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31. 发明申请

US20150202318A1 ABERRANT CELL-RESTRICTED IMMUNOGLOBULINS PROVIDED WITH A TOXIC MOIETY 审中-公开
标题翻译：滥用细胞限制性免疫球蛋白提供毒性作用
公开(公告)号：US20150202318A1
公开(公告)日：2015-07-23
申请号：US14670271
申请日：2015-03-26
申请人： APO-T B.V.
发明人： JOHAN RENES , PAULUS J. G. M. STEVERINK , RALPH ALEXANDER WILLEMSEN
IPC分类号： A61K47/48 , C07K16/28
CPC分类号： A61K47/6813 , A61K47/6809 , A61K47/6849 , A61K47/6851 , A61K47/6883 , A61K2039/505 , A61P35/00 , C07K16/084 , C07K16/085 , C07K16/2833 , C07K16/2884 , C07K16/30 , C07K16/3069 , C07K16/3092 , C07K16/32 , C07K16/40 , C07K2317/32 , C07K2317/34 , C07K2317/569 , C07K2317/76 , C07K2319/33
摘要： Described are immunoglobulins provided with a toxic moiety, comprising at least an immunoglobulin variable region that specifically binds to an MHC-peptide complex preferentially associated with aberrant cells. These immunoglobulins provided with a toxic moiety are preferably used in selectively modulating biological processes. The provided immunoglobulins provided with a toxic moiety are of particular use in pharmaceutical compositions for the treatment of diseases related to cellular aberrancies, such as cancers and autoimmune diseases.
摘要翻译：描述了提供有毒性部分的免疫球蛋白，其包含至少一个特异性结合优先与异常细胞相关的MHC-肽复合物的免疫球蛋白可变区。提供有毒性部分的这些免疫球蛋白优选用于选择性调节生物过程。提供有毒性部分的提供的免疫球蛋白在用于治疗与细胞异常如癌症和自身免疫疾病相关的疾病的药物组合物中特别有用。

32. 发明申请

US20150191530A1 HUMAN MONOCLONAL ANTIBODY AGAINST THE VP1 PROTEIN OF JC VIRUS 有权
标题翻译：人类单克隆抗体对抗JC病毒的VP1蛋白
公开(公告)号：US20150191530A1
公开(公告)日：2015-07-09
申请号：US14410896
申请日：2013-06-26
申请人： POMONA RICERCA S.r.l.
发明人： Roberto Burioni , Massimo Clementi
IPC分类号： C07K16/08 , G01N33/569
CPC分类号： C07K16/081 , A61K2039/505 , C07K16/084 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/76 , G01N33/56983 , G01N2469/10
摘要： A human neutralizing monoclonal antibody is directed against the VP1 protein of JC virus. The JC virus is responsible for progressive multifocal leukoencephalopathy (PML). The antibody is used in a therapeutic or prophylactic treatment of a JCV infection or of a disease associated with a JCV infection, such as progressive multifocal leukoencephalopathy (PML). The antibody is also used in the diagnosis of JCV infections or of diseases associated with JCV infections.
摘要翻译：人中和单克隆抗体针对JC病毒的VP1蛋白。 JC病毒负责进行性多灶性脑白质病（PML）。该抗体用于JCV感染或与JCV感染相关的疾病如渐进性多灶性脑白质病（PML）的治疗或预防性治疗。该抗体也用于诊断JCV感染或与JCV感染有关的疾病。

33. 发明授权

US08999398B2 Polyclonal bispecific antibody compositions and method of use 有权
标题翻译：多克隆双特异性抗体组合物及其使用方法
公开(公告)号：US08999398B2
公开(公告)日：2015-04-07
申请号：US13508182
申请日：2010-11-05
申请人： Lawrence Lum , Manley Huang
发明人： Lawrence Lum , Manley Huang
IPC分类号： A61K35/28 , C12N5/00 , C07K16/00 , C07K16/08 , C07K16/06 , C07K16/10 , C07K16/28
CPC分类号： C07K16/2809 , A61K35/17 , A61K39/42 , A61K2039/505 , C07K16/06 , C07K16/082 , C07K16/084 , C07K16/087 , C07K16/088 , C07K16/109 , C07K2317/31 , C12N5/0638 , C12N2501/2302 , C12N2501/998
摘要： The invention relates to compositions and methods for treating a host infected with a pathogen. The composition comprising a population of polyclonal bispecific binding molecules that can target and eliminate a host cell infected with the pathogen. Methods for activating and arming cytotoxic immune cells with the composition for use in treating a patient infected with a pathogen are also provided.
摘要翻译：本发明涉及用于治疗感染病原体的宿主的组合物和方法。该组合物包含可以靶向和消除感染病原体的宿主细胞的多克隆双特异性结合分子群。还提供了用于治疗感染病原体的患者的组合物来激活和布防细胞毒性免疫细胞的方法。

