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31. 发明授权

US07786262B2 IL-6 binding proteins 有权
标题翻译： IL-6结合蛋白
公开(公告)号：US07786262B2
公开(公告)日：2010-08-31
申请号：US11486246
申请日：2006-07-12
申请人： Alice Bakker , Amy N. Duguay , Qiang Liu , Joshua Silverman , Kevin Moore
发明人： Alice Bakker , Amy N. Duguay , Qiang Liu , Joshua Silverman , Kevin Moore
IPC分类号： C07K14/00 , C07K17/00 , A61K38/00 , C08H1/00 , A01N37/18
CPC分类号： C07K14/715
摘要： Polypeptides comprising monomer domains that bind to IL-6, or portions thereof, are provided.
摘要翻译：提供了包含与IL-6结合的单体结构域的多肽或其部分。

32. 发明申请

US20120231013A1 POLYPEPTIDES THAT BIND TISSUE INHIBITOR OF METALLOPROTEINASE TYPE THREE (TIMP-3), COMPOSITIONS AND METHODS 审中-公开
标题翻译：金属蛋白酶三类（TIMP-3），组合物和方法的结合组织抑制剂的多肽
公开(公告)号：US20120231013A1
公开(公告)日：2012-09-13
申请号：US13388242
申请日：2010-07-29
申请人： Roy A. Black , Peng Li , Joshua Silverman , Chadwick T. King
发明人： Roy A. Black , Peng Li , Joshua Silverman , Chadwick T. King
IPC分类号： A61K38/57 , C12N5/071 , A61K39/395 , A61P19/02 , A61P9/00 , C07K14/81 , C07K16/40
CPC分类号： C07K14/81 , A61K38/00 , A61K38/57 , C07K7/08 , C07K14/8146 , C07K16/38 , C07K2317/21 , C07K2317/76
摘要： The present invention relates to TIMP-3 binding compositions, methods of producing such compositions, and methods of using such compositions, including in the treatment of various conditions.
摘要翻译：本发明涉及TIMP-3结合组合物，制备这种组合物的方法，以及使用这些组合物的方法，包括在各种条件的治疗中。

33. 发明授权

US07507806B2 Nucleic acid sequences of human Rif1 失效
标题翻译：人Rif1的核酸序列
公开(公告)号：US07507806B2
公开(公告)日：2009-03-24
申请号：US11203806
申请日：2005-08-15
申请人： Titia de Lange , Joshua Silverman
发明人： Titia de Lange , Joshua Silverman
IPC分类号： C07H21/04 , C12N15/00
CPC分类号： C12Q1/485 , G01N2500/10 , G01N2800/2835
摘要： The present invention relates to human Rif1 (hRif1) nucleic acid sequences and human Rif1 amino acid sequences encoded therefrom. The invention also encompasses antibodies that are immunologically specific for human Rif1 polypeptides. Also included in the present invention are methods directed to detecting Rif1 foci formed in response to various treatments that induce DNA damage. The formation of foci comprising Rif1 in response to DNA damage serves as a positive indicator of the presence of wild type ATM kinase activity in a cell, whereas the absence of detectable Rif1 foci under such circumstances serves to identify a cell with reduced ATM kinase activity. Modulators of ATM kinase activity and/or Rif1 activity and methods for identifying such modulators are also included in the present invention.
摘要翻译：本发明涉及人Rif1（hRif1）核酸序列和由其编码的人Rif1氨基酸序列。本发明还包括对人Rif1多肽具有免疫学特异性的抗体。本发明还包括用于检测响应诱导DNA损伤的各种治疗形成的Rif1病灶的方法。包含Rif1响应于DNA损伤的病灶的形成作为细胞中存在野生型ATM激酶活性的阳性指标，而在这种情况下不存在可检测的Rif1病灶用于鉴定具有降低的ATM激酶活性的细胞。 ATM激酶活性和/或Rif1活性的调节剂和鉴定这种调节剂的方法也包括在本发明中。

