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31. 发明申请

US20120220688A1 Phosphine-Containing Hydrogel Contact Lenses 有权
标题翻译：含磷的水凝胶隐形眼镜
公开(公告)号：US20120220688A1
公开(公告)日：2012-08-30
申请号：US13404028
申请日：2012-02-24
申请人： Guigui Wang , Yun Zhang , Yuwen Liu , Ye Hong , Charlie Chen , Peter Zhu
发明人： Guigui Wang , Yun Zhang , Yuwen Liu , Ye Hong , Charlie Chen , Peter Zhu
IPC分类号： G02B1/04 , G02C7/04 , B65D85/00
CPC分类号： G02B1/043 , A45C11/005 , B65D81/22 , C08L83/04
摘要： Hydrogel contact lenses that are derived from a polymerizable composition including at least one hydrophilic monomer and at least one phosphine-containing component are described. The hydrogel of the contact lenses can be a silicone hydrogel or a non-silicone hydrogel. Use of polymerizable compositions comprising a phosphine-containing component can be cured under both inert and air atmospheres, and can be used to form hydrogel contact lenses having improved shape retention properties, having improved resistance to discoloration. Batches of hydrogel contact lenses and methods of making hydrogel contact lenses are also described.
摘要翻译：描述了衍生自包含至少一种亲水性单体和至少一种含膦组分的可聚合组合物的水凝胶隐形眼镜。隐形眼镜的水凝胶可以是硅酮水凝胶或非硅氧水凝胶。包含含膦组分的可聚合组合物的使用可以在惰性和空气气氛下固化，并且可用于形成具有改善的变色保持性能的具有改进的抗变色性的水凝胶隐形眼镜。还描述了水凝胶隐形眼镜的批次和制备水凝胶隐形眼镜的方法。

32. 发明授权

US08410190B2 Wettable hydrogel materials for use in ophthalmic applications and methods 有权
标题翻译：用于眼科应用和方法的可湿性水凝胶材料
公开(公告)号：US08410190B2
公开(公告)日：2013-04-02
申请号：US13146414
申请日：2010-09-21
申请人： Peter Zhu , Ying Ye , Yun Zhang , Charlie Chen
发明人： Peter Zhu , Ying Ye , Yun Zhang , Charlie Chen
IPC分类号： G02B1/04
CPC分类号： C08J7/16
摘要： A contact lens is provided that has extended and rechargeable wettability. The contact lens includes a lens body that is a reaction product of a polymerizable composition. A first polyhydric alcohol having a 1,2 diol or 1,3 diol moiety is present on a lens surface of the lens body. A contact lens package including the contact lens, and methods of producing and using the contact lens, are also provided.
摘要翻译：提供了一种具有延长和充分润湿性的隐形眼镜。隐形眼镜包括作为可聚合组合物的反应产物的透镜体。具有1,2-二醇或1,3-二醇部分的第一多元醇存在于透镜体的透镜表面上。还提供了包括隐形眼镜的隐形眼镜包，以及制造和使用隐形眼镜的方法。

33. 发明申请

US20130031873A1 Wettable Silicone Hydrogel Contact Lenses And Related Compositions And Methods 有权
标题翻译：可湿性硅胶水凝胶隐形眼镜及相关成分及方法
公开(公告)号：US20130031873A1
公开(公告)日：2013-02-07
申请号：US13539887
申请日：2012-07-02
申请人： Ye Hong , Charlie Chen , Nick Manesis
发明人： Ye Hong , Charlie Chen , Nick Manesis
IPC分类号： C08L39/06 , B65B63/00
CPC分类号： G02C7/049 , B29D11/00038 , B29D11/00067 , B29D11/0025 , B29K2039/06 , B29K2077/00 , B29K2083/00 , B29K2105/0061 , G02B1/043 , C08L83/04 , C08L51/085
摘要： Silicone hydrogel contact lenses having ophthalmically acceptable surface wettabilities are obtained from pre-extracted polymerized silicone hydrogel contact lens products having relatively large amounts of removable or extractable materials. The silicone hydrogel contact lenses can be obtained from non-polar resin based contact lens molds and without surface treatments or an interpenetrating polymeric network of a polymeric wetting agent. Related lens products, polymerizable compositions, and methods are also described.
摘要翻译：具有眼科可接受的表面润湿性的硅酮水凝胶隐形眼镜由具有相对大量的可移除或可萃取材料的预提取聚合的硅氧水凝胶隐形眼镜产品获得。硅酮水凝胶隐形眼镜可以从非极性树脂基隐形眼镜模具获得，而不用表面处理或聚合润湿剂的互穿聚合物网络获得。还描述了相关的透镜产品，可聚合组合物和方法。

