专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明授权

US08554035B2 Production of optical pulses at a desired wavelength using soliton self-frequency shift in higher-order-mode fiber 有权
标题翻译：使用高次模光纤中的孤子自频移产生所需波长的光脉冲
公开(公告)号：US08554035B2
公开(公告)日：2013-10-08
申请号：US12446619
申请日：2007-10-26
申请人： Chris Xu , James Van Howe , Jennifer Lee
发明人： Chris Xu , James Van Howe , Jennifer Lee
IPC分类号： G02B6/00 , G02B6/26 , G02B6/42 , H01S3/30 , H01S3/10 , G02F1/35 , G02F2/02
CPC分类号： G02F1/3513 , G01N21/6408 , G01N21/6458 , G01N2021/653 , G01N2201/0696 , G02B6/02009 , G02B6/02214 , G02B6/03644 , G02B21/06 , G02B21/16 , G02F2203/17 , G02F2203/26 , G02F2203/54
摘要： The present invention relates to an apparatus for producing optical pulses of a desired wavelength. The apparatus includes an optical pulse source operable to generate input optical pulses at a first wavelength. The apparatus further includes a higher-order-mode (HOM) fiber module operable to receive the input optical pulses at the first wavelength, and thereafter to produce output optical pulses at the desired wavelength by soliton self-frequency shift (SSFS). The present invention also relates to a method of producing optical pulses having a desired wavelength. This method includes generating input optical pulses using an optical pulse source, where the input optical pulses have a first wavelength and a first spatial mode. The input optical pulses are delivered into an HOM fiber module to alter the wavelength of the input optical pulses from the first wavelength to a desired wavelength by soliton self-frequency shift (SSFS) within the HOM fiber module, thereby producing output optical pulses having the desired wavelength.
摘要翻译：本发明涉及一种用于产生所需波长的光脉冲的装置。该装置包括可用于产生第一波长的输入光脉冲的光脉冲源。该装置还包括可操作以接收第一波长的输入光脉冲的高阶模（HOM）光纤模块，之后通过孤子自频移（SSFS）产生所需波长的输出光脉冲。本发明还涉及一种产生具有期望波长的光脉冲的方法。该方法包括使用光脉冲源产生输入光脉冲，其中输入光脉冲具有第一波长和第一空间模式。输入光脉冲被传送到HOM光纤模块中，以通过HOM光纤模块内的孤子自频移（SSFS）将输入光脉冲的波长从第一波长改变到期望的波长，从而产生具有所需波长。

32. 发明授权

US08551554B2 Apple peel powder, methods of making, and uses thereof 有权
标题翻译：苹果皮粉，制作方法及其用途
公开(公告)号：US08551554B2
公开(公告)日：2013-10-08
申请号：US11018833
申请日：2004-12-20
申请人： Rui Hai Liu
发明人： Rui Hai Liu
IPC分类号： A23B7/00
CPC分类号： A23G3/48 , A23B7/02 , A23G9/42 , A23L19/01 , A23L19/07 , A23L33/105 , A23L33/11 , A23L33/15 , A61K36/73 , A61K45/06
摘要： The present invention relates to a method of making a powder from apple peel by providing an apple peel, subjecting the apple peel to a phytochemical preservation treatment, drying the treated apple peel, and grinding the dried, treated apple peel to a powder. A powder from apple peel having a phenolic content and a flavonoid content similar to fresh apple peel on a fresh weight basis, where the powder has a water activity of less than 0.30 is also disclosed. The present invention also relates to a method of treating cancer in a patient by administering a powder from apple peel to a patient under conditions effective to treat cancer. Also disclosed is a method of inhibiting proliferation of cancer cells by contacting cancer cells with a powder from apple peel under conditions effective to inhibit proliferation of the cancer cells.
摘要翻译：本发明涉及一种通过提供苹果皮，通过苹果皮进行植物化学保存处理，干燥处理的苹果皮以及将经干燥处理的苹果皮研磨成粉末的苹果皮来制造粉末的方法。还公开了具有酚含量的苹果皮的粉末和类似于新鲜苹果皮的类黄酮含量，其中粉末的水分活度小于0.30。本发明还涉及通过在有效治疗癌症的条件下向患者施用苹果皮中的粉末来治疗患者的癌症的方法。还公开了通过在有效抑制癌细胞增殖的条件下将癌细胞与来自苹果皮的粉末接触来抑制癌细胞增殖的方法。