34. 发明申请

US20080003611A1 HEAT LYSIS PRODUCTION OF PROTEINS 有权
标题翻译：热蛋白生产蛋白质
公开(公告)号：US20080003611A1
公开(公告)日：2008-01-03
申请号：US11457080
申请日：2006-07-12
申请人： Joshua Silverman , Wayne To
发明人： Joshua Silverman , Wayne To
IPC分类号： G01N33/53 , C12P21/00 , C12Q1/00
CPC分类号： C07K14/715
摘要： The present invention provides methods of producing isolated heat stable polypeptides by expressing the polypeptides in a prokaryotic host cell and subjecting the host cell to heat lysis. The invention further provides screening methods by producing a plurality of isolated heat stable polypeptides by expressing each of the plurality of polypeptides in a prokaryotic host cell and subjecting the host to heat lysis.
摘要翻译：本发明提供了通过在原核宿主细胞中表达多肽并对宿主细胞进行热裂解来产生分离的热稳定多肽的方法。本发明进一步提供了通过在原核宿主细胞中表达多个多肽中的每一个并使宿主热裂解来产生多个分离的热稳定多肽的筛选方法。

35. 发明申请

US20060177831A1 c-MET kinase binding proteins 有权
标题翻译： c-MET激酶结合蛋白
公开(公告)号：US20060177831A1
公开(公告)日：2006-08-10
申请号：US11155989
申请日：2005-06-17
申请人： Willem Stemmer , D. Perlroth , Sanjeev Satyal , Benjamin Alba , Alice Bakker , Amy Duguay , Qiang Liu , Joshua Silverman , Richard Smith , Candace Swimmer
发明人： Willem Stemmer , D. Perlroth , Sanjeev Satyal , Benjamin Alba , Alice Bakker , Amy Duguay , Qiang Liu , Joshua Silverman , Richard Smith , Candace Swimmer
IPC分类号： C12P21/02 , C12Q1/68 , C07K14/705 , C07K16/28
CPC分类号： C07K14/47 , A61K38/00 , C07K14/705 , G01N33/566 , G01N33/574 , G01N2333/4753 , G01N2333/82 , G01N2500/00
摘要： Polypeptides comprising monomer domains that bind to c-MET, or portions thereof, are provided.
摘要翻译：提供了包含与c-MET结合的单体结构域的多肽或其部分。

36. 发明申请

US20060051737A1 Nucleic and amino acid sequences of human Rif1 and methods of use thereof 失效
标题翻译：人Rif1的核酸和氨基酸序列及其使用方法
公开(公告)号：US20060051737A1
公开(公告)日：2006-03-09
申请号：US11203806
申请日：2005-08-15
申请人： Titia Lange , Joshua Silverman
发明人： Titia Lange , Joshua Silverman
IPC分类号： C12Q1/00 , C12Q1/68
CPC分类号： C12Q1/485 , G01N2500/10 , G01N2800/2835
摘要： The present invention relates to human Rif1 (hRif1) nucleic acid sequences and human Rif1 amino acid sequences encoded therefrom. The invention also encompasses antibodies that are immunologically specific for human Rif1 polypeptides. Also included in the present invention are methods directed to detecting Rif1 foci formed in response to various treatments that induce DNA damage. The formation of foci comprising Rif1 in response to DNA damage serves as a positive indicator of the presence of wild type ATM kinase activity in a cell, whereas the absence of detectable Rif1 foci under such circumstances serves to identify a cell with reduced ATM kinase activity. Modulators of ATM kinase activity and/or Rif1 activity and methods for identifying such modulators are also included in the present invention.
摘要翻译：本发明涉及人Rif1（hRif1）核酸序列和由其编码的人Rif1氨基酸序列。本发明还包括对人Rif1多肽具有免疫学特异性的抗体。本发明还包括用于检测响应诱导DNA损伤的各种治疗形成的Rif1病灶的方法。包含Rif1响应于DNA损伤的病灶的形成作为细胞中存在野生型ATM激酶活性的阳性指标，而在这种情况下不存在可检测的Rif1病灶用于鉴定具有降低的ATM激酶活性的细胞。 ATM激酶活性和/或Rif1活性的调节剂和鉴定这种调节剂的方法也包括在本发明中。

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