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31. 发明授权

US11708321B2 Method for preparing (dimethylaminomethylene) malononitrile using a micro reaction system 有权
公开(公告)号：US11708321B2
公开(公告)日：2023-07-25
申请号：US17103520
申请日：2020-11-24
申请人： Fudan University
发明人： Fener Chen , Dang Cheng , Meifen Jiang , Minjie Liu , Huashan Huang , Lulu Wang
IPC分类号： C07C253/20 , B01J19/00 , C07C255/25
CPC分类号： C07C253/20 , B01J19/0093 , B01J2219/00797 , B01J2219/00867 , B01J2219/00891 , B01J2219/00997 , C07C255/25
摘要： A method for preparing (dimethylaminomethylene) malononitrile by using a micro reaction system. Cyanoacetamide, N,N-dimethylformamide and a catalyst are mixed to obtain a mixture, and the mixture and phosphorus oxychloride are simultaneously pumped into the micro reaction system that includes a micromixer and a microchannel reactor connected in series for continuous dehydration condensation. After adjusted to a target pH, the crude product is subjected to continuous liquid-liquid extraction with an organic solvent in a centrifugal extraction unit comprising a plurality of annular centrifugal extractors connected in series. The organic phase is collected to obtain the target product (dimethyl aminomethylene) malononitrile.

32. 发明申请

US20170217874A1 METHOD FOR THE DISTILLATIVE PURIFICATION OF EDA 有权
公开(公告)号：US20170217874A1
公开(公告)日：2017-08-03
申请号：US15125850
申请日：2015-03-11
申请人： BASF SE
发明人： Hermann LUYKEN , Stephanie JAEGLI , Michael LORENZ , Gordon BRASCHE , Markus JEGELKA , Barbara BECKER , Robert BAUMANN , Johann-Peter MELDER , Boris BUSCHHAUS , Thomas KRUG
IPC分类号： C07C209/84
CPC分类号： C07C209/84 , C07C209/16 , C07C209/48 , C07C213/04 , C07C253/08 , C07C253/30 , C07C211/10 , C07C255/16 , C07C255/25 , C07C215/08
摘要： The present invention relates to a process for purifying ethylenediamine (EDA) by distillation, wherein the process comprises the steps a) and b). In step a), a mixture (G1) comprising water, EDA and N-methylethylenediamine (N-MeEDA) is fed into a distillation apparatus (D1), and the major part of the water comprised in the mixture (G1) is separated off overhead at a pressure of greater than 4.8 bara. From the bottom of (D1), the water-enriched mixture (G2) is fed into a distillation apparatus (D2) in step b). At the top of (D2), the major part of the N-MeEDA is distilled off. The stream (S3) obtained from the bottom of (D2) comprises EDA, with the components water and N-MeEDA comprised in the mixture (G1) having been largely or completely removed. Further distillation steps can optionally be carried out in order to obtain pure EDA, for example when diethylenetriamine (DETA) is additionally comprised in the mixture (G1). If ammonia is additionally comprised in the mixture (G1), an ammonia removal is preferably additionally carried out before carrying out the step a) in the process of the invention.

33. 发明授权

US09334232B2 Process to prepare a chelating agent or precursor thereof using a cyanide salt 有权
标题翻译：使用氰化物盐制备螯合剂或其前体的方法
公开(公告)号：US09334232B2
公开(公告)日：2016-05-10
申请号：US13322720
申请日：2010-06-03
申请人： Hans Lammers , Martin Heus , Tjerk Oedse Boonstra , Adrianus Maria Reichwein
发明人： Hans Lammers , Martin Heus , Tjerk Oedse Boonstra , Adrianus Maria Reichwein
IPC分类号： C07C227/18 , C07C253/30 , C07C253/08 , C07C229/24
CPC分类号： C07C253/08 , C07C229/24 , C07C255/25
摘要： The present invention relates to a process comprising the reaction of a cyanide with an amino acid and an aldehyde, characterized in that the cyanide is a cyanide salt, the amino acid is aspartic acid and/or glutamic acid in the acidic form, and the process is performed under acidic pH by the addition of between 0 and 1 equivalent of an acid based on the amount of aspartic or glutamic acid.
摘要翻译：本发明涉及氰化物与氨基酸和醛的反应的方法，其特征在于氰化物是氰化物盐，氨基酸是酸性形式的天冬氨酸和/或谷氨酸，该方法通过加入基于天冬氨酸或谷氨酸的量的0至1当量的酸在酸性pH下进行。

