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31. 发明授权

US09164298B2 Wettable silicone hydrogel contact lenses 有权
标题翻译：可湿性硅酮水凝胶隐形眼镜
公开(公告)号：US09164298B2
公开(公告)日：2015-10-20
申请号：US13983577
申请日：2012-02-23
申请人： Ye Hong , Li Yao , Yuwen Liu , Charlie Chen , Arthur Back
发明人： Ye Hong , Li Yao , Yuwen Liu , Charlie Chen , Arthur Back
IPC分类号： G02C7/04 , G02B1/04 , C08L83/12
CPC分类号： G02C7/049 , C08L83/12 , G02B1/043 , C08L101/14 , C08L83/04 , C08L51/085
摘要： Silicone hydrogel contact lenses are formed from the reaction product of a polymerizable composition comprising at least one acrylate-containing siloxane monomer, at least one hydrophilic vinyl-containing monomer, and at least one vinyl-containing cross-linking agent, wherein the polymerizable composition has a molar ratio of total amount of hydrophilic vinyl-containing monomer to total amount of acrylate-containing siloxane monomer of from 5:1 to 30:1, respectively. The silicone hydrogel contact lenses have good manufacturing processability, can be manufactured without the use of alcohol solvents, and have excellent surface wettability.
摘要翻译：硅氧烷水凝胶隐形眼镜由包含至少一种含丙烯酸酯的硅氧烷单体，至少一种亲水性含乙烯基单体和至少一种含乙烯基交联剂的可聚合组合物的反应产物形成，其中可聚合组合物具有亲水性含乙烯基单体的总量与含丙烯酸酯的硅氧烷单体的总量的摩尔比分别为5:1至30:1。硅酮水凝胶隐形眼镜具有良好的制造加工性，可以在不使用醇溶剂的情况下制造，并且具有优异的表面润湿性。

32. 发明授权

US09057822B2 Silicone hydrogel contact lenses 有权
标题翻译：硅胶水凝胶隐形眼镜
公开(公告)号：US09057822B2
公开(公告)日：2015-06-16
申请号：US13983774
申请日：2012-02-23
申请人： Yuwen Liu , Ye Hong , Junhao Ge , Yuan Xu , Charlie Chen , Charles A. Francis , Li Yao , Arthur Back
发明人： Yuwen Liu , Ye Hong , Junhao Ge , Yuan Xu , Charlie Chen , Charles A. Francis , Li Yao , Arthur Back
IPC分类号： G02B1/04 , C08F283/12 , C08F236/20 , C08F226/00 , C08F283/06 , C08L51/08 , C08J11/02
CPC分类号： G02B1/043 , C08F226/00 , C08F236/20 , C08F283/065 , C08F283/126 , C08J11/02 , C08L51/085 , C08L83/04 , C08L101/14
摘要： Silicone hydrogel contact lenses that are derived from a polymerizable composition including a first siloxane monomer represented by formula (3): wherein m of formula (3) represents one integer from 3 to 10, n of formula (3) represents one integer from 1 to 10, R1 of formula (3) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (3) is independently either a hydrogen atom or a methyl group; and at least one vinyl ether-containing cross-linking agent are described. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described. In one example, the batches of silicone hydrogel contact lenses are dimensionally stable, and the method of making is a method of making dimensionally stable silicone hydrogel contact lenses.
摘要翻译：衍生自包含由式（3）表示的第一硅氧烷单体的可聚合组合物的聚合性组合物的硅氧水凝胶隐形眼镜：式（3）的m表示3〜10的整数，式（3）的n表示1〜 10，式（3）的R 1为碳原子数1〜4的烷基，式（3）的各R 2独立地为氢原子或甲基。和至少一种含乙烯基醚的交联剂。还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。在一个示例中，硅胶水凝胶隐形眼镜的批次是尺寸稳定的，并且制造方法是制备尺寸稳定的硅酮水凝胶隐形眼镜的方法。

