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31. 发明授权

US07919627B2 Processes for the preparation of hydroxylamines 失效
标题翻译：制备羟胺的方法
公开(公告)号：US07919627B2
公开(公告)日：2011-04-05
申请号：US12135299
申请日：2008-06-09
申请人： Datong Tang , Yao-Ling Qiu , Heejin Kim , Yat Sun Or , Zhe Wang
发明人： Datong Tang , Yao-Ling Qiu , Heejin Kim , Yat Sun Or , Zhe Wang
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07D401/14
摘要： The present invention relates generally to novel methods for the synthesis of O-(6-pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine which is an essential reagent in the synthesis of one of the bridged erythromycin derivatives and their respective pharmaceutically acceptable salts in PCT Application WO 03/097659 A1. In particular, the present invention relates to processes and intermediates for the preparation of a compound of formula (Ia):
摘要翻译：本发明一般涉及合成O-（6-吡唑-1-基 - 吡啶-3-基甲基） - 羟胺的新方法，其是合成桥联红霉素衍生物之一及其各自药学上的必需试剂 PCT申请WO 03/097659 A1中的可接受的盐。特别地，本发明涉及制备式（Ia）化合物的方法和中间体：

32. 发明申请

US20050020823A1 23-O-substituted 5-O-mycaminosyltylonide derivatives 审中-公开
标题翻译： 23-O-取代的5-O-碳霉糖基海藻衍生物
公开(公告)号：US20050020823A1
公开(公告)日：2005-01-27
申请号：US10840948
申请日：2004-05-07
申请人： Ly Phan , Yao-Ling Qiu , Yat Or , Nha Vo , Tianying Jian , Ying Hou , Marina BusuyeK
发明人： Ly Phan , Yao-Ling Qiu , Yat Or , Nha Vo , Tianying Jian , Ying Hou , Marina BusuyeK
IPC分类号： A61P31/04 , C07H17/08
CPC分类号： C07H17/08
摘要： There are described novel 5-O-mycaminosyltylonide (OMT) analogs possessing increased antibacterial activity toward Gram positive and Gram negative bacteria as well as macrolide resistant Gram positives and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described are a method for treating bacterial infections by administering to a patient a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds
摘要翻译：描述了具有对革兰氏阳性和革兰氏阴性细菌以及大环内酯抗性革兰氏阳性和药学上可接受的组合物具有增加的抗细菌活性的新型5-O-碳霉糖基托伦（OMT）类似物，其包含治疗有效量的本发明化合物与药学上可接受的载体。还描述了通过向患者施用含有治疗有效量的本发明化合物的药物组合物和用于制备这些化合物的方法来治疗细菌感染的方法

33. 发明申请

US20120237480A1 2'ALLENE-SUBSTITUTED NUCLEOSIDE DERIVATIVES 有权
标题翻译： 2'-取代的核苷衍生物
公开(公告)号：US20120237480A1
公开(公告)日：2012-09-20
申请号：US13422268
申请日：2012-03-16
申请人： YAT SUN OR , Jun Ma , Guoqiang Wang , In Jong Kim , Jiang Long , Yao-Ling Qiu
发明人： YAT SUN OR , Jun Ma , Guoqiang Wang , In Jong Kim , Jiang Long , Yao-Ling Qiu
IPC分类号： A61K31/706 , C07H19/12 , C07H19/173 , C07H19/044 , C07H19/10 , C07H19/20 , C07H19/11 , C07H19/213 , A61K31/7076 , A61K31/708 , A61K31/7068 , A61K31/7072 , A61P31/14 , A61K38/21 , A61P31/04 , A61P31/10 , A61P35/00 , A61P37/02 , C07H19/073
CPC分类号： C07H19/06 , A61K31/7056 , A61K31/706 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K38/55 , A61K45/06 , A61K2300/00 , A61K31/426 , A61K31/13
摘要： The present invention relates to 2′-allene-substituted nucleoside derivatives of the general formula (I): As well as pharmaceutical compositions comprising such compounds and methods to treat or prevent an HIV infection, HBV infection, HCV infection or abnormal cellular proliferation, comprising administering said compounds or compositions. In addition, the present invention includes processes for the preparation of such compounds, and the related β-D and β-L-nucleoside derivatives.
摘要翻译：本发明涉及通式（I）的2'-连烯取代的核苷衍生物：以及包含这些化合物的药物组合物以及治疗或预防HIV感染，HBV感染，HCV感染或异常细胞增殖的方法，包括给药所述化合物或组合物。此外，本发明包括制备这些化合物的方法，以及相关的β-和β-半胱氨酸衍生物。

