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31. 发明授权

US4057544A .alpha.-Alkylsulfobenzyl penicillins 失效
标题翻译： {60-烷基亚磺酰基青霉素
公开(公告)号：US4057544A
公开(公告)日：1977-11-08
申请号：US417527
申请日：1973-11-20
申请人： Keiichi Sugimoto , Koji Nishijima , Hiroshi Akimoto , Tadashi Hanaoka , Nobuharu Kakeya
发明人： Keiichi Sugimoto , Koji Nishijima , Hiroshi Akimoto , Tadashi Hanaoka , Nobuharu Kakeya
IPC分类号： C07D499/12 , A61K31/43 , A61P31/04 , C07D207/08 , C07D307/12 , C07D499/62 , C07D499/68 , C07D499/46
CPC分类号： C07D307/12 , C07D207/08
摘要： Novel penicillins of the formula ##STR1## wherein R is a branched chain alkyl group of from 3 to 14 carbon atoms, and their pharmaceutically acceptable salts, are easily absorbed in the blood and tissues through oral administration and show excellent antimicrobial activity against Gram-positive and Gram-negative bacteria, particularly against microorganisms of the genus Pseudomonas, such as Pseudomonas aeruginosa.
摘要翻译：其中R为3〜14个碳原子的支链烷基及其药学上可接受的盐的新型青霉素通过口服给药容易地吸收在血液和组织中，并显示出优异的抗革兰氏阳性的抗微生物活性和革兰氏阴性细菌，特别是针对假单胞菌属（Pseudomonas）的微生物，如铜绿假单胞菌（Pseudomonas aeruginosa）。

32. 发明授权

US08382527B2 Connector enabling increased density of contacts 有权
公开(公告)号：US08382527B2
公开(公告)日：2013-02-26
申请号：US12924123
申请日：2010-09-21
申请人： Masafumi Okada , Hiroshi Akimoto
发明人： Masafumi Okada , Hiroshi Akimoto
IPC分类号： H01R24/00
CPC分类号： B29C45/00 , B29L2031/3406 , H01R12/57 , H01R12/737
摘要： A plurality of contacts are arranged in a first direction along a side wall of a housing. The housing has a plurality of ribs projecting in a second direction from the side wall and interposed between the contacts, respectively. Each rib has a tapered portion adjacent to the side wall.

33. 发明申请

US20120177776A1 MOLD FOR INJECTION MOLDING, AND INJECTION MOLDING METHOD, INJECTION-MOLDED ARTICLE, AND INJECTION MOLDING MACHINE USING THE MOLD FOR INJECTION MOLDING 有权
标题翻译：注塑成型用模具，注塑成型方法，注塑件，注塑成型机，模具注塑成型
公开(公告)号：US20120177776A1
公开(公告)日：2012-07-12
申请号：US13280958
申请日：2011-10-25
申请人： Yohei KIMITA , Masafumi Okada , Hiroshi Akimoto
发明人： Yohei KIMITA , Masafumi Okada , Hiroshi Akimoto
IPC分类号： B29C45/14 , B29C45/64 , B29C45/00
CPC分类号： B29C33/44 , B29C33/10
摘要： The pin mounting hole used to insert and mount the pin member having a pin-like shape is formed on, among the inner wall surfaces of the cavity, the second side-wall surface that is an inner wall surface other than the inner wall surfaces perpendicular to the mold-removal direction of the injection-molded article. On the second side-wall surface, the protruding portion protruding from the second side-wall surface is formed in the surface area located on the opposite side in the mold-removal direction with respect to the pin mounting hole.
摘要翻译：用于插入和安装具有销状形状的销构件的销安装孔形成在空腔的内壁表面之中的作为内壁表面的第二侧壁表面，内壁表面不是垂直于内壁表面到注塑制品的脱模方向。在第二侧壁面上，从与第二侧壁面突出的突出部相对于销安装孔形成在脱模方向相反一侧的表面区域。