33. 发明申请

US20140016086A1 Silicone Hydrogel Contact Lenses 有权
标题翻译：硅胶水凝胶隐形眼镜
公开(公告)号：US20140016086A1
公开(公告)日：2014-01-16
申请号：US13983774
申请日：2012-02-23
申请人： Yuwen Liu , Ye Hong , Junhao Ge , Yuan Xu , Charlie Chen , Charles A. Francis , Li Yao , Arthur Back
发明人： Yuwen Liu , Ye Hong , Junhao Ge , Yuan Xu , Charlie Chen , Charles A. Francis , Li Yao , Arthur Back
IPC分类号： G02C7/04
CPC分类号： G02B1/043 , C08F226/00 , C08F236/20 , C08F283/065 , C08F283/126 , C08J11/02 , C08L51/085 , C08L83/04 , C08L101/14
摘要： Silicone hydrogel contact lenses that are derived from a polymerizable composition including a first siloxane monomer represented by formula (3): wherein m of formula (3) represents one integer from 3 to 10, n of formula (3) represents one integer from 1 to 10, R1 of formula (3) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (3) is independently either a hydrogen atom or a methyl group; and at least one vinyl ether-containing cross-linking agent are described. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described. In one example, the batches of silicone hydrogel contact lenses are dimensionally stable, and the method of making is a method of making dimensionally stable silicone hydrogel contact lenses.
摘要翻译：衍生自包含由式（3）表示的第一硅氧烷单体的可聚合组合物的聚合性组合物的硅氧水凝胶隐形眼镜：式（3）的m表示3〜10的整数，式（3）的n表示1〜 10，式（3）的R 1为碳原子数1〜4的烷基，式（3）的各R 2独立地为氢原子或甲基。和至少一种含乙烯基醚的交联剂。还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。在一个示例中，硅胶水凝胶隐形眼镜的批次是尺寸稳定的，并且制造方法是制备尺寸稳定的硅酮水凝胶隐形眼镜的方法。

34. 发明授权

US08552085B2 Wettable silicone hydrogel contact lenses and related compositions and methods 有权
公开(公告)号：US08552085B2
公开(公告)日：2013-10-08
申请号：US13539887
申请日：2012-07-02
申请人： Ye Hong , Charlie Chen , Nick Manesis
发明人： Ye Hong , Charlie Chen , Nick Manesis
IPC分类号： G02B1/04 , C08F290/04 , C08F230/08 , C08F283/12 , G02C7/04
CPC分类号： G02C7/049 , B29D11/00038 , B29D11/00067 , B29D11/0025 , B29K2039/06 , B29K2077/00 , B29K2083/00 , B29K2105/0061 , G02B1/043 , C08L83/04 , C08L51/085
摘要： Silicone hydrogel contact lenses having ophthalmically acceptable surface wettabilities are obtained from pre-extracted polymerized silicone hydrogel contact lens products having relatively large amounts of removable or extractable materials. The silicone hydrogel contact lenses can be obtained from non-polar resin based contact lens molds and without surface treatments or an interpenetrating polymeric network of a polymeric wetting agent. Related lens products, polymerizable compositions, and methods are also described.

35. 发明授权

US08501981B2 CXCR2 inhibitors 有权
标题翻译： CXCR2抑制剂
公开(公告)号：US08501981B2
公开(公告)日：2013-08-06
申请号：US12337040
申请日：2008-12-17
申请人： Stephanie Hachtel , Juergen Dedio , Elisabeth DeFossa , Sven Grueneberg , Holger Heitsch , William Bock , Charlie Chen , Raymond Kosley , Chung-Yi Kung , Marcel Patek , Rosy Sher , Stephen Shimshock , Aleksandra Weichsel
发明人： Stephanie Hachtel , Juergen Dedio , Elisabeth DeFossa , Sven Grueneberg , Holger Heitsch , William Bock , Charlie Chen , Raymond Kosley , Chung-Yi Kung , Marcel Patek , Rosy Sher , Stephen Shimshock , Aleksandra Weichsel
IPC分类号： C07C229/00 , C07C69/76 , C07C61/00 , A01N37/12
CPC分类号： C07D333/16 , C07C233/83 , C07C235/66 , C07C237/48 , C07C311/29 , C07C2601/04 , C07C2601/10 , C07C2601/14 , C07C2602/08 , C07D213/65 , C07D215/26 , C07D233/60 , C07D295/088 , C07D307/24 , C07D333/64
摘要： The invention relates to compounds of the formula I in which R1, R2, X, A, B, Z and Y1 to Y4 have the meanings indicated in the claims, and/or a pharmaceutically acceptable salt and/or a prodrug thereof. Because of their properties as inhibitors of chemokine receptors, especially as CXCR2 inhibitors, the compounds of the formula I and the pharmaceutically acceptable salts and prodrugs thereof are suitable for the prevention and treatment of chemokine mediated diseases.
摘要翻译：本发明涉及其中R 1，R 2，X，A，B，Z和Y 1至Y 4具有权利要求中所示含义的式I化合物和/或其药学上可接受的盐和/或前药。由于其作为趋化因子受体的抑制剂的特性，特别是作为CXCR2抑制剂，式I化合物及其药学上可接受的盐和前药适用于预防和治疗趋化因子介导的疾病。

