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31. 发明授权

US5804411A Polypeptide of protein P140 and DNAS encoding it 失效
标题翻译：蛋白质P140的多肽和编码它的DNAS
公开(公告)号：US5804411A
公开(公告)日：1998-09-08
申请号：US571785
申请日：1995-12-13
申请人： Hisao Tajima , Koichiro Kitagawa , Hiroyuki Ohno
发明人： Hisao Tajima , Koichiro Kitagawa , Hiroyuki Ohno
IPC分类号： A61K38/00 , C07K14/47 , C12N1/21 , C12N15/12 , C12P21/08 , C12P21/02 , C07H21/04 , C12N15/63
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention is related to a novel protein p140 polypeptide which is a key protein involved in the signal transmission system of insulin; method for preparation of it; DNA encoding the said polypeptide; vector derived the said DNA; host cells transformed the said vector; antibody of the said polypeptide; pharmaceutical composition containing the said peptide or antibody; method for the prevention and/or treatment of diabetes, which is characterized by tyrosine phosphorylation of the said protein p140; agent for the prevention and/or treatment of diabetes, agent for the prevention and/or treatment of diabetes, which is characterized by containing a compound which can tyrosine phosphorylate of protein p140, as active ingredient and the screening methods of the said prevention and/or treatment agent. Tyrosine phosphorylation of protein p140 is an essential step in the induction of hypoglycemia by glucose uptake. Method and agent of prevention and/or treatment based on tyrosine phosphorylation of protein p140 in the present invention is not only to improve the diabetes-derived hypoglycemic conditions but are also useful for the treatment and/or prevention of diabetes, especially non-insulin dependent diabetes mellitus (NIDDM).
摘要翻译：本发明涉及胰岛素信号传递系统中涉及的关键蛋白质的新型蛋白质p140多肽，制备方法编码所述多肽的DNA; 载体衍生所述DNA; 宿主细胞转化所述载体; 所述多肽的抗体; 含有所述肽或抗体的药物组合物; 用于预防和/或治疗糖尿病的方法，其特征在于所述蛋白质p140的酪氨酸磷酸化; 用于预防和/或治疗糖尿病的药剂，用于预防和/或治疗糖尿病的药剂，其特征在于含有可以将蛋白质p140的酪氨酸磷酸化的化合物作为活性成分，以及所述预防和/ 或治疗剂。蛋白质p140的酪氨酸磷酸化是通过葡萄糖摄取诱导低血糖的关键步骤。基于本发明的蛋白质p140的酪氨酸磷酸化的预防和/或治疗方法和药剂不仅可改善糖尿病衍生的低血糖状况，而且可用于治疗和/或预防糖尿病，特别是非胰岛素依赖性糖尿病（NIDDM）。

32. 发明授权

US5587817A Liquid crystal panel unit having liquid crystal panel affixed to panel fixing using adhesive and height-regulating pins 失效
标题翻译：液晶面板单元具有使用粘合剂和高度调节销固定在面板固定上的液晶面板
公开(公告)号：US5587817A
公开(公告)日：1996-12-24
申请号：US228274
申请日：1994-04-15
申请人： Takao Miyamoto , Hisao Tajima
发明人： Takao Miyamoto , Hisao Tajima
IPC分类号： G02F1/13 , G02F1/1333 , G09F9/00
CPC分类号： G02F1/1333 , G02F2001/133354
摘要： A liquid crystal panel is fixed onto a fixing plate through a reduced number of operational steps by disposing in advance a plurality of height-regulating pins on the fixing plate so as to facilitate the control of a spacing between the liquid crystal panel and the fixing plate before the curing of an adhesive between the liquid crystal panel and the fixing plate. The height-regulating pins after the curing of the adhesive are removed, e.g., by thermal melt-cutting or ultrasonic cutting.
摘要翻译：通过在固定板上预先设置多个高度调节销以便于控制液晶面板和固定板之间的间隔，通过减少操作步骤将液晶面板固定在固定板上在液晶面板和固定板之间的粘合剂固化之前。粘合剂固化后的高度调节销例如通过热熔切割或超声波切割被去除。