34. 发明授权

US07811094B2 Contact member and connector 有权
标题翻译：接触件和接头
公开(公告)号：US07811094B2
公开(公告)日：2010-10-12
申请号：US12256625
申请日：2008-10-23
申请人： Takashi Kuwahara , Seiya Takahashi , Hiroshi Akimoto
发明人： Takashi Kuwahara , Seiya Takahashi , Hiroshi Akimoto
IPC分类号： H01R12/00
CPC分类号： H01R13/2407 , H01R12/592
摘要： A contact member which is resistant to contact failure even if the environment of use is bad. A film is affixed to the surface of a long plate-shaped elastic body which is disposed between two to-be-connected objects. A electrically-conducting path which electrically connects between terminal portions of two to-be-connected objects is provided on the surface of the film. A first conductor contact portion which is capable of being brought into contact with the terminal portion of one of two to-be-connected objects is disposed at one end of the electrically-conducting path, and a second conductor contact portion which is capable of being brought into contact with the terminal portion of the other of two to-be-connected objects is disposed at the other end of the electrically-conducting path. A plurality of holes are formed in the first and second conductor contact portions.
摘要翻译：即使使用环境不良，也能够抵抗接触不良的接触部件。薄膜固定在长板状弹性体的表面上，该长板状弹性体设置在两个被连接物体之间。在膜的表面上设置导电路径，其电连接两个被连接物体的端子部分。能够与两个待连接物体之一的端子部分接触的第一导体接触部分设置在导电路径的一端，以及第二导体接触部分，其能够被与两个被连接物体中的另一个的端子部分接触设置在导电路径的另一端。多个孔形成在第一和第二导体接触部分中。

35. 发明申请

US20090075510A1 Socket 有权
标题翻译：插座
公开(公告)号：US20090075510A1
公开(公告)日：2009-03-19
申请号：US12231645
申请日：2008-09-04
申请人： Akira Kuwahara , Takuya Takahashi , Hiroshi Akimoto , Seiya Takahashi , Yoshiaki Ishiyama , Hiroshi Endo
发明人： Akira Kuwahara , Takuya Takahashi , Hiroshi Akimoto , Seiya Takahashi , Yoshiaki Ishiyama , Hiroshi Endo
IPC分类号： H01R13/62
CPC分类号： H01R12/7076 , H01R13/2414 , H01R13/6641 , H05K3/301 , H05K2201/10106 , H05K2201/10325
摘要： The present invention provides a socket for an element with an element electrode. The socket comprises a base shell, a cover shell and a contact member. The cover shell is engaged with the base shell so that the base shell and the cover shell define a cavity. Each of the base shell and the cover shell is made of a high thermal-conductive material. The contact member comprises an elastic member and a contact electrode provided on the elastic member and are designed and arranged so that the element is mountable on the contact member within the cavity with the element electrode connected to the contact electrode.
摘要翻译：本发明提供了一种用于具有元件电极的元件的插座。插座包括基座壳，盖壳和接触构件。盖壳与基部壳体接合，使得底部壳体和盖壳体限定空腔。每个基壳和盖壳由高导热材料制成。接触构件包括弹性构件和设置在弹性构件上的接触电极，并且被设计和布置成使得元件可安装在腔内的接触构件上，元件电极连接到接触电极。

36. 发明授权

US5817025A Method for diagnosing malignancy diseases 失效
标题翻译：诊断恶性肿瘤的方法
公开(公告)号：US5817025A
公开(公告)日：1998-10-06
申请号：US864239
申请日：1997-05-28
申请人： Sergei Grigorevich Alekseev , Nikolai Borisovich Brandt , Galina Aleksandrovna Mironova , Hiroshi Akimoto , Keiko Akimoto
发明人： Sergei Grigorevich Alekseev , Nikolai Borisovich Brandt , Galina Aleksandrovna Mironova , Hiroshi Akimoto , Keiko Akimoto
IPC分类号： G01N33/49 , A61B10/00 , G01J3/44 , G01N15/00 , G01N21/49 , G01N21/85 , G01N33/52 , A61B6/00
CPC分类号： G01J3/4412
摘要： The method for diagnosing malignancy diseases involving analysis of blood plasma by laser correlational spectroscopy (LSC) techniques includes the steps of: preparing a weak diluted solution of native blood plasma, determining a spectral density of light scattering intensity fluctuations within the frequency range between 1 and 1000 Hz, distinguishing a spectrum core and making a diagnosis from a frequency of a maximum and an intensity-to-half-width ratio of a spectrum core envelope, a malignancy disease being detected when the diagnostic parameters are less than the appropriate rates. The apparatus for diagnosing malignancy diseases includes a nephelometer and a series-connected correlation spectrum analyzer. The nephelometer further includes a second scattered light detector disposed symmetrically about a first scattered light detector, a signal multiplier whose inputs are coupled to outputs of the first and second scattered light detectors, a low pass filter whose input is coupled to an output of the signal multiplier, and an output is coupled to a correlator of the spectrum analyzer, a conventional ampoule for a solvent being used as a measuring cuvette in the nephelometer.
摘要翻译：用于通过激光相关光谱（LSC）技术诊断涉及血浆分析的恶性疾病的方法包括以下步骤：制备天然血浆的弱稀释溶液，确定在1和1之间的频率范围内的光散射强度波动的光谱密度 1000Hz，区分频谱核心并从频谱核心包络的最大值和强度 - 宽度比的频率进行诊断，当诊断参数小于适当速率时，检测恶性疾病。用于诊断恶性肿瘤的装置包括浊度计和串联相关频谱分析仪。散光计进一步包括第二散射光检测器，该第二散射光检测器围绕第一散射光检测器对称地设置，信号乘法器，其输入耦合到第一和第二散射光检测器的输出;低通滤波器，其输入耦合到信号的输出乘法器，并且输出耦合到频谱分析仪的相关器，用于溶剂的常规安瓿用作浊度计中的测量比色皿。

