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    • 32. 发明授权
    • Material inhibiting lipid peroxide-increase
    • 材料抑制脂质过氧化物增加
    • US6087345A
    • 2000-07-11
    • US234122
    • 1999-01-19
    • Atsutane OhtaMasako OtsukiToshio TakizawaTakashi Adachi
    • Atsutane OhtaMasako OtsukiToshio TakizawaTakashi Adachi
    • A23L29/244A01N43/78
    • A23L29/244
    • A material inhibiting lipid peroxide-increase containing fructooligosaccharides is described which can conveniently provide at a low cost a food or drink product which exerts an excellent effect of inhibiting an increase in lipid peroxides without largely changing the daily dietary contents. The intake of the material inhibiting lipid peroxide-increase of the present invention can provide an excellent means for preventing various diseases (cancer, arterial sclerosis, etc.) caused by the formation of lipid peroxides, retarding aging, etc. Moreover, use of the material inhibiting lipid peroxide-increase of the present invention makes it possible to conveniently provide foods and drinks having excellent effects of inhibiting an increase in lipid peroxides at a low cost.
    • 描述了抑制含有低聚果糖的脂质过氧化物增加的材料,其可以以低成本方便地提供在不大幅度地改变日常饮食含量的情况下发挥抑制脂质过氧化物增加的优异效果的食品或饮料产品。 抑制本发明的脂质过氧化物增加的材料的摄入可以提供用于预防由形成脂质过氧化物引起的各种疾病(癌症,动脉硬化症等),延缓衰老等的优异手段。此外,使用 本发明的抑制脂质过氧化物增加的材料能够以低成本方便地提供具有抑制脂质过氧化物增加的优异效果的食品和饮料。
    • 37. 发明授权
    • Process for the preparation of a 3-substituted thio-3-cephem compound
    • 3-取代的硫代-3-头孢烯化合物的制备方法
    • US5294705A
    • 1994-03-15
    • US853730
    • 1992-06-03
    • Yuichi YamamotoTsuneo OkonogiSeiji ShibaharaShigeharu Inoue
    • Yuichi YamamotoTsuneo OkonogiSeiji ShibaharaShigeharu Inoue
    • C07D501/00C07D501/04C07D501/59
    • C07D501/00Y02P20/55
    • An ester of 7-acylamido-3-acylthio-3- or -2-cephem-4-carboxylic acid represented by general formula (1) ##STR1## wherein R.sup.1 is an acyl group, R.sup.2 is a carboxyl-protecting group, R.sup.3 is a lower alkyl group, an aryl group or a substituted aryl group, or a mixture of two or more of said ester is used as the starting compound and is reacted wit a tertiary amine and also a secondary amine. Then the tertiary amine salt compound as formed as the reaction product is reacted with a compound of formula (4)R.sup.4 --X (4)wherein R.sup.4 is a lower alkyl group, a cycloalkyl group or a heterocyclic group or a heterocyclic group-substituted methyl group and X is a leaving group, whereby the desired ester of 7-acylamido-3-substituted thio-3-cephem-4-carboxylic acid of formula (5) ##STR2## can be produced preferentially, conveniently and efficiently.
    • PCT No.PCT / JP90 / 01599 Sec。 371日期:1992年6月3日 102(e)日期1992年6月3日PCT 1990年12月7日PCT PCT。 公开号WO91 / 09037 1991年6月27日,由通式(1)表示的7-酰基氨基-3-酰硫基-3-或2-头孢烯-4-羧酸酯(*化学结构*)(1)其中R1为 酰基,R2为羧基保护基,R3为低级烷基,芳基或取代芳基,或两种或多种所述酯的混合物用作起始化合物,并与叔胺 以及仲胺。 然后将作为反应产物形成的叔胺盐化合物与式(4)R4-X(4)的化合物反应,其中R4是低级烷基,环烷基或杂环基或杂环基取代的甲基 并且X是离去基团,由此可以优选地,方便地制备所需的式(5)的7-酰基酰胺基-3-取代的硫代-3-头孢烯-4-羧酸的酯(*化学结构*)(5) 并有效地。