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31. 发明申请

US20070087957A1 Methods and compositions for oral administration of proteins 有权
标题翻译：口服蛋白质的方法和组合物
公开(公告)号：US20070087957A1
公开(公告)日：2007-04-19
申请号：US11513343
申请日：2006-08-31
申请人： Miriam Kidron
发明人： Miriam Kidron
IPC分类号： A61K38/28 , A61K31/22 , A61K31/202
CPC分类号： A61K38/28 , A61K9/0053 , A61K9/2013 , A61K9/2068 , A61K9/2846 , A61K9/2866 , A61K9/485 , A61K9/4866 , A61K9/4875 , A61K9/4891 , A61K9/5057 , A61K31/202 , A61K31/22 , A61K35/60 , A61K38/56 , A61K45/06 , A61K47/183 , A61K47/28 , A61K2300/00
摘要： This invention provides compositions comprising a protein and an omega-3 fatty acid, method for treating diabetes mellitus, comprising administering same, and methods for oral administration of a protein with an enzymatic activity, comprising orally administering same.
摘要翻译：本发明提供包含蛋白质和ω-3脂肪酸的组合物，治疗糖尿病的方法，包括给药，以及口服给予具有酶活性的蛋白质的方法，包括口服给药。

32. 发明申请

US20060275353A1 Stable topical drug delivery compositions 审中-公开
标题翻译：稳定的局部给药组合物
公开(公告)号：US20060275353A1
公开(公告)日：2006-12-07
申请号：US11506137
申请日：2006-08-17
申请人： Nicholas Perricone , Chim Potini
发明人： Nicholas Perricone , Chim Potini
IPC分类号： A61K38/28 , A61F13/02 , A61L15/16 , A61K38/34 , A61K38/31 , A61K38/24 , A61K38/23 , A61K38/12
CPC分类号： A61K47/24 , A61J3/07 , A61K9/0014 , A61K9/02 , A61K9/06 , A61K9/127 , A61K9/1277 , A61K31/56 , A61K38/02 , A61K38/095 , A61K38/23 , A61K38/24 , A61K38/27 , A61K38/28 , A61K38/31 , A61K38/56 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/34 , C07K14/62 , Y10S514/806 , Y10S514/807 , Y10S514/808 , Y10S514/866 , Y10S514/97
摘要： A method of delivering a drug composition comprises providing a carrier having a phosphatidylcholine component and a drug entrapped therein, and applying the composition to the skin for transdermal delivery of the drug, wherein the composition is stable at room temperature.
摘要翻译：递送药物组合物的方法包括提供具有磷脂酰胆碱成分和被截留在其中的药物的载体，并将该组合物施用于皮肤以透皮递送药物，其中该组合物在室温下是稳定的。

33. 发明授权

US07052704B2 Methods and compositions for lipidization of hydrophilic molecules 失效
标题翻译：亲水分子脂化的方法和组合物
公开(公告)号：US07052704B2
公开(公告)日：2006-05-30
申请号：US09845153
申请日：2001-05-01
申请人： Wei-Chiang Shen , Hossein M. Ekrami
发明人： Wei-Chiang Shen , Hossein M. Ekrami
IPC分类号： A61K38/00 , A61K39/385 , C07K14/00 , C70H21/00
CPC分类号： C07D213/70 , A61K38/56 , A61K47/54 , A61K47/542 , A61K47/64 , C07D213/71 , C07H21/00 , C12N9/0065 , C12N15/111 , C12N2310/3515
摘要： Fatty acid derivatives of sulfhydryl-containing compounds (for example, sulfhydryl-containing peptides or proteins) comprising fatty acid-conjugated products with a disulfide linkage are employed for delivery of the compounds to mammalian cells. This modification markedly increases the absorption of the compounds by mammalian cells relative to the rate of absorption of the unconjugated compounds, as well as prolonging blood and tissue retention of the compounds. Moreover, the disulfide linkage in the conjugate is quite labile in the cells and thus facilitates intracellular release of the intact compounds from the fatty acid moieties.
摘要翻译：使用包含具有二硫键的脂肪酸缀合产物的含巯基化合物（例如，含巯基肽或蛋白质）的脂肪酸衍生物用于将化合物递送至哺乳动物细胞。该修饰显着增加了哺乳动物细胞相对于未缀合化合物的吸收速率的吸收，以及延长了化合物的血液和组织滞留。此外，缀合物中的二硫键在细胞中是非常不稳定的，因此促进完整化合物从脂肪酸部分的细胞内释放。

