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31. 发明授权

US11986680B2 Neutron capture therapy system comprising a beam shaping assembly configured to shape a neutron beam 有权
公开(公告)号：US11986680B2
公开(公告)日：2024-05-21
申请号：US17892254
申请日：2022-08-22
申请人： NEUBORON MEDTECH LTD.
发明人： Chiung-Wen Tsai , Weilin Chen , Ming-Chen Hsiao , Yuanhao Liu
IPC分类号： A61N5/10 , G21G4/00 , G21G4/02 , G21K1/02
CPC分类号： A61N5/1077 , A61N5/10 , A61N5/1048 , A61N5/1064 , A61N5/1065 , A61N5/1067 , A61N5/1071 , A61N5/1078 , G21G4/00 , G21G4/02 , G21K1/02 , G21K1/025 , A61N2005/1012 , A61N2005/1085 , A61N2005/109 , A61N2005/1094
摘要： The present disclosure provides a neutron capture therapy system, including an accelerator for generating a charged particle beam, a neutron generator for generating a neutron beam having neutrons after irradiation by the charged particle beam, and a beam shaping assembly for shaping the neutron beam. The beam shaping assembly includes a moderator and a reflecting assembly surrounding the moderator. The neutron generator generates the neutrons after irradiation by the charged particle beam. The moderator moderates the neutrons generated by the neutron generator to a preset energy spectrum. The reflecting assembly includes a reflecting assembly to deflected neutrons back to the neutron beam and a supporting member to support the reflectors. A lead-antimony alloy is for the reflecting assembly to mitigate a creep effect that occurs when only a lead material is for the reflectors, thereby improving the structural strength of a beam shaping assembly.

32. 发明公开

US20240100356A1 CUSTOMIZED BRACHYTHERAPY NEEDLE TEMPLATE AND METHOD 审中-公开
公开(公告)号：US20240100356A1
公开(公告)日：2024-03-28
申请号：US18532025
申请日：2023-12-07
申请人： Cowles Ventures, LLC
发明人： Emily Lin , Byron Stuck , Kevin Kelley
IPC分类号： A61N5/10
CPC分类号： A61N5/1007 , A61N2005/1012
摘要： A customized template and method create a template that is customized for a particular patient based on a treatment plan of the patient to perform a brachytherapy treatment.

33. 发明授权

US09775638B2 Braced brachytherapy needle 有权
公开(公告)号：US09775638B2
公开(公告)日：2017-10-03
申请号：US13515375
申请日：2010-12-22
申请人： Robert F. Chisholm , Jay Reed , Kevin Helle
发明人： Robert F. Chisholm , Jay Reed , Kevin Helle
IPC分类号： A61N5/10 , A61B17/34
CPC分类号： A61B17/3403 , A61B2017/3405 , A61N5/1027 , A61N2005/1012
摘要： Braces to reduce bending of a brachytherapy needle during insertion into a patient, as well as methods of using the needle braces and kits useful therefor.

34. 发明申请

US20170203128A1 GRID CALIBRATION SYSTEM FOR INTERVENTIONAL PROCEDURES 审中-公开
公开(公告)号：US20170203128A1
公开(公告)日：2017-07-20
申请号：US15324765
申请日：2015-07-09
申请人： KONINKLIJKE PHILIPS N.V.
发明人： CYNTHIA MING-FU KUNG , SHYAM BHARAT
IPC分类号： A61N5/10 , A61B8/12 , A61B8/00 , A61B34/20
CPC分类号： A61N5/1075 , A61B8/12 , A61B8/4209 , A61B8/4263 , A61B8/587 , A61B34/20 , A61B2017/00274 , A61B2034/2051 , A61N5/1007 , A61N5/1027 , A61N2005/1012
摘要： A grid calibration system employing interventional equipment including one or more interventional tools (23), a grid (22) having a hole matrix for supporting and guiding the interventional tool(s) (23) within a calibration area, and an imaging device (24) positioned relative to the grid (22) for generating a tool image illustrative of the interventional tool(s) (23) within the calibration area. The grid calibration system further employs a grid calibration workstation (40) for displaying any alignment adjustments to the relative positioning of the grid (22) and the imaging device (24) as derived from an image registration of the tool image and a virtual grid having a point matrix representative of the hole matrix of the grid.