34. 发明授权

US09126901B2 Process for the preparation of aminonitrile and diamine, and corresponding devices 有权
标题翻译：氨基腈和二胺的制备方法及相应的装置
公开(公告)号：US09126901B2
公开(公告)日：2015-09-08
申请号：US14127526
申请日：2011-07-07
申请人： Zhongjie Lu , Shiquan Diao , Xinjun Zhang , Peijun Xu
发明人： Zhongjie Lu , Shiquan Diao , Xinjun Zhang , Peijun Xu
IPC分类号： C07C209/48 , C07C253/30
CPC分类号： C07C253/30 , C07C209/48 , Y02P20/582 , C07C255/25 , C07C211/09
摘要： The present invention relates to a continuous process for the preparation of an aminonitrile comprising the stages of: a) formation of the aminonitrile by reaction between an alkenyl nitrile, mixed with aminonitrile, and a monoamine introduced in molar excess with respect to the alkenyl nitrile; b) separation of the unreacted monoamine and the aminonitrile; c) reaction between the monoamine separated during stage b) and all or part of the alkenyl nitrile in order to form a mixture of aminonitrile and of unreacted alkenyl nitrile, with the alkenyl nitrile being introduced in molar excess with respect to the said monoamine; d) transfer of the mixture of aminonitrile and alkenyl nitrile resulting from stage c) to the reaction of stage a), and e) in the case where only a portion of the alkenyl nitrile is introduced during stage c), introduction of the remaining molar amount of alkenyl nitrile into the mixture of stage d).
摘要翻译：本发明涉及一种用于制备氨腈的连续方法，包括以下步骤：a）通过与氨基腈混合的烯基腈与相对于烯基腈摩尔过量引入的单胺反应形成氨基腈; b）未反应的单胺和氨基腈的分离; c）在步骤b）期间分离的单胺与全部或部分链烯基腈之间的反应，以形成氨基腈和未反应的烯基腈的混合物，烯基腈相对于所述单胺以摩尔过量引入; d）从阶段c）得到的氨基腈和烯基腈的混合物转移到阶段a）的反应中，e）在步骤c）期间仅引入链烯基腈的一部分的情况下，引入剩余的摩尔烯基腈的量进入阶段d）的混合物中。

35. 发明授权

US08946224B2 Substituted [1,2,4]triazolo[4,3-A]pyrazines for medicaments and pharmaceutical compositions 有权
标题翻译：用于药物和药物组合物的取代的[1,2,4]三唑并[4,3-A]吡嗪
公开(公告)号：US08946224B2
公开(公告)日：2015-02-03
申请号：US13883713
申请日：2011-11-11
申请人： Mark Craighead , Ronald Palin , Neil Murray , Derek Lindsay
发明人： Mark Craighead , Ronald Palin , Neil Murray , Derek Lindsay
IPC分类号： A61K31/4985 , C07D487/04 , C07D498/06 , C07D413/12 , C07C63/64 , C07D213/60 , C07C217/58 , C07D403/06 , C07C69/12 , C07C235/16 , C07D257/04 , C07D313/04 , C07D407/06 , C07C43/205 , C07C215/46 , C07C255/25 , C07D205/08 , C07D281/06 , C07D417/06 , C07D413/04 , C07D401/04 , C07C63/66 , C07D499/88 , C07D401/12 , C07D519/00 , C07D209/18 , C07D307/00 , C07D501/00 , C07C233/22 , C07D473/00 , C07H19/052 , C07C251/40 , C07D403/12 , C07D513/06 , C07C251/54 , C07C257/14 , C07C251/48 , C07C57/00 , C07C233/36 , C07H19/173 , C07D411/10 , C07C229/18 , C07D295/02 , C07H19/06 , C07C235/28 , C07D233/54 , C07J5/00 , C07D471/04 , C07D241/04 , C07D235/16 , C07D277/40 , C07D417/12 , C07D309/32 , C07C237/20 , C07C251/58 , C07D401/14 , C07D491/04
CPC分类号： C07D487/04 , C07C43/205 , C07C57/00 , C07C63/64 , C07C63/66 , C07C69/12 , C07C215/46 , C07C217/58 , C07C229/18 , C07C233/22 , C07C233/36 , C07C235/16 , C07C235/28 , C07C237/20 , C07C251/40 , C07C251/48 , C07C251/54 , C07C251/58 , C07C255/25 , C07C257/14 , C07C2601/16 , C07C2602/10 , C07C2603/74 , C07D205/08 , C07D209/18 , C07D213/60 , C07D233/54 , C07D235/16 , C07D241/04 , C07D257/04 , C07D277/40 , C07D281/06 , C07D295/02 , C07D307/00 , C07D309/32 , C07D313/04 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D407/06 , C07D411/10 , C07D413/04 , C07D413/12 , C07D417/06 , C07D417/12 , C07D471/04 , C07D473/00 , C07D491/04 , C07D498/06 , C07D499/88 , C07D501/00 , C07D513/06 , C07D519/00 , C07H19/052 , C07H19/06 , C07H19/173 , C07J5/00 , C07J71/0031
摘要： The present invention relates to derivatives of known active pharmaceutical compounds. These derivatives are differentiated from the parent active compound by virtue of being redox derivatives of the active compound. This means that one or more of the functional groups in the active compound has been converted to another group in one or more reactions which may be considered to represent a change of oxidation state. We refer to these compounds generally as redox derivatives. The derivatives of the invention may be related to the original parent active pharmaceutical compound by only a single step transformation, or may be related via several synthetic steps including one or more changes of oxidation state. Exemplary derivatives have the formula
摘要翻译：本发明涉及已知的活性药物化合物的衍生物。由于活性化合物的氧化还原衍生物，这些衍生物与母体活性化合物不同。这意味着活性化合物中的一个或多个官能团已经在一个或多个反应中被转化为另一个基团，这可被认为代表氧化态的变化。我们通常将这些化合物称为氧化还原衍生物。本发明的衍生物可以仅通过单步转化与原始的母体活性药物化合物相关，或者可以通过包括氧化态的一个或多个变化的几个合成步骤相关。示例性衍生物具有式