34. 发明申请

US20140178975A1 DETECTION OF EARLY STAGES AND LATE STAGES HPV INFECTION 审中-公开
标题翻译：检测早期阶段和晚期HPV感染
公开(公告)号：US20140178975A1
公开(公告)日：2014-06-26
申请号：US14103376
申请日：2013-12-11
申请人： Shuling Cheng
发明人： Shuling Cheng
IPC分类号： G01N33/569
CPC分类号： G01N33/56983 , C07K16/084 , C12Q1/708 , G01N33/571 , G01N2333/025 , G01N2469/10
摘要： Embodiments of the invention provide methods, monoclonal antibodies, polyclonal antibodies, assays, and kits for detecting HPV infection and HPV related cancer diagnosis, including infection by various HPV genotypes, early and/or late stage HPV-associated or HPV-specific cancers. Various specific or pan monoclonal antibodies recognizing specific epitope for specific HPV protein or HPV type, or common epitope for various HPV proteins or HPV types are obtained. The invention also provides one or more solid surface to coat the testing cell lysate. Also, the anti-HPV antibody can be coated on the solid surface of the invention to capture HPV proteins and detect HPV infection.
摘要翻译：本发明的实施方案提供用于检测HPV感染和HPV相关癌症诊断的方法，单克隆抗体，多克隆抗体，测定和试剂盒，包括各种HPV基因型，早期和/或晚期HPV相关或HPV特异性癌症的感染。获得识别特定HPV蛋白或HPV型特异性表位或各种HPV蛋白或HPV类型的常见表位的各种特异性或泛单克隆抗体。本发明还提供了一个或多个固体表面以涂覆测试细胞裂解物。此外，抗HPV抗体可以涂覆在本发明的固体表面上以捕获HPV蛋白质并检测HPV感染。

35. 发明申请

US20140037581A1 METHODS TO DIAGNOSE AND IMMUNIZE AGAINST THE VIRUS CAUSING HUMAN MERKEL CELL CARCINOMA 有权
标题翻译：用于诊断和免疫病毒导致人类细胞癌的方法
公开(公告)号：US20140037581A1
公开(公告)日：2014-02-06
申请号：US13951679
申请日：2013-07-26
申请人： The United States of America, as Represented by the Secretary, Department of Health and Human Serv , University of Pittsburgh - Of the Commonwealth System of Higher Education
发明人： Patrick S. Moore , Yuan Chang , Huichen Feng , Christopher Brian Buck , Diana V. Pastrana
IPC分类号： C07K14/005 , G01N33/68
CPC分类号： C07K16/081 , A61K2039/5258 , C07K14/005 , C07K16/084 , C07K2317/14 , C07K2317/20 , C12N7/00 , C12N2710/22022 , C12N2710/22023 , C12Q1/18 , G01N33/56983 , G01N33/574 , G01N33/6893
摘要： The present invention provides isolated or substantially purified polypeptides, nucleic acids, and virus-like particles (VLPs) derived from a Merkel cell carcinoma virus (MCV), which is a newly-discovered virus. The invention further provides monoclonal antibody molecules that bind to MCV polypeptides. The invention further provides diagnostic, prophylactic, and therapeutic methods relating to the identification, prevention, and treatment of MCV-related diseases.
摘要翻译：本发明提供衍生自新发现的病毒的默克尔细胞癌病毒（MCV）的分离或基本纯化的多肽，核酸和病毒样颗粒（VLP）。本发明还提供了结合MCV多肽的单克隆抗体分子。本发明还提供了与鉴别，预防和治疗MCV相关疾病相关的诊断，预防和治疗方法。

36. 发明申请

US20130337438A1 MONOCLONAL ANTIBODY RECOGNIZING HUMAN PAPILLOMAVIRUS (HPV) L2 PROTEIN AND METHOD FOR MEASURING HPV-NEUTRALIZING ANTIBODY TITER USING THE SAME 有权
标题翻译：识别人类羊毛病（HPV）L2蛋白的单克隆抗体和使用其的HPV中和抗体TITER的测定方法
公开(公告)号：US20130337438A1
公开(公告)日：2013-12-19
申请号：US13997902
申请日：2011-12-26
申请人： Seiichiro Mori , Tadahito Kanda
发明人： Seiichiro Mori , Tadahito Kanda
IPC分类号： C12Q1/70
CPC分类号： G01N33/6854 , A61K47/6901 , A61K2039/505 , C07K16/084 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12Q1/70 , G01N33/56983 , G01N33/57411 , G01N2333/025 , G01N2800/26 , G01N2800/52
摘要： The present invention relates to the development of a monoclonal antibody which has binding activity to many high-risk types of HPV, etc. The present invention also provides a simple and high-throughput method for measuring cross-neutralizing antibody titers, which is used for assay of cross-neutralizing antibody against HPV in serum samples from subjects, etc. The method of the present invention for measuring cross-neutralizing antibody titers comprises the steps of: preparing a monoclonal antibody against a peptide having a specific amino acid sequence common to high-risk types of HPV; and assaying cross-neutralizing antibody using this monoclonal antibody.
摘要翻译：本发明涉及对许多高风险类型的HPV等具有结合活性的单克隆抗体的开发。本发明还提供了用于测量交叉中和抗体滴度的简单且高通量的方法，其用于测定来自受试者的血清样品中的交叉中和抗体的方法等。本发明的用于测量交叉中和抗体滴度的方法包括以下步骤：制备针对具有高共有特异性氨基酸序列的肽的单克隆抗体类型的HPV; 并使用该单克隆抗体测定交叉中和抗体。

