专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明申请

US20050064308A1 Fluorescent probe for zinc 有权
标题翻译：锌荧光探针
公开(公告)号：US20050064308A1
公开(公告)日：2005-03-24
申请号：US10994380
申请日：2004-11-23
申请人： Tetsuo Nagano , Kazuya Kikuchi , Tomoya Hirano
发明人： Tetsuo Nagano , Kazuya Kikuchi , Tomoya Hirano
IPC分类号： C07D311/82 , C07D493/10 , C09B11/24 , C09B11/28 , G03C5/00
CPC分类号： C07D493/10 , C07D311/82 , C09B11/24 , C09B11/245 , C09B11/28 , Y02P20/55
摘要： A compound represented by general formula (IA) or a salt thereof useful as a fluorescent probe for zinc: wherein R1 and R2 represent a hydrogen atom or a group represented by formula (A), wherein X1, X2, X3, and X4 represent a hydrogen atom, an alkyl group, a 2-pyridylmethyl group, or a protective group for an-amino group, and m and n represent 0 or 1, provided that R1 and R2 do not simultaneously represent hydrogen atoms; R3 and R4 represent a hydrogen atom or a halogen atom; and R5 and R6 represent a hydrogen atom, an alkylcarbonyl group, or an alkylcarbonyloxymethyl group, and R7 represents a hydrogen atom or an alkyl group.
摘要翻译：用作锌荧光探针的通式（IA）表示的化合物或其盐：其中R 1和R 2表示氢原子或由式（A）表示的基团，其中X 1， X 2，X 3和X 4表示氢原子，烷基，2-吡啶基甲基或氨基的保护基，m和n表示0或1，条件是R 1和R 2不同时代表氢原子; R 3和R 4代表氢原子或卤素原子; R 5和R 6表示氢原子，烷基羰基或烷基羰氧基甲基，R 7表示氢原子或烷基。

32. 发明授权

US06656927B1 Ip3 receptor ligands 失效
标题翻译： Ip3受体配体
公开(公告)号：US06656927B1
公开(公告)日：2003-12-02
申请号：US09926664
申请日：2001-11-30
申请人： Tetsuo Nagano , Kazuya Kikuchi , Takanari Inoue , Masamitsu Iino , Kenzo Hirose
发明人： Tetsuo Nagano , Kazuya Kikuchi , Takanari Inoue , Masamitsu Iino , Kenzo Hirose
IPC分类号： A61K3800
CPC分类号： C07F9/6561 , C07F9/117 , C07F9/65522
摘要： A compound represented by the general formula (I) or a salt thereof, wherein R represents a group represented by the following formula (A), (B) or (C) wherein R1 and R2 independently represent a C1-6 alkyl group, R3 represents an amino group, a mono(C1-6 alkyl)amino group, a di(C1-6 alkyl)amino group or a C1-6 alkoxy group and X-represents an anion, and n represents an integer of 2 to 5. The compound or a salt is useful as a ligand of inositol-1,4,5-trisphosphate (IP3) receptor.
摘要翻译：由通式（I）表示的化合物或其盐，其中R表示由下式（A），（B）或（C）表示的基团，其中R 1和R 2独立地表示C1 -6烷基，R 3表示氨基，单（C 1-6烷基）氨基，二（C 1-6烷基）氨基或C 1-6烷氧基，X代表阴离子，和 n表示2〜5的整数。化合物或其盐可用作肌醇-1,4,5-三磷酸（IP3）受体的配体。

33. 发明申请

US20140248654A1 ACIDIC ENVIRONMENT-DETECTING FLUORESCENT PROBE 有权
标题翻译：酸性环境检测荧光探针
公开(公告)号：US20140248654A1
公开(公告)日：2014-09-04
申请号：US14343033
申请日：2012-09-06
申请人： Yasuteru Urano , Tetsuo Nagano , Daisuke Asanuma , Kenzo Hirose , Shigeyuki Namiki , Yousuke Takaoka
发明人： Yasuteru Urano , Tetsuo Nagano , Daisuke Asanuma , Kenzo Hirose , Shigeyuki Namiki , Yousuke Takaoka
IPC分类号： G01N33/52
CPC分类号： G01N33/52 , C07D311/82 , C07D405/04 , C07D405/14 , C09B11/24 , C09B69/00 , C09B69/103 , C09K11/06 , C09K2211/1044 , C09K2211/1088 , G01N21/6428 , G01N33/5005
摘要： Provided is a compound represented by formula (I), which can be used as a fluorescent probe that becomes highly fluorescent only in an intracellular acidic environment and can be adapted to the fluorescent imaging of an intracellular vesicle that is a microstructure. In the formula, R1 and R2 independently represent a hydrogen atom, or an alkyl group which may be substituted (wherein R1 and/or R2 represents an alkyl group which may be substituted); R3, R4, R5, R6, R7 and R8 independently represent a hydrogen atom, a halogen atom, or the like; X represents a functional group to which a labeling site or a target-accumulating site can be introduced, or the like; Y represents a halogen atom, an alkyl group which may be substituted, or the like; m represents an integer of 0 to 5; and n represents an integer of 0 to 5.
摘要翻译：提供由式（I）表示的化合物，其可以用作仅在细胞内酸性环境中变得高度荧光的荧光探针，并且可以适用于作为微结构的细胞内小泡的荧光成像。在该式中，R 1和R 2独立地表示氢原子或可被取代的烷基（其中R 1和/或R 2表示可被取代的烷基）; R 3，R 4，R 5，R 6，R 7和R 8独立地表示氢原子，卤素原子等; X表示可以引入标记位点或靶标积累位点的官能团等; Y表示卤原子，可被取代的烷基等; m表示0〜5的整数， n表示0〜5的整数。

