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31. 发明授权

US08549933B2 All electric piezoelectric finger sensor (PEFS) for soft material stiffness measurement 有权
公开(公告)号：US08549933B2
公开(公告)日：2013-10-08
申请号：US13268225
申请日：2011-10-07
申请人： Wan Y. Shih , Wei-Heng Shih , Anna Markidou , Steven T. Szweczyk , Hakki Yegingil
发明人： Wan Y. Shih , Wei-Heng Shih , Anna Markidou , Steven T. Szweczyk , Hakki Yegingil
IPC分类号： G01L1/04
CPC分类号： G01N33/4833 , A61B5/0053 , A61B5/0057 , A61B5/4312 , A61B5/441 , A61B5/442 , A61B5/444 , A61B2562/0247 , A61B2562/046 , G01L1/16 , G01N3/08 , G01N3/24 , G01N19/00 , G01N2203/0025 , G01N2203/0089 , G01N2203/0094
摘要： A PEFS (Piezoelectric Finger Sensor) acts as an “electronic finger” capable of accurately and non-destructively measuring both the Young's compression modulus and shear modulus of tissues with gentle touches to the surface. The PEFS measures both the Young's compression modulus and shear modulus variations in tissue generating a less than one-millimeter spatial resolution up to a depth of several centimeters. This offers great potential for in-vivo early detection of diseases. A portable hand-held device is also disclosed. The PEF offers superior sensitivity.

32. 发明授权

US08481335B2 Specificity and sensitivity enhancement in cantilever sensing 有权
标题翻译：悬臂传感器的特异性和灵敏度增强
公开(公告)号：US08481335B2
公开(公告)日：2013-07-09
申请号：US12677613
申请日：2008-10-03
申请人： Wei-Heng Shih , Wan Y. Shih
发明人： Wei-Heng Shih , Wan Y. Shih
IPC分类号： G01N33/551
CPC分类号： G01N33/53 , G01N29/036 , G01N33/54373 , G01N2291/0257
摘要： The invention is directed to a sensor system including at least one sensor and target specific receptors bound substrates for purposes of enhancing detection sensitivity. Optionally, the sensor system may include quantum dots for independently verifying the presence of a target molecule or compound. The sensor system may be particularly beneficial in the field of medical diagnostics, bio-defense, food safety, water safety and general chemical detection.
摘要翻译：本发明涉及包含至少一个传感器和靶特异性受体结合的基底的传感器系统，以增强检测灵敏度。可选地，传感器系统可以包括用于独立地验证靶分子或化合物的存在的量子点。传感器系统在医学诊断，生物防御，食品安全，水安全和一般化学检测领域可能是特别有益的。

33. 发明授权

US08475706B2 Method of making mixed metal oxide ceramics 有权
标题翻译：混合金属氧化物陶瓷的制备方法
公开(公告)号：US08475706B2
公开(公告)日：2013-07-02
申请号：US12773146
申请日：2010-05-04
申请人： Wei-Heng Shih , Huiming Gu , Wan Y. Shih
发明人： Wei-Heng Shih , Huiming Gu , Wan Y. Shih
IPC分类号： B28B3/00
CPC分类号： C04B35/6281 , C01G25/006 , C01G33/006 , C01G35/006 , C01P2002/34 , C01P2006/10 , C01P2006/40 , C04B35/491 , C04B35/499 , C04B35/62823 , C04B2235/3206 , C04B2235/3234 , C04B2235/3251 , C04B2235/3296 , C04B2235/6562 , C04B2235/77
摘要： A method of making dielectric ceramics containing mixed metal oxides is provided. The method comprises the steps of at least partially coating a metal oxide powder with a metal hydroxide or metal oxide, compacting the coated powder with one or more additional metal compounds or metal compound precursors, and directly sintering the compact in a single step. The method of the invention may be used to avoid occurrence of significant quantities of one or more undesired but thermodynamically or kinetically favored side products. The method of the invention may also be used to synthesize perovskites, in particular lead-magnesium-niobium (PMN), lead-magnesium-niobium-lead-titanium (PMN-PT) perovskites, or lead zirconate titanate (PZT).
摘要翻译：提供了制造含有混合金属氧化物的电介质陶瓷的方法。该方法包括以下步骤：用金属氢氧化物或金属氧化物至少部分地涂覆金属氧化物粉末，用一种或多种另外的金属化合物或金属化合物前体压实涂覆的粉末，并在一个步骤中直接烧结该压块。本发明的方法可用于避免大量产生一种或多种不需要但热力学或动力学上有利的副产物。本发明的方法也可用于合成钙钛矿，特别是铅 - 镁 - 铌（PMN），铅 - 镁 - 铌 - 铅 - 钛（PMN-PT）钙钛矿或锆钛酸铅（PZT）。

