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31. 发明申请

US20100196944A1 METHOD OF BIOASSAYING YOKUKANSAN 有权
标题翻译：生活方式YOKUKANSAN
公开(公告)号：US20100196944A1
公开(公告)日：2010-08-05
申请号：US12668519
申请日：2008-06-27
申请人： Yasushi Ikarashi , Zenji Kawakami
发明人： Yasushi Ikarashi , Zenji Kawakami
IPC分类号： C12Q1/02
CPC分类号： G01N33/5058
摘要： To find out an in-vitro bioassay system capable of ensuring qualities of yokukansan to a higher degree, it is intended to provide a method of bioassaying yokukansan characterized by comprising adding a yokukansan-containing test sample to astroglial cells to be cultivated under the condition of thiamine deficiency, and then determining the pharmacological activity value of yokukansan based on the glutamic acid or neutral red intake level in the cultivated astroglial cells.
摘要翻译：为了找出能够更高程度地确保洋葱素质量的体外生物测定系统，其目的是提供一种生物测定yokukansan的方法，其特征在于包括将含有Yokukansan的测试样品添加到待培养的星形胶质细胞中，硫胺素缺乏症，然后根据培养的星形胶质细胞中的谷氨酸或中性红摄取水平确定洋葱素的药理活性值。

32. 发明申请

US20100062515A1 MICROBIAL CULTURE MEDIUM AND MICROBIAL CULTURE METHOD 有权
标题翻译：微生物培养基和微生物培养方法
公开(公告)号：US20100062515A1
公开(公告)日：2010-03-11
申请号：US12442773
申请日：2007-09-25
申请人： Hiroaki Yamamoto
发明人： Hiroaki Yamamoto
IPC分类号： C12N1/20
CPC分类号： C12Q1/045 , C12N1/20
摘要： There is provided a microbial culture medium and a microbial culture method for adequately growing a target bacterium contained in an antibacterial test sample.The microbial culture medium for growing a target bacterium contained in an antibacterial test sample is composed of a basal medium for microbial culture, and acid clay or activated clay contained in the basal medium. The microbial culture method for growing a target bacterium contained in an antibacterial test sample using a microbial culture medium includes adding acid clay or activated clay to a solution of the test sample. It is preferred that the acid clay or activated clay be combined with activated carbon.
摘要翻译：提供了用于充分生长抗菌试验样品中所含的靶细菌的微生物培养基和微生物培养方法。用于生长抗菌试验样品中的目标细菌的微生物培养基由微生物培养的基础培养基和包含在基础培养基中的酸性粘土或活性粘土组成。使用微生物培养基生长抗菌试验样品中所含的目标细菌的微生物培养方法包括向测试样品的溶液中加入酸性粘土或活性粘土。优选将酸性粘土或活性粘土与活性炭组合。

33. 发明申请

US20090053334A1 GHRELIN PRODUCTION PROMOTER 审中-公开
标题翻译： GHRELIN生产促销
公开(公告)号：US20090053334A1
公开(公告)日：2009-02-26
申请号：US12162864
申请日：2006-12-18
申请人： Masahiro Asaka , Hiroshi Takeda , Ryuuji Takasaki , Tomohisa Hattori
发明人： Masahiro Asaka , Hiroshi Takeda , Ryuuji Takasaki , Tomohisa Hattori
IPC分类号： A61K36/258 , A61P25/28 , A61P9/10 , A61P11/00
CPC分类号： A61K36/28 , A61K36/07 , A61K36/23 , A61K36/48 , A61K36/75 , A61K2300/00
摘要： The objectives are to find a substance or a composition capable of promoting the production of ghrelin with physiological activities such as growth hormone secretion effect, and to provide a pharmaceutical comprising it as the active ingredient. The pharmaceutical is a ghrelin production promoter comprising Rikkunshi-to as the active ingredient.
摘要翻译：其目的是找到能够促进生长激素分泌作用等生理活性促进生长素释放肽的物质或组合物，提供含有作为活性成分的药物。药物是含有Rikkunshi的生长素释放肽生产促进剂作为活性成分。

