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31. 发明授权

US07652041B2 Cinnamide and hydrocinnamide derivatives with kinase inhibitory activity 失效
标题翻译：具有激酶抑制活性的辛酰胺和氢化己内酰胺衍生物
公开(公告)号：US07652041B2
公开(公告)日：2010-01-26
申请号：US11332674
申请日：2006-01-12
申请人： Ruth S. Adams , Emily F. Calderwood , Alexandra E. Gould , Paul D. Greenspan , Matthew J LaMarche , Yuan Tian , Tricia J. Vos
发明人： Ruth S. Adams , Emily F. Calderwood , Alexandra E. Gould , Paul D. Greenspan , Matthew J LaMarche , Yuan Tian , Tricia J. Vos
IPC分类号： C07D403/02 , C07D413/02 , A61K31/44
CPC分类号： C07D213/73 , C07D213/56 , C07D213/68 , C07D213/74 , C07D213/75 , C07D213/78 , C07D213/79 , C07D213/81 , C07D213/84 , C07D231/18 , C07D233/32 , C07D237/24 , C07D239/34 , C07D239/47 , C07D261/12 , C07D277/64 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D473/02 , C07D473/30 , C07D487/04
摘要： The present invention provides novel cinnamide compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
摘要翻译：本发明提供了可用作蛋白激酶抑制剂的新颖的肉桂酰胺化合物。本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。

32. 发明申请

US20070144915A1 PROCESS AND COMPOSITION FOR PASSIVATING A SUBSTRATE DURING ELECTROCHEMICAL MECHANICAL POLISHING 审中-公开
标题翻译：电化学机械抛光过程中用于剥离基材的方法和组合
公开(公告)号：US20070144915A1
公开(公告)日：2007-06-28
申请号：US11613918
申请日：2006-12-20
申请人： Yuan Tian , Renhe Jia , Feng Liu , Yongqi Hu , Stan Tsai , Liang-Yuh Chen , Robert Ewald
发明人： Yuan Tian , Renhe Jia , Feng Liu , Yongqi Hu , Stan Tsai , Liang-Yuh Chen , Robert Ewald
IPC分类号： B23H7/00 , H05K3/07
CPC分类号： C25F3/02 , B23H5/08 , H01L21/32125
摘要： Compositions and methods for processing a substrate having a conductive material layer disposed thereon are provided. In one embodiment, a method of electrochemically processing a substrate using a conductive polishing article is provided. The method includes disposing a substrate having a conductive material layer formed thereon in a process apparatus comprising a cathode coupled to the conductive polishing article and an anode, wherein the substrate is in electrical contact with the anode, supplying a polishing composition comprising a cathodic inhibitor and an anodic inhibitor, forming a protective film on the cathode to prevent corrosion of the cathode, and polishing the substrate. In another embodiment, a composition for processing a substrate having a conductive material layer disposed thereon is provided which composition includes a corrosion inhibitor selected from the group of an amino acid based inhibitor, a polymeric based corrosion inhibitor, an oxidizer, a chelating inhibitor or combinations thereof.
摘要翻译：提供了用于处理其上设置有导电材料层的基板的组合物和方法。在一个实施例中，提供了使用导电抛光制品电化学处理衬底的方法。该方法包括将包括形成在其上的导电材料层的衬底放置在包括耦合到导电抛光制品的阴极和阳极的处理装置中，其中衬底与阳极电接触，提供包含阴极抑制剂的抛光组合物，阳极抑制剂，在阴极上形成保护膜以防止阴极腐蚀，并抛光衬底。在另一个实施方案中，提供了一种用于处理其上设置有导电材料层的基材的组合物，其组成包括选自氨基酸基抑制剂，聚合物基腐蚀抑制剂，氧化剂，螯合抑制剂或组合的腐蚀抑制剂其中。

