专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明授权

US07718430B2 Disposable tubing set for use with a cell expansion apparatus and method for sterile sampling 有权
标题翻译：用于细胞膨胀装置的一次性管组和无菌取样方法
公开(公告)号：US07718430B2
公开(公告)日：2010-05-18
申请号：US12021013
申请日：2008-01-28
申请人： Glen Delbert Antwiler
发明人： Glen Delbert Antwiler
IPC分类号： C12M1/12
CPC分类号： C12M23/42 , C12M23/28 , C12M23/48 , C12M29/04 , C12M33/00
摘要： A disposable apparatus for cell expansion, having at least one bioreactor. The bioreactor has a cellular growth area and a supply area, the cellular growth area being separated from said supply area by a membrane. A fluid recirculation path in fluid communication with the cellular growth area allows for hermetically removing a sample containing cellular matter. This may comprise an elongated tube, or a plurality of parallel tube segments. The parallel tube segments have inflow ends and outflow ends, and the inflow ends are joined at a first common juncture and the outflow ends are joined at a second common juncture. The common junctures may comprise valves.
摘要翻译：一种用于细胞膨胀的一次性装置，具有至少一个生物反应器。生物反应器具有细胞生长区域和供应区域，细胞生长区域通过膜与所述供应区域分离。与细胞生长区域流体连通的流体再循环路径允许气密地去除含有细胞物质的样品。这可以包括细长的管或多个平行的管段。平行管段具有流入端和流出端，并且流入端在第一共同接合点处接合，并且流出端在第二共同接合处连接。共同的接合点可以包括阀。

32. 发明申请

US20100105138A1 PREMOUNTED FLUID CONVEYANCE ASSEMBLY FOR CELL EXPANSION SYSTEM AND METHOD OF USE ASSOCIATED THEREWITH 有权
标题翻译：用于细胞扩增系统的预制流体输送装置及其使用方法
公开(公告)号：US20100105138A1
公开(公告)日：2010-04-29
申请号：US12606064
申请日：2009-10-26
申请人： Jon A. DODD , Thomas G. DILORENZO , Frank CORBIN
发明人： Jon A. DODD , Thomas G. DILORENZO , Frank CORBIN
IPC分类号： C12N5/02 , C12M1/00
CPC分类号： C12M23/48 , C12M23/42 , C12M25/10 , C12M25/12 , C12M29/00
摘要： A premounted fluid conveyance assembly for use with a cell expansion machine comprises a tubing-organizer and a fluid conveyance system. The fluid conveyance system is at least partially attached to the tubing-organizer, and the fluid conveyance system comprises an oxygenator or gas transfer module, a length of tubing and a bioreactor all fluidly interconnected. The premounted fluid conveyance assembly is adapted to be detachably-attached to the cell expansion machine. Accordingly, after a premounted fluid conveyance assembly is used, it is removed from the cell expansion machine by disengaging it from the cell expansion machine. Thereafter, another premounted fluid conveyance assembly can be attached in place of the previously used premounted fluid conveyance assembly.
摘要翻译：用于细胞膨胀机的预先安装的流体输送组件包括管组织器和流体输送系统。流体输送系统至少部分地附接到管道 - 组织器，并且流体输送系统包括充气器或气体传递模块，一段管道和生物反应器全部流体互连。预先安装的流体输送组件适于可拆卸地附接到电池膨胀机。因此，在使用预先安装的流体输送组件之后，通过使其从电池膨胀机脱离而从电池膨胀机移除。此后，可以安装另一个预先安装的流体输送组件来代替先前使用的预先安装的流体输送组件。

33. 发明申请

US20100078392A1 Blood Processing Apparatus with Incipient Spill-Over Detection 有权
标题翻译：血液处理装置与初期溢出检测
公开(公告)号：US20100078392A1
公开(公告)日：2010-04-01
申请号：US12241846
申请日：2008-09-30
申请人： William SWEAT
发明人： William SWEAT
IPC分类号： B01D21/32 , B01D21/26
CPC分类号： G01N15/042 , G01N15/05 , G01N2015/0073 , G01N2015/045
摘要： A density centrifuge blood processing system comprising a separation chamber rotating about a central rotation axis, the separation chamber being coupled to an elutriation chamber, a first detector for the separation chamber to detect light from an observation region, a computational apparatus distinguishing at least two regions in the observation region and distinguishing incipient spill over of cellular components out of the elutriation chamber as a function of light intensity received from the at least two regions in the separation chamber, and a controller regulating speed of at least one pump or of the separation chamber in response to signals from the computational apparatus to avoid spill over.
摘要翻译：一种密度离心机血液处理系统，包括围绕中心旋转轴线旋转的分离室，所述分离室联接到淘洗室，所述分离室的第一检测器用于检测来自观察区域的光，计算装置，区分至少两个区域在所述观察区域中，根据从所述分离室中的所述至少两个区域接收的光强度的函数，将所述淘洗室中的细胞成分的初期溢出区分开，并且控制器调节至少一个泵或所述分离室响应于来自计算设备的信号以避免溢出。