34. 发明申请

US20130289256A1 FLUORESCENT PROBE 有权
标题翻译：荧光探针
公开(公告)号：US20130289256A1
公开(公告)日：2013-10-31
申请号：US13980215
申请日：2012-01-19
申请人： Tetsuo Nagano , Kenjiro Hanaoka , Yuichiro Koide , Takahiro Egawa , Kazuhisa Hirabayashi
发明人： Tetsuo Nagano , Kenjiro Hanaoka , Yuichiro Koide , Takahiro Egawa , Kazuhisa Hirabayashi
IPC分类号： C07F7/08
CPC分类号： C09B11/24 , C07C211/44 , C07C211/52 , C07F7/081 , C07F7/0816 , C07F7/10 , C07F7/1804 , C07F7/2208 , C07F7/30 , C09B69/008 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1096 , G01N21/6428 , G01N33/84 , G01N2021/6439 , H05B33/10
摘要： A compound represented by the formula (I) (R1 represents hydrogen atom or a monovalent substituent; R2 and R3 represent hydrogen atom, an alkyl group, or a halogen atom; R4 and R5 represent an alkyl group or an aryl group; R6 and R7 represent hydrogen atom, an alkyl group, or a halogen atom; R8 represent hydroxy group or a dialkoxyboranetriyl group; and X represents silicon atom, germanium atom, or tin atom), which is a novel fluorophore usable as a mother nucleus of an off/on type fluorescent probe not utilizing the intramolecular photoinduced electron transfer.
摘要翻译：由式（I）表示的化合物（R1表示氢原子或一价取代基; R2和R3表示氢原子，烷基或卤素原子; R4和R5表示烷基或芳基; R6和R7 表示氢原子，烷基或卤素原子; R8表示羟基或二烷氧基硼烷三基; X表示硅原子，锗原子或锡原子），其是可用作脱/ 不使用分子内光诱导电子转移的荧光探针。

35. 发明申请

US20130023675A1 DIAGNOSTIC FOR CANCER 审中-公开
标题翻译：癌症诊断
公开(公告)号：US20130023675A1
公开(公告)日：2013-01-24
申请号：US13521326
申请日：2011-01-12
申请人： Yasuteru Urano , Tetsuo Nagano , Masayo Sakabe
发明人： Yasuteru Urano , Tetsuo Nagano , Masayo Sakabe
IPC分类号： C07D493/10
CPC分类号： A61K49/0043 , A61K31/352 , A61K49/0041 , C07D493/10
摘要： An agent for diagnosing cancer comprising, as an active ingredient, a compound represented by the following formula (I) (R1 represents hydrogen atom, or a substituent; R2 to R7 represent hydrogen atom, hydroxyl group, an alkyl group, or a halogen atom; R8 and R9 represent hydrogen atom, or an alkyl group; and X represents a C1-C3 alkylene group), which specifically emits fluorescence in a cancerous tissue within a short time when applied to a part in which presence of a cancerous tissue is suspected.
摘要翻译：作为活性成分的下述式（I）表示的化合物（R1表示氢原子或取代基），R2〜R7表示氢原子，羟基，烷基或卤素原子，作为活性成分 ; R8和R9表示氢原子或烷基，X表示C1-C3亚烷基），当在怀疑存在癌组织的部位应用时，在短时间内特异性地发生癌组织中的荧光。