33. 发明申请

US20060169597A1 Method and composition for polishing a substrate 审中-公开
标题翻译：抛光基材的方法和组合物
公开(公告)号：US20060169597A1
公开(公告)日：2006-08-03
申请号：US11356352
申请日：2006-02-15
申请人： Feng Liu , Tianbao Du , Alain Duboust , Wei-Yung Hsu , Robert Ewald , Yuan Tian , You Wang , Stan Tsai
发明人： Feng Liu , Tianbao Du , Alain Duboust , Wei-Yung Hsu , Robert Ewald , Yuan Tian , You Wang , Stan Tsai
IPC分类号： B23H9/00 , B23H7/00
CPC分类号： C25F3/02 , B23H5/08
摘要： Polishing compositions and methods for removing conductive materials from a substrate surface are provided. In one aspect, a composition includes an acid based electrolyte system, a corrosion inhibitor having an azole group, an organic acid salt, a pH adjusting agent to provide a pH between about 2 and about 10, and a solvent, and a solvent. The composition may be used in a conductive material removal process including disposing a substrate having a conductive material layer formed thereon in a process apparatus comprising an electrode, providing the composition between the electrode and substrate, applying a bias between the electrode and the substrate, and removing conductive material from the conductive material layer. The polishing compositions and methods described herein improve the effective removal rate of materials from the substrate surface, such as copper, with a reduction in planarization type defects and yielding a desirable surface finish.
摘要翻译：提供了抛光组合物和从衬底表面去除导电材料的方法。在一个方面，组合物包括酸基电解质体系，具有唑基的腐蚀抑制剂，有机酸盐，pH调节剂以提供约2至约10的pH以及溶剂和溶剂。该组合物可以用于导电材料去除工艺中，包括在包括电极的工艺设备中设置其上形成有导电材料层的衬底，在电极和衬底之间提供组合物，在电极和衬底之间施加偏压，以及从导电材料层去除导电材料。本文所述的抛光组合物和方法提高了材料从衬底表面（例如铜）的有效去除速率，同时平坦化型缺陷减少并产生理想的表面光洁度。

34. 发明申请

US20060021974A1 Method and composition for polishing a substrate 审中-公开
标题翻译：抛光基材的方法和组合物
公开(公告)号：US20060021974A1
公开(公告)日：2006-02-02
申请号：US10948958
申请日：2004-09-24
申请人： Feng Liu , Stan Tsai , Martin Wohlert , Yuan Tian , Renhe Jia , Yongqi Hu , Liang-Yuh Chen
发明人： Feng Liu , Stan Tsai , Martin Wohlert , Yuan Tian , Renhe Jia , Yongqi Hu , Liang-Yuh Chen
IPC分类号： C03C15/00 , C09K13/00
CPC分类号： H01L21/7684 , C25F3/16 , C25F3/26 , H01L21/32125
摘要： Polishing compositions and methods for removing conductive materials from a substrate surface are provided. In one aspect, a composition is provided for removing at least a conductive material from a substrate surface including sulfuric acid or derivative, phosphoric acid or derivative, a first chelating agent including an organic salt, a pH adjusting agent to provide a pH between about 2 and about 10 and a solvent. The composition may further include a second chelating agent. The composition may be used in a single step or two step electrochemical mechanical planarization process. The polishing compositions and methods described herein improve the effective removal rate of materials from the substrate surface, such as tungsten, with a reduction in planarization type defects.
摘要翻译：提供了抛光组合物和从衬底表面去除导电材料的方法。在一个方面，提供一种组合物，用于从包括硫酸或衍生物，磷酸或衍生物的底物表面至少去除导电材料，包括有机盐的第一螯合剂，pH调节剂以提供约2 约10和溶剂。组合物还可以包括第二螯合剂。组合物可以用于单步或两步电化学机械平面化工艺。本文所述的抛光组合物和方法提高了材料从衬底表面（例如钨）的有效去除速率，同时平坦化型缺陷的减少。

35. 发明申请

US20050092680A1 Purification of silicone containing compounds by supercritical fluid extraction 失效
标题翻译：通过超临界流体萃取法纯化含硅化合物
公开(公告)号：US20050092680A1
公开(公告)日：2005-05-05
申请号：US10699417
申请日：2003-10-31
申请人： Shivkumar Mahadevan , Frank Molock , Robert Ward , Yuan Tian , Shanger Wang , James Serpilio
发明人： Shivkumar Mahadevan , Frank Molock , Robert Ward , Yuan Tian , Shanger Wang , James Serpilio
IPC分类号： C07F7/20 , C02F1/26
CPC分类号： C08G77/34 , C07F7/20 , Y02P20/544
摘要： The present invention relates to a process for the purification of silicone containing compounds via supercritical fluid extraction. Specifically, the present invention relates to a process comprising the steps of contacting at least one silicone containing compound with a supercritical fluid having a density of between about 0.2 and about 0.8 g/ml, decreasing said density so that two phases are formed a first phase comprising said at least one silicone containing compound and a second phase comprising at least one impurity and separating said second phase from said first phase.
摘要翻译：本发明涉及通过超临界流体萃取纯化含硅氧烷化合物的方法。具体地说，本发明涉及一种方法，该方法包括以下步骤：使至少一种含硅氧烷的化合物与密度为约0.2至约0.8g / ml的超临界流体接触，降低所述密度，使得两相形成第一相包括所述至少一种含硅氧烷化合物和包含至少一种杂质的第二相，并将所述第二相与所述第一相分离。