34. 发明申请

US20050152952A1 Phaseolamin compositions and methods for using the same 有权
公开(公告)号：US20050152952A1
公开(公告)日：2005-07-14
申请号：US10997315
申请日：2004-11-24
申请人： Dilip Chokshi
发明人： Dilip Chokshi
IPC分类号： A21D2/02 , A21D2/26 , A23D7/005 , A23L1/304 , A23L1/305 , A61K33/24 , A61K35/74 , A61K35/745 , A61K35/747 , A61K38/16 , A61P3/10 , C07K14/195
CPC分类号： A61K35/747 , A21D2/02 , A21D2/266 , A21D2/267 , A21D2/368 , A21D13/06 , A21D13/80 , A23D7/0056 , A23L33/105 , A23L33/16 , A23L33/165 , A23L33/185 , A23L33/195 , A61K33/24 , A61K35/745 , A61K36/064 , A61K38/56 , A61K2300/00
摘要： The present invention is for compositions containing phaseolamin and a mineral, such as chromium or vanadium or both, where the mineral is bound by a glycoprotein matrix. The present invention is also directed to methods for controlling carbohydrate cravings, inducing weight loss, reducing insulin requirements in a diabetic, and inhibiting the absorption of dietary starch by administering a composition of the invention.

35. 发明授权

US06887498B2 Method of making Bowman-Birk inhibitor product 失效
标题翻译：制备Bowman-Birk抑制剂产品的方法
公开(公告)号：US06887498B2
公开(公告)日：2005-05-03
申请号：US10197297
申请日：2002-07-16
申请人： Arthur H. Konwinski , Bernard F. Szuhaj
发明人： Arthur H. Konwinski , Bernard F. Szuhaj
IPC分类号： A23J1/14 , A23L1/305 , A61K38/56 , A61P35/00 , A61P43/00 , A61K35/78
CPC分类号： A61K38/56 , A23J1/142 , A23L33/185
摘要： A method for preparing a Bowman-Birk inhibitor (BBI) product from soybeans is provided. The product produced in accordance with the method of the invention and compositions including the product are also provided. BBI product produced in accordance with the invention is a significantly improved inhibiter of malignant cell transformation and methods for its administration to prevent or inhibit progression of cancer are provided.
摘要翻译：提供了一种从大豆制备Bowman-Birk抑制剂（BBI）产品的方法。还提供了根据本发明方法生产的产品和包括该产品的组合物。根据本发明生产的BBI产品是恶性细胞转化的显着改善的抑制剂，并且提供了其用于预防或抑制癌症进展的施用方法。

36. 发明申请

US20040142050A1 Use of Bowman Birk Inhibitor for the treatment of multiple sclerosis and other autoimmune diseases 有权
标题翻译：使用Bowman Birk抑制剂治疗多发性硬化症和其他自身免疫性疾病
公开(公告)号：US20040142050A1
公开(公告)日：2004-07-22
申请号：US10743250
申请日：2003-12-22
发明人： Abdolmohamad Rostami , Ann R. Kennedy
IPC分类号： A61K035/78
CPC分类号： A61K38/56 , Y10S514/825 , Y10S514/885 , Y10S514/903
摘要： The present invention provides a non-toxic therapy and a novel use for Bowman Birk Inhibitor (BBI), as administered in Bowman Birk Inhibitor Concentrate (BBIC), for the treatment of autoimmune diseases in a patient, wherein the disease is characterized by chronic inflammation, such as rheumatoid arthritis; and more particularly for the treatment of those diseases that are characterized by chronic neuroinflammation and/or demyelination, such as Multiple Sclerosis (MS) and Guillain Barre Syndrome (GBS). In addition, the present invention provides methods for using BBI/BBIC to reduce, inhibit, suppress or prevent the chronic inflammation in such patients; and more particularly, to reduce, inhibit, suppress or prevent the chronic neuroinflammation and demyelination that occurs when the patient's nerve tissues is affected by the disease.
摘要翻译：本发明提供了在Bowman Birk抑制剂浓缩物（BBIC）中给予的Bowman Birk抑制剂（BBI）的无毒疗法和新用途，用于治疗患者的自身免疫疾病，其中该疾病的特征在于慢性炎症，如类风湿关节炎; 特别是用于治疗以慢性神经炎症和/或脱髓鞘为特征的疾病，例如多发性硬化（MS）和格林巴利综合征（GBS）。此外，本发明提供了使用BBI / BBIC减少，抑制，抑制或预防这些患者的慢性炎症的方法。更具体地，减少，抑制，抑制或预防当患者的神经组织受到疾病影响时发生的慢性神经炎症和脱髓鞘。

37. 发明申请

US20030185897A1 COMPOSITION COMPRISING ZOANTHUS SP. EXTRACT WITH ANTI-FOULING ACTIVITY AND A METHOD THEREOF 失效
标题翻译：包含ZOANTHUS SP的组合物提取具有抗真菌活性及其方法
公开(公告)号：US20030185897A1
公开(公告)日：2003-10-02
申请号：US10108760
申请日：2002-03-27
申请人： Council of Scientific and Industrial Research
发明人： Cynthia Olimpia Lydia Gonsalves , Chittur Thelakkat Achuthankutty , Perunninakulath Parameswaran Subrayan , Chandrakant Govind Naik
IPC分类号： A61K035/12
CPC分类号： A61K38/56
摘要： The present invention relates to a composition useful as an anti-fouling agent by inhibiting microbial growth, said composition comprising extract and/or its fractions from Zoanthus sp. and optionally de-odorizing agents and a method of producing said extract and its fractions having about 100% anti-bacterial activity fouling microbes.
摘要翻译：本发明涉及通过抑制微生物生长用作防污剂的组合物，所述组合物包含来自Zoanthus sp。的提取物和/或其馏分。和任选的除臭剂以及产生所述提取物及其部分的方法，其具有约100％的抗细菌活性污染微生物。