35. 发明申请

US20160000519A1 INSTRUMENT LOCALIZATION IN GUIDED HIGH DOSE RATE BRACHYTHERAPY 审中-公开
标题翻译：仪器本地化在指导高剂量率BRACHYTHERAPY
公开(公告)号：US20160000519A1
公开(公告)日：2016-01-07
申请号：US14769134
申请日：2014-03-25
申请人： KONINKLIJKE PHILIPS N.V.
发明人： EHSAN DEHGHAN MARVAST
IPC分类号： A61B19/00 , A61N5/10
CPC分类号： A61B34/20 , A61B8/0841 , A61B8/12 , A61B34/10 , A61B2017/00274 , A61B2017/3411 , A61B2018/00547 , A61B2034/2051 , A61B2034/2061 , A61B2090/364 , A61B2090/3782 , A61N5/1001 , A61N5/1007 , A61N5/1027 , A61N2005/1012 , A61N2005/1051 , A61N2005/1058
摘要： A system for localizing one or more medical instruments includes a guidance grid (162) disposed in an operative relationship with a Workstation subject for receiving the one or more medical instruments (102) when deployed. An ultrasound imaging system (110) is configured to image a volume where the one or more medical instruments are deployed. A program module (136) is configured to register positions of the one or more medical instruments, using tracked position information and grid information, to the volume such that the positions of the one or more medical instruments can be visually monitored during a procedure.
摘要翻译：用于定位一个或多个医疗器械的系统包括与部署时用于接收所述一个或多个医疗器械（102）的工作站受试者以可操作关系设置的引导网格（162）。超声成像系统（110）被配置成对部署了一个或多个医疗器械的体积进行成像。程序模块（136）被配置为使用跟踪位置信息和网格信息将一个或多个医疗器械的位置记录到体积上，使得可以在过程期间可视觉地监视一个或多个医疗器械的位置。

36. 发明申请

US20150105606A1 Real Time Radiation Treatment Planning System 审中-公开
标题翻译：实时辐射治疗计划系统
公开(公告)号：US20150105606A1
公开(公告)日：2015-04-16
申请号：US14260009
申请日：2014-04-23
申请人： Nucletron Operations B.V.
发明人： Johann Kindlein , Dimos Baltas , Georgios Sakas , Frans Kuipers , Hans Martin Schot
IPC分类号： A61N5/10
CPC分类号： A61N5/1031 , A61N5/1001 , A61N5/1007 , A61N5/1039 , A61N2005/1012 , A61N2005/1032 , A61N2005/1074 , G06F19/00 , G06F19/3481
摘要： The invention relates to a real time radiation treatment planning system for use in effecting radiation therapy of a pre-selected anatomical portion of an animal body using hollow needles. According to embodiments of the invention, the system may include a processing means processing means-configured to perform a three-dimensional imaging algorithm and a three-dimensional image segmentation algorithm, with respect to one or more specific organs within the pre-selected anatomical portion and with respect to the needles, for converting the image data obtained with an imaging means into a three-dimensional image of the anatomical portion, using at least one single or multi-objective anatomy-based genetic optimization algorithm. For pre-planning or virtual simulation purposes, the processing means is arranged to determine in real time the optimal number and position of at least one of the needles, positions of energy emitting sources within the needles, and the dwell times of the energy emitting sources at the positions. For post-planning purposes, the processing means is arranged to determine, based on three-dimensional image information, in real time the real needle positions and the dwell times of the energy emitting sources for the positions.
摘要翻译：本发明涉及一种实时放射治疗计划系统，用于使用空心针对动物体的预先选择的解剖部分进行放射治疗。根据本发明的实施例，系统可以包括处理装置处理装置，其被配置为相对于预先选择的解剖部分内的一个或多个特定器官执行三维成像算法和三维图像分割算法并且相对于针，用于使用至少一个单目标或多目标基于解剖的遗传优化算法将用成像装置获得的图像数据转换成解剖部分的三维图像。对于预先规划或虚拟模拟目的，处理装置被布置成实时确定针中的至少一个针的最佳数量和位置，针内的能量发射源的位置以及能量发射源的停留时间在职位。为了规划后的目的，处理装置被布置成基于三维图像信息实时确定位置的能量发射源的实际针位置和停留时间。