33. 发明授权

US07608411B2 Prostaglandin receptor EP1 失效
标题翻译：前列腺素受体EP1
公开(公告)号：US07608411B2
公开(公告)日：2009-10-27
申请号：US11470213
申请日：2006-09-05
申请人： Hisao Tajima
发明人： Hisao Tajima
IPC分类号： G01N33/53
CPC分类号： G01N33/88 , A61K38/00 , A61K2039/505 , C07K14/72 , C07K16/2869
摘要： (1) A novel polypeptide prostaglandin E receptor, (2) a cDNA encoding the polypeptide and a fragment selectively hybridized to the sequence of the cDNA, (3) a replication or expression vector carrying the DNA, (4) a host cell transformed with the replication or the expression vector, (5) a method for producing the polypeptide which comprises culturing the host cells, (6) a monoclonal or polyclonal antibody against the polypeptide, (7) a pharmaceutical composition containing the polypeptide or the antibody, in association with pharmaceutically acceptable excipient and/or antibody, (8) a screening method for a compound having agonistic or antagonistic activity against EP1, comprising using the polypeptide or the host cell.The polypeptide of the present invention can be used for treating diseases, which is caused by over production of PGE2, such as pain, fever and pollakiuria.
摘要翻译：（1）一种新的多肽前列腺素E受体，（2）编码多肽的cDNA和与cDNA序列有选择性杂交的片段，（3）载有DNA的复制或表达载体，（4）复制或表达载体，（5）生产多肽的方法，其包括培养宿主细胞，（6）针对多肽的单克隆抗体或多克隆抗体，（7）包含多肽或抗体的药物组合物与药学上可接受的赋形剂和/或抗体，（8）对EP1具有激动作用或拮抗活性的化合物的筛选方法，包括使用多肽或宿主细胞。本发明的多肽可用于治疗由过度产生PGE2引起的疾病，例如疼痛，发热和尿频。

34. 发明申请

US20070167490A1 Imino ether derivative compounds and drugs containing the compounds as the active ingredient 审中-公开
标题翻译：亚胺基醚衍生物化合物和含有这些化合物作为活性成分的药物
公开(公告)号：US20070167490A1
公开(公告)日：2007-07-19
申请号：US10548650
申请日：2004-03-12
申请人： Akiharu Ishida , Shinya Kusuda , Yoshisuke Nakayama , Hisao Tajima , Tomoyuki Kido , Tetsuya Kitamine
发明人： Akiharu Ishida , Shinya Kusuda , Yoshisuke Nakayama , Hisao Tajima , Tomoyuki Kido , Tetsuya Kitamine
IPC分类号： A61K31/4439 , A61K31/44 , A61K31/381 , A61K31/415
CPC分类号： C07D213/30 , C07C251/54 , C07D207/20 , C07D209/08 , C07D211/70 , C07D213/50 , C07D213/53 , C07D213/55 , C07D231/12 , C07D233/54 , C07D249/08 , C07D257/04 , C07D277/04 , C07D295/13 , C07D307/52 , C07D319/08 , C07D333/22 , C07D403/12 , C07D407/10 , C07D407/12 , C07D409/04 , C07D417/10
摘要： The compound represented by formula (I) (wherein R1 and R2 are cyclic group which may have a substituent(s) and so on; W is a spacer of which main chain has an atom number of 1-6.; X is —O— and so on; ring A is cyclic group which may have a substituent(s); Y is a spacer of which main chain has an atom number of 1-6 and so on; Z is acidic group.) a salt thereof, a solvent thereof or an N-oxide thereof, or a prodrug thereof Since the compounds in the present invention have a regulatory activity for peroxisome proliferator activated receptor, the compounds in the present invention are useful as a preventive and/or therapeutic agent for diseases associating metabolic disorders (e.g., hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipidemia, atherosclerosis, hypertension, circulatory diseases, overeating, ischemic heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or a VLDL cholesterol-lowering agent and a drug for relief from risk factors of diabetes or metabolic syndrom.
摘要翻译：由式（I）表示的化合物（其中R 1和R 2）是可以具有取代基等的环状基团; W是其中的间隔基主链的原子数为1-6; X为-O-等;环A为可具有取代基的环状基团; Y为主链的原子数为1〜 6等等; Z是酸性基团）其盐，其溶剂或其N-氧化物或其前药由于本发明的化合物对过氧化物酶体增殖物激活受体具有调节活性，所以化合物本发明可用作将代谢紊乱（例如高胆固醇血症，高脂蛋白血症等），高脂血症，动脉粥样硬化，高血压，循环系统疾病，暴饮暴食，缺血性心脏病等相关的疾病的预防和/或治疗剂，HDL胆固醇 - 升高剂，LDL胆固醇和/或VLDL胆固醇降低剂和用于缓解ris的药物 k因素糖尿病或代谢综合征。

