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31. 发明申请

US20070105796A1 Method for inhibiting telomerase activity and inhibitor thereof 审中-公开
标题翻译：抑制端粒酶活性的方法及其抑制剂
公开(公告)号：US20070105796A1
公开(公告)日：2007-05-10
申请号：US10563074
申请日：2005-04-28
申请人： Naoya Wada , Takashi Okamoto , Keiji Tanigaki , Hirofumi Doi , Yasuhiro Kikuchi , Kensaku Imai
发明人： Naoya Wada , Takashi Okamoto , Keiji Tanigaki , Hirofumi Doi , Yasuhiro Kikuchi , Kensaku Imai
IPC分类号： A61K48/00
CPC分类号： C12N9/1205
摘要： The present invention provides a method for inhibiting the activation of telomerase and an agent for inhibiting the activation of telomerase, a method for inhibiting telomerase activity and an agent for inhibiting telomerase activity, a method for preventing and/or a method for treating a cancer disease, an agent for preventing and/or an agent for treating a cancer disease, all of which comprises inhibiting the binding of MAPKAPK3 to TERT that is a catalytic subunit of telomerase or inhibiting the phosphorylation of TERT by active MAPKAPK3; a method of identifying a compound that inhibits the binding of MAPKAPK3 to TERT or a compound that inhibits the phosphorylation of TERT by active MAPKAPK3; and a reagent kit.
摘要翻译：本发明提供抑制端粒酶活化的方法和抑制端粒酶活化的试剂，抑制端粒酶活性的方法和抑制端粒酶活性的方法，预防和/或治疗癌症的方法，用于预防和/或治疗癌症疾病的药物，所有这些都包括抑制MAPKAPK3与作为端粒酶催化亚基的TERT的结合或抑制活性MAPKAPK3的TERT磷酸化; 鉴定抑制MAPKAPK3与TERT结合的化合物或抑制活性MAPKAPK3磷酸化TERT的化合物的方法; 和试剂盒。

32. 发明申请

US20070097954A1 PHOTONIC NETWORK PACKET ROUTING METHOD AND PACKET ROUTER FOR PHOTONIC NETWORK 有权
公开(公告)号：US20070097954A1
公开(公告)日：2007-05-03
申请号：US11613848
申请日：2006-12-20
申请人： Naoya Wada , Hideyuki Sotobayashi , Ken-ichi Kitayama
发明人： Naoya Wada , Hideyuki Sotobayashi , Ken-ichi Kitayama
IPC分类号： H04L12/28
CPC分类号： H04Q11/0005 , H04J14/0227 , H04J14/08 , H04L45/00 , H04L45/502 , H04Q11/0066 , H04Q2011/002 , H04Q2011/0024 , H04Q2011/0039 , H04Q2011/0041 , H04Q2011/0077
摘要： A photonic network packet routing method includes the steps of optically encoding destination address information attached to an IP packet using light attributes, discriminating the encoded address information of the IP packet by optical correlation processing, switching to an output path for the IP packet based on a result of the discrimination, and outputting the IP packet labeled with prescribed address information on the output path selected by the switching step. A packet router for a photonic network includes a device for encoding by use of light attributes destination address information attached to an IP packet, a branching device for sending the IP packet having the encoded destination address information onto two paths, an address processing device for subjecting one IP packet received from the branching device to optical correlation processing and outputting a switch control signal based on a result of the discrimination, and a switch device for selectively outputting the packet by switching an output path of the other packet received from the branching device based on the address control signal from the address control device.