38. 发明申请

US20030082168A1 Compositions and methods for facilitating weight loss 审中-公开
标题翻译：促进减肥的组合物和方法
公开(公告)号：US20030082168A1
公开(公告)日：2003-05-01
申请号：US10027827
申请日：2001-10-22
发明人： Inna Yegorova
IPC分类号： A61K038/47 , A61K031/198 , A61K031/202 , A61K035/78 , A61K031/045
CPC分类号： A61K38/56 , A61K31/045 , A61K31/198 , A61K31/202 , A61K36/42 , A61K36/82 , A61K38/47 , A61K2300/00
摘要： Compositions and methods for facilitating weight loss by inhibiting carbohydrate absorption, enhancing lipolysis, and modulating the metabolism of glucose in a human. The compositions comprise wheat alpha amylase, conjugated linoleic acid, Momordica charantia, lipotrophic vitamins and green tea.
摘要翻译：通过抑制碳水化合物吸收，增强脂肪分解和调节人体葡萄糖代谢来促进体重减轻的组合物和方法。组合物包含小麦α淀粉酶，共轭亚油酸，苦瓜属，脂肪营养维生素和绿茶。

39. 发明申请

US20030059403A1 Phaseolamin compositions and methods for using the same 有权
标题翻译： Phaseolamin组合物及其使用方法
公开(公告)号：US20030059403A1
公开(公告)日：2003-03-27
申请号：US10233643
申请日：2002-09-03
申请人： Pharmachem Laboratories, Inc.
发明人： Dilip Chokshi
IPC分类号： A61K045/00
CPC分类号： A61K35/747 , A21D2/02 , A21D2/266 , A21D2/267 , A21D2/368 , A21D13/06 , A21D13/80 , A23D7/0056 , A23L33/105 , A23L33/16 , A23L33/165 , A23L33/185 , A23L33/195 , A61K33/24 , A61K35/745 , A61K36/064 , A61K38/56 , A61K2300/00
摘要： The present invention is for compositions containing phaseolamin and a mineral, such as chromium or vanadium or both, where the mineral is bound by a glycoprotein matrix. The present invention is also directed to methods for controlling carbohydrate cravings, inducing weight loss, reducing insulin requirements in a diabetic, and inhibiting the absorption of dietary starch by administering a composition of the invention.
摘要翻译：本发明涉及含有相质烯烃和矿物质如铬或钒或两者的组合物，其中矿物被糖蛋白基质结合。本发明还涉及通过施用本发明的组合物来控制碳水化合物渴望，诱导体重减轻，减少糖尿病患者中的胰岛素需求以及抑制膳食淀粉的吸收的方法。

40. 发明授权

US5217717A Method of making soybean Bowman-Birk inhibitor concentrate and use of same as a human cancer preventative and therapy 失效
标题翻译：制备大豆Bowman-Birk抑制剂浓缩物的方法和使用它作为人类癌症预防和治疗
公开(公告)号：US5217717A
公开(公告)日：1993-06-08
申请号：US824719
申请日：1992-01-17
申请人： Ann R. Kennedy , Bernard F. Szuhaj
发明人： Ann R. Kennedy , Bernard F. Szuhaj
IPC分类号： A61K38/00 , A61K38/56 , C07K14/81
CPC分类号： A61K38/56 , C07K14/811
摘要： A method for preparing a Bowman-Birk inhibitor (BBI) from soybeans comprising diluting soybean solubles with water, separating purified soybean solubles from the soluble starting material, diluting the purified solubles with water and then ultrafiltrating to produce a crude BBI concentrate which is diluted with water and then spray dried to produce a BBI concentrate product is provided. In another embodiment of the invention, ultrafiltration is eliminated by starting with soy solubles and applying acetone treatment. BBI concentrate product produced in accordance with the invention is a significantly improved inhibiter of malignant cell transformation and methods for its administration to prevent or inhibit progression of cancer are provided.
摘要翻译：一种从大豆制备Bowman-Birk抑制剂（BBI）的方法，包括用水稀释大豆可溶物，从可溶性起始原料中分离纯化的大豆可溶物，然后用水稀释纯化的可溶物，然后超滤以产生粗制BBI浓缩物，水，然后喷雾干燥以制备BBI浓缩物产品。在本发明的另一个实施方案中，通过从大豆可溶物开始并施加丙酮处理来消除超滤。根据本发明生产的BBI浓缩物产品是恶性细胞转化的显着改善的抑制剂，并且提供其用于预防或抑制癌症进展的施用方法。

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