35. 发明授权

US07220864B2 Dihydronaphthalene derivative compounds and agent comprising the derivative as active ingredient 失效
标题翻译：二氢萘衍生物化合物和包含该衍生物作为活性成分的试剂
公开(公告)号：US07220864B2
公开(公告)日：2007-05-22
申请号：US10451679
申请日：2001-12-21
申请人： Hisao Tajima , Yoshisuke Nakayama , Daikichi Fukushima
发明人： Hisao Tajima , Yoshisuke Nakayama , Daikichi Fukushima
IPC分类号： C07D263/32
CPC分类号： C07D407/04 , C07D263/32 , C07D277/40 , C07D277/42 , C07D413/04 , C07D413/12 , C07D417/04
摘要： The compound 3-(5-(2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)ethoxy)-3,4-dihydronaphthalene-1-yl)propanoic acid or a nontoxic salt thereof. Because this compound has activity of regulating peroxisome proliferators activated receptor regulator, it is useful as a hyperglycemic agent, a hypolipidemic agent, a preventative and/or treatment agent for diseases associated with metabolic disorders etc.
摘要翻译：化合物3-（5-（2-（2-（4-甲基苯基）-5-甲基恶唑-4-基）乙氧基）-3,4-二氢萘-1-基）丙酸或其无毒盐。因为这种化合物具有调节过氧化物酶体增殖物激活受体调节剂的活性，所以它可用作高血糖剂，降血脂剂，与代谢紊乱相关疾病的预防和/或治疗剂。