33. 发明授权

US07195894B2 MKK7 activation inhibitor 失效
标题翻译： MKK7激活抑制剂
公开(公告)号：US07195894B2
公开(公告)日：2007-03-27
申请号：US10519465
申请日：2003-06-27
申请人： Hirofumi Doi , Shinya Hosogi , Naoya Wada
发明人： Hirofumi Doi , Shinya Hosogi , Naoya Wada
IPC分类号： C12N15/09
CPC分类号： C07K14/47 , A61K38/1709 , G01N2500/00 , A61K2300/00
摘要： PAK4 and JIK, both of which bind to MKK7 and directly phosphorylate MKK7, were found in the present invention. The present invention provides an inhibitor of c-Jun phosphorylation caused by JNK3 and a method for inhibiting the same, and an agent for preventing and/or treating a disorder attributable to c-Jun phosphorylation caused by JNK3 and a method for preventing and/or treating the same, all of which comprise inhibiting one member selected from the following: the binding of PAK4 to MKK7, the phosphorylation of MKK7 by PAK4, the binding of JIK to MKK7, and the phosphorylation of MKK7 by JIK. Further, the present invention provides a method for identifying a compound that inhibits the binding of PAK4 to MKK7, the phosphorylation of MKK7 caused by PAK4, the binding of JIK to MKK7, or the phosphorylation of MKK7 caused by JIK, as well as the compound obtained thereby. Furthermore, the present invention provides a pharmaceutical composition containing an effective amount of at least one member selected from the group consisting of the aforementioned compound and the aforementioned inhibitor.
摘要翻译：在本发明中发现PAK4和JIK两者都结合MKK7并直接磷酸化MKK7。本发明提供了由JNK3引起的c-Jun磷酸化抑制剂及其抑制方法，以及用于预防和/或治疗由JNK3引起的由c-Jun磷酸化引起的病症的药剂，以及用于预防和/或所有这些都包括抑制选自以下的一种：PAK4与MKK7的结合，PAK4的MKK7的磷酸化，JIK与MKK7的结合以及通过JIK的MKK7的磷酸化。此外，本发明提供了鉴定抑制PAK4与MKK7结合的化合物，由PAK4引起的MKK7的磷酸化，JIK与MKK7的结合或由JIK引起的MKK7的磷酸化的化合物的方法，以及化合物由此获得。此外，本发明提供含有有效量的选自上述化合物和上述抑制剂中的至少一种的药物组合物。

34. 发明申请

US20060228362A1 Novel protease gene 审中-公开
标题翻译：新型蛋白酶基因
公开(公告)号：US20060228362A1
公开(公告)日：2006-10-12
申请号：US11452363
申请日：2006-06-14
申请人： Hiroshi Yokota , Yasuko Arai , Naoya Wada , Tatsuya Inoue , Yoshiyuki Saeki
发明人： Hiroshi Yokota , Yasuko Arai , Naoya Wada , Tatsuya Inoue , Yoshiyuki Saeki
IPC分类号： G01N33/53 , C07H21/04 , C12P21/06 , A61K39/395 , C12N9/64
CPC分类号： C12N9/6489 , C12Y304/24016 , G01N33/6896
摘要： A neurolysin-like substance having an activity of degrading a synthetic substrate Mcc-Pro-Leu-Gly-Pro-D-Lys(DNP)—OH, diagnostic means and pharmaceutical compositions employing it.
摘要翻译：具有降解合成底物Mcc-Pro-Leu-Gly-Pro-D-Lys（DNP）-OH的活性的神经溶解素样物质，诊断方法和使用它的药物组合物。

35. 发明授权

US09019591B2 Burst mode rare earth-doped fiber amplifier 有权
标题翻译：突发模式稀土掺杂光纤放大器
公开(公告)号：US09019591B2
公开(公告)日：2015-04-28
申请号：US12530784
申请日：2008-03-12
申请人： Yoshinari Awaji , Hideaki Furukawa , Naoya Wada , Ray Man , Peter Chan , Eddie Kong
发明人： Yoshinari Awaji , Hideaki Furukawa , Naoya Wada , Ray Man , Peter Chan , Eddie Kong
IPC分类号： H04B10/17 , H04B10/296 , H04B10/294 , H04B10/12 , H01S3/067 , H01S3/16
CPC分类号： H04B10/296 , H01S3/06708 , H01S3/06716 , H01S3/0672 , H01S3/06729 , H01S3/06758 , H01S3/1608 , H04B10/2941
摘要： It is an object of the present invention to provide a rare earth doped fiber whose transient response is suppressed and an optical amplifier for optical packet communication having a good characteristic even if there is little traffic.The above-mentioned problem is solved by an optical amplifier for optical packet communication comprising a first rare earth doped fiber (EDFA) having an active region whose diameter is between 3.4 μm and 10 μm, inclusive, an intermediate gain equalizing filter, and a second EDF, wherein the first EDFA is shorter than the second EDFA, and wherein the intermediate gain equalizing filter adjusts the intensity of each wavelength channel so as to equalize the light intensity of each wavelength channel having transmitted through the second EDF.
摘要翻译：本发明的目的是提供一种其瞬时响应被抑制的稀土掺杂光纤，并且即使交通量少的话，光分组通信的光放大器也具有良好的特性。上述问题由用于光分组通信的光放大器解决，该光放大器包括具有直径在3.4μm和10μm之间的有源区的第一稀土掺杂光纤（EDFA），包括中间增益均衡滤波器，第二稀土掺杂光纤 EDF，其中所述第一EDFA比所述第二EDFA短，并且其中所述中间增益均衡滤波器调整每个波长信道的强度，以便均衡通过所述第二EDF的每个波长信道的光强度。

