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31. 发明授权

US06596739B2 N-(1-phenylethyl)-5-phenyl-imidazole-2-amine compounds, their compositions and uses 失效
标题翻译： N-（1-苯基乙基）-5-苯基 - 咪唑-2-胺化合物，其组成和用途
公开(公告)号：US06596739B2
公开(公告)日：2003-07-22
申请号：US10149880
申请日：2002-06-14
申请人： Song Liu , Benjamin Eric Blass , David Edward Portlock
发明人： Song Liu , Benjamin Eric Blass , David Edward Portlock
IPC分类号： C07D23354
CPC分类号： C07D233/88
摘要： The subject invention involves compounds having structure (I): wherein each R1 is independently alkyl, aryl, or heterocycle; each R2, R4, R7, and R8 is independently hydrogen or other substituent; A is aryl or heterocycle; and pharmaceutically acceptable forms thereof. The subject invention also involves pharmaceutical compositions containing such compounds, and methods for treating or preventing diseases or disorders using such compounds.
摘要翻译：本发明涉及具有结构（I）的化合物：其中每个R 1独立地是烷基，芳基或杂环; 每个R 2，R 4，R 7和R 8独立地是氢或其它取代基; A是芳基或杂环; 及其药学上可接受的形式。本发明还涉及含有这些化合物的药物组合物，以及使用这些化合物治疗或预防疾病或病症的方法。

32. 发明授权

US5849889A Oligosaccharide-containing 14 aminosteroid compounds and novel diastereoselective aminosteroid process chemistry 失效
标题翻译：含寡糖的14种氨基甾体化合物和新型非对映选择性氨基甾体过程化学
公开(公告)号：US5849889A
公开(公告)日：1998-12-15
申请号：US802491
申请日：1997-02-20
申请人： Paul Michael Dybas , Roland Norman Johnson , Randy Stuart Muth , Song Liu , David Edward Portlock
发明人： Paul Michael Dybas , Roland Norman Johnson , Randy Stuart Muth , Song Liu , David Edward Portlock
IPC分类号： A61K31/7036 , A61K31/704 , A61P9/00 , C07J3/00 , C07J17/00 , C07J19/00 , C07J41/00 , A61K31/705
CPC分类号： C07J41/0011 , C07J17/005 , C07J19/005 , C07J3/005 , C07J41/00 , C07J41/0038
摘要： The present invention relates to new 14-aminosteroids, pharmaceutical compositions containing the new compounds and methods of treatment for humans or other mammals afflicted with congestive heart failure.
摘要翻译：本发明涉及新的14-氨基甾体，含有新化合物的药物组合物和治疗患有充血性心力衰竭的人或其他哺乳动物的方法。

33. 发明授权

US08903876B2 File storage system based on coordinated exhaustible and non-exhaustible storage 有权
标题翻译：文件存储系统基于协调的可耗尽和不可耗尽的存储
公开(公告)号：US08903876B2
公开(公告)日：2014-12-02
申请号：US13585967
申请日：2012-08-15
申请人： Amir Meir Michael , Song Liu , Jason Matthew Taylor , Yael Maguire , Per Brashers , Eitan Frachtenberg
发明人： Amir Meir Michael , Song Liu , Jason Matthew Taylor , Yael Maguire , Per Brashers , Eitan Frachtenberg
IPC分类号： G06F17/30
CPC分类号： G06F17/30168 , G06F17/30194 , G06F17/30221
摘要： A file storage system is implemented by coordinating non-exhaustible and exhaustible storage devices. The exhaustible storage devices include lower grade flash based storage devices. The non-exhaustible storage devices are based on magnetic recording mechanisms or higher grade flash storage. The file storage system stores received content items on the exhaustible storage devices, and stores metadata for the content items and/or the file storage system on the non-exhaustible storage devices. During operation, the file storage system globally optimizes the content items on the exhaustible storage devices such that more heavily accessed items are moved to exhaustible storage devices that have experienced relatively few data operations. The file storage system moves less frequently accessed content items to exhaustible storage devices that have experienced a relatively large number of data operations. As such, the operation lifetime of the exhaustible storage devices as a whole can be prolonged.
摘要翻译：文件存储系统通过协调不可耗尽和可耗尽的存储设备来实现。可耗尽的存储设备包括较低级别的闪存存储设备。不可耗尽的存储设备基于磁记录机构或更高等级的闪存存储。文件存储系统将可接收的内容项目存储在可耗尽的存储装置上，并将用于内容项目和/或文件存储系统的元数据存储在不可耗尽的存储装置上。在操作期间，文件存储系统全局地优化可耗尽存储设备上的内容项目，使得更多访问的项目被移动到经历相对较少的数据操作的可耗尽的存储设备。文件存储系统将经常访问的内容项目移动到经历了相对大量数据操作的可耗尽的存储设备。因此，可以延长整个可消耗的存储装置的操作寿命。

