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31. 发明授权

US08938292B2 Estimating cardiovascular pressure and volume using impedance measurements 有权
标题翻译：使用阻抗测量估算心血管压力和体积
公开(公告)号：US08938292B2
公开(公告)日：2015-01-20
申请号：US12263065
申请日：2008-10-31
申请人： Douglas A. Hettrick , Yong K. Cho , Mattias Rouw , Shantanu Sarkar , Todd M. Zielinski
发明人： Douglas A. Hettrick , Yong K. Cho , Mattias Rouw , Shantanu Sarkar , Todd M. Zielinski
IPC分类号： A61B5/05 , A61N1/365 , A61B5/0215 , A61B5/053 , A61B5/021 , A61B5/00
CPC分类号： A61N1/36521 , A61B5/021 , A61B5/0215 , A61B5/02158 , A61B5/053 , A61B5/0535 , A61B5/0538 , A61B5/7239 , A61N1/36564
摘要： Techniques for estimating a cardiac chamber or vascular pressure based upon impedance are described. A device or system may measure an impedance between at least two electrodes implanted within or proximate to a cardiovascular system. The device or system may estimate a pressure of an element of the cardiovascular system based on a relationship between impedance and volume of the element, and based on a empirical relationship between the volume and the pressure. The device or system may also estimate the dimension of the element based on the impedance-volume relationship, or other characteristics based on the impedance. Because the impedance measurements may be obtained, in some examples, by using electrodes and leads implanted within the cardiovascular system and coupled to an implantable medical device, a practical estimation of a cardiovascular pressure can be obtained on a chronic basis without requiring the use other invasive sensors, such as micronanometer transducers.
摘要翻译：描述了基于阻抗估计心室或血管压力的技术。装置或系统可以测量植入在心血管系统内或其附近的至少两个电极之间的阻抗。装置或系统可以基于元件的阻抗和体积之间的关系，并且基于体积和压力之间的经验关系来估计心血管系统的元件的压力。装置或系统还可以基于阻抗 - 体积关系或基于阻抗的其它特性来估计元件的尺寸。由于可以获得阻抗测量值，在一些示例中，通过使用植入心血管系统内并连接到可植入医疗装置的电极和引线，可以长期获得心血管压力的实际估计，而不需要使用其它侵入性传感器，如微量计传感器。

32. 发明授权

US08926523B2 Method and apparatus for cardiac function monitoring 有权
标题翻译：用于心脏功能监测的方法和装置
公开(公告)号：US08926523B2
公开(公告)日：2015-01-06
申请号：US13794898
申请日：2013-03-12
申请人： Medtronic, Inc.
发明人： Zhendong Song , Xiaohong Zhou
IPC分类号： A61B5/02 , A61N1/00 , A61B5/0215 , A61N1/365 , A61B5/0245 , A61N1/362 , A61B7/04 , A61N1/05
CPC分类号： A61B7/04 , A61B5/02158 , A61B5/0245 , A61B6/12 , A61B6/487 , A61N1/056 , A61N1/362 , A61N1/36564 , A61N1/36578 , A61N1/36585
摘要： An implantable medical device that includes a first elongated lead body having an outer surface and an opening along the outer surface, a sensor positioned along the lead body and configured to receive acoustic signals through the opening of the first lead body and generate an electrical signal representative of sounds produced at a targeted location along a patient's cardiovascular system. A therapy delivery module is capable of delivering a cardiac therapy via predetermined electrodes of a plurality of electrodes, and a processor is configured to detect a cardiac event in response to the sensed cardiac electrical signals, determine a plurality of time intervals between the electrical signals and acoustic signals, determine a correlation between the electrical signals and the acoustic signals, and control the therapy delivery module to deliver therapy in response to the determined correlation.
摘要翻译：一种可植入医疗装置，其包括具有外表面和沿着外表面的开口的第一细长引线本体，沿着引线本体定位并被配置为通过第一引线体的开口接收声信号并产生电信号代表在沿着患者心血管系统的目标位置产生的声音。治疗递送模块能够通过多个电极的预定电极递送心脏治疗，并且处理器被配置为响应于所感测的心脏电信号来检测心脏事件，确定电信号与电信号之间的多个时间间隔声信号，确定电信号和声信号之间的相关性，并且响应于确定的相关性来控制治疗递送模块递送治疗。