36. 发明授权

US08859812B2 Compound reagents and method for synthesizing enantiomerically enriched amino acids 有权
标题翻译：用于合成对映异构体富集的氨基酸的复合试剂和方法
公开(公告)号：US08859812B2
公开(公告)日：2014-10-14
申请号：US13394693
申请日：2010-09-08
申请人： Eric N. Jacobsen , Stephan J. Zuend
发明人： Eric N. Jacobsen , Stephan J. Zuend
IPC分类号： C07C335/00 , C07C253/08 , C07D307/52 , C07D333/20 , C07C227/26 , C07C335/16
CPC分类号： C07C253/08 , C07C227/26 , C07C335/16 , C07C2601/14 , C07C2601/16 , C07C2603/74 , C07D307/52 , C07D333/20 , C07C229/10 , C07C229/14 , C07C255/25 , C07C255/26 , C07C255/30 , C07C255/31 , C07C255/42 , C07C255/43 , C07C255/58
摘要： Described herein are compounds of formula (I), related compositions, and their use, for example in the formation of α-amino acids or a precursor thereof such as an α-aminonitrile.
摘要翻译：本文描述了式（I）的化合物，相关组合物及其在α-氨基酸或其前体如α-氨基腈的形成中的用途。

37. 发明授权

US08802894B2 Process for the preparation of aqueous solutions of methylglycine-N,N-diacetic acid trialkali metal salts 有权
标题翻译：制备甲基甘氨酸-N，N-二乙酸三烷基金属盐水溶液的方法
公开(公告)号：US08802894B2
公开(公告)日：2014-08-12
申请号：US13431381
申请日：2012-03-27
申请人： Alfred Oftring , Gerold Braun , Arnulf Lauterbach
发明人： Alfred Oftring , Gerold Braun , Arnulf Lauterbach
IPC分类号： C07C227/18
CPC分类号： C07C253/00 , C07C227/26 , C07C255/25 , C07C229/12
摘要： A process for preparing an aqueous solution of a methylglycine-N,N-diacetic acid trialkali metal salt at a high yield and purity by Strecker synthesis, the process including: reacting an aqueous solution containing α-alanine with formaldehyde and hydrocyanic acid, to obtain α-alanine-N,N-diacetonitrile in one reaction unit; and saponification of the α-alanine-N,N-diacetonitrile with a base, to obtain the methylglycine-N,N-diacetic acid trialkali metal salt, wherein the α-alanine is partially neutralized and the addition of formaldehyde and hydrocyanic acid are controlled such that a concentration of free hydrocyanic acid in the liquid reaction mixture at any time is limited such that secondary reactions that produce formaldehyde cyanohydrin, consecutive reactions of formaldehyde cyanohydrin, and the polymerization of hydrocyanic acid, only occur insofar as the specification requirements, such as nitrilotriacetic acid content and color, for methylglycine-N,N-diacetic acid trialkali metal salts are observed.
摘要翻译：一种通过Strecker合成以高产率和纯度制备甲基甘氨酸-N，N-二乙酸三烷基金属盐的水溶液的方法，该方法包括：使含有α-丙氨酸的水溶液与甲醛和氢氰酸反应，得到 α-丙氨酸-N，N-二乙腈在一个反应单元中; 并用碱对α-丙氨酸-N，N-二乙腈进行皂化，得到甲基甘氨酸-N，N-二乙酸三碱金属盐，其中α-丙氨酸被部分中和，加入甲醛和氢氰酸被控制使得在任何时候液体反应混合物中的游离氢氰酸的浓度受到限制，使得产生甲醛氰醇的二次反应，甲醛氰醇的连续反应和氢氰酸的聚合仅发生在规范要求的范围内，例如观察到甲基甘氨酸-N，N-二乙酸三烷基金属盐的次氮基三乙酸含量和颜色。