36. 发明授权

US08178669B2 Fluorescent probe for peroxynitrite 有权
标题翻译：过氧亚硝酸荧光探针
公开(公告)号：US08178669B2
公开(公告)日：2012-05-15
申请号：US12093479
申请日：2006-11-14
申请人： Tetsuo Nagano , Yasuteru Urano , Tasuku Ueno
发明人： Tetsuo Nagano , Yasuteru Urano , Tasuku Ueno
IPC分类号： C07F5/02
CPC分类号： C07F5/022 , C07F5/003 , G01N31/228
摘要： A compound represented by the following general formula (I): {R1, R3, R6 and R8 are methyl groups and the like, R2 and R7 are cyano groups and the like, R4 and R5 are fluorine atoms and the like, and X is a group represented by the formula (A) [R11 is a monocarboxy-substituted C1-8 alkoxy group and the like, R12, R14 and R15 are hydrogen atoms and the like, and R13 is hydroxy group and the like], provided that the combination of the aforementioned substituents is such a combination that the compound represented by the formula (I) can be substantially non-fluorescent before reacting with peroxynitrite, and the compound represented by the formula (I) in which the group represented by the formula (A) is nitrated after reacting with peroxynitrite can be substantially highly fluorescent}, or a salt thereof, which is useful as a fluorescent probe for peroxynitrite measurement.
摘要翻译：由以下通式（I）表示的化合物：{R1，R3，R6和R8是甲基等，R2和R7是氰基等，R4和R5是氟原子等，X是由式（A）表示的基团[R 11是单羧基取代的C 1-8烷氧基等，R 12，R 14和R 15为氢原子等，R 13为羟基等]，条件是上述取代基的组合是这样的组合，即式（I）表示的化合物在与过氧亚硝酸盐反应之前可以基本上不发生荧光，而由式（I）表示的基团与式）与过氧亚硝酸盐反应后硝化可以是基本上高度荧光的}或其盐，其可用作过氧亚硝酸盐测量的荧光探针。

37. 发明申请

US20120052518A1 FLUORESCENT PROBE FOR MEASURING PROTEASE 有权
标题翻译：用于测量蛋白质的荧光探针
公开(公告)号：US20120052518A1
公开(公告)日：2012-03-01
申请号：US13201537
申请日：2010-02-19
申请人： Tetsuo Nagano , Yasuteru Urano , Masayo Sakabe
发明人： Tetsuo Nagano , Yasuteru Urano , Masayo Sakabe
IPC分类号： C12Q1/48 , C07D493/10
CPC分类号： C07D493/10 , C09B11/24
摘要： A compound represented by the formula (I) or a salt thereof (R1 represents hydrogen atom, or a substituent; R2 to R7 represent hydrogen atom, hydroxyl group, an alkyl group, or a halogen atom; R8 and R9 represent hydrogen atom, or an alkyl group; X represents a C1-C3 alkylene group; and R10 represents an acyl group), which promptly causes a structural change from a non-fluorescent closed ring structure to a strongly fluorescent open ring structure by hydrolysis of an acyl group, and is useful as a fluorescent probe for measuring a protease showing superior suitability for quantification.
摘要翻译：由式（I）表示的化合物或其盐（R1表示氢原子或取代基; R2表示氢原子，羟基，烷基或卤素原子; R8和R9表示氢原子或烷基; X表示C1-C3亚烷基; R10表示酰基），其通过酰基水解迅速导致从非荧光闭环结构向强荧光开环结构的结构变化，以及作为用于测定显示出优异的定量适用性的蛋白酶的荧光探针是有用的。

38. 发明授权

US07696245B2 Fluorescent probe for zinc 失效
标题翻译：锌荧光探针
公开(公告)号：US07696245B2
公开(公告)日：2010-04-13
申请号：US10767334
申请日：2004-01-30
申请人： Kensuke Komatsu , Tomoya Hirano , Kazuya Kikuchi , Tetsuo Nagano
发明人： Kensuke Komatsu , Tomoya Hirano , Kazuya Kikuchi , Tetsuo Nagano
IPC分类号： A61K31/353 , C07D311/80
CPC分类号： C07D405/12 , C07D405/14 , C07D493/10 , G01N33/582 , G01N33/84
摘要： A compound represented by the following general formula (IA) or (IB) or a salt thereof which specifically traps a zinc ion and emits fluorescence, and is useful as a fluorescent probe for zinc: wherein R1 and R2 represent a hydrogen atom or a group represented by the following formula (A): wherein X1 to X4 represent a hydrogen atom, a 2-pyridylmethyl group, a 2-pyridylethyl group, a 2-methyl-6-pyridylmethyl group, or a 2-methyl-6-pyridylethyl group, provided that at least one is the group except a 2-pyridylmethyl group, and m and n represent 0 or 1, provided that they are not simultaneously 0; provided that R1 and R2 are not simultaneously hydrogen atoms; R3 and R4 represent a hydrogen atom or a halogen atom; R5 and R6 represent a hydrogen atom, an alkylcarbonyl group, or an alkylcarbonyloxymethyl group; and R7 represents a hydrogen atom or an alkyl group.
摘要翻译：由以下通式（IA）或（IB）表示的化合物或其盐特异性捕获锌离子并发射荧光，并且可用作锌的荧光探针：其中R1和R2表示氢原子或基团由下式（A）表示：其中X 1至X 4表示氢原子，2-吡啶基甲基，2-吡啶基乙基，2-甲基-6-吡啶基甲基或2-甲基-6-吡啶基乙基条件是至少一个是除2-吡啶基甲基以外的基团，m和n表示0或1，条件是它们不同时为0; 条件是R1和R2不同时为氢原子; R3和R4表示氢原子或卤素原子; R5和R6表示氢原子，烷基羰基或烷基羰氧基甲基; 并且R 7表示氢原子或烷基。