33. 发明申请

US20140330333A1 METHODS AND DEVICES FOR MODIFYING VASCULAR PARAMETERS 有权
标题翻译：用于修改血管参数的方法和装置
公开(公告)号：US20140330333A1
公开(公告)日：2014-11-06
申请号：US14332700
申请日：2014-07-16
申请人： METACURE LIMITED
发明人： Shlomo Ben-Haim , Nissim Darvish , Yuval Mika , Maier Fenster
IPC分类号： A61N1/05 , A61N1/20
CPC分类号： A61N1/05 , A61N1/20 , A61N1/205 , A61N1/32 , A61N1/36007 , A61N1/36071 , A61N1/36117 , A61N1/36564 , A61N1/372
摘要： A method of promoting the healing of a lesion in a smooth muscle (200), comprises selecting a smooth muscle portion having a lesion, and applying a non-excitory electric field (210) to the portion, which reduces the mechanical activity of the portion.
摘要翻译：一种促进平滑肌（200）中病变愈合的方法，包括选择具有病变的平滑肌部分，并向该部分施加非排除性电场（210），这降低了部分的机械活动。

34. 发明申请

US20140324115A1 VAGAL STIMULATION 有权
公开(公告)号：US20140324115A1
公开(公告)日：2014-10-30
申请号：US14330915
申请日：2014-07-14
申请人： Medtronic, Inc.
发明人： Paul D. Ziegler , Lillian Kornet , Xiaohong Zhou , Richard N.M. Comelussen , Robert Stadler , Eduardo Warman , Karen J. Kleckner , Alberto Della Scala
IPC分类号： A61N1/36 , A61N1/368 , A61N1/372
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36114 , A61N1/3621 , A61N1/3627 , A61N1/36564 , A61N1/3682 , A61N1/3702 , A61N1/37235 , A61N1/3962
摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

35. 发明授权

US08805501B2 Baroreflex stimulation to treat acute myocardial infarction 有权
标题翻译： Baroreflex刺激治疗急性心肌梗死
公开(公告)号：US08805501B2
公开(公告)日：2014-08-12
申请号：US13357932
申请日：2012-01-25
申请人： Imad Libbus
发明人： Imad Libbus
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36117 , A61N1/36564
摘要： An aspect of the present subject relates to an implantable medical system. An embodiment of the system includes a baroreflex stimulator, a myocardial infarction detector, and a controller. The baroreflex stimulator applies a baroreflex stimulation signal through an electrode. The myocardial infarction detector detects an event indicative of myocardial infarction, The controller is connected to the baroreflex stimulator and to the myocardial infarction detector, and is adapted to apply a baroreflex therapy in response to a detected event indicative of myocardial infarction. Other aspects are provided herein.
摘要翻译：本发明的一个方面涉及可植入医疗系统。系统的一个实施例包括压力反射刺激器，心肌梗死检测器和控制器。压力反射刺激器通过电极施加压力反射刺激信号。心肌梗死检测器检测到指示心肌梗死的事件。控制器连接到压力反射刺激器和心肌梗塞检测器，并且适于对检测到的指示心肌梗塞的事件应用压力反射治疗。本文提供了其他方面。