38. 发明申请

US20130066109A1 COMPOUNDS AND RELATED METHODS OF USE 有权
标题翻译：化合物及其相关使用方法
公开(公告)号：US20130066109A1
公开(公告)日：2013-03-14
申请号：US13394693
申请日：2010-09-08
申请人： Eric N. Jacobsen , Stephan J. Zuend
发明人： Eric N. Jacobsen , Stephan J. Zuend
IPC分类号： C07C335/22
CPC分类号： C07C253/08 , C07C227/26 , C07C335/16 , C07C2601/14 , C07C2601/16 , C07C2603/74 , C07D307/52 , C07D333/20 , C07C229/10 , C07C229/14 , C07C255/25 , C07C255/26 , C07C255/30 , C07C255/31 , C07C255/42 , C07C255/43 , C07C255/58
摘要： Described herein are compounds of formula (I), related compositions, and their use, for example in the formation of α-amino acids or a precursor thereof such as an α-aminonitrile.
摘要翻译：本文描述了式（I）的化合物，相关组合物及其在α-氨基酸或其前体如α-氨基腈的形成中的用途。

39. 发明授权

US07880036B2 Production method for ethyleneamine mixtures 有权
标题翻译：乙烯胺混合物的生产方法
公开(公告)号：US07880036B2
公开(公告)日：2011-02-01
申请号：US12529087
申请日：2008-02-27
申请人： Kirsten Dahmen , Alfred Oftring , Katrin Baumann , Randolf Hugo , Thilo Hahn , Johann-Peter Melder
发明人： Kirsten Dahmen , Alfred Oftring , Katrin Baumann , Randolf Hugo , Thilo Hahn , Johann-Peter Melder
IPC分类号： C07C209/48
CPC分类号： C07C209/48 , C07C211/10 , C07C211/13 , C07C211/14 , C07C253/30 , C07C255/25
摘要： The invention relates to a process for preparing an ethylene amine mixture, which comprises hydrogenating an amino nitrile mixture comprising at least two α-amino nitriles in an amount of at least 5% by weight in each case in the presence of a catalyst and, if appropriate, a solvent.
摘要翻译：本发明涉及一种制备乙烯胺混合物的方法，该方法包括在催化剂存在下，将包含至少两种α-氨基腈的氨基腈混合物氢化为至少5重量％，如果适当的溶剂。

40. 发明授权

US07880035B2 Method for producing ethyleneamines 有权
标题翻译：乙撑胺生产方法
公开(公告)号：US07880035B2
公开(公告)日：2011-02-01
申请号：US12529079
申请日：2008-02-28
申请人： Alfred Oftring , Kirsten Dahmen , Thilo Hahn , Randolf Hugo , Katrin Baumann , Johann-Peter Melder
发明人： Alfred Oftring , Kirsten Dahmen , Thilo Hahn , Randolf Hugo , Katrin Baumann , Johann-Peter Melder
IPC分类号： C07C209/48
CPC分类号： C07C209/48 , C07C253/30 , C07C211/10 , C07C211/14 , C07C255/25
摘要： The invention relates to a process for preparing an ethylene amine mixture, which comprises hydrogenating an amino nitrile mixture comprising at least 30% by weight of aminoacetonitrile (AAN) and at least 5% by weight of iminodiacetonitrile (IDAN) in the presence of a catalyst. Ethylenediamine (EDA) and/or diethylenetriamine (DETA) and, if appropriate, further ethylene amines can be isolated from the ethylene amine mixtures obtained.
摘要翻译：本发明涉及一种制备乙烯胺混合物的方法，该方法包括在催化剂存在下氢化包含至少30重量％氨基乙腈（AAN）和至少5重量％亚氨基二乙腈（IDAN）的氨基腈混合物。乙二胺（EDA）和/或二亚乙基三胺（DETA）和（如果合适的话）其它亚乙基胺可以从获得的乙烯胺混合物中分离出来。

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