专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明授权

US5693650A 4-(Quinolin-2-yl-methoxy)-phenyl-acetic acid derivatives 失效
标题翻译： 4-（喹啉-2-基 - 甲氧基） - 苯基 - 乙酸衍生物
公开(公告)号：US5693650A
公开(公告)日：1997-12-02
申请号：US567764
申请日：1995-12-05
申请人： Ulrich Muller , Richard Connell , Siegfried Goldmann , Klaus-Helmut Mohrs , Rolf Angerbauer , Matthias Muller-Gliemann , Ulrich Niewohner , Rudi Grutzmann , Martin Beuck , Stefan Wohlfeil , Hilmar Bischoff , Dirk Denzer
发明人： Ulrich Muller , Richard Connell , Siegfried Goldmann , Klaus-Helmut Mohrs , Rolf Angerbauer , Matthias Muller-Gliemann , Ulrich Niewohner , Rudi Grutzmann , Martin Beuck , Stefan Wohlfeil , Hilmar Bischoff , Dirk Denzer
IPC分类号： A61K31/47 , A61K31/495 , A61K31/535 , A61P9/08 , A61P9/10 , C07D215/14 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07H13/04 , C07D215/12
CPC分类号： C07D401/12 , C07D215/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07H13/04
摘要： 4-(Quinolin-2-yl-methoxy)-phenyl-acetic acid derivatives are prepared by reacting quinoline-methoxy-phenyl-acetic acids with the corresponding glycinol derivatives, if appropriate with activation of the carboxylic acid function. The new compounds are suitable as active compounds in medicaments, in particular in antiatherosclerotic medicaments.
摘要翻译： 4-（喹啉-2-基 - 甲氧基） - 苯基 - 乙酸衍生物是通过使喹啉 - 甲氧基 - 苯基 - 乙酸与相应的甘油醇衍生物反应制备的，如果合适的话，羧酸官能团的活化。新化合物适合作为药物中的活性化合物，特别是抗动脉粥样硬化药物。

32. 发明授权

US5691337A Oxy-phenyl-(phenyl)glycinolamides with heterocyclic substituents 失效
标题翻译：具有杂环取代基的氧 - 苯基 - （苯基）甘氨酰胺
公开(公告)号：US5691337A
公开(公告)日：1997-11-25
申请号：US785146
申请日：1997-01-13
申请人： Ulrich Muller , Richard Connell , Siegfried Goldmann , Klaus-Helmut Mohrs , Siegfried Raddatz , Michael Matzke , Rudi Grutzmann , Martin Beuck , Stefan Wohlfeil , Hilmar Bischoff , Dirk Denzer
发明人： Ulrich Muller , Richard Connell , Siegfried Goldmann , Klaus-Helmut Mohrs , Siegfried Raddatz , Michael Matzke , Rudi Grutzmann , Martin Beuck , Stefan Wohlfeil , Hilmar Bischoff , Dirk Denzer
IPC分类号： A61K31/165 , A61K31/38 , A61K31/381 , A61K31/47 , A61K31/472 , A61K31/495 , A61P9/08 , A61P9/10 , C07C231/02 , C07C235/34 , C07D215/14 , C07D215/18 , C07D215/26 , C07D217/16 , C07D241/42 , C07D333/56 , C07D401/12 , C07D405/12 , C07F7/10 , C07D217/00
CPC分类号： C07D401/12 , C07C235/34 , C07D215/14 , C07D215/18 , C07D215/26 , C07D241/42 , C07D333/56 , C07D405/12
摘要： Oxy-phenyl-(phenyl)glycinolamides with heterocyclic substituents are prepared by reaction of the corresponding oxyphenylcarboxylic acids with heterocyclic substituents with phenylglycinol. The new substances are suitable as active compounds in medicaments, in particular in agents having an antiatherosclerotic action.
摘要翻译：具有杂环取代基的羟基 - 苯基 - （苯基）甘氨酰胺通过相应的氧基苯基羧酸与杂环取代基与苯基甘氨醇的反应来制备。这些新物质适合作为药物中的活性化合物，特别是具有抗动脉粥样硬化作用的药物。

33. 发明授权

US5684201A Preparation of aliphatic and cycloaliphatic oximes 失效
标题翻译：脂肪族和脂环族肟的制备
公开(公告)号：US5684201A
公开(公告)日：1997-11-04
申请号：US492906
申请日：1995-06-20
申请人： Norbert Rieber , Peter Lingelbach , Tom Witzel , Ulrich Muller
发明人： Norbert Rieber , Peter Lingelbach , Tom Witzel , Ulrich Muller
IPC分类号： B01J21/06 , B01J31/02 , C07B61/00 , C07C249/04 , C07C251/38 , C07C251/40 , C07C251/44
CPC分类号： C07C249/04
摘要： Aliphatic or cycloaliphatic oximes are prepared by treating aliphatic or cycloaliphatic imines with oxygen or with an oxygen-containing gas in the presence of a catalyst.
摘要翻译：通过在催化剂存在下用氧或含氧气体处理脂族或脂环族亚胺来制备脂肪族或脂环族肟。