36. 发明申请

US20050077188A1 Endpoint for electrochemical processing 审中-公开
标题翻译：电化学处理终点
公开(公告)号：US20050077188A1
公开(公告)日：2005-04-14
申请号：US10940603
申请日：2004-09-14
申请人： Daxin Mao , Renhe Jia , Zhihong Wang , Yuan Tian , Feng Liu , Vladimir Galburt , Sen Ko , Stan Tsai , Liang-Yuh Chen
发明人： Daxin Mao , Renhe Jia , Zhihong Wang , Yuan Tian , Feng Liu , Vladimir Galburt , Sen Ko , Stan Tsai , Liang-Yuh Chen
IPC分类号： B23H5/08 , B24B37/013 , B24B49/04 , B24B49/10 , C25F7/00 , H01L21/304 , H01L21/3063 , C25F3/00
CPC分类号： B24B37/013 , B23H5/08 , B24B49/04 , B24B49/10
摘要： A method and apparatus for electrochemically processing a substrate is provided. In one embodiment, a method for electrochemically processing a substrate includes the steps of establishing an electrically-conductive path through an electrolyte between an exposed layer of barrier material on the substrate and an electrode, electrochemically removing a portion of the exposed layer during a first electrochemical processing step in a barrier processing station, detecting an endpoint of the first electrochemical processing step at or just prior to breakthrough of the exposed layer of barrier material, electrochemically processing the exposed layer of barrier material in a second electrochemical processing step in the barrier processing station, and detecting an endpoint of the second electrochemical processing step.
摘要翻译：提供了一种用于电化学处理衬底的方法和设备。在一个实施例中，用于电化学处理衬底的方法包括以下步骤：在基底上的暴露的阻挡材料层与电极之间建立通过电解质的导电路径，在第一次电化学过程中电化学去除暴露层的一部分在屏障处理站中的处理步骤，在暴露的阻挡材料层的穿透之前或之前检测第一电化学处理步骤的端点，在屏障处理站中的第二电化学处理步骤中电化学处理阻挡材料的暴露层并且检测第二电化学处理步骤的端点。

37. 发明授权

US09023767B2 γ-Secretase substrates and methods of use 有权
标题翻译： γ-分泌酶底物和使用方法
公开(公告)号：US09023767B2
公开(公告)日：2015-05-05
申请号：US12776141
申请日：2010-05-07
申请人： Christopher Chad Shelton , Yuan Tian , Yueming Li
发明人： Christopher Chad Shelton , Yuan Tian , Yueming Li
IPC分类号： C40B30/04 , C07K14/47 , G01N33/542 , G01N33/573
CPC分类号： G01N33/573 , C07K14/4711 , G01N33/542 , G01N2333/4709 , G01N2333/948 , G01N2500/02 , G01N2800/2814 , G01N2800/2821
摘要： Polypeptide substrates based on modifications or fragments of the various APP isoforms, assay methods based on the use of these substrates, and screening methods directed toward identifying inhibitors of γ-secretase activity. The assay methods and the screening methods are adapted for use in high throughput multi-well plate assay apparatuses. In many embodiments the substrate polypeptides are labeled for ease of detection, and/or may bind specific ligands that themselves are labeled. Generally the labels promote high specificity as well as high sensitivity of detection. These features render the assay and screening methods that employ the labeled substrates especially suited for use in high throughput assay formats. This disclosure further identifies small polypeptides based on a subsequence motif of Aβ that are shown herein to be potent inhibitors of the activity of γ-secretase.
摘要翻译：基于各种APP同种型的修饰或片段的多肽底物，基于这些底物的使用的测定方法以及用于鉴定γ-分泌酶活性抑制剂的筛选方法。测定方法和筛选方法适用于高通量多孔板测定装置。在许多实施方案中，底物多肽被标记以便于检测，和/或可以结合其本身被标记的特异性配体。通常，标记物具有高度的特异性和高灵敏度的检测。这些特征使得使用标记底物的测定和筛选方法特别适用于高通量测定形式。本公开进一步基于A＆bgr的亚序列基序识别小多肽; 这在本文中显示为γ-分泌酶活性的有效抑制剂。