34. 发明申请

US20140322788A1 method for increasing protein thermal stability 有权
标题翻译：增加蛋白质热稳定性的方法
公开(公告)号：US20140322788A1
公开(公告)日：2014-10-30
申请号：US13870509
申请日：2013-04-25
申请人： Jian Chen , Guocheng Du , Xinyao Lu , Song Liu , Juan Zhang
发明人： Jian Chen , Guocheng Du , Xinyao Lu , Song Liu , Juan Zhang
IPC分类号： C12N9/96 , C12N9/26 , C12N9/10 , C12N9/02
CPC分类号： C12N9/96 , C12N9/0069 , C12N9/1044 , C12N9/2411
摘要： The invention provides a simple and effective method for increasing thermal stability of a wide range of proteins, comprising fusing a self-assembling amphipathic peptide to the C- or N-terminal of target proteins. The fusion protein can have a half life up to 26 times longer than that of the wild type protein.
摘要翻译：本发明提供了一种用于增加大范围蛋白质的热稳定性的简单且有效的方法，其包括将自组装两亲肽融合到靶蛋白的C-或N-末端。融合蛋白的半衰期比野生型蛋白质长达26倍。

35. 发明申请

US20140141724A1 NOISE CANCELING SYSTEM AND METHOD, SMART CONTROL METHOD AND DEVICE AND COMMUNICATION EQUIPMENT 有权
标题翻译：噪声消除系统和方法，智能控制方法和设备和通信设备
公开(公告)号：US20140141724A1
公开(公告)日：2014-05-22
申请号：US14119611
申请日：2011-11-08
申请人： Song Liu , Jian Zhao , Shasha Lou
发明人： Song Liu , Jian Zhao , Shasha Lou
IPC分类号： H04B1/12
CPC分类号： H04B1/12 , H04R1/1083 , H04R3/02 , H04R2410/05 , H04R2460/01 , H04R2499/13
摘要： The present invention discloses a noise canceling system and method, a smart control method and device and a communication equipment. Said smart control method includes: when it is detected there is no voice signal output at a receiving end of a communication equipment, receiving an outside noise signal from a reference microphone away from ears and a detection signal from a monitoring microphone near ears; implementing performance analysis on said received outside noise signal and said detection signal to estimate a noise reduction performance curve after said feed-forward active noise cancellation; and regulating parameters of the control circuit in said feed-forward active noise cancellation according to said estimated noise reduction performance curve and the preset noise reduction performance curve to make a difference between said estimated noise reduction performance curve and said preset noise reduction performance curve within a preset range.
摘要翻译：本发明公开了一种噪声消除系统和方法，智能控制方法和装置以及通信设备。所述智能控制方法包括：当检测到通信设备的接收端没有语音信号输出时，从参考麦克风远离耳朵接收外部噪声信号和从耳朵附近的监测麦克风接收的检测信号; 对所述接收的外部噪声信号和所述检测信号执行性能分析，以估计所述前馈有源噪声消除之后的噪声降低性能曲线; 以及根据所述估计的噪声降低性能曲线和预设的降噪性能曲线来调节所述前馈有源噪声消除中的控制电路的参数，以使所述估计的降噪性能曲线与所述预设噪声降低性能曲线之间的差异预设范围。

36. 发明申请

US20140067778A1 SELECTIVE OFFLINING STORAGE MEDIA FILESYSTEM 审中-公开
标题翻译：选择性离线存储媒体文件系统
公开(公告)号：US20140067778A1
公开(公告)日：2014-03-06
申请号：US13601733
申请日：2012-08-31
申请人： Dhruba Borthakur , Per Brashers , Song Liu , Tomasz Nykiel
发明人： Dhruba Borthakur , Per Brashers , Song Liu , Tomasz Nykiel
IPC分类号： G06F17/30
CPC分类号： G06F16/185
摘要： A method of operation of a storage control system includes: configuring a state change policy on a data server, the state change policy including an online duration for a storage device; activating the storage device based on the state change policy; mounting the storage device based on the state change policy; and scheduling a filesystem maintenance task to be performed on the storage device based on the state change policy.
摘要翻译：存储控制系统的操作方法包括：在数据服务器上配置状态改变策略，所述状态改变策略包括存储设备的在线持续时间; 基于状态改变策略激活存储设备; 根据国家变更政策安装存储设备; 并根据状态改变策略调度对存储设备执行的文件系统维护任务。