36. 发明申请

US20140190031A1 Crushing Drying Device 有权
标题翻译：破碎干燥装置
公开(公告)号：US20140190031A1
公开(公告)日：2014-07-10
申请号：US14125925
申请日：2012-06-14
申请人： Naoya Wada , Katsu Matsumoto , Hiroaki Kajiyama , Masuyuki Mieda , Kazuhiro Yamamoto , Natsuki Takemoto
发明人： Naoya Wada , Katsu Matsumoto , Hiroaki Kajiyama , Masuyuki Mieda , Kazuhiro Yamamoto , Natsuki Takemoto
IPC分类号： F26B25/00
CPC分类号： F26B25/001 , B02C13/06 , B02C13/282 , B02C13/288 , B02C23/12 , B02C2013/28654 , F26B1/005 , F26B17/107 , F26B17/24 , F26B2200/24
摘要： A crushing drying device includes an object-to-be-treated supply port from which an object is supplied into a main body, a crushing portion for crushing the object by hammers rotated on a drive shaft, and a classifying portion having a space for circulating the object to be treated at a position away from the crushing portion, the crushing portion has a dry gas supply port from which the heated air is supplied in a predetermined direction along an inner surface of the device main body, and the classifying portion has discharge portions from which the crushed object is discharged together with the heated air, and deviation plates for changing a flow of the object transferred to the classifying portion, so that the crushing drying device is one machine.
摘要翻译：破碎干燥装置包括：被处理物供给口，将物体从主体供给到主体;破碎部，其通过在驱动轴上旋转的锤击碎物体;破碎部，其具有循环空间; 在离开破碎部的位置处处理的物体，破碎部具有干燥气体供给口，沿着装置主体的内表面沿规定方向供给加热空气，分选部具有排出口破碎物体与加热空气一起排出的部分，以及用于改变传送到分级部分的物体的流动的偏差板，使得破碎干燥装置是一台机器。

37. 发明授权

US08199265B2 Optical waveform shaping device 有权
标题翻译：光波形整形装置
公开(公告)号：US08199265B2
公开(公告)日：2012-06-12
申请号：US12664661
申请日：2008-06-13
申请人： Naoya Wada , Seitetsu Boku , Takuya Yoda , Yuki Komai , Fumi Moritsuka , Kashiko Kodate
发明人： Naoya Wada , Seitetsu Boku , Takuya Yoda , Yuki Komai , Fumi Moritsuka , Kashiko Kodate
IPC分类号： G02F1/1335
CPC分类号： G02B27/286 , G01J2003/1213 , G02B6/2706 , G02B27/0905 , G02B27/0944 , G02B27/0977 , G02B27/1086 , G02B27/42 , G02B27/4244 , G02B27/4261 , G02F2203/26
摘要： The present invention provides an optical waveform shaping device (10) of high resolution comprising a branching filter (1) for branching the light beam from a light source into light beams of each frequency, a condensing part (2) for condensing a plurality of light beams branched by the branching filter (1), a polarizing plate (3) for adjusting the polarization planes of the light beams having passed through the condensing part (2), and a spatial light modulator (4) having a phase modulation part and an intensity modulation part where the light beams having passed through the polarizing plate (3) are incident.
摘要翻译：本发明提供了一种高分辨率的光波形整形装置（10），包括一个用于将来自光源的光束分成每个频率的光束的分束滤波器（1），用于聚光多个光的聚光部分（2）由分支滤波器（1）分支的光束，用于调节通过聚光部分（2）的光束的偏振面的偏振板（3）和具有相位调制部分的空间光调制器（4）通过偏光板（3）的光束入射的强度调制部。

