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31. 发明授权

US09012462B2 Phosphorous derivatives as kinase inhibitors 有权
标题翻译：磷酸衍生物作为激酶抑制剂
公开(公告)号：US09012462B2
公开(公告)日：2015-04-21
申请号：US12736910
申请日：2009-05-21
申请人： Yihan Wang , Wei-Sheng Huang , Shuangying Liu , William C. Shakespeare , R. Mathew Thomas , Jiwei Qi , Feng Li , Xiaotian Zhu , Anna Kohlman , David C. Dalgarno , Jan Antoinette C. Romero , Dong Zou
发明人： Yihan Wang , Wei-Sheng Huang , Shuangying Liu , William C. Shakespeare , R. Mathew Thomas , Jiwei Qi , Feng Li , Xiaotian Zhu , Anna Kohlman , David C. Dalgarno , Jan Antoinette C. Romero , Dong Zou
IPC分类号： A61K31/506 , C07F9/30 , C07D239/48 , C07F9/6509 , C07F9/6512 , C07F9/6521 , C07F9/6558 , C07F9/6561 , C07F9/6568 , C07F9/6571
CPC分类号： C07F9/6533 , C07D239/48 , C07F9/58 , C07F9/650905 , C07F9/6512 , C07F9/6521 , C07F9/65218 , C07F9/65583 , C07F9/65586 , C07F9/6561 , C07F9/65616 , C07F9/65685 , C07F9/657172 , C07F9/65846
摘要： The invention features compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译：本发明的特征在于其中可变基团如本文所定义的通式（I）的化合物及其制备和用途。

32. 发明申请

US20110294806A1 AZAINDOLE DERIVATIVES AS KINASE INHIBITORS 有权
标题翻译：亚胺衍生物作为激酶抑制剂
公开(公告)号：US20110294806A1
公开(公告)日：2011-12-01
申请号：US12998873
申请日：2009-12-11
申请人： Jiwei Qi , Yihan Wang , Feng Li , William C. Shakespeare , Anna Kohlmann , David C. Dalgarno , Xiaotian Zhu
发明人： Jiwei Qi , Yihan Wang , Feng Li , William C. Shakespeare , Anna Kohlmann , David C. Dalgarno , Xiaotian Zhu
IPC分类号： A61K31/437 , A61P35/00 , A61K31/506 , C07D471/04 , A61K31/5377
CPC分类号： A61K31/44 , C07D471/04
摘要： This invention relates to compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译：本发明涉及其中可变基团如本文所定义的通式（I）的化合物及其制备和用途。

33. 发明申请

US20140045826A1 METHODS AND COMPOSITIONS FOR TREATING NEURODEGENERATIVE DISEASES 审中-公开
标题翻译：用于治疗神经损伤性疾病的方法和组合物
公开(公告)号：US20140045826A1
公开(公告)日：2014-02-13
申请号：US14009565
申请日：2012-04-06
申请人： William C. Shakespeare , Frank G. Haluska
发明人： William C. Shakespeare , Frank G. Haluska
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： C07D487/04 , A61K31/495 , C07D471/04
摘要： The invention discloses methods and compositions for treating or preventing neurodegenerative disease by administering a compound of Formula I: or a pharmaceutically acceptable salt, solvate or hydrate thereof, wherein the variables are defined as herein.
摘要翻译：本发明公开了通过给予式I化合物或其药学上可接受的盐，溶剂合物或水合物来治疗或预防神经变性疾病的方法和组合物，其中变量如本文所定义。

34. 发明授权

US06197963B1 Non-peptide peptidomimetics 有权
标题翻译：非肽肽模拟物
公开(公告)号：US06197963B1
公开(公告)日：2001-03-06
申请号：US09133546
申请日：1998-08-13
申请人： Ralph Hirschmann , John Hynes, Jr. , Maria A. Cichy-Knight , Rachel D. van Rijn , Paul A. Sprengeler , P. Grant Spoors , William C. Shakespeare , Sherrie Pietranico-Cole , Amos B. Smith, III
发明人： Ralph Hirschmann , John Hynes, Jr. , Maria A. Cichy-Knight , Rachel D. van Rijn , Paul A. Sprengeler , P. Grant Spoors , William C. Shakespeare , Sherrie Pietranico-Cole , Amos B. Smith, III
IPC分类号： C07D20910
CPC分类号： C07H3/02
摘要： Compounds are provided which are crossreactive with peptides such as those which bind G-protein-linked receptors, together with preparative and therapeutic methods therefor. The compounds have the general structure: wherein at least one of R1, R2, R3, R4, or R5 comprises a functional group which is chemically similar to that found in the peptide of interest.
摘要翻译：提供了与肽结合反应的化合物，例如结合G蛋白连接的受体的那些，以及与其制备和治疗方法。所述化合物具有以下通式结构：其中R 1，R 2，R 3，R 4或R 5中的至少一个包含与目的肽中发现的化学相似的官能团。