34. 发明授权

US08421313B2 Energy harvesting device 有权
标题翻译：能量收集装置
公开(公告)号：US08421313B2
公开(公告)日：2013-04-16
申请号：US13357291
申请日：2012-01-24
申请人： Wei-Heng Shih , Wan Y. Shih , Hakki Yegingil
发明人： Wei-Heng Shih , Wan Y. Shih , Hakki Yegingil
IPC分类号： H01L41/113
CPC分类号： H01L41/1136 , H01L41/1875 , H02N2/188
摘要： A piezoelectric energy harvesting device (PEHD) comprising a driving element, conducting element, piezoelectric layer and non-piezoelectric layer capable of converting ambient mechanical energy into electrical energy. The piezoelectric layer may be constructed from PMN-PT or PZT having a thickness of about 1-150 μm. The PEHD may be used to generate about 1 W. The harvested energy may be stored and used to power microelectronic devices and rechargeable battery technologies.
摘要翻译：一种压电能量收集装置（PEHD），包括能够将环境机械能转换为电能的驱动元件，导电元件，压电层和非压电层。压电层可以由具有约1-150μm厚度的PMN-PT或PZT构成。 PEHD可用于产生约1W。收获的能量可以被存储并用于为微电子器件和可充电电池技术供电。

35. 发明授权

US08197757B2 Electrical insulation of devices with thin layers 有权
标题翻译：薄层器件电气绝缘
公开(公告)号：US08197757B2
公开(公告)日：2012-06-12
申请号：US12306968
申请日：2007-07-06
申请人： Wan Y. Shih , Wei-Heng Shih , Joseph Capobianco
发明人： Wan Y. Shih , Wei-Heng Shih , Joseph Capobianco
IPC分类号： B01L99/00 , B32B9/04
CPC分类号： G01N33/553 , G01N33/54353 , Y10T428/26 , Y10T428/265 , Y10T428/31663 , Y10T428/31678
摘要： A novel, economical electrical insulation method for the production of ultra-thin insulation layers using a solution coating method. Thin hydrophobic self-assembled bi-functional layers of less than 10 nm thick were deposited by a simple solution method and demonstrated to electrically insulate micro-/nano-devices for in-water detection applications. The insulation layer includes a hydrophobic group which repels water and permits superb insulation properties of the ultra-thin layers. The insulation layer has the additional advantages that it binds to a metal or metal oxide surface and to sensing receptors by covalent bonding using standard silane chemistry.
摘要翻译：一种新颖，经济的电绝缘方法，用于使用溶液涂布法生产超薄绝缘层。通过简单的溶液方法沉积小于10nm厚的薄疏水自组装双功能层，并证明将微/纳米器件电绝缘在水中检测应用。绝缘层包括排斥水的疏水基团，并且允许超薄层的绝佳绝缘性能。绝缘层具有附加的优点，即它与金属或金属氧化物表面结合，并通过使用标准硅烷化学的共价键来感测受体。