34. 发明申请

US20070253953A1 Molecular Signature of the Pten Tumor Suppressor 审中-公开
标题翻译： Pten肿瘤抑制因子的分子标记
公开(公告)号：US20070253953A1
公开(公告)日：2007-11-01
申请号：US10582841
申请日：2004-12-15
申请人： Charlie Chen , Charles Sawyers
发明人： Charlie Chen , Charles Sawyers
IPC分类号： A61K39/395 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136
摘要： The present invention relates to the identification a molecular signature for PTEN tumor suppressor. The molecular signature comprising a gene or genes that are of use for diagnosis, prognosis, drug research and development and therapeutics. Specifically, the present invention relates to identification of IGFBP2 gene, its mRNA and/or protein products that closely associate with PTEN mutations. The present invention further demonstrates that IGFBP2 expression is negatively regulated by PTEN, positively regulated by PI3K and Akt activation, that IGFBP2 plays a functional role in the PTEN signaling and is required for Akt transformation. The use of IGFBP2 gene, its gene product such as its RNA transcript, protein and molecular probes in diagnosis, prognosis, drug discovery and validation and therapeutic target and therapeutics is also contemplated.
摘要翻译：本发明涉及鉴定PTEN肿瘤抑制因子的分子特征。该分子标记包括用于诊断，预后，药物研究和开发以及治疗用途的基因或基因。具体地说，本发明涉及与PTEN突变密切相关的IGFBP2基因，其mRNA和/或蛋白质产物的鉴定。本发明进一步证明IGFBP2表达受PTEN负调节，由PI3K和Akt活化正调节，IGFBP2在PTEN信号中起着功能作用，是Akt转化所必需的。还考虑使用IGFBP2基因，其基因产物如其RNA转录物，蛋白质和分子探针在诊断，预后，药物发现和验证以及治疗靶标和治疗剂中。

35. 发明申请

US20060152893A1 Portable information device having a lift function 审中-公开
标题翻译：具有升降功能的便携式信息装置
公开(公告)号：US20060152893A1
公开(公告)日：2006-07-13
申请号：US11033635
申请日：2005-01-13
申请人： Charlie Chen
发明人： Charlie Chen
IPC分类号： G06F1/16
CPC分类号： G06F1/1681 , G06F1/1616
摘要： A portable information device, such as a personal digital assistant or a notebook, having a lift function, has a mainframe, a monitor, a pivotal structure, and a guiding rod. The guiding rod has an end connected to the pivotal structure. The monitor is liftably connected to the other end of the guiding rod. The monitor can be lifted and adjusted to an appropriate height, so that the user can watch the monitor comfortably.
摘要翻译：具有升降功能的便携式信息装置，例如个人数字助理或笔记本，具有主机，监视器，枢轴结构和引导杆。引导杆的端部连接到枢转结构。显示器可升降地连接到导杆的另一端。显示器可以提升并调整到适当的高度，以便用户可以舒适地观看显示器。

36. 发明申请

US20060117606A1 Shoe having a protective wrap 审中-公开
标题翻译：鞋子有保护膜
公开(公告)号：US20060117606A1
公开(公告)日：2006-06-08
申请号：US11003300
申请日：2004-12-03
申请人： Eddie Chen , Charlie Chen , Paul Yang
发明人： Eddie Chen , Charlie Chen , Paul Yang
IPC分类号： A43C11/00 , A43B7/22
CPC分类号： A43B7/223 , A43B7/1495 , A43B19/00 , A43B23/07 , A43C1/04 , A43C11/00
摘要： A shoe includes a protective wrap disposed inside an upper and includes a sole portion disposed removably on a sole unit, and two side portions extending upwardly and respectively from two sides of the sole portion and connected to a fastening unit. When the fastening unit is tightened, the fastening unit pulls the side portions, and the side portions lift the sole portion so that the protective wrap is wrapped tightly around the foot of the wearer.
摘要翻译：靴子包括设置在鞋面内部的保护性包裹物，其包括可拆卸地设置在鞋底单元上的底部部分和分别从鞋底部分的两侧向上延伸并连接到紧固单元的两个侧部。当紧固单元被紧固时，紧固单元拉动侧部，并且侧部提起鞋底部分，使得保护性包裹物紧紧地包裹在穿着者的脚下。

37. 发明授权

US08646907B2 Materials for use in ophthalmic applications and methods 有权
标题翻译：用于眼科应用的材料和方法
公开(公告)号：US08646907B2
公开(公告)日：2014-02-11
申请号：US13395134
申请日：2010-09-21
申请人： Yun Zhang , Charlie Chen , Peter Zhu , Ying Ye , Hongjin Qiu
发明人： Yun Zhang , Charlie Chen , Peter Zhu , Ying Ye , Hongjin Qiu
IPC分类号： G02C7/04
CPC分类号： C08J7/16
摘要： A lens body comprising at least one form of boronic acid, boronic ester or boronic anhydride is provided. The lens body is contacted with a solution comprising at least one form of TRIS. A contact lens package including the contact lens, and methods of producing and using the contact lens, are also provided.
摘要翻译：提供了包含至少一种形式的硼酸，硼酸酯或硼酸酐的透镜体。透镜体与包含至少一种形式的TRIS的溶液接触。还提供了包括隐形眼镜的隐形眼镜包，以及制造和使用隐形眼镜的方法。