34. 发明授权

US5646162A Oxy-phenyl-(phenyl)glycinolamides with heterocyclic substituents 失效
标题翻译：具有杂环取代基的氧 - 苯基 - （苯基）甘氨酰胺
公开(公告)号：US5646162A
公开(公告)日：1997-07-08
申请号：US566460
申请日：1995-12-01
申请人： Ulrich Muller , Richard Connell , Siegfried Goldmann , Klaus-Helmut Mohrs , Siegfried Raddatz , Michael Matzke , Rudi Grutzmann , Martin Beuck , Stefan Wohlfeil , Hilmar Bischoff , Dirk Denzer
发明人： Ulrich Muller , Richard Connell , Siegfried Goldmann , Klaus-Helmut Mohrs , Siegfried Raddatz , Michael Matzke , Rudi Grutzmann , Martin Beuck , Stefan Wohlfeil , Hilmar Bischoff , Dirk Denzer
IPC分类号： A61K31/165 , A61K31/38 , A61K31/381 , A61K31/47 , A61K31/472 , A61K31/495 , A61P9/08 , A61P9/10 , C07C231/02 , C07C235/34 , C07D215/14 , C07D215/18 , C07D215/26 , C07D217/16 , C07D241/42 , C07D333/56 , C07D401/12 , C07D405/12 , C07F7/10
CPC分类号： C07D401/12 , C07C235/34 , C07D215/14 , C07D215/18 , C07D215/26 , C07D241/42 , C07D333/56 , C07D405/12
摘要： Oxy-phenyl-(phenyl)gycinolamides with heterocyclic substituents are prepared by reaction of the corresponding oxyphenylcarboxylic acids with heterocyclic substituents with phenylglycinol. The new substances are suitable as active compounds in medicaments, in particular in agents having an antiatherosclerotic action.
摘要翻译：具有杂环取代基的羟基 - 苯基 - （苯基）吉他胺酰胺通过相应的氧基苯基羧酸与杂环取代基与苯基甘氨醇的反应来制备。这些新物质适合作为药物中的活性化合物，特别是具有抗动脉粥样硬化作用的药物。

35. 发明授权

US5530016A Substituted 2,4-imidazolidinediones 失效
标题翻译：取代的2,4-咪唑烷二酮
公开(公告)号：US5530016A
公开(公告)日：1996-06-25
申请号：US245328
申请日：1994-05-18
申请人： Thomas Kramer , Rudolf Hanko , Jurgen Dressel , Peter Fey , Walter Hubsch , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Hilmar Bischoff , Stefan Wohlfeil , Dirk Denzer , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Siegfried Zaiss
发明人： Thomas Kramer , Rudolf Hanko , Jurgen Dressel , Peter Fey , Walter Hubsch , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Hilmar Bischoff , Stefan Wohlfeil , Dirk Denzer , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Siegfried Zaiss
IPC分类号： A61K31/415 , A61P9/10 , A61P9/12 , C07D207/48 , C07D257/04 , C07D403/10 , C07D403/12 , A61K31/41 , C07D257/00
CPC分类号： C07D403/10 , C07D403/12
摘要： Novel substituted 2,4-imidazolidinediones are prepared either by reaction of .alpha.-aminocarboxylic acid derivatives with appropriately substituted biphenylmethyl halides and subsequent cyclization with isocyanates or by reaction of N-benzyl-substituted .alpha.-aminocarboxylic acid derivatives with tetrazolylphenylboronic acids or by reaction of sulphonyl-substituted benzyl halides with .alpha.-aminocarboxylic acid derivatives and subsequent cyclization with isocyanates. The compounds according to the invention can be employed as active compounds in medicaments, preferably for the treatment of arterial hypertension and arteriosclerosis.
摘要翻译：新型取代的2,4-咪唑烷二酮通过α-氨基羧酸衍生物与适当取代的联苯甲基卤化物反应，随后与异氰酸酯环化或通过N-苄基取代的α-氨基羧酸衍生物与四唑基苯基硼酸的反应或通过磺酰基 - 取代的苄基卤与α-氨基羧酸衍生物反应，随后用异氰酸酯环化。根据本发明的化合物可以用作药物中的活性化合物，优选用于治疗动脉高血压和动脉硬化。