39. 发明申请

US20090263910A1 METHOD FOR MEASURING HYPOCHLORITE ION 审中-公开
标题翻译：测量高碘离子的方法
公开(公告)号：US20090263910A1
公开(公告)日：2009-10-22
申请号：US12493995
申请日：2009-06-29
申请人： Ken-Ichi Setsukinai , Yasuteru Urano , Tetsuo Nagano
发明人： Ken-Ichi Setsukinai , Yasuteru Urano , Tetsuo Nagano
IPC分类号： G01N33/00
CPC分类号： G01N21/6428 , G01N2021/7786 , Y10T436/14 , Y10T436/19 , Y10T436/196666 , Y10T436/200833
摘要： A method for measuring hypochlorite ion, which comprises the steps of:(A) reacting, with hypochlorite ion, a compound represented by the following general formula (I): wherein R1 represents a 2-carboxyphenyl group which may be substituted; R2 represents a phenyl group which is substituted with a substituted or unsubstituted amino group; X1 and X2 each independently represents either hydrogen atom or a halogen atom; or a salt thereof; and (B) measuring fluorescence of a dearylated compound generated in the aforementioned step (A) or a salt thereof.
摘要翻译：一种测定次氯酸根离子的方法，包括以下步骤：（A）与次氯酸根离子反应由以下通式（I）表示的化合物：其中R1表示可被取代的2-羧基苯基; R2表示被取代或未取代的氨基取代的苯基; X1和X2各自独立地表示氢原子或卤素原子; 或其盐; 和（B）测量在上述步骤（A）中产生的脱芳基化合物的荧光或其盐。

40. 发明申请

US20090258434A1 FLUORESCENT PROBE FOR PEROXYNITRITE 有权
标题翻译：过氧化物荧光探针
公开(公告)号：US20090258434A1
公开(公告)日：2009-10-15
申请号：US12093479
申请日：2006-11-14
申请人： Tetsuo Nagano , Yasuteru Urano , Tasuku Ueno
发明人： Tetsuo Nagano , Yasuteru Urano , Tasuku Ueno
IPC分类号： G01N33/566 , C07F5/02
CPC分类号： C07F5/022 , C07F5/003 , G01N31/228
摘要： A compound represented by the following general formula (I): {R1, R3, R6 and R8 are methyl groups and the like, R2 and R7 are cyano groups and the like, R4 and R5 are fluorine atoms and the like, and X is a group represented by the formula (A) [R11 is a monocarboxy-substituted C1-8 alkoxy group and the like, R12, R14 and R15 are hydrogen atoms and the like, and R13 is hydroxy group and the like], provided that the combination of the aforementioned substituents is such a combination that the compound represented by the formula (I) can be substantially non-fluorescent before reacting with peroxynitrite, and the compound represented by the formula (I) in which the group represented by the formula (A) is nitrated after reacting with peroxynitrite can be substantially highly fluorescent}, or a salt thereof, which is useful as a fluorescent probe for peroxynitrite measurement.
摘要翻译：由以下通式（I）表示的化合物：{R1，R3，R6和R8是甲基等，R2和R7是氰基等，R4和R5是氟原子等，X是由式（A）表示的基团[R 11是单羧基取代的C 1-8烷氧基等，R 12，R 14和R 15为氢原子等，R 13为羟基等]，条件是上述取代基的组合是这样的组合，即式（I）表示的化合物在与过氧亚硝酸盐反应之前可以基本上不发生荧光，而由式（I）表示的基团与式）与过氧亚硝酸盐反应后硝化可以是基本上高度荧光的}或其盐，其可用作过氧亚硝酸盐测量的荧光探针。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式