37. 发明授权

US08543364B2 Method for optimizing well production in reservoirs having flow barriers 有权
标题翻译：在具有流动障碍的水库中优化井的生产方法
公开(公告)号：US08543364B2
公开(公告)日：2013-09-24
申请号：US12561830
申请日：2009-09-17
申请人： Song Liu , Lixin Tian , Xian-Huan Wen , Chunming Zhao , Qinghong Yang , Peng Zhang , Dengen Zhou , Bo Li , Lichuan Lan , Lizhen Ge , Xinwu Liao , Fengli Zhang , Michael Sheng-Wei Wei
发明人： Song Liu , Lixin Tian , Xian-Huan Wen , Chunming Zhao , Qinghong Yang , Peng Zhang , Dengen Zhou , Bo Li , Lichuan Lan , Lizhen Ge , Xinwu Liao , Fengli Zhang , Michael Sheng-Wei Wei
IPC分类号： G06G7/48
CPC分类号： E21B43/00
摘要： Computer-implemented systems and methods are provided for optimizing hydrocarbon recovery from subsurface formations, including subsurface formations having bottom water or edgewater. A system and method can be configured to receive data indicative of by-pass oil areas in the subsurface formation from reservoir simulation, identify flow barriers in the subsurface formation based on the by-pass oil areas identified by the reservoir simulation, and predict the lateral extension of the identified flow barriers in the subsurface formation. Infill horizontal wells can be placed at areas of the subsurface formation relative to the flow barriers such that production from a horizontal well in the subsurface formation optimizes hydrocarbon recovery.
摘要翻译：提供计算机实现的系统和方法，用于优化地下构造的烃回收，包括具有底部水或污水的地下地层。一种系统和方法可以被配置为接收指示来自储层模拟的地下地层旁路油区的数据，基于由油藏模拟识别的旁路油区，识别地下地层中的流动障碍，并预测横向在地下构造中识别的流动障碍的扩展。填充水平井可以放置在相对于流动屏障的地下地层的区域，使得地下地层中的水平井的生产优化了烃回收。

38. 发明申请

US20130024194A1 SPEECH ENHANCING METHOD AND DEVICE, AND NENOISING COMMUNICATION HEADPHONE ENHANCING METHOD AND DEVICE, AND DENOISING COMMUNICATION HEADPHONES 有权
标题翻译：语音增强方法和设备，以及通信通信耳机增强方法和设备，以及通信通信耳机
公开(公告)号：US20130024194A1
公开(公告)日：2013-01-24
申请号：US13637715
申请日：2011-11-25
申请人： Jian Zhao , Song Liu , Bo Li , Yang Hua
发明人： Jian Zhao , Song Liu , Bo Li , Yang Hua
IPC分类号： G10L21/02
CPC分类号： G10L21/0208 , G10L2021/02165 , H04R1/083 , H04R3/005 , H04R2201/107 , H04R2410/05
摘要： The present invention discloses a speech enhancing method, a speech enhancing device and a denoising communication headphone. In the solutions of the present invention, a first sound signal that comprises a user's speech signal transmitted through coupling vibration and an ambient noise signal transmitted through the air and a second sound signal that is mainly an ambient noise signal transmitted through the air are picked up by a primary vibration microphone and a secondary vibration microphone, respectively, that have a specific relative positional relationship therebetween, and the ambient noise signals picked up by the two vibration microphones are correlated with each other; a control parameter used to control an updating speed of an adaptive filter is determined according to the first sound signal and the second sound signal; the first sound signal is denoised and filtered according to the second sound signal and the control parameter; and the denoised and filtered speech signal is further denoised and speech high-frequency enhancement is performed thereon. The technical solutions of the present invention can effectively improve the signal to noise ratio (SNR) and the quality of speech in an environment of highly intense noises.
摘要翻译：本发明公开了一种语音增强方法，语音增强装置和去噪通信耳机。在本发明的解决方案中，拾取包括通过耦合振动发送的用户语音信号和通过空气传输的环境噪声信号的第一声音信号和主要通过空气传输的环境噪声信号的第二声音信号通过分别具有特定相对位置关系的主振动麦克风和二次振动麦克风，并且由两个振动麦克风拾取的环境噪声信号彼此相关; 根据第一声音信号和第二声音信号确定用于控制自适应滤波器的更新速度的控制参数; 根据第二声音信号和控制参数对第一声音信号进行去噪和滤波; 并且去噪和滤波的语音信号被进一步去噪，并且在其上执行语音高频增强。本发明的技术方案可以在高度强烈的噪声环境中有效提高信噪比（SNR）和语音质量。