36. 发明申请

US20070105959A1 Cynnamyl alcohol derivative compounds and drugs containing the compounds as active ingredient 审中-公开
标题翻译：辛醇衍生物化合物和含有这些化合物的药物作为活性成分
公开(公告)号：US20070105959A1
公开(公告)日：2007-05-10
申请号：US10548474
申请日：2004-03-10
申请人： Shinya Kusuda , Yoshisuke Nakayama , Hisao Tajima , Sachiko Kato
发明人： Shinya Kusuda , Yoshisuke Nakayama , Hisao Tajima , Sachiko Kato
IPC分类号： A61K31/192 , C07C62/30
CPC分类号： C07D277/24 , A61K31/192 , A61K31/222 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/4409 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07C51/00 , C07C69/734 , C07C235/34 , C07C255/37 , C07C311/51 , C07C323/19 , C07D211/18 , C07D213/30 , C07D213/55 , C07D257/04 , C07D263/32 , C07D271/07 , C07D277/30 , C07D277/42 , C07D277/64 , C07D285/08 , C07D291/04 , C07D317/54 , C07D333/24 , C07D413/04 , C07D413/10
摘要： A compound represented by formula (I) (wherein all the symbols are as defined in the specification) or a salt thereof Since the compound represented by formula (I) or a salt thereof has a regulatory activity for peroxisome proliferator activated receptor, the compound represented by formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or therapeutic agent for diseases associating metabolic disorders (e.g., diabetes, adiposity, metabolic syndrome, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipidemia, atherosclerosis, hypertension, circulatory diseases, overeating, ischemic heart diseases, etc., a HDL cholesterol-elevating agent, a LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diabetes or metabolic syndrome.
摘要翻译：由式（I）表示的化合物或其盐由式（I）表示的化合物（其中所有符号如说明书中所定义）或其盐由于由式（I）表示的化合物或其盐具有对过氧化物酶体增殖物激活受体的调节活性，式（I）可用作降血糖剂，降血脂剂，与代谢紊乱（例如糖尿病，肥胖，代谢综合征，高胆固醇血症，高脂蛋白血症等）相关疾病，预防和/或治疗剂，高脂血症，动脉粥样硬化，高血压，循环系统疾病，暴饮暴食，缺血性心脏病等，HDL胆固醇升高剂，LDL胆固醇和/或VLDL胆固醇降低剂以及用于缓解糖尿病或代谢综合征危险因素的药物。

37. 发明授权

US07034902B2 Image display system, image display apparatus and peripheral devices of image display apparatus 有权
标题翻译：图像显示系统，图像显示装置和图像显示装置的外围设备
公开(公告)号：US07034902B2
公开(公告)日：2006-04-25
申请号：US09941592
申请日：2001-08-30
申请人： Hisao Tajima
发明人： Hisao Tajima
IPC分类号： H04N5/64
CPC分类号： G06F1/1601 , G06F1/1605 , G06F1/1607 , G06F2200/1612 , H04N5/64 , H04N5/642 , Y10S248/918
摘要： An image display system has an image display apparatus and a peripheral device that can be mounted on the image display apparatus. The image display apparatus includes a first electrode for electrically connecting the image display apparatus and peripheral device, and the peripheral device includes a second electrode for electrically connecting the image display apparatus and peripheral device. These electrodes are placed so as to have contact with one another when the peripheral device is mounted on the image display apparatus. In addition, the image display system moves the mounting position of the peripheral device on the image display apparatus as appropriate. The system minimizes cables used for electrical connections between the image display apparatus and peripheral devices, makes the apparatus compact and allows adoption of a variety of layouts.
摘要翻译：图像显示系统具有能够安装在图像显示装置上的图像显示装置和外围装置。图像显示装置包括用于电连接图像显示装置和外围装置的第一电极，并且外围装置包括用于电连接图像显示装置和外围装置的第二电极。当外围设备安装在图像显示装置上时，这些电极被放置成彼此接触。此外，图像显示系统适当地移动图像显示装置上的外围设备的安装位置。该系统最小化了用于图像显示设备和外围设备之间的电气连接的电缆，使设备紧凑并允许采用各种布局。

38. 发明申请

US20050250824A1 Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient 失效
标题翻译：羧酸衍生物和含有该衍生物作为活性成分的药物组合物
公开(公告)号：US20050250824A1
公开(公告)日：2005-11-10
申请号：US11178639
申请日：2005-07-12
申请人： Hisao Tajima , Yoshisuke Nakayama , Daikichi Fukushima
发明人： Hisao Tajima , Yoshisuke Nakayama , Daikichi Fukushima
IPC分类号： A61K31/00 , A61K31/421 , C07C59/66 , C07C59/68 , C07C59/72 , C07C323/52 , C07D213/30 , C07D213/65 , C07D263/32 , C07D263/34 , C07D263/48 , C07D277/24 , C07D317/54 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/10
CPC分类号： C07D213/30 , A61K31/00 , C07C59/66 , C07C59/68 , C07C59/72 , C07C323/52 , C07D213/65 , C07D263/32 , C07D263/34 , C07D263/48 , C07D277/24 , C07D317/54 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/10
摘要： A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as active ingredient. Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or a remedy for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diseases or syndrome X.
摘要翻译：含有式（I）的羧酸衍生物（其中所有符号如说明书中所定义），其无毒性酸或其水合物作为活性成分的过氧化物酶体增殖物激活受体调节剂。由于具有调节PPAR的作用，式（I）化合物可用作降血糖剂，降血脂药，用于代谢紊乱（糖尿病，肥胖症，综合征X，高胆固醇血症，高脂蛋白血症）的疾病的预防和/或补救措施等），高脂血症，动脉粥样硬化，高血压，循环系统疾病，暴饮暴食，冠心病等，HDL胆固醇升高剂，LDL胆固醇和/或VLDL胆固醇降低剂和用于缓解危险因素的药物疾病或综合征X.