36. 发明申请

US20090264553A1 Wettable Silicone Hydrogel Contact Lenses and Related Compositions and Methods 有权
标题翻译：可湿性硅胶水凝胶隐形眼镜及相关成分及方法
公开(公告)号：US20090264553A1
公开(公告)日：2009-10-22
申请号：US12496228
申请日：2009-07-01
申请人： Charlie Chen , Ye Hong , Nick Manesis
发明人： Charlie Chen , Ye Hong , Nick Manesis
IPC分类号： B29D11/00 , C08G77/04 , C08L83/06
CPC分类号： C08L83/14 , G02B1/043
摘要： Silicone hydrogel contact lenses having ophthalmically acceptable surface wettabilities are obtained from pre-extracted polymerized silicone hydrogel contact lens products having relatively large amounts of removable or extractable materials. The silicone hydrogel contact lenses can be obtained from non-polar resin based contact lens molds and without surface treatments or an interpenetrating polymeric network of a polymeric wetting agent. Related lens products, polymerizable compositions, and methods are also described.
摘要翻译：具有眼科可接受的表面润湿性的硅酮水凝胶隐形眼镜由具有相对大量的可移除或可萃取材料的预提取聚合的硅氧水凝胶隐形眼镜产品获得。硅酮水凝胶隐形眼镜可以从非极性树脂基隐形眼镜模具获得，而不用表面处理或聚合润湿剂的互穿聚合物网络获得。还描述了相关的透镜产品，可聚合组合物和方法。

37. 发明申请

US20080258322A1 USE OF SURFACTANTS IN EXTRACTION PROCEDURES FOR SILICONE HYDROGEL OPHTHALMIC LENSES 有权
标题翻译：表面活性剂在硅胶水性眼镜提取程序中的应用
公开(公告)号：US20080258322A1
公开(公告)日：2008-10-23
申请号：US11737059
申请日：2007-04-18
申请人： Jay Scott Daulton , Charlie Chen , Tim Warren
发明人： Jay Scott Daulton , Charlie Chen , Tim Warren
IPC分类号： B29D11/00
CPC分类号： B29D11/00067 , B29C33/60 , B29C37/0067 , B29D11/0025 , Y10S425/808
摘要： Methods of producing silicone hydrogel ophthalmic lenses include contacting one or more delensed silicone hydrogel ophthalmic lens with a liquid composition that contains alcohol, water, and a surfactant. The methods can be steps of an extraction/hydration procedure used in the production of silicone hydrogel contact lenses. In some examples, contacting silicone hydrogel ophthalmic lens products with a liquid composition that contains alcohol, water, and a surfactant can significantly reduce or prevent surface distortion of the ophthalmic lens resulting from the extraction procedure. Some methods include subsequently contacting the silicone hydrogel ophthalmic lens with a liquid composition consisting essentially of water and a surfactant.
摘要翻译：生产硅酮水凝胶眼科镜片的方法包括将一种或多种疏水性硅氧水凝胶眼用透镜与含有醇，水和表面活性剂的液体组合物接触。该方法可以是用于生产硅酮水凝胶隐形眼镜的提取/水合程序的步骤。在一些实例中，将硅酮水凝胶眼用透镜产品与含有醇，水和表面活性剂的液体组合物接触可显着降低或防止由提取程序引起的眼科镜片的表面变形。一些方法包括随后使硅氧水凝胶眼用透镜与基本上由水和表面活性剂组成的液体组合物接触。