34. 发明授权

US07326427B2 Tablet composition containing Kampo medicinal extract and its manufacturing process 有权
标题翻译：包含汉方药用提取物的片剂组合物及其制造工艺
公开(公告)号：US07326427B2
公开(公告)日：2008-02-05
申请号：US10521016
申请日：2003-07-10
申请人： Kazuhiro Matsumoto , Hideyuki Maruyama , Yoshihiko Nagano , Masayuki Ishimaru
发明人： Kazuhiro Matsumoto , Hideyuki Maruyama , Yoshihiko Nagano , Masayuki Ishimaru
IPC分类号： A61K36/65 , A61K36/076 , A61K36/232 , A61K36/234 , A61K36/284
CPC分类号： A61K45/06 , A61K9/2009 , A61K9/2054 , A61K33/00 , A61K36/076 , A61K36/185 , A61K36/232 , A61K36/233 , A61K36/258 , A61K36/481 , A61K36/488 , A61K36/54 , A61K36/65 , A61K36/708 , A61K36/718 , A61K2300/00
摘要： A Kampo medicinal extract-containing tablet composition contains a Kampo medicinal extract powder, cellulose glycolate and sodium hydrogen carbonate. It preferably further contains silicic anhydride. A process to manufacture a Kampo medicinal extract-containing tablet composition by the step of adding silicic anhydride and water to a Kampo medicinal extract powder, stirring and granulating the mixture, and the step of mixing the granulated substance with cellulose glycolate and sodium hydrogen carbonate. The Kampo medicinal extract-containing tablet composition can be satisfactorily disintegrated and dissolved and a process for manufacturing the same, by formulating specific compounds to a Kampo medicinal extract powder.
摘要翻译：含有汉方药用提取物的片剂组合物含有汉方药用提取物粉末，乙醇酸纤维素和碳酸氢钠。优选还含有硅酸酐。通过向汉方药用提取物粉末中添加硅酸酐和水，搅拌和造粒混合物的步骤，以及将造粒物质与乙醇酸纤维素和碳酸氢钠混合的工序，制造含有含有药物提取物的组合物的方法。含有汉方药用提取物的片剂组合物可以令人满意地分解溶解，也可以通过向汉方药膏提取粉末配制特定的化合物来制造。

35. 发明授权

US5734014A Elafin derivative 失效
标题翻译：埃拉芬衍生物
公开(公告)号：US5734014A
公开(公告)日：1998-03-31
申请号：US379437
申请日：1995-03-27
申请人： Yoshiaki Ishima , Noriyuki Okawa , Masaya Yoshida , Sakae Amagaya , Akira Kaji
发明人： Yoshiaki Ishima , Noriyuki Okawa , Masaya Yoshida , Sakae Amagaya , Akira Kaji
IPC分类号： A61K38/00 , C07K14/47 , C07K14/81 , C12N1/19 , C12N1/21 , C12N15/09 , C12N15/15 , C12P21/02 , C07K7/00
CPC分类号： C07K14/811 , A61K38/00
摘要： Disclosed herein are elafin derivatives represented by an amino acid sequence of the following formula (I): ##STR1## wherein X represents leucine, isoleucine or valine, or represented by an amino acid sequence having homology to the first-mentioned amino acid sequence. The elafin derivatives of the present invention are stable to oxidation compared with natural elafin so that they can be advantageously used as drugs such as an elastase inhibitors.
摘要翻译： PCT No.PCT / JP93 / 01133 Sec。 371日期：1995年3月27日 102（e）日期1995年3月27日PCT提交1992年8月11日PCT公布。公开号WO94 / 04697 日本公报1994年3月3日公开是由下式（I）的氨基酸序列表示的埃拉芬衍生物：Ala-Gln-Glu-Pro-Val-Lys-Gly-Pro-Val-Ser-Thr-Lys-Pro- Gly-Ser-（I）Cys-Pro-Ile-Ile-Leu-Ile-Arg-Cys-Ala-X-Leu-Asn-Pro-Pro-Asn-Arg-Cys-Leu-Lys-Asp-Thr-Asp -Cys-Pro-Gly-Ile-Lys-Lys-Cys-Cys-Glu-Gly-Ser-Cys-Gly-Met-Ala-Cys-Phe-Val-Pro-Gln其中X表示亮氨酸，异亮氨酸或缬氨酸，或由与前述氨基酸序列具有同源性的氨基酸序列表示。本发明的elafin衍生物与天然的elafin相比是稳定的，因此可有利地用作药物如弹性蛋白酶抑制剂。