39. 发明授权

US06664281B1 Carboxylic acid derivatives and drugs containing the same as the active ingredient 失效
标题翻译：羧酸衍生物和含有与活性成分相同的药物
公开(公告)号：US06664281B1
公开(公告)日：2003-12-16
申请号：US09763575
申请日：2001-02-26
申请人： Hisao Tajima , Yoshisuke Nakayama , Daikichi Fukushima
发明人： Hisao Tajima , Yoshisuke Nakayama , Daikichi Fukushima
IPC分类号： C07D26332
CPC分类号： C07D413/04 , C07D263/32 , C07D493/08
摘要： A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as active ingredient. Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or a remedy for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diabetes or syndrome X.
摘要翻译：含有式（I）的羧酸衍生物（其中所有符号如本说明书中所定义），其无毒性酸或其水合物作为活性成分的过氧化物酶体增殖物激活受体调节剂。由于具有调节PPAR的作用，式（I）化合物可用作降血糖药，降血脂药，与代谢紊乱相关疾病（糖尿病，肥胖症，综合征X，高胆固醇血症，高脂蛋白血症等），高脂血症，动脉粥样硬化的预防和/或补救措施高血压，循环系统疾病，暴饮暴食，冠心病等，HDL胆固醇升高剂，LDL胆固醇和/或VLDL胆固醇降低剂以及用于缓解糖尿病或综合征X危险因素的药物。

40. 发明授权

US06494429B2 Panel support structure, display panel supported by panel support structure, and image forming apparatus using display panel 失效
标题翻译：面板支撑结构，由面板支撑结构支撑的显示面板，以及使用显示面板的图像形成装置
公开(公告)号：US06494429B2
公开(公告)日：2002-12-17
申请号：US09127977
申请日：1998-08-03
申请人： Hisao Tajima
发明人： Hisao Tajima
IPC分类号： A47F114
CPC分类号： G09F15/00 , G09F7/18 , Y10S248/903 , Y10S248/918
摘要： A panel support structure for supporting a flat display panel capable of reducing the weight of the panel support structure while a sufficient structural strength is maintained and capable of preventing the display performance of the flat display panel from being lowered by a change in an ambient temperature. A flat display panel is fixedly supported by an X-character shaped supporting member via dampers fitted in the four corners of the flat display panel by the flat panel fixing parts of the supporting member. The supporting member is disposed along diagonal lines extending between the four corners of the flat display panel and has a rectangular cross section whose longer side is directed in the thickness direction of the flat display panel.
摘要翻译：一种用于支撑平板显示面板的面板支撑结构，其能够在保持足够的结构强度的同时减小面板支撑结构的重量，并且能够通过环境温度的变化来防止平板显示面板的显示性能降低。平板显示面板通过由平板显示面板的四个角落中的阻尼器由支撑构件的平板固定部分固定地支撑在X字形支撑构件上。支撑构件沿着在平面显示面板的四个角之间延伸的对角线布置，并且具有矩形横截面，其长边在平板显示面板的厚度方向上指向。

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