37. 发明授权

US5356599A Continuous powder catalyst supply apparatus and catalyst supply system 失效
标题翻译：连续粉末催化剂供应装置和催化剂供应系统
公开(公告)号：US5356599A
公开(公告)日：1994-10-18
申请号：US17289
申请日：1993-02-12
申请人： Yasuhiro Miura , Kozo Miyazaki , Yoshio Iino , Mitsuru Tamura , Yukio Fukada , Hiroshi Akimoto
发明人： Yasuhiro Miura , Kozo Miyazaki , Yoshio Iino , Mitsuru Tamura , Yukio Fukada , Hiroshi Akimoto
IPC分类号： B65G65/48 , B01J8/00 , C08F10/00 , B01J8/08 , B67D5/00
CPC分类号： B01J8/0035 , B01J8/002 , C08F10/00
摘要： A continuous powder catalyst supply apparatus and a catalyst supply system that is suitable for olefin gas phase polymerization. The supply apparatus comprises a catalyst storage chamber having a catalyst inlet port and a catalyst supply port for transmitting the catalyst to the reactor. Inside the catalyst storage chamber is a catalyst supply mechanism which substantially continuously supplies the catalyst to the catalyst supply port, and a forcible discharge mechanism which forcibly discharges the catalyst, supplied from the catalyst supply mechanism, through the catalyst supply port with a pressurized gas. The apparatus can be used to supply the catalyst to the reactor with low amounts of pressurized gas. Further, the system can be configured so as to avoid contamination of stored catalyst by reactant gas.
摘要翻译：连续粉末催化剂供应装置和适用于烯烃气相聚合的催化剂供应系统。供给装置包括具有催化剂入口和用于将催化剂传递到反应器的催化剂供给口的催化剂储存室。在催化剂储存室内部是催化剂供给机构，其将催化剂连续地供给到催化剂供给口，强制排出机构将从催化剂供给机构供给的催化剂强制地排出通过加压气体的催化剂供给口。该装置可用于将催化剂供给具有少量加压气体的反应器。此外，该系统可以被配置为避免反应气体污染储存的催化剂。

38. 发明授权

US5349064A Production of pyrrolopyrimidines 失效
标题翻译：吡咯并嘧啶的生产
公开(公告)号：US5349064A
公开(公告)日：1994-09-20
申请号：US29310
申请日：1993-03-08
申请人： Hiroshi Akimoto , Takenori Hitaka , Tetsuo Miwa
发明人： Hiroshi Akimoto , Takenori Hitaka , Tetsuo Miwa
IPC分类号： A61K31/505 , A61P35/00 , C07D239/48 , C07D239/49 , C07D239/50 , C07D487/04
CPC分类号： C07D239/48 , C07D239/50 , C07D487/04
摘要： There is provided an improved process for producing novel compounds represented by the general formula: ##STR1## wherein the ring A represents a pyrrole ring which may be hydrogenated; X represents an amino, hydroxyl or mercapto group; R.sup.1, R.sup.2 and R.sup.3 each being the same as or different from the other, represents hydrogen or an alkyl, alkenyl or alkynyl group which may be substituted; R.sup.4 represents OR.sup.5 wherein R.sup.5 represents hydrogen or a hydrocarbon group which may be substituted or NHCH(COOR.sup.6)CH.sub.2 CH.sub.2 COOR.sup.7 wherein R.sup.6 and R.sup.7 each represents hydrogen or a hydrocarbon group which may be substituted; and n represents an integer of 1 to 4, or a salt thereof from compounds represented by the general formula: ##STR2## wherein X, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and n are the same as defined above; Y.sup.1 and Y.sup.2 each represents oxygen or sulfur atom; R.sup.8 and R.sup.9 each, being the same as or different from the other, represents a hydrocarbon group which may be substituted, or salts thereof by an intramolecular ring closure reaction to form a pyrrolopyrimidine ring and, if necessary, reducing the pyrrole ring thus formed to a pyrroline ring. The compounds are useful as antitumor agents.
摘要翻译：提供了用于制备由以下通式表示的新化合物的改进方法：其中环+ E，crc / A /代表可被氢化的吡咯环; X表示氨基，羟基或巯基; R 1，R 2和R 3各自彼此相同或不同，表示氢或可被取代的烷基，烯基或炔基; R4表示OR5，其中R5表示氢或可被取代的烃基或NHCH（COOR6）CH2CH2COOR7，其中R6和R7各自表示氢或可被取代的烃基; 其中X，R1，R2，R3，R4和n与上述定义相同; n表示1〜4的整数，或其盐由通式： Y1和Y2各自表示氧或硫原子; R 8和R 9各自相同或不同，表示可以被取代的烃基，或其盐通过分子内闭环反应形成吡咯并嘧啶环，如果需要，将由此形成的吡咯环还原成吡咯啉环。该化合物可用作抗肿瘤剂。