38. 发明申请

US20120172486A1 Wettable Hydrogel Materials For Use In Ophthalmic Applications And Methods 有权
标题翻译：可湿性水凝胶材料用于眼科应用和方法
公开(公告)号：US20120172486A1
公开(公告)日：2012-07-05
申请号：US13146414
申请日：2010-09-21
申请人： Peter Zhu , Ying Ye , Yun Zhang , Charlie Chen
发明人： Peter Zhu , Ying Ye , Yun Zhang , Charlie Chen
IPC分类号： C08L43/00 , B29D11/00
CPC分类号： C08J7/16
摘要： A contact lens is provided that has extended and rechargeable wettability. The contact lens includes a lens body that is a reaction product of a polymerizable composition. A first polyhydric alcohol having a 1,2 diol or 1,3 diol moiety is present on a lens surface of the lens body. A contact lens package including the contact lens, and methods of producing and using the contact lens, are also provided.
摘要翻译：提供了一种具有延长和充分润湿性的隐形眼镜。隐形眼镜包括作为可聚合组合物的反应产物的透镜体。具有1,2-二醇或1,3-二醇部分的第一多元醇存在于透镜体的透镜表面上。还提供了包括隐形眼镜的隐形眼镜包，以及制造和使用隐形眼镜的方法。

39. 发明授权

US07968018B2 Use of surfactants in extraction procedures for silicone hydrogel ophthalmic lenses 有权
标题翻译：硅胶水凝胶眼科镜片提取方法中使用表面活性剂
公开(公告)号：US07968018B2
公开(公告)日：2011-06-28
申请号：US11737059
申请日：2007-04-18
申请人： Jay Scott Daulton , Charlie Chen , Tim Warren
发明人： Jay Scott Daulton , Charlie Chen , Tim Warren
IPC分类号： B29D11/00 , B65D85/38 , B29C71/00
CPC分类号： B29D11/00067 , B29C33/60 , B29C37/0067 , B29D11/0025 , Y10S425/808
摘要： Methods of producing silicone hydrogel ophthalmic lenses include contacting one or more delensed silicone hydrogel ophthalmic lens with a liquid composition that contains alcohol, water, and a surfactant. The methods can be steps of an extraction/hydration procedure used in the production of silicone hydrogel contact lenses. In some examples, contacting silicone hydrogel ophthalmic lens products with a liquid composition that contains alcohol, water, and a surfactant can significantly reduce or prevent surface distortion of the ophthalmic lens resulting from the extraction procedure. Some methods include subsequently contacting the silicone hydrogel ophthalmic lens with a liquid composition consisting essentially of water and a surfactant.
摘要翻译：生产硅酮水凝胶眼科镜片的方法包括将一种或多种疏水性硅氧水凝胶眼用透镜与含有醇，水和表面活性剂的液体组合物接触。该方法可以是用于生产硅酮水凝胶隐形眼镜的提取/水合程序的步骤。在一些实例中，将硅酮水凝胶眼用透镜产品与含有醇，水和表面活性剂的液体组合物接触可显着降低或防止由提取程序引起的眼科镜片的表面变形。一些方法包括随后使硅氧水凝胶眼用透镜与基本上由水和表面活性剂组成的液体组合物接触。

40. 发明申请

US20070004753A1 Diarylhydantoin compounds 有权
标题翻译：二芳基乙内酰脲化合物
公开(公告)号：US20070004753A1
公开(公告)日：2007-01-04
申请号：US11433829
申请日：2006-05-15
申请人： Charles Sawyers , Michael Jung , Charlie Chen , Samedy Ouk , Derek Welsbie , Chris Tran , John Wongvipat , Dongwon Yoo
发明人： Charles Sawyers , Michael Jung , Charlie Chen , Samedy Ouk , Derek Welsbie , Chris Tran , John Wongvipat , Dongwon Yoo
IPC分类号： A61K31/496 , A61K31/4166 , C07D403/02
CPC分类号： C07D235/02 , C07D233/70 , C07D233/74 , C07D233/86 , C07D471/10
摘要： The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.
摘要翻译：本发明涉及二芳基乙内酰脲化合物，包括二芳基硫代乙内酰脲及其合成方法，并用于治疗激素难治性前列腺癌。

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