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31. 发明申请

US20080038798A1 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 有权
公开(公告)号：US20080038798A1
公开(公告)日：2008-02-14
申请号：US11781867
申请日：2007-07-23
申请人： Craig Weaver , Ross Zirkle , James Metz
发明人： Craig Weaver , Ross Zirkle , James Metz
IPC分类号： C12N1/20 , C07H21/04 , C12N5/10 , C12P7/64
CPC分类号： C12P7/6472 , C07K14/195 , C12N9/001 , C12N9/1029 , C12N15/52 , C12N15/8247 , C12P7/62 , C12P7/6427
摘要： Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.

32. 发明申请

US20080032367A1 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 有权
公开(公告)号：US20080032367A1
公开(公告)日：2008-02-07
申请号：US11781871
申请日：2007-07-23
申请人： Craig Weaver , Ross Zirkle , James Metz
发明人： Craig Weaver , Ross Zirkle , James Metz
IPC分类号： C12P7/64 , C12N1/20 , C12N15/00 , C12N15/11 , C12N5/04
CPC分类号： C12P7/6472 , C07K14/195 , C12N9/001 , C12N9/1029 , C12N15/52 , C12N15/8247 , C12P7/62 , C12P7/6427
摘要： Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.

33. 发明授权

US07217856B2 PUFA polyketide synthase systems and uses thereof 有权
标题翻译： PUFA聚酮化合物系统及其用途
公开(公告)号：US07217856B2
公开(公告)日：2007-05-15
申请号：US10965017
申请日：2004-10-13
申请人： Craig A. Weaver , Ross Zirkle , James G. Metz
发明人： Craig A. Weaver , Ross Zirkle , James G. Metz
IPC分类号： A01H1/00 , C07H21/04 , C12N5/00 , C12P7/64
CPC分类号： C12P7/6472 , C07K14/195 , C12N9/001 , C12N9/1029 , C12N15/52 , C12N15/8247 , C12P7/62 , C12P7/6427
摘要： Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.
摘要翻译：公开了来自细菌微生物Shewanella japonica和Shewanella olleyana的完全多不饱和脂肪酸（PUFA）聚酮化合物（PKS）系统及其生物活性片段和同系物。更具体地，本发明涉及编码这种PUFA PKS系统的核酸，其包含这种PUFA PKS系统的蛋白质和结构域到包含这种PUFA PKS系统的转基因生物（植物和微生物），以及制备和使用本文公开的PUFA PKS系统。本发明还涉及基因修饰的植物和微生物以及通过操作PUFA聚酮化合物合酶（PKS）系统来有效地产生富含多种不饱和脂肪酸（PUFA）以及其它生物活性分子的脂质的方法。

34. 发明授权

US09414612B2 Thraustochytrids, fatty acid compositions, and methods of making and uses thereof 有权
标题翻译： Thraustochytrids，脂肪酸组合物及其制备方法和用途
公开(公告)号：US09414612B2
公开(公告)日：2016-08-16
申请号：US13220259
申请日：2011-08-29
申请人： Kirk E. Apt , Joseph W. Pfeifer, III , Jon Milton Hansen , Paul Warren Behrens , Ross Zirkle , Tracey Lynn Stahl
发明人： Kirk E. Apt , Joseph W. Pfeifer, III , Jon Milton Hansen , Paul Warren Behrens , Ross Zirkle , Tracey Lynn Stahl
IPC分类号： A23D9/00 , A23K1/16 , A23K1/18 , A23L1/30 , A61K31/20 , C12P7/64 , C12R1/89 , A61K35/00
CPC分类号： A23K20/158 , A23D9/00 , A23K50/00 , A23K50/80 , A23L33/115 , A23L33/12 , A23L33/135 , A23V2002/00 , A61K8/99 , A61K31/20 , A61K31/202 , A61K36/02 , A61K2035/11 , A61K2800/74 , A61Q19/00 , C12P7/6427 , C12P7/6472 , C12R1/89
摘要： The present invention is directed to isolated thraustochytrid microorganisms as well as strains and mutants thereof. The invention is further directed to biomasses, microbial oils, compositions, cultures, methods of producing microbial oils, and methods of using the isolated thraustochytrids, biomasses, and microbial oils.
摘要翻译：本发明涉及分离的破釜状菌属微生物以及其菌株和突变体。本发明进一步涉及生物量，微生物油，组合物，培养物，生产微生物油的方法，以及使用分离的破釜蛇疮，生物质和微生物油的方法。

35. 发明授权

US07897393B2 PUFA polyketide synthase systems and uses thereof 有权
标题翻译： PUFA聚酮化合物系统及其用途
公开(公告)号：US07897393B2
公开(公告)日：2011-03-01
申请号：US11781880
申请日：2007-07-23
申请人： Craig A. Weaver , Ross Zirkle , James G. Metz
发明人： Craig A. Weaver , Ross Zirkle , James G. Metz
IPC分类号： C12N15/82 , C12N5/12 , C12N1/20 , C07H21/04
CPC分类号： C12P7/6472 , C07K14/195 , C12N9/001 , C12N9/1029 , C12N15/52 , C12N15/8247 , C12P7/62 , C12P7/6427
摘要： Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.
摘要翻译：公开了来自细菌微生物Shewanella japonica和Shewanella olleyana的完全多不饱和脂肪酸（PUFA）聚酮化合物（PKS）系统及其生物活性片段和同系物。更具体地，本发明涉及编码这种PUFA PKS系统的核酸，其包含这种PUFA PKS系统的蛋白质和结构域到包含这种PUFA PKS系统的转基因生物（植物和微生物），以及制备和使用本文公开的PUFA PKS系统。本发明还涉及基因修饰的植物和微生物以及通过操作PUFA聚酮化合物合酶（PKS）系统来有效地产生富含多种不饱和脂肪酸（PUFA）以及其它生物活性分子的脂质的方法。