39. 发明授权

US5106974A Pyrrolopyrimidine derivatives 失效
标题翻译：吡咯烷酮衍生物
公开(公告)号：US5106974A
公开(公告)日：1992-04-21
申请号：US578258
申请日：1990-09-06
申请人： Hiroshi Akimoto , Takenori Hitaka , Tetsuo Miwa
发明人： Hiroshi Akimoto , Takenori Hitaka , Tetsuo Miwa
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： A compound of the formula ##STR1## wherein the ring A is a pyrrole or pyrroline ring, X is an amino group or a hydroxyl group, Y is a hydrogen atom, an amino group or a hydroxyl group, R is a hydrogen atom, a fluorine atom, an alkyl group, an alkenyl group or an alkynyl group, --COOR.sup.1 and --COOR.sup.2 are independently carboxyl groups which may be esterified and n is an integer of 2 to 4, and R may be different in each of the n repeating units, and salts thereof have excellent antitumor effects, and can be used as antitumor agents in mammals.

40. 发明授权

US4260608A Maytansinoids, pharmaceutical compositions thereof and methods of use thereof 失效
标题翻译：美登木素生物碱，其药物组合物及其使用方法
公开(公告)号：US4260608A
公开(公告)日：1981-04-07
申请号：US92953
申请日：1979-11-09
申请人： Osamu Miyashita , Hiroshi Akimoto
发明人： Osamu Miyashita , Hiroshi Akimoto
IPC分类号： A61K31/535 , A61P35/00 , C07D498/18 , C07D498/16
CPC分类号： C07D498/18
摘要： Novel maytansinoids of the formula: ##STR1## wherein R.sup.1 is hydrogen atom, an alkyl group which may optionally be substituted or a group of the formula: --A.sup.1 --Y.sup.1 wherein A.sup.1 is an alkylene group or a bond, and Y.sup.1 is a cycloalkyl, phenyl, indolyl or imidazolyl group which may optionally be substituted,R.sup.2 is hydrogen atom, an alkyl, cycloalkyl or benzyl group,R.sup.3 is hydrogen atom, an alkyl group which may optionally be substituted, alkoxy, bornyloxy, isobornyloxy, benzyloxy group or a group of the formula: --A.sup.2 --Y.sup.2 wherein A.sup.2 is an alkylene group or a bond, and Y.sup.2 is an alicyclic hydrocarbon, phenyl or heterocyclic group which may optionally be substituted,provided that R.sup.3 is not an unsubstituted C.sub.1-4 alkyl group when both R.sup.1 and R.sup.2 are methyl groups, have antimicrobial antimitotic and antitumor activities.
摘要翻译：新型美登木素素，其分子式如下：其中R 1为氢原子，可任意取代的烷基或下式基团-A1-Y1其中A1为亚烷基或键，Y1为环烷基，苯基，吲哚基或咪唑基，其可以任选被取代，R 2是氢原子，烷基，环烷基或苄基，R 3是氢原子，可任意被取代的烷基，烷氧基，苄氧基，其中A2是亚烷基或键，Y2是可任选被取代的脂环烃，苯基或杂环基，条件是当R 3不是未取代的C 1-4烷基时，和R2是甲基，具有抗微生物抗生素和抗肿瘤活性。

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