37. 发明申请

US20130295553A1 COMPOSITIONS AND METHODS RELATING TO MOUSE PAPILLOMA VIRUS 审中-公开
标题翻译：与小鼠斑疹病毒相关的组合物和方法
公开(公告)号：US20130295553A1
公开(公告)日：2013-11-07
申请号：US13801516
申请日：2013-03-13
申请人： THE JACKSON LABORATORY , UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION
发明人： John P. Sundberg , Joongho Joh , A. Bennett Jenson , Shin-Je Ghim
IPC分类号： C12Q1/70 , G01N33/68
CPC分类号： C07K14/005 , A61D19/00 , C07K16/084 , C12N7/00 , C12N2710/20021 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034 , C12Q1/708 , G01N33/56983 , G01N33/6893 , G01N2333/025
摘要： Methods and compositions for detecting MusPV, also known as MmuPv1, infection of a rodent subject are described according to aspects of the present invention. In specific aspects, the present invention relates to assays for detecting MusPV infection of a rodent subject; vaccine compositions for inducing an immunological response against MusPV in a rodent subject; methods of inducing an immunological response to MusPV in a rodent subject; isolated MusPV protein; isolated antibodies which specifically binds to an MusPV protein, a fragment or variant thereof; isolated recombinantly expressed MusPV proteins; expression constructs comprising a nucleic acid encoding an MusPV protein; host cells comprising the expression construct; and hybridoma cell lines expressing an anti-MusPV monoclonal antibody specific for MusPV.
摘要翻译：根据本发明的方面描述了用于检测MusPV的方法和组合物，也称为MmuPv1，啮齿动物受试者的感染。在具体方面，本发明涉及用于检测啮齿动物受试者的MusPV感染的测定法; 在啮齿动物受试者中诱导针对MusPV的免疫应答的疫苗组合物; 在啮齿动物受试者中诱导对MusPV的免疫应答的方法; 分离的MusPV蛋白; 分离的抗体，其特异性结合MusPV蛋白，其片段或变体; 分离的重组表达的MusPV蛋白; 包含编码MusPV蛋白的核酸的表达构建体; 包含表达构建体的宿主细胞; 和表达对MusPV特异性的抗MusPV单克隆抗体的杂交瘤细胞系。

38. 发明授权

US08524248B2 Methods to diagnose and immunize against the virus causing human Merkel cell carcinoma 有权
标题翻译：用于诊断和免疫引起人类Merkel细胞癌的病毒的方法
公开(公告)号：US08524248B2
公开(公告)日：2013-09-03
申请号：US12808042
申请日：2008-12-15
申请人： Patrick S. Moore , Yuan Chang , Huichen Feng , Christopher Brian Buck , Diana V. Pastrana
发明人： Patrick S. Moore , Yuan Chang , Huichen Feng , Christopher Brian Buck , Diana V. Pastrana
IPC分类号： A61K39/275 , A61K35/12 , A61K31/675 , A61K31/7076 , A61K38/21 , A61K31/436 , A61K31/7088 , A61K38/16 , C12Q1/70 , C12Q1/68 , C07H21/00 , C07K14/065 , C40B40/10 , A61P31/20 , A61P35/00 , A61P37/04
CPC分类号： C07K16/081 , A61K2039/5258 , C07K14/005 , C07K16/084 , C07K2317/14 , C07K2317/20 , C12N7/00 , C12N2710/22022 , C12N2710/22023 , C12Q1/18 , G01N33/56983 , G01N33/574 , G01N33/6893
摘要： The present invention provides isolated or substantially purified polypeptides, nucleic acids, and virus-like particles (VLPs) derived from a Merkel cell carcinoma virus (MCV), which is a newly-discovered virus. The invention further provides monoclonal antibody molecules that bind to MCV polypeptides. The invention further provides diagnostic, prophylactic, and therapeutic methods relating to the identification, prevention, and treatment of MCV-related diseases.
摘要翻译：本发明提供衍生自新发现的病毒的默克尔细胞癌病毒（MCV）的分离或基本纯化的多肽，核酸和病毒样颗粒（VLP）。本发明还提供了结合MCV多肽的单克隆抗体分子。本发明还提供了与鉴别，预防和治疗MCV相关疾病相关的诊断，预防和治疗方法。