34. 发明授权

US08242156B2 Linked dibenzimidazole derivatives 有权
公开(公告)号：US08242156B2
公开(公告)日：2012-08-14
申请号：US12702802
申请日：2010-02-09
申请人： Yao-Ling Qiu , Ce Wang , Xiaowen Peng , Lu Ying , Yat Sun Or
发明人： Yao-Ling Qiu , Ce Wang , Xiaowen Peng , Lu Ying , Yat Sun Or
IPC分类号： A61K31/4184 , C07D403/04 , C07D235/14
CPC分类号： C07F9/65583 , A61K31/4184 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/423 , A61K31/4245 , A61K31/427 , A61K31/444 , A61K31/454 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C12N2770/24211
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

35. 发明申请

US20110189129A1 HEPATITIS C VIRUS INHIBITORS 有权
标题翻译： HEPATITIS C病毒抑制剂
公开(公告)号：US20110189129A1
公开(公告)日：2011-08-04
申请号：US13013212
申请日：2011-01-25
申请人： Yao-Ling Qiu , Ce Wang , Xiaowen Peng , Lu Ying , Hui Cao , Yat Sun Or
发明人： Yao-Ling Qiu , Ce Wang , Xiaowen Peng , Lu Ying , Hui Cao , Yat Sun Or
IPC分类号： A61K38/21 , C07D487/14 , A61K31/4188 , A61K31/7056 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/41 , A61K31/427 , A61K31/675 , A61K31/422 , A61K31/439 , A61K31/4196 , A61K31/4245 , A61K31/506 , A61P31/12 , C12N7/04 , A61K39/12 , A61P37/04 , A61P1/16 , A61P31/18 , A61K38/19
CPC分类号： C07D498/18 , C07D519/00 , C07F9/6561
摘要： The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, esters, or prodrugs thereof: Q-G-A-L-B—W (I), which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译：本发明公开了式（I）的化合物及其药学上可接受的盐，酯或前药：抑制含RNA病毒，特别是丙型肝炎病毒（HCV）的Q-G-A-L-B-W（I）因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

36. 发明申请

US20110064695A1 HEPATITIS C VIRUS INHIBITORS 有权
标题翻译： HEPATITIS C病毒抑制剂
公开(公告)号：US20110064695A1
公开(公告)日：2011-03-17
申请号：US12879025
申请日：2010-09-10
申请人： Yao-Ling Qiu , Ce Wang , Lu Ying , Xiaowen Peng , Yat Sun Or
发明人： Yao-Ling Qiu , Ce Wang , Lu Ying , Xiaowen Peng , Yat Sun Or
IPC分类号： A61K31/4178 , C07D403/14 , C07D401/14 , A61K31/444 , C07D405/14 , A61K31/4545 , C07D413/14 , A61K31/5377 , A61K31/496 , C07D417/14 , A61K31/427 , A61K31/506 , A61K38/21 , A61P31/14
CPC分类号： C07D233/64 , A61K31/4178 , A61K31/427 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K38/21 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D473/00 , C07D487/04 , C07D487/08 , C07F9/65583 , C12N2770/24211 , A61K2300/00
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention relates to novel antiviral compounds represented herein above, pharmaceutical compositions comprising such compounds, and methods for the treatment or prophylaxis of viral (particularly HCV) infection in a subject in need of such therapy with said compounds.
摘要翻译：本发明公开了式（I）化合物或其药学上可接受的盐，酯或前药：其抑制含RNA病毒，特别是丙型肝炎病毒（HCV）。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。本发明涉及上文所示的新的抗病毒化合物，包含这些化合物的药物组合物，以及用于治疗或预防需要用所述化合物治疗的受试者中的病毒（特别是HCV）感染的方法。

