱
公开(公告)号：US07943142B2
公开(公告)日：2011-05-17
申请号：US12566884
申请日：2009-09-25
申请人： Paul V. Zimba , Kevin R. Beauchesne , Peter D. Moeller , Richard E. Triemer
发明人： Paul V. Zimba , Kevin R. Beauchesne , Peter D. Moeller , Richard E. Triemer
IPC分类号： A01N43/40 , A01P13/00 , C07D211/22 , C12P17/12
CPC分类号： C12P17/12 , A01N43/40 , A01N65/03 , C07D211/22 , C12R1/90
摘要： Disclosed herein is a purified toxin isolated from Euglena sanguinea. More specifically the toxin, termed euglenophycin, is an alkaloid having herbicidal and cytotoxicity against plant and mammalian cells.
摘要翻译：本文公开了从金球菌分离的纯化毒素。更具体地说，称为白念珠菌的毒素是对植物和哺乳动物细胞具有除草和细胞毒性的生物碱。

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