39. 发明申请

US20130202632A1 MINIMAL MOTIFS OF LINEAR B-CELL EPITOPES IN L1 PROTEIN FROM HUMAN PAPILLOMAVIRUS TYPE 58 AND THEIR APPLICATIONS 失效
标题翻译：来自人类羊毛病菌类型58的L1蛋白质中的线性B细胞外膜的最小运动及其应用
公开(公告)号：US20130202632A1
公开(公告)日：2013-08-08
申请号：US13364952
申请日：2012-02-02
申请人： Wanxiang Xu , Shaohua Gu , Yaping He , Chaoneng Ji , Haiping Tang , Jian Wang , Zhida Sun , Yi Xie
发明人： Wanxiang Xu , Shaohua Gu , Yaping He , Chaoneng Ji , Haiping Tang , Jian Wang , Zhida Sun , Yi Xie
IPC分类号： A61K39/00 , A61P37/04 , C07K16/00 , C07K7/06 , C07K5/10
CPC分类号： A61K39/12 , C07K5/1008 , C07K5/1019 , C07K5/1021 , C07K5/1024 , C07K16/084 , C12N2710/20022 , C12N2710/20034
摘要： Minimal Motifs of linear B-cell epitopes in L1 structure protein from human papillomavirus type 58 (HPV 58) and their applications are disclosed. Eighteen linear epitope motifs and their extended 8-mer peptides in the L1 protein from HPV 58 are described, which can be used as antigens separately or in combination to specifically detect the serum from subjects with HPV 58 infection, or to develop preventive or therapeutic multi-epitope peptide vaccines against HPV 58 by inducing humoral immunity. Of the eighteen B-cell epitope motifs, ten of them are 100% conservative and one is highly conservative among many homologous proteins of high-risk HPVs. They can be used as candidate “universal” epitopes to develop preventive or therapeutic HPV vaccines. The amino acid sequences of the epitope motifs and the 8-mer peptide formula of the invention are shown below in SEQ ID No. 1-2, 2B, 3, 3B, 4-18, 18B, 19, 19B, and 20-32.
摘要翻译：公开了来自人乳头状瘤病毒58型（HPV 58）的L1结构蛋白中线性B细胞表位的最小基序及其应用。描述了来自HPV58的L1蛋白中的十八个线性表位基序及其延伸的8聚体肽，其可以单独或组合用作抗原，以特异性检测来自具有HPV58感染的受试者的血清，或用于开发预防或治疗多 - 通过诱导体液免疫来抗HPV 58的表面肽疫苗。在十八个B细胞表位图案中，其中十个是100％保守的，一个在高风险HPV的许多同源蛋白中是高度保守的。它们可以用作候选“通用”表位，以开发预防或治疗性HPV疫苗。本发明的表位基序和8-聚体肽配方的氨基酸序列如SEQ ID No.1-2,2B，3,3B，4-18,18B，19,19B和20-32所示。

40. 发明申请

US20130183307A1 ABERRANT CELL-RESTRICTED IMMUNOGLOBULINS PROVIDED WITH A TOXIC MOIETY 审中-公开
公开(公告)号：US20130183307A1
公开(公告)日：2013-07-18
申请号：US13739974
申请日：2013-01-11
申请人： Johan Renes , Paulus J. G. M. Steverink , Ralph Alexander Willemsen
发明人： Johan Renes , Paulus J. G. M. Steverink , Ralph Alexander Willemsen
IPC分类号： A61K47/48 , C07K16/28
CPC分类号： A61K47/6813 , A61K47/6809 , A61K47/6849 , A61K47/6851 , A61K47/6883 , A61K2039/505 , A61P35/00 , C07K16/084 , C07K16/085 , C07K16/2833 , C07K16/2884 , C07K16/30 , C07K16/3069 , C07K16/3092 , C07K16/32 , C07K16/40 , C07K2317/32 , C07K2317/34 , C07K2317/569 , C07K2317/76 , C07K2319/33
摘要： Described are immunoglobulins provided with a toxic moiety, comprising at least an immunoglobulin variable region that specifically binds to an MHC-peptide complex preferentially associated with aberrant cells. These immunoglobulins provided with a toxic moiety are preferably used in selectively modulating biological processes. The provided immunoglobulins provided with a toxic moiety are of particular use in pharmaceutical compositions for the treatment of diseases related to cellular aberrancies, such as cancers and autoimmune diseases.

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