35. 发明申请

US20140066434A1 Methods and Compositions for Treating Parkinson's Disease 审中-公开
标题翻译：治疗帕金森病的方法和组合
公开(公告)号：US20140066434A1
公开(公告)日：2014-03-06
申请号：US14009511
申请日：2012-04-06
申请人： William C. Shakespeare
发明人： William C. Shakespeare
IPC分类号： C07D487/04 , C07D473/34 , C07D471/04
CPC分类号： C07D487/04 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/5025 , A61K31/519 , C07D471/04 , C07D473/34
摘要： The invention discloses methods and compositions for treating or preventing Parkinson's disease by administering a compound of Formula (I): or a pharmaceutically acceptable salt, solvate or hydrate thereof, wherein the variables are defined as herein.
摘要翻译：本发明公开了通过给予式（I）化合物或其药学上可接受的盐，溶剂化物或水合物来治疗或预防帕金森病的方法和组合物，其中变量如本文所定义。

36. 发明申请

US20120316137A1 Methods and Compositions for Treating Cancer 审中-公开
标题翻译：治疗癌症的方法和组成
公开(公告)号：US20120316137A1
公开(公告)日：2012-12-13
申请号：US13504251
申请日：2010-11-01
申请人： Wei-Sheng Huang , Victor M. Rivera , Timothy P. Clackson , William C. Shakespeare , Rachel M. Squillace , Joseph M. Gozgit
发明人： Wei-Sheng Huang , Victor M. Rivera , Timothy P. Clackson , William C. Shakespeare , Rachel M. Squillace , Joseph M. Gozgit
IPC分类号： A61K31/5025 , A61P35/02 , A61K31/553 , A61K31/5377 , A61K31/519 , A61K31/53 , A61P35/00 , A61K31/675
CPC分类号： C07D487/04 , A61K31/5025
摘要： The invention features methods, kits, and pharmaceutical compositions for treating cancer using 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)-methyl)-3-(trifluoromethyl)phenyl)benzamide.
摘要翻译：本发明的特征在于使用3-（咪唑并[1,2-b]哒嗪-3-基乙炔基）-4-甲基-N-（4 - （（4-甲基哌嗪-1-基）） - 甲基）-3-（三氟甲基）苯基）苯甲酰胺。

37. 发明授权

US08136438B2 Arborist's climbing rope 有权
标题翻译：植树枝爬绳
公开(公告)号：US08136438B2
公开(公告)日：2012-03-20
申请号：US12660786
申请日：2010-03-04
申请人： William C. Shakespeare
发明人： William C. Shakespeare
IPC分类号： D04C1/00
CPC分类号： A62B1/16 , A63B29/028 , D04C1/12 , D07B1/04 , D07B1/185 , D07B2201/102 , D07B2201/1096 , D07B2201/2056 , D07B2201/2057 , D07B2201/209 , D07B2501/2069 , D07B2801/24
摘要： An arborist's climbing rope in which an eye splice having a splice tuck can be formed at one end includes in one embodiment a core of polypropylene, a first braided tubular sheath of nylon disposed about the core and a second braided tubular sheath of a polyester disposed about the first braided tubular sheath, the cross-sectional diameter of the fiber material of the core area being in the range of 1 to 10% of the total cross-sectional diameter of the arborist's climbing rope. In forming the eye splice a portion of the core is intentionally removed near the eye splice to form a space within the first tubular sheath where the core has been removed and the splice tuck is buried in and substantially completely fills the space within the first tubular sheath where the core has been intentionally removed.
摘要翻译：其中具有接头折页的接头可以在其一端形成的一个手柄的攀爬绳包括在一个实施例中包括聚丙烯芯，设置在芯周围的第一编织尼龙管状护套和布置在其周围的聚酯的第二编织管状护套第一编织管状护套，芯部区域的纤维材料的横截面直径在该树冠攀爬绳的总横截面直径的1至10％的范围内。在形成眼睛接合时，芯部的一部分被有意地在眼睛接头附近移除，以在第一管状护套内形成空间，其中芯已经被移除，并且接合套被埋在第一管状护套中并基本上完全填充第一管状护套内的空间核心被故意删除的地方。