36. 发明授权

US5521206A Heterocyclically substituted phenylacetic acid derivatives and their use in medicaments 失效
标题翻译：杂环取代的苯乙酸衍生物及其在药物中的应用
公开(公告)号：US5521206A
公开(公告)日：1996-05-28
申请号：US227913
申请日：1994-04-15
申请人： Ulrich Muller , Klaus Mohrs , Jurgen Dressel , Rudolf Hanko , Walter Hubsch , Michael Matzke , Ulrich Niewohner , Siegfried Raddatz , Thomas Kramer , Matthias Muller-Gliemann , Hans-Peter Belleman , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil
发明人： Ulrich Muller , Klaus Mohrs , Jurgen Dressel , Rudolf Hanko , Walter Hubsch , Michael Matzke , Ulrich Niewohner , Siegfried Raddatz , Thomas Kramer , Matthias Muller-Gliemann , Hans-Peter Belleman , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil
IPC分类号： A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4184 , A61P7/10 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P13/12 , A61P15/00 , A61P43/00 , C07D207/30 , C07D231/12 , C07D231/14 , C07D231/56 , C07D233/54 , C07D233/60 , C07D233/64 , C07D233/68 , C07D233/90 , C07D235/06 , C07D235/08 , C07D235/14 , C07D235/16 , C07D249/04 , C07D249/08 , C07D249/12 , C07D249/14 , C07D249/18 , C07D403/10 , C07D405/06 , C07D409/06 , C07D471/04 , C07D521/00
CPC分类号： C07D249/08 , C07D231/12 , C07D231/14 , C07D231/56 , C07D233/56 , C07D233/64 , C07D233/68 , C07D233/90 , C07D235/06 , C07D235/08 , C07D235/14 , C07D235/16 , C07D249/18 , C07D403/10 , C07D409/06 , C07D471/04
摘要： The invention relates to phenylacetic acid derivatives of the formula ##STR1## which are substituted by a five-membered nitrogen heterocycle bonded via an N atom. They are prepared by reaction of phenylacetic acid derivatives substituted with leaving groups with the appropriate nitrogen heterocycles and can be used as active substances in medicaments for the treatment of high blood pressure and atherosclerosis.
摘要翻译：本发明涉及由通过N原子键合的五元氮杂环取代的式“IMAGE”的苯乙酸衍生物。它们通过用离去基团取代的苯乙酸衍生物与适当的氮杂环的反应制备，并且可以用作治疗高血压和动脉粥样硬化的药物中的活性物质。

37. 发明授权

US5414003A Pyridinylmethyl-substituted pyridines and pyridones 失效
标题翻译：吡啶基甲基取代的吡啶和吡啶酮
公开(公告)号：US5414003A
公开(公告)日：1995-05-09
申请号：US235770
申请日：1994-04-29
申请人： Peter Fey , Jurgen Dressel , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Hilmar Bischoff , Stefan Wohlfeil , Dirk Denzer , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Siegfried Zaiss
发明人： Peter Fey , Jurgen Dressel , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Hilmar Bischoff , Stefan Wohlfeil , Dirk Denzer , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Siegfried Zaiss
IPC分类号： A61K31/44 , A61K31/4418 , A61K31/4425 , A61K31/4427 , A61P9/10 , A61P9/12 , C07B61/00 , C07D213/64 , C07D401/04 , C07D401/14 , C07F5/02 , A61K31/50 , A61K31/53
CPC分类号： C07D401/14
摘要： Pyridinylmethyl-substituted pyridines and pyridones are prepared by reacting pyridine- or pyridone-substituted halogenopyridines with tetrazolylphenylboronic acids. The substances according to the invention can be used as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.
摘要翻译：吡啶基甲基取代的吡啶和吡啶酮通过吡啶或吡啶酮取代的卤代吡啶与四唑基苯基硼酸反应来制备。根据本发明的物质可以用作药物中的活性化合物，特别是用于治疗动脉高血压和动脉粥样硬化。

38. 发明授权

US5376671A Propenoyl-imidazole derivatives 失效
标题翻译：丙烯酰 - 咪唑衍生物
公开(公告)号：US5376671A
公开(公告)日：1994-12-27
申请号：US43779
申请日：1993-04-06
申请人： Matthias Muller-Gliemann , Jurgen Dressel , Peter Fey , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Ulrich Muller , Martin Beuck , Stanislav Kazda , Andreas Knorr , Johannes-Peter Stasch , Stefan Wohlfeil
发明人： Matthias Muller-Gliemann , Jurgen Dressel , Peter Fey , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Ulrich Muller , Martin Beuck , Stanislav Kazda , Andreas Knorr , Johannes-Peter Stasch , Stefan Wohlfeil
IPC分类号： A61K31/415 , C07D233/64 , C07D233/68
CPC分类号： C07D233/68
摘要： Propenoyl-imidazole derivatives are prepared by reaction of appropriate imidazoylaldehydes with CH-acidic compounds and subsequent dehydration of the intermediates. The propenoyl-imidazole derivatives can be employed as active compounds in medicaments for the treatment of arterial hypertension and atherosclerosis.
摘要翻译：丙烯酰 - 咪唑衍生物通过合适的咪唑基醛与CH-酸性化合物的反应制备，随后中间体脱水。丙烯酰 - 咪唑衍生物可用作用于治疗动脉高血压和动脉粥样硬化的药物中的活性化合物。