39. 发明申请

US20120136654A1 Apparatus And Method For Cancelling Echo In Joint Time Domain And Frequency Domain 有权
标题翻译：在联合时域和频域中消除回波的装置和方法
公开(公告)号：US20120136654A1
公开(公告)日：2012-05-31
申请号：US13389367
申请日：2010-12-22
申请人： Shasha Lou , Song Liu
发明人： Shasha Lou , Song Liu
IPC分类号： G10L19/14
CPC分类号： H04M9/082 , H04B3/23
摘要： Disclosed in the present invention is a method for cancelling echo in joint time domain and frequency domain. The method includes: receiving an input receiver signal and an input transmitter signal; implementing echo cancellation on the received transmitter signal, based on the received receiver signal, by using a first echo canceller which is either a time domain echo canceller or a frequency domain echo canceller, to obtain a first echo-cancelled signal; implementing echo cancellation again on the first echo-cancelled signal, based on the received receiver signal, by using a second echo canceller which is the other one of the time domain echo canceller and the frequency domain echo canceller, to obtain a second echo-cancelled signal; wherein, the filter parameters of the second filter of the second echo canceller is updated based on the second echo-cancelled signal, and the first and second echo canceller respectively include the corresponding first and second filters. By using said method in the present invention, fast response to echo reflecting environment can be achieved with little residual echo, thus the effect of echo cancellation is entirely improved.
摘要翻译：在本发明中公开了一种消除联合时域和频域中的回波的方法。该方法包括：接收输入接收机信号和输入发射机信号; 通过使用作为时域回波消除器或频域回波消除器的第一回波消除器，基于接收到的接收机信号，对所接收的发射机信号实现回波消除，以获得第一回声消除信号; 通过使用作为时域回波消除器和频域回波消除器中的另一个的第二回波消除器，基于接收到的接收器信号，在第一回波消除信号上再次实现回波消除，以获得第二回声消除信号; 其中，基于所述第二回波消除信号来更新所述第二回波消除器的所述第二滤波器的滤波器参数，并且所述第一和第二回波消除器分别包括相应的第一和第二滤波器。通过使用本发明的方法，可以实现对回波反射环境的快速响应，具有很少的残余回波，从而完全改善了回声消除的效果。

40. 发明申请

US20120035194A1 SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：取代的2-AMINO-FUSED杂环化合物
公开(公告)号：US20120035194A1
公开(公告)日：2012-02-09
申请号：US13204741
申请日：2011-08-08
申请人： Liming Huang , Song Liu , Elizabeth A. Lunney , Simon P. Planken
发明人： Liming Huang , Song Liu , Elizabeth A. Lunney , Simon P. Planken
IPC分类号： A61K31/517 , C07D405/12 , C07D239/84 , A61P9/00 , C07D409/12 , A61P3/10 , A61P3/00 , A61P3/04 , A61P3/06 , A61P19/10 , A61P9/10 , A61P25/24 , A61P31/12 , A61P29/00 , A61P1/16 , C07D401/12
CPC分类号： C07D239/84 , C07D401/04 , C07D401/12 , C07D403/12
摘要： The present invention relates to compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein: R1, R2, Z1, t, and ring A are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of JNK, such as diabetes, the method comprising administering to a mammal an effective amount of a compound of formula (I).
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐或溶剂合物，其中：R1，R2，Z1，t和环A如说明书中所定义。本发明还涉及包含式（I）化合物的药物组合物和治疗由调节JNK介导的病症如糖尿病的方法，所述方法包括向哺乳动物施用有效量的式（I）化合物一世）。

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