36. 发明申请

US20110124124A1 ENHANCED DETECTION SENSITIVITY WITH PIEZOELECTRIC MICROCANTILEVER SENSORS 有权
标题翻译：用压电微型传感器增强检测灵敏度
公开(公告)号：US20110124124A1
公开(公告)日：2011-05-26
申请号：US12921756
申请日：2009-03-04
申请人： Wan Y. Shih , Wei-Heng Shih , Qing Zhu
发明人： Wan Y. Shih , Wei-Heng Shih , Qing Zhu
IPC分类号： G01N33/53 , B01J19/00
CPC分类号： G01N29/2437 , G01N29/036 , G01N33/54373 , G01N2291/0257
摘要： A method for enhancing the detection sensitivity of a piezoelectric microcantilever sensor. The method may involve providing a piezoelectric microcantilever and inducing a change in the Young's modulus during detection of a species of interest. The change in the Young's modulus may be induced or enhanced by the application of a DC bias electric field to the piezoelectric layer that enhances non-180° polarization domain switching of the piezoelectric layer. The change in the Young's modulus may also result from binding of the species of interest to the piezoelectric microcantilever sensor or a combination of binding and application of a DC bias electric field Significantly enhanced detection sensitivity results from the changed Young's modulus of the piezoelectric layer.
摘要翻译：一种提高压电微悬臂梁传感器检测灵敏度的方法。该方法可以包括提供压电微悬臂梁并在感兴趣的物种的检测期间引起杨氏模量的变化。杨氏模量的变化可以通过向压电层施加直流偏压电场而引起或增强，这增强了压电层的非180°极化域切换。杨氏模量的变化也可以由感兴趣的物质与压电微悬臂梁传感器的结合或直流偏置电场的结合和施加的组合引起。显着增强的检测灵敏度来自压电层的改变的杨氏模量。

37. 发明申请

US20100239463A1 LEAD-FREE PIEZOELECTRIC CERAMIC FILMS AND A METHOD FOR MAKING THEREOF 有权
标题翻译：无铅压电陶瓷薄膜及其制造方法
公开(公告)号：US20100239463A1
公开(公告)日：2010-09-23
申请号：US12741790
申请日：2008-11-20
申请人： Wei-Heng Shih , Wan Y. Shih , Huidong Li
发明人： Wei-Heng Shih , Wan Y. Shih , Huidong Li
IPC分类号： G01N33/50 , H01L41/18 , H01L41/187 , B32B9/00
CPC分类号： G01N27/12 , H01L41/1873 , H01L41/314 , H01L41/43
摘要： This invention relates to lead-free piezoelectric ceramic films and a method of making thereof. Specifically, the invention is directed to a method for fabricating lead-free piezoelectric free standing films having enhanced piezoelectric properties. The films may be used for a number of applications including incorporation in microelectronic devices such as energy harvesting devices and sensor technologies.
摘要翻译：本发明涉及无铅压电陶瓷膜及其制造方法。具体地，本发明涉及一种制造具有增强的压电性能的无铅压电自立式膜的方法。这些膜可以用于许多应用，包括并入诸如能量收集装置和传感器技术的微电子器件中。

38. 发明授权

US07458265B2 Piezoelectric cantilever sensors 有权
标题翻译：压电悬臂传感器
公开(公告)号：US07458265B2
公开(公告)日：2008-12-02
申请号：US10595570
申请日：2004-10-27
申请人： Wan Y. Shih , Wei-Heng Shih , Zuyan Shen
发明人： Wan Y. Shih , Wei-Heng Shih , Zuyan Shen
IPC分类号： G01N5/04 , G01N25/08
CPC分类号： G01N29/022 , G01N5/02 , G01N29/036 , G01N2291/0255 , G01N2291/0256 , G01N2291/02818 , G01N2291/0422 , G01N2291/0426 , G01N2291/0427
摘要： A piezoelectric cantilever with a non-piezoelectric, or piezoelectric tip useful as mass and viscosity sensors. The change in the cantilever mass can be accurately quantified by monitoring a resonance frequency shift of the cantilever. For bio-detection, antibodies or other specific receptors of target antigens may be immobilized on the cantilever surface, preferably on the non-piezoelectric tip. For chemical detection, high surface-area selective absorbent materials are coated on the cantilever tip. Binding of the target antigens or analytes to the cantilever surface increases the cantilever mass. Detection of target antigens or analytes is achieved by monitoring the cantilever's resonance frequency and determining the resonance frequency shift that is due to the mass of the adsorbed target antigens on the cantilever surface. The use of a piezoelectric unimorph cantilever allows both electrical actuation and electrical sensing. Incorporating a non-piezoelectric tip (14) enhances the sensitivity of the sensor. In addition, the piezoelectric cantilever can withstand damping in highly viscous liquids and can be used as a viscosity sensor in wide viscosity range.
摘要翻译：具有非压电或压电尖端的压电悬臂，可用作质量和粘度传感器。通过监测悬臂的共振频率偏移可以准确量化悬臂质量的变化。为了生物检测，靶抗原的抗体或其他特异性受体可以固定在悬臂表面上，优选地固定在非压电尖端上。对于化学检测，高表面积选择性吸收材料涂覆在悬臂尖端。目标抗原或分析物与悬臂表面的结合增加了悬臂质量。通过监测悬臂的共振频率并确定由于悬臂表面上吸附的靶抗原的质量而引起的共振频移，实现了靶抗原或分析物的检测。使用压电单块悬臂可以实现电致动和电感测。结合非压电尖端（14）增强了传感器的灵敏度。此外，压电悬臂可以承受高粘度液体中的阻尼，可用作宽粘度范围内的粘度传感器。

