会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 31. 发明授权
    • Method of and composite for in situ fluorescent hybridization
    • 原位荧光杂交法及复合方法
    • US6043039A
    • 2000-03-28
    • US122661
    • 1998-07-27
    • Irit Bar-AmCathy JanishYuval GariniDario CabibRobert A. Buckwald
    • Irit Bar-AmCathy JanishYuval GariniDario CabibRobert A. Buckwald
    • G01N33/53C12N15/09C12Q1/68G01N33/533G01N33/566
    • C12Q1/6841
    • A fluorescent in situ hybridization method including the steps of (a) obtaining a chromosome spread of a species; (b) preparing a hybridization composite containing a plurality of chromosomal paints each of the plurality of chromosomal paints being labeled with a different fluorophore-or-combination-of-fluorophores, such that an averaged specific activity of highly repetitive sequences in the hybridization composite substantially equals an averaged specific activity of unique sequences in the hybridization composite; (c) denaturing the hybridization composite and subjecting the hybridization composite to conditions for allowing at least a part of the highly repetitive sequences in the hybridization composite to reanneal while at least a part of the unique sequences in the hybridization composite remaining single stranded; (d) contacting under hybridization conditions the hybridization composite with the chromosome spread; (e) washing away excess of the hybridization composite; and (d) analyzing and presenting images of the now hybridized chromosome spread.
    • 一种荧光原位杂交方法,包括以下步骤:(a)获得物种的染色体扩散; (b)制备含有多个染色体涂料的杂化复合物,所述多个染色体涂料中的每一个用不同的荧光团或荧光团组合进行标记,使得所述杂交复合物中高度重复序列的平均比活性基本上 等于杂交复合物中独特序列的平均比活性; (c)使杂交复合物变性并对杂交复合物进行条件以允许杂交复合物中的至少一部分高度重复序列进行再冷凝,同时杂交复合物中至少一部分独特序列保持单链; (d)在杂交条件下使杂交复合物与染色体扩散接触; (e)洗去杂交组合物的过量; 和(d)分析和呈现现在杂交的染色体扩增的图像。
    • 33. 发明授权
    • Spectral bio-imaging methods for biological research, medical
diagnostics and therapy
    • 用于生物研究,医学诊断和治疗的光谱生物成像方法
    • US5784162A
    • 1998-07-21
    • US571047
    • 1995-12-12
    • Dario CabibRobert A. BuckwaldZvi MalikYuval GariniNir KatzirDirk G. Soeknsen
    • Dario CabibRobert A. BuckwaldZvi MalikYuval GariniNir KatzirDirk G. Soeknsen
    • G01B11/00A61B3/00A61B3/12A61B5/00A61B10/00C12Q1/68G01J3/02G01J3/12G01J3/26G01J3/28G01J3/44G01J3/443G01J3/45G01J3/453G01N21/27G01N21/64G01N33/48G01N33/483G01N33/50G01N33/569G01N33/58G02B21/36G06K9/00G06K9/76G01B9/02
    • G01N21/6458C12Q1/6841C12Q1/6883G01J3/12G01J3/1256G01J3/26G01J3/2823G01J3/4406G01J3/453G01N21/6428G01N21/6486G01N33/5005G01N33/56966G01N33/582G06K9/00127G06K9/76G01J2003/2866G01J3/02G01N2021/6417G01N2021/6423
    • According to the present invention there are provided spectral imaging methods for biological research, medical diagnostics and therapy comprising the steps of (a) preparing a sample to be spectrally imaged; (b) viewing the sample through an optical device, the optical device being optically connected to an imaging spectrometer, the optical device and the imaging spectrometer obtaining a spectrum of each pixel of the sample by: (i) collecting incident light simultaneously from all pixels of the sample using collimating optics; (ii) passing the incident collimated light through an interferometer system having a number of elements, to form an exiting light beam; (iii) passing the exiting light beam through a focusing optical system which focuses the exiting light beam on a detector having a two-dimensional array of detector elements, so that at each instant each of the detector elements is the image of one pixel of the sample, so that the real image of the sample is stationary on the plane of the detector array, and so that each of the detector elements produces a signal which is a particular linear combination of light intensity emitted by the pixel at different wavelengths, wherein the linear combination is a function of the instantaneous optical path difference; (iv) rotating one or more of the elements of the interferometer system, so that the optical path difference between the two coherent beams generated by the interferometer system is scanned simultaneously for all the pixels of the sample; and (v) recording signals of each of the detector elements as function of time using a recording device to form a first spectral cube of data; and (c) interpreting the first spectral cube of data using a mathematical algorithm.
    • 根据本发明,提供了用于生物学研究,医学诊断和治疗的光谱成像方法,其包括以下步骤:(a)制备待成像的样品; (b)通过光学装置观察样品,光学装置光学连接到成像光谱仪,光学装置和成像光谱仪通过以下步骤获得样品的每个像素的光谱:(i)从所有像素同时收集入射光 的样品使用准直光学; (ii)使入射的准直光通过具有多个元件的干涉仪系统,以形成出射的光束; (iii)使出射的光束通过聚焦光学系统,该聚焦光学系统将出射的光束聚焦在具有检测器元件的二维阵列的检测器上,使得在每个瞬间,每个检测器元件是 样本,使得样本的真实图像在检测器阵列的平面上是静止的,并且使得每个检测器元件产生信号,其是由不同波长的像素发射的光强度的特定线性组合,其中 线性组合是瞬时光程差的函数; (iv)旋转干涉仪系统的一个或多个元件,使得由干涉仪系统产生的两个相干光束之间的光程差同时扫描样品的所有像素; 以及(v)使用记录装置记录每个检测器元件的信号作为时间的函数,以形成数据的第一光谱立方体; 和(c)使用数学算法解释数据的第一个频谱立方体。