39. 发明授权

US5089534A Process for preparing flexible polyurethane foam 失效
标题翻译：制备柔性聚氨酯泡沫的方法
公开(公告)号：US5089534A
公开(公告)日：1992-02-18
申请号：US498160
申请日：1990-03-23
申请人： Johan A. Thoen , Robert A. Sewell , Ulrich Muller
发明人： Johan A. Thoen , Robert A. Sewell , Ulrich Muller
IPC分类号： C08G18/16
CPC分类号： C08G18/168 , C08G2101/0008 , C08G2101/0041 , C08G2101/0083 , C08G2105/06
摘要： This invention relates to the use of phosphorus-containing compounds, specifically cyclic organophosphorus compounds, as carbodiimidization catalysts in the preparation of open-celled flexible polyurethane foam for the purpose of controlling foam density and providing softer foams. foams that are softer and of lower density can be prepared with significantly reduced quantities of blowing agents in comparison to foams prepared in the absence of such phosphorus-containing compounds. Additionally, use of such catalysts provides for a reduced reaction exotherm during the preparation of the foam thereby minimizing foam discoloration or scorching. Preferred phosphorus-containing compounds are the 1-alkyl-1-oxophospholenes, especially 1-methyl-1-oxophospholene.
摘要翻译：本发明涉及含磷化合物，特别是环状有机磷化合物作为碳二亚胺化催化剂在制备开孔软质聚氨酯泡沫塑料中的用途，用于控制泡沫密度和提供较软的泡沫。与不存在这种含磷化合物制备的泡沫相比，可以与发泡剂相比显着减少量来制备较软和较低密度的泡沫。另外，使用这种催化剂可在泡沫制备过程中减少反应放热，从而使泡沫变色或焦烧最小化。优选的含磷化合物是1-烷基-1-氧代磷酰，特别是1-甲基-1-氧代苯氧基。

40. 发明授权

US4639853A Time-discrete adaptive switching on-off controller 失效
标题翻译：时间离散自适应开关控制器
公开(公告)号：US4639853A
公开(公告)日：1987-01-27
申请号：US616196
申请日：1984-06-01
申请人： Heinrich Rake , Ulrich Hoffmann , Ulrich Muller , Rudolf Breddermann , Rainer Blumbach
发明人： Heinrich Rake , Ulrich Hoffmann , Ulrich Muller , Rudolf Breddermann , Rainer Blumbach
IPC分类号： G05B11/16 , G05B13/02 , G05B13/04 , G05B21/02 , G05B13/00
CPC分类号： G05B13/048
摘要： The present invention relates to an arrangement for the discrete-time adaptive on-off switching control of a continuous-time process with a binary switching actuator, which uses for the determination of the on-off actuating signal a prediction of a process output sequence over several future sampling intervals as reaction to a possible process input sequence that is applied to a discrete-time linear process model and which estimates and updates in every sampling interval the parameters of the process model by means of a parameter estimation device in order to adapt them to the process to be controlled, even when the process behavior changes, and which has a device for the input and change of the setpoint, the limits of the process output and the sampling time as well as a measuring device for the periodical measurement of the process input. The arrangement further comprises two alternatively working control devices one of which is active in the stationary phase and the other of which is active in the start-up phase of the process or after setpoint changes, and a switching device which activates one or the other said control device in dependence of the result of the measurement of the process output and of input current setpoint, wherein the actuator is served by the active control device.
摘要翻译：本发明涉及一种用于二进制切换致动器的连续时间处理的离散时间自适应开关切换控制的装置，其用于确定开关致动信号对过程输出序列的预测几个未来的采样间隔作为对可能的过程输入序列的反应，其应用于离散时间线性过程模型，并且在每个采样间隔中通过参数估计装置估计和更新过程模型的参数以便使其适应即使过程行为发生变化，并且具有用于输入和改变设定值的装置，过程输出的限制和采样时间以及用于周期性测量的测量装置的控制过程过程输入。该装置还包括两个备选的工作控制装置，其中一个工作控制装置在静止相中是有效的，另一个工作控制装置在过程的启动阶段或在设定点改变之后是有效的，以及激活一个或另一个所述控制装置，其依赖于过程输出和输入电流设定点的测量结果，其中致动器由主动控制装置服务。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式