33. 发明授权

US08465732B2 Endothelial cells expressing adenovirus E4ORF1 and methods of use thereof 有权
标题翻译：表达腺病毒E4ORF1的内皮细胞及其使用方法
公开(公告)号：US08465732B2
公开(公告)日：2013-06-18
申请号：US12523372
申请日：2008-01-18
申请人： Shahin Rafii , Fan Zhang , Marco Seandel
发明人： Shahin Rafii , Fan Zhang , Marco Seandel
IPC分类号： A61K48/00 , C12N5/00 , C12N15/00
CPC分类号： C12N5/0606 , C07K14/005 , C12N5/0647 , C12N5/069 , C12N5/0693 , C12N15/1131 , C12N15/1136 , C12N2310/14 , C12N2501/998 , C12N2710/10322 , C12N2740/10043
摘要： The present invention relates to adenovirus E4ORF 1 gene and to endothelial cells engineered to express the E40RF 1 gene. The present invention also relates to uses of the E40RF 1 gene, and cells expressing the E40RF1 gene, and to compositions comprising the E4ORF 1 gene, or comprising cells expressing the E4ORF 1 gene.
摘要翻译：本发明涉及腺病毒E4ORF1基因和工程化表达E40RF1基因的内皮细胞。本发明还涉及E40RF1基因和表达E40RF1基因的细胞的用途，以及包含E4ORF1基因或包含表达E4ORF1基因的细胞的组合物。

34. 发明授权

US08338465B2 Cyclic carboxylic acid rhodanine derivatives for the treatment and prevention of tuberculosis 有权
标题翻译：环状羧酸罗丹明衍生物用于治疗和预防结核病
公开(公告)号：US08338465B2
公开(公告)日：2012-12-25
申请号：US12303896
申请日：2007-06-08
申请人： Jasbir Singh , Carl F. Nathan , Ruslana Bryk , Raghu Samy , Krzysztof Pupek , Mark Gurney
发明人： Jasbir Singh , Carl F. Nathan , Ruslana Bryk , Raghu Samy , Krzysztof Pupek , Mark Gurney
IPC分类号： A61K31/425 , C07D277/00
CPC分类号： C07D417/06
摘要： Disclosed are methods for the prevention or treatment of tuberculosis in a subject infected with Mycobacterium tuberculosis by administering rhodanine derivatives of formula (I), as well as some novel such compounds. Other embodiments are also disclosed.
摘要翻译：公开了通过施用式（I）的绕丹宁衍生物以及一些新的这种化合物来预防或治疗感染结核分枝杆菌的受试者的结核病的方法。还公开了其他实施例。

35. 发明授权

US08323794B2 Injectable hydrogel microspheres from aqueous two-phase system 有权
标题翻译：注射水凝胶微球从水相两相体系
公开(公告)号：US08323794B2
公开(公告)日：2012-12-04
申请号：US12855429
申请日：2010-08-12
申请人： Chih-Chang Chu , Xian-Zheng Zhang , Da-Qing Wu
发明人： Chih-Chang Chu , Xian-Zheng Zhang , Da-Qing Wu
IPC分类号： B32B5/16 , B32B9/00 , B32B15/02 , B32B17/02 , B01J13/02 , A61K9/127
CPC分类号： A61K9/0024 , A61K9/1641 , A61K9/1694 , Y10T428/2984 , Y10T428/2985
摘要： Injectable hydrogel microspheres are prepared by forming an emulsion where hydrogel precursors are in a disperse aqueous phase and polymerizing the hydrogel precursors. In a preferred case, the hydrogel precursors are poly(ethylene glycol) diacrylate and N-isopropylacrylamide and the continuous phase of the emulsion is an aqueous solution of dextran and a dextran solubility reducer. The microspheres will load protein, e.g., cytokines, from aqueous solution.
摘要翻译：可注射的水凝胶微球通过形成其中水凝胶前体处于分散水相中并使水凝胶前体聚合的乳液来制备。在优选的情况下，水凝胶前体是聚（乙二醇）二丙烯酸酯和N-异丙基丙烯酰胺，乳液的连续相是葡聚糖和葡聚糖溶解度降低剂的水溶液。微球体将从水溶液中加载蛋白质，例如细胞因子。