36. 发明授权

US07897391B2 PUFA polyketide synthase systems and uses thereof 有权
公开(公告)号：US07897391B2
公开(公告)日：2011-03-01
申请号：US11781867
申请日：2007-07-23
申请人： Craig A. Weaver , Ross Zirkle , James G. Metz
发明人： Craig A. Weaver , Ross Zirkle , James G. Metz
IPC分类号： C12N15/82 , C12N5/12 , C12N1/20 , C07H21/04
CPC分类号： C12P7/6472 , C07K14/195 , C12N9/001 , C12N9/1029 , C12N15/52 , C12N15/8247 , C12P7/62 , C12P7/6427
摘要： Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.

37. 发明申请

US20100266564A1 Polyunsaturated Fatty Acid Synthase Nucleic Acid Molecules and Polypeptides, Compositions, and Methods of Making and Uses Thereof 有权
标题翻译：多不饱和脂肪酸合成酶核酸分子和多肽，组合物及其制备和使用方法
公开(公告)号：US20100266564A1
公开(公告)日：2010-10-21
申请号：US12727851
申请日：2010-03-19
申请人： Kirk E. Apt , Leslie Richter , David Simpson , Ross Zirkle
发明人： Kirk E. Apt , Leslie Richter , David Simpson , Ross Zirkle
IPC分类号： C12N15/52 , C12N15/63 , C12N5/10 , C12N1/00 , C12P7/64 , C12N9/00 , A61K38/43 , A61K48/00 , A61P3/00
CPC分类号： C12N15/52 , A61K38/00 , C12N9/0006 , C12N9/001 , C12N9/1029 , C12N9/88 , C12N15/8247 , C12P7/6427 , C12P7/6472 , C12Y101/01 , C12Y103/01 , C12Y203/01039 , C12Y203/01041 , C12Y402/01 , C12Y402/01059 , Y02P20/52
摘要： The present invention is directed to isolated nucleic acid molecules and polypeptides of thraustochytrid polyunsaturated fatty acid (PUFA) synthases involved in the production of PUFAs, including PUFAs enriched in docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), or a combination thereof. The present invention is directed to vectors and host cells comprising the nucleic acid molecules, polypeptides encoded by the nucleic acid molecules, compositions comprising the nucleic acid molecules or polypeptides, and methods of making and uses thereof.
摘要翻译：本发明涉及涉及PUFA生产的分离的核酸分子和多烯突变多不饱和脂肪酸（PUFA）合成酶，包括富含二十二碳六烯酸（DHA），二十碳五烯酸（EPA）或其组合的PUFA。本发明涉及包含核酸分子，核酸分子编码的多肽，包含核酸分子或多肽的组合物及其制备和用途的载体和宿主细胞。

38. 发明授权

US07629450B2 PUFA polyketide synthase systems and uses thereof 失效
公开(公告)号：US07629450B2
公开(公告)日：2009-12-08
申请号：US11781870
申请日：2007-07-23
申请人： Craig A. Weaver , Ross Zirkle , James G. Metz
发明人： Craig A. Weaver , Ross Zirkle , James G. Metz
IPC分类号： C12N15/52 , C12N15/54 , C12N15/74 , C12N15/80 , C12N15/81 , C12N15/82 , C12N5/04
CPC分类号： C12P7/6472 , C07K14/195 , C12N9/001 , C12N9/1029 , C12N15/52 , C12N15/8247 , C12P7/62 , C12P7/6427
摘要： Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.

39. 发明授权

US07626009B2 PUFA polyketide synthase systems and uses thereof 失效
公开(公告)号：US07626009B2
公开(公告)日：2009-12-01
申请号：US11689459
申请日：2007-03-21
申请人： Craig A. Weaver , Ross Zirkle , James G. Metz
发明人： Craig A. Weaver , Ross Zirkle , James G. Metz
IPC分类号： C12N15/52 , C12N15/53 , C12N15/74 , C12N15/80 , C12N15/81 , C12N15/82 , C12N5/04
CPC分类号： C12P7/6472 , C07K14/195 , C12N9/001 , C12N9/1029 , C12N15/52 , C12N15/8247 , C12P7/62 , C12P7/6427
摘要： Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.

40. 发明申请

US20080032368A1 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 失效
公开(公告)号：US20080032368A1
公开(公告)日：2008-02-07
申请号：US11781874
申请日：2007-07-23
申请人： Craig Weaver , Ross Zirkle , James Metz
发明人： Craig Weaver , Ross Zirkle , James Metz
IPC分类号： C07H21/04 , C12N5/04 , C12P7/64
CPC分类号： C12P7/6472 , C07K14/195 , C12N9/001 , C12N9/1029 , C12N15/52 , C12N15/8247 , C12P7/62 , C12P7/6427
摘要： Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.

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