37. 发明授权

US08808156B1 Minimally invasive applicator for intraoperative radiotherapy 有权
标题翻译：微创用于术中放疗
公开(公告)号：US08808156B1
公开(公告)日：2014-08-19
申请号：US13102050
申请日：2011-05-05
申请人： Loren Godfrey, Jr. , Loren Godfrey, Sr.
发明人： Loren Godfrey, Jr. , Loren Godfrey, Sr.
IPC分类号： A61N5/00 , A61N5/10
CPC分类号： A61N5/1007 , A61N2005/1012
摘要： The present invention relates to an applicator for delivering any of a plurality of predetermined radiation fields to a target in intraoperative radiotherapy. In a variant, the applicator comprises: a panel and at least one first pair of first and second grippers pivotally connected to the panel with each gripper having loop on an end. The loop is connected to an arm and the arm pivotally attached to the panel. The first and second grippers are configured to rotate in opposite directions to form an open position and come to a stopping point. The loops of the grippers are configured to slide under one another while rotating into a retracted configuration. Two end units are disposed on opposite ends of the panel, configured for being grasped by two independent graspers for fixing the applicator in position.
摘要翻译：本发明涉及一种用于在术中放射治疗中将多个预定辐射场中的任一个传送到目标的施加器。在一个变型中，施用器包括：面板和至少一个第一对第一和第二夹持器，其枢转地连接到面板，每个夹具在一端具有环。该环连接到一个臂上，并且该臂可枢转地连接到面板上。第一和第二夹持器构造成沿相反方向旋转以形成打开位置并到达停止点。夹持器的环被构造成在旋转到缩回构型的同时彼此滑动。两个端部单元布置在面板的相对端上，构造成由两个独立的夹紧器抓住用于将施用器固定就位。

38. 发明授权

US08758213B1 Minimally invasive applicators for robotic and non-robotic-assisted intraoperative radiotherapy 有权
标题翻译：用于机器人和非机器人辅助术中放疗的微创手术器械
公开(公告)号：US08758213B1
公开(公告)日：2014-06-24
申请号：US12416677
申请日：2009-04-01
申请人： Loren Godfrey, Jr. , Loren Godfrey, Sr.
发明人： Loren Godfrey, Jr. , Loren Godfrey, Sr.
IPC分类号： A61N5/00
CPC分类号： A61N5/1007 , A61N5/1083 , A61N2005/1012
摘要： An applicator is provided, for manipulating one or more catheters carrying a radiation generating device, for delivering a radiation field to a target, the applicator having a proximal end and a distal end. The applicator includes: a spring mechanism; at least one catheter grasper for grasping one or more catheters carrying a radiation generating material, the catheter grasper being attached to the spring mechanism; and a sheath, for covering at least a portion the spring mechanism. The spring mechanism is designed for being retracted within the sheath, in a closed configuration of the applicator. The spring mechanism is designed for being released into a predetermined arrangement when moved out of a distal end of the sheath, in an open configuration of the applicator. The applicator is designed to be repeatedly switched between the closed configuration and the open configuration.
摘要翻译：提供了一种施用器，用于操纵携带辐射产生装置的一个或多个导管，用于将辐射场传送到靶，所述施放器具有近端和远端。涂抹器包括：弹簧机构; 至少一个用于抓住携带辐射产生材料的一个或多个导管的导管夹持器，所述导管夹持器附接到弹簧机构; 以及用于覆盖弹簧机构的至少一部分的护套。弹簧机构设计成在护套中缩回，处于封闭构造中。弹簧机构被设计成当以涂敷器的打开构造移动离开护套的远端时被释放成预定的布置。施加器设计成在关闭构型和打开构型之间重复切换。