36. 发明申请

US20120270272A1 DETECTION OF NUCLEIC ACID SEQUENCE DIFFERENCES USING COUPLED LIGASE DETECTION AND POLYMERASE CHAIN REACTIONS 失效
公开(公告)号：US20120270272A1
公开(公告)日：2012-10-25
申请号：US13543365
申请日：2012-07-06
申请人： Francis BARANY , Matthew LUBIN , George BARANY , Robert P. HAMMER
发明人： Francis BARANY , Matthew LUBIN , George BARANY , Robert P. HAMMER
IPC分类号： C12P19/34
CPC分类号： C12Q1/6876 , C12Q1/6813 , C12Q1/6827 , C12Q1/683 , C12Q1/6851 , C12Q1/6853 , C12Q1/6858 , C12Q1/686 , C12Q1/6862 , C12Q1/6869 , C12Q1/6881 , C12Q2600/156 , C12Q2600/16 , C12Q2561/125 , C12Q2531/113 , C12Q2525/161 , C12Q2545/114 , C12Q2535/131 , C12Q2521/501 , C12Q2537/143 , C12Q2533/107 , C12Q2525/131 , C12Q2525/125 , C12Q2521/319 , C12Q2521/531 , C12Q2525/155
摘要： The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligation detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the amplified ligation product, and identifying the target nucleotide sequence. Such coupling of the ligase detection reaction and the polymerase chain reaction permits multiplex detection of nucleic acid sequence difference.

37. 发明申请

US20120270220A1 DETECTION OF NUCLEIC ACID SEQUENCE DIFFERENCES USING COUPLED LIGASE DETECTION AND POLYMERASE CHAIN REACTIONS 失效
标题翻译：使用联合寡核苷酸检测和聚合酶链反应检测核酸序列差异
公开(公告)号：US20120270220A1
公开(公告)日：2012-10-25
申请号：US13543432
申请日：2012-07-06
申请人： Francis BARANY , Matthew LUBIN , George BARANY , Robert P. HAMMER
发明人： Francis BARANY , Matthew LUBIN , George BARANY , Robert P. HAMMER
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6813 , C12Q1/6827 , C12Q1/683 , C12Q1/6851 , C12Q1/6853 , C12Q1/6858 , C12Q1/686 , C12Q1/6862 , C12Q1/6869 , C12Q1/6881 , C12Q2600/156 , C12Q2600/16 , C12Q2561/125 , C12Q2531/113 , C12Q2525/161 , C12Q2545/114 , C12Q2535/131 , C12Q2521/501 , C12Q2537/143 , C12Q2533/107 , C12Q2525/131 , C12Q2525/125 , C12Q2521/319 , C12Q2521/531 , C12Q2525/155
摘要： The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligation detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the amplified ligation product, and identifying the target nucleotide sequence. Such coupling of the ligase detection reaction and the polymerase chain reaction permits multiplex detection of nucleic acid sequence difference.
摘要翻译：本发明涉及鉴定靶核苷酸序列的方法。该方法包括在连接检测反应混合物中的靶核苷酸序列上形成连接产物，扩增连接产物以在聚合酶链式反应（PCR）混合物中形成扩增的连接产物，检测扩增的连接产物，并鉴定靶核苷酸序列。连接酶检测反应和聚合酶链式反应的这种偶联允许核酸序列差异的多重检测。

38. 发明授权

US08288521B2 Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays 有权
标题翻译：使用具有可寻址阵列的连接酶检测反应检测核酸序列差异
公开(公告)号：US08288521B2
公开(公告)日：2012-10-16
申请号：US13072442
申请日：2011-03-25
申请人： Francis Barany , George Barany , Robert P. Hammer , Maria Kempe , Herman Blok , Monib Zirvi
发明人： Francis Barany , George Barany , Robert P. Hammer , Maria Kempe , Herman Blok , Monib Zirvi
IPC分类号： C07H21/04 , C12N15/11
CPC分类号： C12Q1/6827 , B01J19/0046 , B01J2219/00432 , B01J2219/00527 , B01J2219/00529 , B01J2219/00536 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B01J2219/00729 , B82Y30/00 , C12Q1/6816 , C12Q1/6837 , C12Q1/6876 , C12Q2600/156 , C40B40/06 , C40B60/14 , Y02A50/58 , C12Q2565/501 , C12Q2561/125 , C12Q2537/143 , C12Q2565/514
摘要： The present invention describes a method for identifying one or more of a plurality of sequences differing by one or more single base changes, insertions, deletions, or translocations in a plurality of target nucleotide sequences. The method includes a ligation phase, a capture phase, and a detection phase. The ligation phase utilizes a ligation detection reaction between one oligonucleotide probe, which has a target sequence-specific portion and an addressable array-specific portion, and a second oligonucleotide probe, having a target sequence-specific portion and a detectable label. After the ligation phase, the capture phase is carried out by hybridizing the ligated oligonucleotide probes to a solid support with an array of immobilized capture oligonucleotides at least some of which are complementary to the addressable array-specific portion. Following completion of the capture phase, a detection phase is carried out to detect the labels of ligated oligonucleotide probes hybridized to the solid support.
摘要翻译：本发明描述了用于鉴定多个靶核苷酸序列中一个或多个单碱基变化，插入，缺失或易位不同的多个序列中的一个或多个的方法。该方法包括连接阶段，捕获阶段和检测阶段。连接阶段利用具有目标序列特异性部分的一个寡核苷酸探针与可寻址阵列特异性部分之间的连接检测反应和具有靶序列特异性部分和可检测标记的第二寡核苷酸探针。在连接阶段之后，捕获阶段通过将连接的寡核苷酸探针与具有固定化捕获寡核苷酸阵列的固体支持物杂交进行，其中至少一些与可寻址阵列特异性部分互补。捕获阶段完成后，进行检测阶段以检测与固体支持物杂交的连接的寡核苷酸探针的标记。