38. 发明授权

US07899327B2 Photonic network packet routing method and packet router for photonic network 有权
公开(公告)号：US07899327B2
公开(公告)日：2011-03-01
申请号：US11613848
申请日：2006-12-20
申请人： Naoya Wada , Hideyuki Sotobayashi , Ken-ichi Kitayama
发明人： Naoya Wada , Hideyuki Sotobayashi , Ken-ichi Kitayama
IPC分类号： H04B10/00
CPC分类号： H04Q11/0005 , H04J14/0227 , H04J14/08 , H04L45/00 , H04L45/502 , H04Q11/0066 , H04Q2011/002 , H04Q2011/0024 , H04Q2011/0039 , H04Q2011/0041 , H04Q2011/0077
摘要： A photonic network packet routing method includes the steps of optically encoding destination address information attached to an IP packet using light attributes, discriminating the encoded address information of the IP packet by optical correlation processing, switching to an output path for the IP packet based on a result of the discrimination, and outputting the IP packet labeled with prescribed address information on the output path selected by the switching step. A packet router for a photonic network includes a device for encoding by use of light attributes destination address information attached to an IP packet, a branching device for sending the IP packet having the encoded destination address information onto two paths, an address processing device for subjecting one IP packet received from the branching device to optical correlation processing and outputting a switch control signal based on a result of the discrimination, and a switch device for selectively outputting the packet by switching an output path of the other packet received from the branching device based on the address control signal from the address control device.

39. 发明授权

US07873275B2 Photonic network packet routing method and packet router for photonic network 有权
公开(公告)号：US07873275B2
公开(公告)日：2011-01-18
申请号：US11613873
申请日：2006-12-20
申请人： Naoya Wada , Hideyuki Sotobayashi , Ken-ichi Kitayama
发明人： Naoya Wada , Hideyuki Sotobayashi , Ken-ichi Kitayama
IPC分类号： H04B10/00
CPC分类号： H04Q11/0005 , H04J14/0227 , H04J14/08 , H04L45/00 , H04L45/502 , H04Q11/0066 , H04Q2011/002 , H04Q2011/0024 , H04Q2011/0039 , H04Q2011/0041 , H04Q2011/0077
摘要： A photonic network packet routing method includes the steps of optically encoding destination address information attached to an IP packet using light attributes, discriminating the encoded address information of the IP packet by optical correlation processing, switching to an output path for the IP packet based on a result of the discrimination, and outputting the IP packet labeled with prescribed address information on the output path selected by the switching step. A packet router for a photonic network includes a device for encoding by use of light attributes destination address information attached to an IP packet, a branching device for sending the IP packet having the encoded destination address information onto two paths, an address processing device for subjecting one IP packet received from the branching device to optical correlation processing and outputting a switch control signal based on a result of the discrimination, and a switch device for selectively outputting the packet by switching an output path of the other packet received from the branching device based on the address control signal from the address control device.

40. 发明申请

US20100141857A1 OPTICAL WAVEFORM SHAPING DEVICE 有权
标题翻译：光波形成器件
公开(公告)号：US20100141857A1
公开(公告)日：2010-06-10
申请号：US12664659
申请日：2008-06-12
申请人： Naoya Wada , Seitetsu Boku , Takuya Yoda
发明人： Naoya Wada , Seitetsu Boku , Takuya Yoda
IPC分类号： G02F1/1335
CPC分类号： G02B27/0977 , G02B27/0905 , G02B27/0944 , G02F1/093 , G02F2203/26
摘要： It is an object of the present invention to provide an optical waveform shaping device of high resolution.The above-mentioned problem is solved by an optical waveform shaping device (10) comprising a branching filter (11) for dividing the light beam from a light source into light beams of each frequency, a condensing part (12) for condensing a plurality of light beams divided by the branching filter (11), a polarization separation means (13) for adjusting the polarizing planes of the light beams having passed through the condensing part (12), and a spatial light modulator (14) having a phase modulation part and an intensity modulation part where the light beams having passed through the polarizing plate (13) are incident.
摘要翻译：本发明的目的是提供一种高分辨率的光波形整形装置。上述问题由光波形整形装置（10）解决，光波形整形装置（10）包括用于将来自光源的光束分成每个频率的光束的分束滤波器（11），用于冷凝多个由分支滤波器（11）分割的光束，用于调节通过聚光部分（12）的光束的偏振面的偏振光分离装置（13）和具有相位调制部分的空间光调制器（14）以及通过偏振片（13）的光束入射的强度调制部。

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