36. 发明授权

US5658265A Adaptor for connecting tubes to an animal 失效
标题翻译：用于将管连接到动物的适配器
公开(公告)号：US5658265A
公开(公告)日：1997-08-19
申请号：US490867
申请日：1995-06-15
申请人： Masahiro Hiruta
发明人： Masahiro Hiruta
IPC分类号： A61D7/00 , A61M39/10 , F16L39/06 , A61M25/00
CPC分类号： A61M39/1055 , F16L39/06 , A61D7/00 , A61M2039/1077
摘要： Coaxial infusion pipes are disposed in a fixed shaft body and the ends of the pipes pass into a rotary shaft body. The fixed shaft body and the rotary shaft body are rotatably joined by bearings. Packings are provided inside the rotary shaft body in correspondence with the pipes. Only lip portions of the packings are in sliding contact with the pipes. The sliding resistance between the infusion pipes and the packings as seal members is low, and the rotary shaft body can rotate extremely lightly and with high precision.
摘要翻译：同轴输液管设置在固定轴体中，管的端部进入旋转轴体。固定轴体和旋转轴体通过轴承可旋转地连接。填充物与管道相对应地设置在旋转轴体的内部。填料只有唇部与管道滑动接触。输液管与密封件之间的密封件的滑动阻力低，旋转体主体能够极其轻微，高精度地旋转。

37. 发明授权

US5521216A Chromone derivative, and aldose reductase inhibitor comprising said compound as active ingredient 失效
标题翻译：色酮衍生物和醛糖还原酶抑制剂，其包含所述化合物作为活性成分
公开(公告)号：US5521216A
公开(公告)日：1996-05-28
申请号：US182028
申请日：1994-05-12
申请人： Yasushi Igarashi , Takuji Yamaguchi , Kunio Hosaka
发明人： Yasushi Igarashi , Takuji Yamaguchi , Kunio Hosaka
IPC分类号： A61K31/35 , A61K31/352 , A61P3/08 , A61P3/10 , A61P13/02 , A61P15/00 , A61P27/02 , A61P27/12 , C07D311/54 , C07D311/16
CPC分类号： C07D311/54
摘要： The present invention relates to a chromone derivative of formula (1): ##STR1## (wherein R.sub.1 and R.sub.2 are the same or different and independently represent a hydrogen atom or a lower alkyl group) as well as a synthetic intermediate thereof and an aldose reductase inhibitor comprising said derivative as an active ingredient. The chromone derivatives of the present invention can be easily synthesized, and are useful as aldose reductase inhibitor with an excellent inhibitory action on aldose reductase.
摘要翻译： PCT No.PCT / JP93 / 00699 Sec。 371日期：1994年5月12日 102（e）日期1994年5月12日PCT提交1993年5月26日PCT公布。第WO93 / 24477号PCT公告本发明涉及式（1）的色酮衍生物：其中R1和R2相同或不同并且独立地表示氢原子或低级烷基）作为以及其合成中间体和包含所述衍生物作为活性成分的醛糖还原酶抑制剂。本发明的色酮衍生物可以容易地合成，可用作对醛糖还原酶具有优异抑制作用的醛糖还原酶抑制剂。