38. 发明申请

US20140024620A1 Methods for Inhibiting Cell Proliferation in EGFR-Driven Cancers 审中-公开
标题翻译：抑制EGFR驱动癌细胞增殖的方法
公开(公告)号：US20140024620A1
公开(公告)日：2014-01-23
申请号：US13878744
申请日：2011-10-14
申请人： David C. Dalgarno , William C. Shakespeare , Xiaotian Zhu , Victor M. Rivera , Juan J. Miret
发明人： David C. Dalgarno , William C. Shakespeare , Xiaotian Zhu , Victor M. Rivera , Juan J. Miret
IPC分类号： C07F9/6558 , C07D401/12 , C07F9/6568 , C07F9/6561
CPC分类号： C07F9/65583 , A61K31/505 , C07D401/12 , C07F9/6561 , C07F9/6568
摘要： The invention features a method for treating patients who have an EGFR-driven cancer, which is, or has become, refractory to a tyrosine kinase inhibitor, such as eriotinib and gefitinib, by administering a compound of formula (I) to the patient. The invention also features treating EGFR-driven cancers having an EGFR mutation identified herein.
摘要翻译：本发明的特征在于通过向患者施用式（I）化合物来治疗患有EGFR驱动的癌症的患者的方法，所述癌症已经或已经成为对酪氨酸激酶抑制剂如埃替替尼和吉非替尼难治的患者。本发明还特征在于治疗具有本文鉴定的EGFR突变的EGFR驱动的癌症。

39. 发明申请

US20100162882A1 Arborist's climbing rope 有权
标题翻译：植树枝爬绳
公开(公告)号：US20100162882A1
公开(公告)日：2010-07-01
申请号：US12660786
申请日：2010-03-04
申请人： William C. Shakespeare
发明人： William C. Shakespeare
IPC分类号： D04C1/00
CPC分类号： A62B1/16 , A63B29/028 , D04C1/12 , D07B1/04 , D07B1/185 , D07B2201/102 , D07B2201/1096 , D07B2201/2056 , D07B2201/2057 , D07B2201/209 , D07B2501/2069 , D07B2801/24
摘要： An arborist's climbing rope in which an eye splice having a splice tuck can be formed at one end includes in one embodiment a core of polypropylene, a first braided tubular sheath of nylon disposed about the core and a second braided tubular sheath of a polyester disposed about the first braided tubular sheath, the core cross-sectional diameter being in the range of 1 to 10% of the total cross-sectional diameter of the arborist's climbing rope. In forming the eye splice a portion of the core is intentionally removed near the eye splice to form a space within the first tubular sheath where the core has been removed and the splice tuck is buried in and substantially completely fills the space within the first tubular sheath where the core has been intentionally removed.
摘要翻译：其中具有接头折页的接头可以在其一端形成的一个手柄的攀爬绳包括在一个实施例中包括聚丙烯芯，设置在芯周围的第一编织尼龙管状护套和布置在其周围的聚酯的第二编织管状护套第一编织管状护套，芯横截面直径在树冠攀爬绳的总截面直径的1至10％的范围内。在形成眼睛接合时，芯部的一部分被有意地在眼睛接头附近移除，以在第一管状护套内形成空间，其中芯已经被移除，并且接合套被埋在第一管状护套中并基本上完全填充第一管状护套内的空间核心被故意删除的地方。

40. 发明授权

US07703372B1 Climbing rope 失效
标题翻译：爬绳
公开(公告)号：US07703372B1
公开(公告)日：2010-04-27
申请号：US11893066
申请日：2007-08-14
申请人： William C. Shakespeare
发明人： William C. Shakespeare
IPC分类号： D04C1/06
CPC分类号： D07B1/04 , A62B1/16 , A63B29/028 , D04C1/12 , D07B1/185 , D07B2201/102 , D07B2201/1096 , D07B2201/2051
摘要： A rope is disclosed that is firm for climbing purposes and in which the end of the rope can be spliced. The rope includes a core of a plurality of strands; a first braided tubular sheath disposed about the core; and a second braided tubular sheath disposed about the first braided tubular sheath. The plurality of strands fill at least a length of a center void formed in the first braided tubular sheath. The plurality of core strands are formed in an un-braided manner in at least one of twisted and non-twisted strands. At the splice the splice tucks fill the center void while the core strands fill only center void outside of the splice.
摘要翻译：公开了一种用于攀爬目的的绳索，绳索的末端可以被拼接。绳子包括多根股线的芯部; 设置在芯周围的第一编织管状护套; 以及围绕第一编织管状护套设置的第二编织管状护套。多个股线填充形成在第一编织管状护套中的中心空隙的至少一段长度。多个芯股线以非编织方式形成在绞合线和非绞合线中的至少一个中。在接合处，接头折叠填充中心空隙，而芯线仅填充接头外部的中心空隙。

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