36. 发明授权

US08805495B2 Adaptive medium voltage therapy for cardiac arrhythmias 有权
标题翻译：心律失常的适应性中压治疗
公开(公告)号：US08805495B2
公开(公告)日：2014-08-12
申请号：US13921290
申请日：2013-06-19
申请人： Galvani, Ltd.
发明人： Byron L. Gilman , Mark Kroll , James E. Brewer
IPC分类号： A61N1/00
CPC分类号： A61N1/3925 , A61N1/3605 , A61N1/362 , A61N1/3621 , A61N1/36564 , A61N1/39 , A61N1/3956 , A61N1/3968 , A61N1/3993
摘要： Aspects of the invention are directed to advanced monitoring and control of medium voltage therapy (MVT) in implantable and external devices. Apparatus and methods are disclosed that facilitate dynamic adjustment of MVT parameter values in response to new and changing circumstances such as the patient's condition before, during, and after administration of MVT. Administration of MVT is automatically and dynamically adjusted to achieve specific treatment or life-support objectives, such as prolongation of the body's ability to endure and respond to MVT, specifically addressing the type of arrhythmia or other pathologic state of the patient with targeted treatment, a tiered-intensity MVT treatment strategy, and supporting patients in non life-critical conditions where the heart may nevertheless benefit from a certain level of assistance.
摘要翻译：本发明的方面涉及可植入和外部设备中的中压治疗（MVT）的高级监视和控制。公开了用于响应于新的和变化的情况（例如在MVT管理之前，之中和之后的患者状况）MVT参数值的动态调整的装置和方法。自动动态地调整MVT的管理，以达到特定的治疗或生命维持目标，例如延长身体耐受和应对MVT的能力，具体针对靶向治疗患者的心律失常或其他病理状态，分层强度的MVT治疗策略，并支持非生命危险条件下的患者，心脏可能受益于一定程度的帮助。

37. 发明授权

US08781582B2 Vagal stimulation 有权
标题翻译：迷走神经刺激
公开(公告)号：US08781582B2
公开(公告)日：2014-07-15
申请号：US13353802
申请日：2012-01-19
申请人： Paul D. Ziegler , Lilian Kornet , Xiaohong Zhou , Richard N. M. Cornelussen , Robert Stadler , Eduardo Warman , Karen J. Kleckner , Alberto Della Scala
发明人： Paul D. Ziegler , Lilian Kornet , Xiaohong Zhou , Richard N. M. Cornelussen , Robert Stadler , Eduardo Warman , Karen J. Kleckner , Alberto Della Scala
IPC分类号： A61N1/37
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36114 , A61N1/3621 , A61N1/3627 , A61N1/36564 , A61N1/3682 , A61N1/3702 , A61N1/37235 , A61N1/3962
摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.
摘要翻译：本文的公开内容一般涉及使用迷走神经刺激治疗心脏病症的方法，还涉及用于进行这种治疗的系统和装置。这样的方法可以包括监测患者的生理参数，检测心脏状况，以及向患者输送迷走神经刺激（例如，对迷走神经或具有副交感神经功能的神经元的电刺激）以治疗检测到的心脏状况。

38. 发明申请

US20140128934A1 Cardiac Stimulation Apparatus And Method For The Control Of Hypertension 有权
标题翻译：心脏刺激装置及控制高血压的方法
公开(公告)号：US20140128934A1
公开(公告)日：2014-05-08
申请号：US13854283
申请日：2013-04-01
申请人： BackBeat Medical, Inc.
发明人： Robert S. Schwartz , Robert A. Van Tassel
IPC分类号： A61N1/365
CPC分类号： A61N1/36514 , A61N1/3627 , A61N1/36564
摘要： A method that electrically stimulates a heart muscle to alter the ejection profile of the heart, to control the mechanical function of the heart and reduce the observed blood pressure of the patient. The therapy may be invoked by an implantable blood pressure sensor associated with a pacemaker like device. In some cases, where a measured pretreatment blood pressure exceeds a treatment threshold, a patient's heart may be stimulated with an electrical stimulus timed relative to the patient's cardiac ejection cycle. This is done to cause dyssynchrony between at least two cardiac chambers or within a cardiac chamber, which alters the patient's cardiac ejection profile from a pretreatment cardiac ejection profile. This has the effect of reducing the patient's blood pressure from the measured pretreatment blood pressure.
摘要翻译：一种电刺激心肌以改变心脏的射血分布，控制心脏的机械功能并降低观察到的患者血压的方法。该治疗可以由与起搏器相似的装置相关联的可植入血压传感器来调用。在一些情况下，在测量的预处理血压超过治疗阈值的情况下，可以以相对于患者的心脏射血周期计时的电刺激来刺激患者的心脏。这是为了在至少两个心室之间或心室内引起不同步，其改变患者的心脏射血分布从预处理的心脏射血分布。这具有从测量的预处理血压降低患者的血压的效果。