39. 发明授权

US07335345B2 Synthesis of water soluble nanocrystalline quantum dots and uses thereof 有权
标题翻译：水溶性纳米晶体量子点的合成及其用途
公开(公告)号：US07335345B2
公开(公告)日：2008-02-26
申请号：US11136653
申请日：2005-05-24
申请人： Wei-Heng Shih , Wan Y. Shih , Hui Li , Melissa Colleen Schillo
发明人： Wei-Heng Shih , Wan Y. Shih , Hui Li , Melissa Colleen Schillo
IPC分类号： H01M9/08
CPC分类号： C09K11/565 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C09K11/883 , Y10S977/774
摘要： An economic, direct synthetic method for producing water soluble QDs that are ready for bioconjugation is provided. The method can produce aqueous QDs with emission wavelengths varying from 400 nm to 700 nm. Highly luminescent metal sulfide (MS) QDs are produced via an aqueous synthesis route. MS QDs are capped with thiol-containing charged molecules in a single step. The resultant MS QDs exhibit the distinctive excitonic photoluminescence desired of QDs and can be fabricated to avoid undesirable broadband emissions at higher wavelengths. This provides a significant improvement over the present complex and expensive commercial processes for the production of QDs. The aqueous QDs are stable in biological fluids over a long period of time. In addition, nontoxic ZnS QDs have been produced with good photoluminescence properties by refluxing the ZnS QD suspensions over a period of time.
摘要翻译：提供了一种用于生产水溶性量子点的经济，直接的合成方法，可用于生物共轭。该方法可以产生发射波长从400nm到700nm变化的含水量子点。高度发光的金属硫化物（MS）量子点通过水性合成路线生产。在一个步骤中，MS量子点被含硫醇的带电分子封盖。所得的MS量子点显示量子点所需的独特的激子光致发光，并且可以被制造以避免在较高波长处的不期望的宽带发射。这提供了相对于目前用于生产量子点的复杂和昂贵的商业过程的显着改进。水质量子在长时间内在生物体液中是稳定的。此外，通过在一段时间内回流ZnS QD悬浮液，已经生产出具有良好光致发光性质的无毒ZnS量子点。

40. 发明申请

US20190120833A1 Piezoelectric Plate Sensor and Uses Thereof 审中-公开
公开(公告)号：US20190120833A1
公开(公告)日：2019-04-25
申请号：US16216848
申请日：2018-12-11
申请人： Wan Y. Shih , Wei Wu , Wei-Heng Shih , Mehmet Cagri Soylu , Haitao Guo , Suresh G. Joshi , Ceyhun Ekrim Kirimli , Ying-Hsiu Su
发明人： Wan Y. Shih , Wei Wu , Wei-Heng Shih , Mehmet Cagri Soylu , Haitao Guo , Suresh G. Joshi , Ceyhun Ekrim Kirimli , Ying-Hsiu Su
IPC分类号： G01N33/543 , G01N29/02 , G01N29/036 , C12Q1/6825
摘要： A piezoelectric plate sensor comprising a piezoelectric layer; two electrodes; and an insulation layer. The insulation layer is produced by soaking the piezoelectric layer and two electrodes in a mercaptopropyltrimethoxysilane solution with an amount of water from 0.1 v/v. % to about 1 v/v % and at pH from about 8 to about 150 for a period from about 8 to about 15 hours, and the mercaptopropyltrimethoxysilane solution has a concentration of mercaptopropyltrimethoxysilane from about 0.01 v/v % to about 0.5 v/v %. A method of detecting a biomolecule in a sample using the piezoelectric plate sensor in particular, that of detecting a genetic marker with PCR sensitivity and specificity without the need of DNA isolation or amplification is also provided. The piezoelectric plate sensor may be used to diagnose various diseases including breast cancer, myocardial infarction, diarrhea, Clostridium difficile infection, and hepatitis B infection.

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