34. 发明授权

US07686279B2 Non-reopenable clamp for tubing sets 有权
标题翻译：管道套件不可开启的夹具
公开(公告)号：US07686279B2
公开(公告)日：2010-03-30
申请号：US11612625
申请日：2006-12-19
申请人： Karen Melissa Nerbonne , Jeffrey Lee Spray
发明人： Karen Melissa Nerbonne , Jeffrey Lee Spray
IPC分类号： F16K7/04
CPC分类号： A61M39/284 , Y10T24/3427
摘要： A non-reopenable, single-use clamp for receiving and pinching collapsible resilient tubing thus forming a mechanical tubing seal and having an open position for insertion of tubing, a neutral position for holding the tubing and a closed position for non-reopenably closing the tubing with a locking mechanism with locking hooks.
摘要翻译：一个不可重复打开的一次性夹具，用于接收和夹紧可折叠的弹性管，从而形成机械管道密封，并具有用于插入管道的打开位置，用于保持管道的中间位置和用于不可重复地封闭管道的闭合位置具有带锁钩的锁定机构。

35. 发明授权

US07682329B2 Methods and apparatus for leukoreduction of red blood cells 有权
标题翻译：红细胞白细胞减少的方法和装置
公开(公告)号：US07682329B2
公开(公告)日：2010-03-23
申请号：US11278884
申请日：2006-04-06
申请人： Bruce W. Gibbs , Jon Herskovits
发明人： Bruce W. Gibbs , Jon Herskovits
IPC分类号： A61M37/00
CPC分类号： A61M1/3633 , A61M1/0209 , A61M1/0218 , A61M1/0231 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2202/0439 , A61M2205/12 , A61M2205/123
摘要： A method and apparatus for red blood collection and filtration is provided wherein a red blood cell collection assembly provides for leukoreduction filtration concurrent with or soon after the red blood cell separation and collection procedure. Such procedures involve filtering the separated red blood cells in a diluted state after and/or prior to flushing the filter with storage solution. Storage solution may thus be passed through the leukoreduction filter before, with and/or after the RBCs have been filtered therethrough. The red blood cell collection, filtration and storage assembly is preferably preconnected to a blood component separation disposable assembly, including, for example, a centrifuge vessel and a blood removal/return assembly for removing blood from a donor, passing the blood to the centrifuge vessel for separation of the blood into components for collection and providing for filtration of the separated red blood cell component.
摘要翻译：提供了一种用于红血液收集和过滤的方法和装置，其中红细胞收集组件与红血细胞分离和收集程序同时或之后提供白细胞减少过滤。这种方法包括在用储存溶液冲洗过滤器之后和/或之前以稀释状态过滤分离的红细胞。因此，在RBC已经过滤之前，之后和/或之后，储存溶液可以通过白细胞减少滤过器。红细胞收集，过滤和储存组件优选地预先连接到血液成分分离一次性组件，包括例如离心机容器和用于从供体去除血液的除血/返回组件，使血液通过离心机容器用于将血液分离成用于收集的组分并提供用于分离的红细胞组分的过滤。