38. 发明申请

US20070291223A1 Wettable Silicone Hydrogel Contact Lenses and Related Compositions and Methods 有权
标题翻译：可湿性硅胶水凝胶隐形眼镜及相关成分及方法
公开(公告)号：US20070291223A1
公开(公告)日：2007-12-20
申请号：US11761272
申请日：2007-06-11
申请人： Charlie Chen , Ye Hong , Nick Manesis
发明人： Charlie Chen , Ye Hong , Nick Manesis
IPC分类号： G02C7/04
CPC分类号： C08L83/14 , C08F283/12 , C08F290/068 , C08L51/085 , G02B1/043 , C08L2666/02
摘要： Silicone hydrogel contact lenses having ophthalmically acceptable surface wettabilities are obtained from pre-extracted polymerized silicone hydrogel contact lens products produced from a polymerizable composition comprising a combination of particular components. The silicone hydrogel contact lenses can be obtained from non-polar resin based contact lens molds and without surface treatments or an interpenetrating polymeric network of a polymeric wetting agent. Related lens products, polymerizable compositions, and methods are also described.
摘要翻译：具有眼睛可接受的表面润湿性的硅酮水凝胶隐形眼镜是由包含特定组分的组合的可聚合组合物制备的预提取聚合的硅氧水凝胶隐形眼镜产品获得的。硅酮水凝胶隐形眼镜可以从非极性树脂基隐形眼镜模具获得，而不用表面处理或聚合润湿剂的互穿聚合物网络获得。还描述了相关的透镜产品，可聚合组合物和方法。

39. 发明申请

US20070191443A1 Methods and materials for assessing prostate cancer therapies and compounds 有权
标题翻译：用于评估前列腺癌疗法和化合物的方法和材料
公开(公告)号：US20070191443A1
公开(公告)日：2007-08-16
申请号：US10590445
申请日：2005-02-23
申请人： Michael Jung , Samedy Ouk , Charles Sawyers , Charlie Chen , Derek Welsbie
发明人： Michael Jung , Samedy Ouk , Charles Sawyers , Charlie Chen , Derek Welsbie
IPC分类号： A61K31/4166 , C07D233/84
CPC分类号： A61K31/426
摘要： A modest (2-5 fold) increase in androgen receptor (AR) mRNA is the only expression change consistently associated with developing resistance to antiandrogen therapy. Increased levels of AR confer resistance to anti-androgens by amplifying signal output from low levels of residual ligand and altering the normal response to antagonists. This invention provides cell based assays for use in the examination of new therapeutic modalities and provides for the design of novel antiandrogen compounds.
摘要翻译：雄激素受体（AR）mRNA的适度（2-5倍）增加是与抗雄激素治疗发展抵抗力的唯一表达变化。增加的AR水平通过放大来自低水平的残留配体的信号输出并改变对拮抗剂的正常反应来赋予抗雄激素抗性。本发明提供用于检查新的治疗方式的基于细胞的测定法，并提供新的抗雄激素化合物的设计。

40. 发明授权

US09360594B2 High water content silicone hydrogel contact lenses 有权
标题翻译：高含水硅胶水凝胶隐形眼镜
公开(公告)号：US09360594B2
公开(公告)日：2016-06-07
申请号：US13985109
申请日：2012-02-23
申请人： Yuwen Liu , Charlie Chen , Ye Hong , Charles A. Francis , Li Yao , Arthur Back
发明人： Yuwen Liu , Charlie Chen , Ye Hong , Charles A. Francis , Li Yao , Arthur Back
IPC分类号： C08L101/14 , G02B1/04 , G02C7/04 , C08G77/04 , C08L51/08 , C08F283/06
CPC分类号： G02B1/043 , C08F283/065 , C08L51/085 , C08L101/14
摘要： Silicone hydrogel contact lenses having a high water content are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (1) is independently either a hydrogen atom or a methyl group; the lenses also include units derived from a second siloxane monomer having a number average molecular weight of at least 7,000 daltons, and at least one vinyl-containing cross-linking agent. The lenses have average equilibrium water contents from about 30% wt/wt to about 70% wt/wt when fully hydrated. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.
摘要翻译：描述了具有高水含量的硅氧烷水凝胶隐形眼镜。透镜衍生自包含由式（1）表示的第一硅氧烷单体的可聚合组合物：其中式（1）的m表示3至10的一个整数，式（1）的n表示1至10的整数，R 1 式（1）的烷基是碳原子数为1〜4的烷基，式（1）的各R 2独立地为氢原子或甲基。透镜还包括衍生自数均分子量为至少7,000道尔顿的第二硅氧烷单体的单元和至少一种含乙烯基交联剂。当完全水合时，透镜具有约30重量％至约70重量％的平均水含量。还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。

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