39. 发明申请

US20130317276A1 BRACHYTHERAPY TANDEM AND OVOID IMPLANTATION DEVICES AND METHODS 审中-公开
公开(公告)号：US20130317276A1
公开(公告)日：2013-11-28
申请号：US13478794
申请日：2012-05-23
申请人： Mark A. D'Andrea
发明人： Mark A. D'Andrea
IPC分类号： A61M36/10 , A61M36/02
CPC分类号： A61N5/1016 , A61B18/04 , A61B2017/22051 , A61B2017/22054 , A61B2017/22055 , A61B2017/22061 , A61B2017/22062 , A61B2017/22068 , A61B2017/22069 , A61B2018/00273 , A61B2018/00285 , A61B2018/00559 , A61B2018/046 , A61B2090/033 , A61B2090/0445 , A61B2090/0481 , A61N5/1067 , A61N5/1071 , A61N2005/1003 , A61N2005/1012 , A61N2005/1094
摘要： Intracavitary brachytherapy tandem and ovoid oncology treatment systems and methods are provided. One such system and method employs a multi-part tandem having a detachable distal section retained within a body cavity during and between radiation treatments. This can be for single-patient use and disposed of after completion of a multiple-dose radiation treatment session. Real time in vivo detection and monitoring and hytpertherapy features can be included. Tandem or ovoid colpostats can feature bendability to tailor the system to the specific body and patient being treated. Other systems and methods incorporate balloon devices that assist in spacing radiation doses away from chosen body sites. Balloon devices also can be provided for adjusting and maintaining separation spacing between two ovoid colpostats.
摘要翻译：提供腔内近距离放射治疗系统和卵巢肿瘤治疗系统和方法。一种这样的系统和方法采用多部分串联，其中在放射治疗期间和之间具有保持在体腔内的可分离远端部分。这可以用于单次患者使用，并在多剂量放射治疗会话完成后进行处置。可以包括实时的体内检测和监测和疗法特征。串联或卵球蛋白凝块可以具有弯曲性，可以将系统定制到特定身体和被治疗的患者。其他系统和方法包括有助于将辐射剂量与所选择的身体部位隔开的球囊装置。还可以提供气球装置用于调节和保持两个卵巢凝块体之间的间隔。

40. 发明申请

US20120302890A1 CRADLE APPARATUS FOR A STEPPER TO HOLD ULTRA-SOUND PROBE 审中-公开
标题翻译：用于保持超声波探头的踏板的折叠装置
公开(公告)号：US20120302890A1
公开(公告)日：2012-11-29
申请号：US13116071
申请日：2011-05-26
申请人： David Strong
发明人： David Strong
IPC分类号： A61B8/00
CPC分类号： A61B8/4209 , A61N5/1027 , A61N2005/1012 , A61N2005/1058
摘要： A cradle is connected to a stepper-stabilizer via a plurality of cradle fix holes, wherein said cradle further comprises, a locking knob that is attached to a side of said cradle used for tightening and loosening; a capture knob that is mounted inside said locking knob; a clamp that is connected on top of said cradle used to wrap over and on top of a probe; a probe lock fixer that is attached to said clamp; a cradle base affixed between said cradle and said stepper-stabilizer that allows for movement change in angular rotation of the horizontal axis of said cradle while being connected to said stepper-stabilizer; a plurality of roller-bearings attached between said cradle base and said cradle; and a perpendicular locker attached along a rail of said cradle base used to fix said cradle in a set predetermine angle.
摘要翻译：支架通过多个支架固定孔连接到步进稳定器，其中所述支架还包括锁定旋钮，所述锁定旋钮附接到用于紧固和松开的所述支架的一侧; 安装在所述锁定旋钮内的捕获旋钮; 连接在所述支架顶部的用于覆盖并在探头顶部的夹具; 附接到所述夹具的探针锁固定器; 固定在所述支架和所述步进稳定器之间的托架基座，其允许所述托架的水平轴线在与所述步进稳定器相连接时的角度旋转的变化; 安装在所述支架底座和所述支架之间的多个滚子轴承; 以及沿着所述托架底座的轨道附接的垂直锁定件，用于将所述支架固定成预定角度。

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