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    • 32. 发明授权
    • Scanning probe microscope and measuring method using same
    • 扫描探针显微镜及其测量方法
    • US09423416B2
    • 2016-08-23
    • US14416968
    • 2012-08-28
    • Akira NambuTsuyoshi YamamotoHideaki KoizumiTomihiro HashizumeSeiji Heike
    • Akira NambuTsuyoshi YamamotoHideaki KoizumiTomihiro HashizumeSeiji Heike
    • G01Q10/04G01Q30/02G01Q30/14G01Q60/22
    • G01Q10/04G01Q30/02G01Q30/14G01Q60/22
    • Provided is a scanning probe microscope that takes measurements at high spatial resolution on physical information such as array structure of water molecules at a specimen-culture fluid interface in a culture fluid as well as irregularities of the surface of a specimen and composition distribution and array structure of molecules, proteins, etc. even in the atmosphere, an ambient air, vacuum, among others. The scanning probe microscope includes: a probing needle (1); a specimen holder (11) in which a specimen (3) is mounted; an oscillator (2) that produces a periodic oscillation to change the probing needle position; a pulse oscillation type laser light source (27, 28) that emits light toward a spot, which is put under measurement by the probing needle, on the specimen; a detector (25) that measures intensity of output light which is output from the specimen by energy spectroscopy; and a control device (26). The control device decreases amplitude of the periodic oscillation to change the probing needle position by the oscillator, shortens a relative distance between the probing needle and the specimen, and synchronizes shortening of the distance between the probing needle and the specimen and emission of pulse oscillation laser light, thus optimizing efficiency of tip-enhanced detection.
    • 提供了一种扫描探针显微镜,其以高空间分辨率对物理信息进行测量,例如在培养液中的标本培养液界面处的水分子的阵列结构以及样品表面的不规则性以及组成分布和阵列结构 的分子,蛋白质等,甚至在大气中,环境空气,真空等。 扫描探针显微镜包括:探针(1); 其中安装有试样(3)的试样保持器(11) 振荡器(2),其产生周期性振荡以改变探针位置; 对被检测体进行测量的点发光的脉冲振荡型激光光源(27,28); 检测器(25),其通过能量谱测量从所述样本输出的输出光的强度; 和控制装置(26)。 控制装置减小周期性振荡的振幅,通过振荡器改变探针位置,缩短探针与试样之间的相对距离,同步缩短探针与试样之间的距离,并发出脉冲振荡激光 轻,从而优化提示增强检测的效率。
    • 33. 发明申请
    • SCANNING PROBE MICROSCOPE AND MEASURING METHOD USING SAME
    • 扫描探针显微镜和使用它的测量方法
    • US20150177275A1
    • 2015-06-25
    • US14416968
    • 2012-08-28
    • Akira NambuTsuyoshi YamamotoHideaki KoizumiTomihiro HashizumeSeiji Heike
    • Akira NambuTsuyoshi YamamotoHideaki KoizumiTomihiro HashizumeSeiji Heike
    • G01Q10/04
    • G01Q10/04G01Q30/02G01Q30/14G01Q60/22
    • Provided is a scanning probe microscope that takes measurements at high spatial resolution on physical information such as array structure of water molecules at a specimen-culture fluid interface in a culture fluid as well as irregularities of the surface of a specimen and composition distribution and array structure of molecules, proteins, etc. even in the atmosphere, an ambient air, vacuum, among others. The scanning probe microscope includes: a probing needle (1); a specimen holder (11) in which a specimen (3) is mounted; an oscillator (2) that produces a periodic oscillation to change the probing needle position; a pulse oscillation type laser light source (27, 28) that emits light toward a spot, which is put under measurement by the probing needle, on the specimen; a detector (25) that measures intensity of output light which is output from the specimen by energy spectroscopy; and a control device (26). The control device decreases amplitude of the periodic oscillation to change the probing needle position by the oscillator, shortens a relative distance between the probing needle and the specimen, and synchronizes shortening of the distance between the probing needle and the specimen and emission of pulse oscillation laser light, thus optimizing efficiency of tip-enhanced detection.
    • 提供了一种扫描探针显微镜,其以高空间分辨率对物理信息进行测量,例如在培养液中的标本培养液界面处的水分子的阵列结构以及样品表面的不规则性以及组成分布和阵列结构 的分子,蛋白质等,甚至在大气中,环境空气,真空等。 扫描探针显微镜包括:探针(1); 其中安装有试样(3)的试样保持器(11) 振荡器(2),其产生周期性振荡以改变探针位置; 对被检测体进行测量的点发光的脉冲振荡型激光光源(27,28); 检测器(25),其通过能量谱测量从所述样本输出的输出光的强度; 和控制装置(26)。 控制装置减小周期性振荡的振幅,通过振荡器改变探针位置,缩短探针与试样之间的相对距离,同步缩短探针与试样之间的距离,并发出脉冲振荡激光 轻,从而优化提示增强检测的效率。