39. 发明申请

US20120252696A1 DETECTION OF NUCLEIC ACID SEQUENCE DIFFERENCES USING COUPLED LIGASE DETECTION AND POLYMERASE CHAIN REACTIONS 失效
公开(公告)号：US20120252696A1
公开(公告)日：2012-10-04
申请号：US13523252
申请日：2012-06-14
申请人： Francis BARANY , Matthew LUBIN , George BARANY , Robert P. HAMMER
发明人： Francis BARANY , Matthew LUBIN , George BARANY , Robert P. HAMMER
IPC分类号： C12Q1/68 , C40B30/04 , G01N27/26 , G01N21/64 , G01N27/72 , G01N21/76
CPC分类号： C12Q1/6876 , C12Q1/6813 , C12Q1/6827 , C12Q1/683 , C12Q1/6851 , C12Q1/6853 , C12Q1/6858 , C12Q1/686 , C12Q1/6862 , C12Q1/6869 , C12Q1/6881 , C12Q2600/156 , C12Q2600/16 , C12Q2561/125 , C12Q2531/113 , C12Q2525/161 , C12Q2545/114 , C12Q2535/131 , C12Q2521/501 , C12Q2537/143 , C12Q2533/107 , C12Q2525/131 , C12Q2525/125 , C12Q2521/319 , C12Q2521/531 , C12Q2525/155
摘要： The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligation detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the amplified ligation product, and identifying the target nucleotide sequence. Such coupling of the ligase detection reaction and the polymerase chain reaction permits multiplex detection of nucleic acid sequence difference.

40. 发明授权

US08206699B2 Myelination of congenitally dysmyelinated forebrains using oligodendrocyte progenitor cells 有权
标题翻译：使用少突胶质细胞祖细胞的先天性去神经系膜前纤的髓鞘形成
公开(公告)号：US08206699B2
公开(公告)日：2012-06-26
申请号：US12111839
申请日：2008-04-29
申请人： Steven A. Goldman , Neeta Singh Roy , Martha Windrem
发明人： Steven A. Goldman , Neeta Singh Roy , Martha Windrem
IPC分类号： A01N63/00 , A01N65/00
CPC分类号： C12N5/0623 , A61K35/12 , A61K35/30 , C12N5/0618 , C12N5/0619 , C12N5/0622 , C12N2510/00 , G01N33/5005 , G01N33/56966 , Y02A50/467
摘要： One form of the present invention is directed to a method of remyelinating demyelinated axons by treating the demyelinated axons with oligodendrocyte progenitor cells under conditions which permit remyelination of the axons. Another aspect of the present invention relates to a method of treating a subject having a condition mediated by a loss of myelin or a loss of oligodendrocytes by administering to the subject oligodendrocyte progenitor cells under conditions effective to treat the condition mediated by a loss of myelin or a loss of oligodendrocytes. A further aspect of the present invention relates to an in vitro method of identifying and separating oligodendrocyte progenitor cells from a mixed population containing other mammalian brain or spinal cord cell types. This further aspect of the present invention involves removing neurons and neuronal progenitor cells from the mixed population to produce a treated mixed population. Oligodendrocyte progenitor cells are then separated from the treated mixed population to form an enriched population of oligodendrocyte progenitor cells.
摘要翻译：本发明的一种形式涉及通过在允许轴突再髓鞘化的条件下用少突胶质祖细胞处理脱髓鞘化的轴突来再髓鞘化轴突再髓鞘的方法。本发明的另一方面涉及一种通过在有效治疗由髓磷脂损失介导的病症治疗的条件下向受试者少突胶质祖细胞施用治疗具有由髓磷脂损失或少突胶质细胞损失介导的病症的受试者的方法，或少突胶质细胞的丧失。本发明的另一方面涉及从含有其它哺乳动物脑或脊髓细胞类型的混合群体中鉴定和分离少突胶质祖细胞祖细胞的体外方法。本发明的另一方面涉及从混合群体中去除神经元和神经元祖细胞以产生经处理的混合群体。然后从处理的混合群体中分离少突胶质细胞祖细胞以形成少突胶质细胞祖细胞的富集群体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式