38. 发明授权

US5447719A .beta.-glucuronidase inhibitor 失效
标题翻译： β-葡萄糖醛酸苷酶抑制剂
公开(公告)号：US5447719A
公开(公告)日：1995-09-05
申请号：US30346
申请日：1993-03-25
申请人： Tetsuya Kamataki
发明人： Tetsuya Kamataki
IPC分类号： A61K31/47 , A61K31/70 , A61K36/00 , A61K36/53 , A61K36/538 , A61K36/539 , A61P1/00 , A61P35/00 , A61P43/00 , C07H17/00 , C07H17/07 , A61K35/78
CPC分类号： C07H17/00 , A61K31/70 , A61K36/538 , A61K36/539
摘要： A .beta.-glucuronidase inhibitor comprising at least one compound selected from the group consisting of baicalin, oroxylin A-7-O-glucuronide and luteolin-3'-glucuronide; an extract of scutellaria root (baikal skullcap; Scutellariae Radix) and/or schizonepeta spike (Japanese catnip; Schizonepelae Spica); or a Chinese and Japanese traditional prescription comprised of scutellaria root (baikal skullcap; Scutellariae Radix) and/or schizonepeta spike (Japanese catnip; Schizonepelae Spica) as a crude drug. The .beta.-glucuronidase inhibitor can relieve the adverse effect, especially diarrhea, caused in the administration of a compound represented by the following formula I ##STR1##
摘要翻译： PCT No.PCT / JP92 / 00988 Sec。 371日期1993年3月25日 102（e）1993年3月25日PCT提交1992年8月3日PCT公布。出版物WO93 / 02684 日本二月十八日，1993年。一种β-葡糖醛酸糖苷酶抑制剂，其包含至少一种选自黄芩苷，奥曲霉素A-7-O-葡糖苷酸和木犀草素-3'-葡糖苷酸的化合物; 黄芩提取物（白al cap;黄芩）和/或荆芥（Schizonepeta spike）（日本catnip; Schizonepelae Spica）; 或由中国和日本传统处方组成的黄芩根（贝加尔骷髅帽，黄芩）和/或荆芥（Schizonepeta spike）（日本猫鼬），作为生药。 β-葡萄糖醛酸苷酶抑制剂可以缓解由下式I表示的化合物给药引起的副作用，特别是腹泻

39. 发明授权

US5272172A Iridoid derivatives and the use thereof as a drug 失效
标题翻译：铱类衍生物及其作为药物的用途
公开(公告)号：US5272172A
公开(公告)日：1993-12-21
申请号：US859501
申请日：1992-08-06
申请人： Yuuichi Fujii , Ichiro Arai , Akira Hatta , Akemi Tatsugi , Hiroshi Mitsuhashi , Mieko Mitsuhashi , Hiroyuki Mitsuhashi , Tomoyuki Mitsuhashi , Masaharu Kigawa
发明人： Yuuichi Fujii , Ichiro Arai , Akira Hatta , Akemi Tatsugi , Hiroshi Mitsuhashi , Mieko Mitsuhashi , Hiroyuki Mitsuhashi , Tomoyuki Mitsuhashi , Masaharu Kigawa
IPC分类号： C07C31/20 , C07C31/27 , C07C33/12 , C07D303/14 , C07D311/94 , C07D313/00 , C07D321/12 , C07D407/12 , A61K31/335
CPC分类号： C07D407/12 , C07C31/20 , C07C31/272 , C07C33/12 , C07D303/14 , C07D311/94 , C07D313/00 , C07D321/12
摘要： Iridoid derivatives synthesized using genipin, which is an aglycon of geniposide, as the starting material are useful as an anti-hyperlipemia agent and as a cholagogue.

40. 发明授权

US5106859A Certain 1,3,4-thiadiazole derivatives and anti-ulcer agent comprising said derivatives as active ingredient 失效
标题翻译：某些1,3,4-噻二唑衍生物和包含作为活性成分的所述衍生物的抗真菌剂
公开(公告)号：US5106859A
公开(公告)日：1992-04-21
申请号：US613693
申请日：1990-07-30
申请人： Yoshihiro Hasegawa , Toshihiko Yanagisawa , Kunio Hosaka , Hiroshi Mitsuhashi
发明人： Yoshihiro Hasegawa , Toshihiko Yanagisawa , Kunio Hosaka , Hiroshi Mitsuhashi
IPC分类号： A61K31/44 , A61P1/04 , C07D417/14
CPC分类号： C07D417/14
摘要： A novel thiadiazole derivative represented by the following formula I: ##STR1## wherein when n is 0, m is 0, and when n is 1, m is 0 or 1, and the preparation of this derivative and the use of this derivative as an anti-ulcer agent.

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