37. 发明申请

US20100260715A1 HEPATITIS C VIRUS INHIBITORS 有权
标题翻译： HEPATITIS C病毒抑制剂
公开(公告)号：US20100260715A1
公开(公告)日：2010-10-14
申请号：US12714576
申请日：2010-03-01
申请人： Yat Sun Or , Ce Wang , Lu Ying , Xiaowen Peng , Yao-Ling Qiu
发明人： Yat Sun Or , Ce Wang , Lu Ying , Xiaowen Peng , Yao-Ling Qiu
IPC分类号： A61K31/397 , C07D471/04 , A61K31/437 , C07D403/14 , A61K31/497 , C07D413/14 , A61K31/5377 , A61K31/506 , A61K38/21 , A61K38/19 , A61K39/00 , A61P31/12
CPC分类号： C07D401/14 , A61K38/212 , A61K38/215 , A61K38/217 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , A61K2300/00
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译：本发明公开了式（I）化合物或其药学上可接受的盐，酯或前药：其抑制含RNA病毒，特别是丙型肝炎病毒（HCV）。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

38. 发明申请

US20100135960A1 ANTIVIRAL ACYLSULFONAMIDE DERIVATIVES 审中-公开
标题翻译：抗病毒酰胺酰胺衍生物
公开(公告)号：US20100135960A1
公开(公告)日：2010-06-03
申请号：US12619974
申请日：2009-11-17
申请人： Yat Sun Or , Lu Ying , Ce Wang , Xiaowen Peng , Yao-Ling Qiu
发明人： Yat Sun Or , Lu Ying , Ce Wang , Xiaowen Peng , Yao-Ling Qiu
IPC分类号： A61K38/21 , A61K39/00 , A61K38/19 , A61K31/4439 , A61K31/427 , A61K31/422 , C07D401/02 , C07D417/02 , C07D413/02 , A61P31/14
CPC分类号： C07D417/14 , A61K38/21 , C07D231/12 , C07D401/12 , C07D413/12 , C07D417/12 , A61K2300/00
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention relates to novel antiviral compounds represented herein above, pharmaceutical compositions comprising such compounds, and methods for the treatment or prophylaxis of viral (particularly HCV) infection in a subject in need of such therapy with said compounds.
摘要翻译：本发明公开了式（I）化合物或其药学上可接受的盐，酯或前药：其抑制含RNA病毒，特别是丙型肝炎病毒（HCV）。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。本发明涉及上文所示的新的抗病毒化合物，包含这些化合物的药物组合物，以及用于治疗或预防需要用所述化合物治疗的受试者中的病毒（特别是HCV）感染的方法。

39. 发明申请

US20090326019A1 3,4-BICYCLIC PYRROLIDINE ANTIVIRALS 审中-公开
标题翻译： 3,4-双环吡啶类抗生素
公开(公告)号：US20090326019A1
公开(公告)日：2009-12-31
申请号：US12482804
申请日：2009-06-11
申请人： Yat Sun Or , Jiang Long , Ce Wang , Lu Ying , Yao-Ling Qiu
发明人： Yat Sun Or , Jiang Long , Ce Wang , Lu Ying , Yao-Ling Qiu
IPC分类号： A61K31/427 , C07D417/04 , C12N7/06 , A61P31/12
CPC分类号： C07D417/04 , A61K31/427 , A61K45/06 , A61K2300/00
摘要： The present invention discloses compounds of formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention relates to novel antiviral compounds represented herein above, pharmaceutical compositions comprising such compounds, and methods for the treatment or prophylaxis of viral (particularly HCV) infection in a subject in need of such therapy with said compounds.
摘要翻译：本发明公开了式（I）化合物或其药学上可接受的盐，酯或前药：其抑制含RNA病毒，特别是丙型肝炎病毒（HCV）。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。本发明涉及上文所示的新的抗病毒化合物，包含这些化合物的药物组合物，以及用于治疗或预防需要用所述化合物治疗的受试者中的病毒（特别是HCV）感染的方法。

40. 发明授权

US08188132B2 Linked dibenzimidazole derivatives 有权
标题翻译：连接的二苯并咪唑衍生物
公开(公告)号：US08188132B2
公开(公告)日：2012-05-29
申请号：US12702692
申请日：2010-02-09
申请人： Yat Sun Or , Ce Wang , Xiaowen Peng , Lu Ying , Yao-Ling Qiu
发明人： Yat Sun Or , Ce Wang , Xiaowen Peng , Lu Ying , Yao-Ling Qiu
IPC分类号： A61K31/4184 , C07D403/04 , C07D235/14
CPC分类号： A61K31/4184 , A61K31/427 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5377 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译：本发明公开了式（I）化合物或其药学上可接受的盐，酯或前药：其抑制含RNA病毒，特别是丙型肝炎病毒（HCV）。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

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