38. 发明授权

US07884171B2 Control of polymer surface molecular architecture via amphipathic endgroups 有权
标题翻译：通过两亲性端基控制聚合物表面分子结构
公开(公告)号：US07884171B2
公开(公告)日：2011-02-08
申请号：US12638371
申请日：2009-12-15
申请人： Robert S. Ward , Keith R. McCrea , Yuan Tian , James P. Parakka
发明人： Robert S. Ward , Keith R. McCrea , Yuan Tian , James P. Parakka
IPC分类号： C08G18/00 , C08G77/04 , C08G77/22
CPC分类号： C08G18/6287 , A61L27/18 , A61L29/06 , A61L31/06 , C08G18/0823 , C08G18/12 , C08G18/283 , C08G18/2865 , C08G18/289 , C08G18/5024 , C08G18/5039 , C08G18/6283 , C08G18/6795 , C08L75/04 , C08G18/3228
摘要： Polymers whose surfaces are modified by endgroups that include amphipathic surface-modifying moieties. An amphipathic endgroup of a polymer molecule is an endgroup that contains at least two moieties of significantly differing composition, such that the amphipathic endgroup spontaneously rearranges its positioning in a polymer body to position the moiety on the surface of the body, depending upon the composition of the medium with which the body is in contact, when that re-positioning causes a reduction in interfacial energy. An example of an amphipathic surface-modifying endgroup is one that has both a hydrophobic moiety and a hydrophilic moiety in a single endgroup. For instance, a hydrophilic poly(ethylene oxide) terminated with a hydrophilic hydroxyl group is not surface active in air when the surface-modifying endgroup is bonded to a more hydrophobic base polymer. If the hydroxyl group on the oligomeric poly(ethylene oxide) is replaced by a hydrophobic methoxy ether terminus, the poly(ethylene oxide) becomes surface active in air, and allows the poly(ethylene oxide) groups to crystallize in the air-facing surface. In this example, immersion in water destroys the crystallinity as the poly(ethylene oxide) sorbs water and the hydrophobic methoxy group retreats below the surface of the polymer. Also disclosed are methods and articles of manufacture that make use of these polymers.
摘要翻译：其表面被包括两亲表面改性部分的端基修饰的聚合物。聚合物分子的两亲端基是含有至少两个具有显着不同组成的部分的端基，使得两亲性端基在聚合物体中自发地重排其定位，以将该部分定位在身体的表面上，这取决于当该重新定位导致界面能量降低时，与身体接触的介质。两亲性表面改性端基的实例是在单个端基具有疏水部分和亲水部分的实例。例如，当表面改性端基键合到更疏水的基础聚合物上时，用亲水羟基封端的亲水性聚（环氧乙烷）在空气中不是表面活性的。如果低聚聚（环氧乙烷）上的羟基被疏水性甲氧基醚末端所代替，则聚（环氧乙烷）在空气中变得表面活性，并允许聚（环氧乙烷）基团在面向空气的表面中结晶。在该实施例中，当聚（环氧乙烷）吸附水和疏水性甲氧基在聚合物表面下方退缩时，浸入水中会破坏结晶度。还公开了利用这些聚合物的方法和制品。

39. 发明申请

US20100310605A1 ANTI-HCV VACCINE AND PREPARATION METHODS AND USES THEREOF 审中-公开
标题翻译：抗HCV疫苗及其制备方法及其用途
公开(公告)号：US20100310605A1
公开(公告)日：2010-12-09
申请号：US12809132
申请日：2007-12-18
申请人： Lai Wei , Yuan Tian
发明人： Lai Wei , Yuan Tian
IPC分类号： A61K39/29 , A61P31/14
CPC分类号： A61K39/29 , A61K39/12 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N2710/10343 , C12N2770/24222 , C12N2770/24234
摘要： An anti-HCV vaccine, which is prepared through recombination of an NS gene in series, including NS3/NS4 and NS4/NS5, with an adenovirus vector. The preparation methods and uses of the anti-HCV vaccine.
摘要翻译：通过将NS基因（包括NS3 / NS4和NS4 / NS5）与腺病毒载体重组而制备的抗HCV疫苗。抗HCV疫苗的制备方法和用途。

40. 发明授权

US07687586B2 Biosensor membrane material 有权
标题翻译：生物传感器膜材料
公开(公告)号：US07687586B2
公开(公告)日：2010-03-30
申请号：US11404528
申请日：2006-04-14
申请人： Robert S. Ward , Yuan Tian , W. Kenneth Ward , Ellen Anderson , Jody House
发明人： Robert S. Ward , Yuan Tian , W. Kenneth Ward , Ellen Anderson , Jody House
IPC分类号： C08G77/42
CPC分类号： C08G64/18 , C08G77/448 , C08G77/458
摘要： Embodiments of the present invention provide various multipolymers and permselective membranes for use with biosensors and other implantable medical devices and prostheses. Embodiments of the present invention may provide structural strength and integrity, and further may control the influx of glucose, oxygen and/or water. Embodiments of the present invention may, for example, minimize or reduce the influx of glucose by minimizing the percentage of hydrophilic segments, which in turn minimizes the percentage of water uptake and the degree of glucose transport.
摘要翻译：本发明的实施方案提供了用于生物传感器和其它可植入医疗装置和假体的各种多聚体和选择渗透膜。本发明的实施方案可以提供结构强度和完整性，并且还可以控制葡萄糖，氧气和/或水的流入。例如，本发明的实施方案可以通过使亲水段的百分比最小化来最小化或减少葡萄糖的流入，从而使吸水的百分比和葡萄糖转运的程度最小化。

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