36. 发明申请

US20090166298A1 Methods And Apparatus For Controlled Addition Of Solutions To Blood Components 有权
标题翻译：用于控制添加血液成分溶液的方法和装置
公开(公告)号：US20090166298A1
公开(公告)日：2009-07-02
申请号：US12234960
申请日：2008-09-22
申请人： Logan FENDER
发明人： Logan FENDER
IPC分类号： A61K35/14 , B01D21/26 , B01D21/34
CPC分类号： A61M1/3693 , A61M1/0209 , A61M1/0231 , A61M1/30 , A61M1/303 , A61M1/3696 , A61M1/38 , A61M2205/123
摘要： A centrifugal blood processing apparatus comprising a centrifuge rotor, a separation chamber, a tubing set for conducting blood components and fluids and having an inlet line, an outlet line and a storage solution line in fluid communication with the outlet line at a junction. The apparatus controls pumps to conduct a predetermined quantity of storage solution to a collected blood component. The apparatus also purges blood components in the tubing set by applying a negative pressure and positive pressure. A disposable blood processing set has a separation chamber; a tubing set including an inlet line in fluid and an outlet and a storage solution line connected to the outlet line at a junction.
摘要翻译：一种离心式血液处理设备，包括离心机转子，分离室，用于传导血液成分和流体的管道组件，并具有在连接处与出口管线流体连通的入口管线，出口管线和储存溶液管线。该装置控制泵以对收集的血液成分进行预定量的储存溶液。该装置还通过施加负压和正压来清洗管组中的血液成分。一次性血液处理装置具有分离室; 管路组件包括流体中的入口管线和出口以及在连接处连接到出口管线的储存溶液管线。

37. 发明申请

US20090043237A1 METHODS AND DEVICES FOR PROCESSING BLOOD 有权
标题翻译：用于处理血液的方法和装置
公开(公告)号：US20090043237A1
公开(公告)日：2009-02-12
申请号：US12187988
申请日：2008-08-07
申请人： Robert W. Langley , Thomas J. Felt , Geert Van Waeg , Marlene Adele Bainbridge
发明人： Robert W. Langley , Thomas J. Felt , Geert Van Waeg , Marlene Adele Bainbridge
IPC分类号： A61M1/14
CPC分类号： A61M1/3693 , A61M1/304 , A61M1/3639 , A61M1/3656 , A61M1/3696
摘要： Methods, devices and device components are presented for blood processing. Particularly, methods, devices and device components are presented for separating blood into blood components and collecting one or more separated blood components, which reduce the incidence of blood vessel infiltration and enhance donor comfort. In one aspect, the invention provides blood processing methods having a return flow rate which decreases systematically during a return time. In another aspect, the invention provides blood processing methods having a removal flow rate, return flow rate or both which are derived from a subject's total blood volume. In another aspect, the present invention provides blood processing methods wherein the fraction by volume of removed blood corresponding to collected components is selected to optimize blood processing efficiency and enhance the purities of collected blood components.
摘要翻译：提出了用于血液处理的方法，装置和装置部件。特别地，提出了用于将血液分离成血液成分并收集一种或多种分离的血液成分的方法，装置和装置部件，其减少血管浸润的发生率并增强供体的舒适度。一方面，本发明提供了具有在返回时间内系统地减少的返回流速的血液处理方法。另一方面，本发明提供了血液处理方法，其具有从受检者的总血液体积得到的去除流速，回流流量或两者。另一方面，本发明提供了血液处理方法，其中选择相应于所收集的组分的去除血液的体积份数以优化血液处理效率并增强收集的血液成分的纯度。

38. 发明授权

US07422693B2 Monitoring and control system for blood processing 有权
标题翻译：血液处理监控系统
公开(公告)号：US07422693B2
公开(公告)日：2008-09-09
申请号：US10884877
申请日：2004-07-01
申请人： Lee F. Carter , Jeremy P. Kolenbrander , James R. Ladtkow , Joseph A. Scibona , Jeffrey A. Steward , Chris Fletcher
发明人： Lee F. Carter , Jeremy P. Kolenbrander , James R. Ladtkow , Joseph A. Scibona , Jeffrey A. Steward , Chris Fletcher
IPC分类号： B04B9/10
CPC分类号： G01N15/042 , A61M1/3693 , B04B13/00 , B04B2013/006 , G01N15/05 , G01N2015/047
摘要： The invention relates generally to methods of monitoring and controlling the processing of blood and blood samples, particularly the separation of blood and blood samples into its components. In one aspect, the invention relates to optical methods, devices and device components for measuring two-dimensional distributions of transmitted light intensities, scattered light intensities or both from a separation chamber of a density centrifuge. In embodiment, two-dimensional distributions of transmitted light intensities, scattered light intensities or both measured by the methods of the present invention comprise images of a separation chamber or component thereof, such as an optical cell of a separation chamber. In another aspect, the present invention relates to multifunctional monitoring and control systems for blood processing, particularly blood processing via density centrifugation. Feedback control systems are provided wherein two-dimensional distributions of transmitted light intensities, scattered light intensities or both are measured, processed in real time and are used as the basis of output signals for controlling blood processing. In another aspect, optical cells and methods of using optical cells for monitoring and control blood processing are provided.
摘要翻译：本发明一般涉及监测和控制血液和血液样品的处理，特别是将血液和血液样品分离成其组分的方法。一方面，本发明涉及用于测量来自密度离心机的分离室的透射光强度，散射光强度或二者的二维分布的光学方法，装置和装置部件。在实施例中，通过本发明的方法测量的透射光强度，散射光强度或二者的二维分布包括分离室或其分量（诸如分离室的光学单元）的图像。另一方面，本发明涉及用于血液处理的多功能监测和控制系统，特别是通过密度离心进行血液处理。提供反馈控制系统，其中测量透射光强度，散射光强度或二者的二维分布，实时处理，并用作控制血液处理的输出信号的基础。在另一方面，提供了光学单元和使用光学单元来监测和控制血液处理的方法。