39. 发明申请

US20140128750A1 Catheter System for Acute Neuromodulation 审中-公开
标题翻译：导管系统急性神经调节
公开(公告)号：US20140128750A1
公开(公告)日：2014-05-08
申请号：US14151755
申请日：2014-01-09
申请人： Interventional Autonomics Corporation
发明人： Terrance J Ransbury , Richard S Stack , William E Sanders , Stephen C Masson
IPC分类号： A61N1/05 , A61N1/365 , A61B5/0215
CPC分类号： A61N1/056 , A61B5/0215 , A61N1/3605 , A61N1/36114 , A61N1/36564
摘要： A neuromodulation system includes a first therapy element adapted for positioning within a superior vena cava, and a second therapy element adapted for positioning within a pulmonary artery. The first therapy element is carried on a first elongate flexible shaft, and the second therapy element is carried on a second elongate flexible shaft. One of the first and second shafts is slidably received within a lumen of the other of the first and second shafts—so that the second therapy element may be advanced within the body relative to the first therapy element. A stimulator is configured to energize the first therapy element within the first blood vessel to deliver therapy to a first nerve fiber disposed external to the superior vena cava and to energize the second therapy element within the pulmonary artery to deliver sympathetic therapy to a second nerve fiber disposed external to the pulmonary artery. For treatment of heart failure, the first nerve fiber may be a vagus nerve and the second nerve fiber may be a sympathetic nerve fiber.
摘要翻译：神经调节系统包括适于定位在上腔静脉内的第一治疗元件和适于定位在肺动脉内的第二治疗元件。第一治疗元件承载在第一细长柔性轴上，第二治疗元件承载在第二细长柔性轴上。第一和第二轴之一可滑动地容纳在第一和第二轴中的另一个的内腔中，使得第二治疗元件可相对于第一治疗元件在身体内前进。刺激器被配置为对第一血管内的第一治疗元件通电，以将治疗递送到设置在上腔静脉外部的第一神经纤维，并激励肺动脉内的第二治疗元件以向第二神经纤维递送交感神经疗法位于肺动脉外部。为了治疗心力衰竭，第一神经纤维可能是迷走神经，第二神经纤维可能是交感神经纤维。

40. 发明授权

US08649865B2 Method and system for hemodynamic optimization using plethysmography 有权
标题翻译：使用体积描记法进行血液动力学优化的方法和系统
公开(公告)号：US08649865B2
公开(公告)日：2014-02-11
申请号：US12964625
申请日：2010-12-09
申请人： Gene A. Bornzin , Wenbo Hou , Edward Karst , Brian J. Wenzel , Timothy A Fayram
发明人： Gene A. Bornzin , Wenbo Hou , Edward Karst , Brian J. Wenzel , Timothy A Fayram
IPC分类号： A61N1/00
CPC分类号： A61N1/36585 , A61B5/02416 , A61B5/726 , A61N1/3627 , A61N1/36564 , A61N1/3684 , A61N1/3686
摘要： Time delays between a feature of a signal indicative of electrical activity of a patient's heart and a feature of a plethysmograph signal indicative of changes in arterial blood volume are used to arrange the operation of an implantable device, such as a pacemaker. Shorter time delays between the feature of the signal indicative of electrical activity of a patient's heart and the feature of the plethysmograph signal indicative of changes in arterial blood volume are indicative of larger cardiac stroke volumes. The time delay can be used to select a pacing site or combination of pacing sites and/or to select a pacing interval set.
摘要翻译：使用指示患者心脏的电活动的信号的特征与指示动脉血容量变化的体积描记信号的特征之间的时间延迟来布置诸如起搏器的可植入装置的操作。指示患者心脏的电活动的信号的特征与指示动脉血容量变化的体积描记器信号的特征之间的更短的时间延迟指示较大的心脏搏动量。时间延迟可用于选择起搏站点或起搏站点的组合和/或选择起搏间隔集。

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