39. 发明申请

US20120089930A1 Customizable Methods and Systems of Growing and Harvesting Cells in a Hollow Fiber Bioreactor System 有权
标题翻译：可定制的中空纤维生物反应器系统中生长和收获细胞的方法和系统
公开(公告)号：US20120089930A1
公开(公告)日：2012-04-12
申请号：US13269351
申请日：2011-10-07
申请人： Edward Allan STANTON, IV , Glen Delbert ANTWILER , Patrick J. HOWLEY , Michael E. KINZIE , Jon A. DODD , Casey V. Medina
发明人： Edward Allan STANTON, IV , Glen Delbert ANTWILER , Patrick J. HOWLEY , Michael E. KINZIE , Jon A. DODD , Casey V. Medina
IPC分类号： G06F3/048
CPC分类号： C12M41/44 , C12M23/42 , C12M23/44 , C12M25/10 , C12M25/12 , C12M29/16 , C12M29/20 , C12M41/48 , G06F8/38
摘要： Embodiments described herein generally relate to methods and systems for customizing protocols for use with a cell expansion system. Through a user interface, a user may create a custom task for loading, growing and/or harvesting cells. A custom task may comprise one or more steps, in which a user may add or omit steps, as desired. Data may be entered for settings associated with a custom task, in which embodiments provide for such data to be entered each time the custom task is performed. In another embodiment, the settings for a custom task may be configured, in which such settings may be stored and retrieved upon selection of the custom task. Customization and configuration of a custom task may occur using a diagram view of the cell expansion system, in which process settings are associated with graphical user interface elements.
摘要翻译：本文描述的实施例通常涉及用于定制用于细胞扩增系统的协议的方法和系统。通过用户界面，用户可以创建用于加载，增长和/或收获单元的自定义任务。自定义任务可以包括一个或多个步骤，其中用户可以根据需要添加或省略步骤。可以为与自定义任务相关联的设置输入数据，其中实施例提供在每次执行自定义任务时输入这样的数据。在另一个实施例中，可以配置自定义任务的设置，其中可以在选择自定义任务时存储和检索这样的设置。自定义任务的定制和配置可以使用单元扩展系统的图视图进行，其中过程设置与图形用户界面元素相关联。

40. 发明申请

US20110312481A1 Multi-Unit Blood Processor With Isolated Valves for Radio Frequency Sealing 有权
标题翻译：用于射频密封的隔离阀多单位血液处理器
公开(公告)号：US20110312481A1
公开(公告)日：2011-12-22
申请号：US13110548
申请日：2011-05-18
申请人： Hong Duc NGUYEN , Bruce ELLINGBOE , Darryl Hudock
发明人： Hong Duc NGUYEN , Bruce ELLINGBOE , Darryl Hudock
IPC分类号： B04B9/14 , B65D30/00
CPC分类号： B04B5/0428 , A61M1/0209 , A61M1/0218 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M1/3698 , B04B13/00
摘要： An apparatus for separating at least two discrete volumes of a composite liquid into components, comprising a valve design that facilitates loading and unloading of sets of blood bags. The valves comprise a jaw mounted on a shaft, the jaw being adapted to apply radio frequency energy to seal a tube, a stepper motor section, and at least two position sensors. The valve sections are mounted on an upper plate, and the stepper motor sections are mounted on a lower plate. A main radio frequency coil is selectively electrically coupled to each of the valves through a multiplexing switch.
摘要翻译：一种用于将至少两个离散体积的复合液体分离成部件的装置，包括便于装载和卸载血袋组的阀设计。阀包括安装在轴上的钳口，钳口适于施加射频能量以密封管，步进电机部分和至少两个位置传感器。阀部安装在上板上，步进马达部分安装在下板上。主要的射频线圈通过复用开关选择性地电耦合到每个阀。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式