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31. 发明申请

US20120122146A1 NANOPARTICLE SCREENING METHODS EMPLOYING INSECTS WITH BLOOD BRAIN BARRIER 审中-公开
标题翻译：使用血液屏障的纳米技术筛选方法
公开(公告)号：US20120122146A1
公开(公告)日：2012-05-17
申请号：US13387094
申请日：2010-08-10
申请人： Peter Aadal , Gunnar Andersson , Olga Andersson
发明人： Peter Aadal , Gunnar Andersson , Olga Andersson
IPC分类号： C12Q1/02 , B82Y5/00
CPC分类号： G01N33/5085 , G01N2333/43552
摘要： There is provided an insect model for determining the penetration of nanoparticles through the BBB. The model is also directed to the use of insects for studying the environmental safety of nanoparticles. The particles are administered into the hemolymf of an insect having a BBB, such as the locust, and the uptake into the brain is analysed. Thus, in this model it is possible to investigate the potential up-take into the brain of nanoparticles circulating in the blood.
摘要翻译：提供了用于确定纳米颗粒穿过BBB的穿透性的昆虫模型。该模型还针对使用昆虫研究纳米颗粒的环境安全性。将颗粒施用于具有BBB的昆虫的血淋巴，例如蝗虫，并分析对大脑的摄取。因此，在该模型中，可以研究在血液中循环的纳米颗粒的脑中的潜在上升。

32. 发明申请

US20120119081A1 INSECT-BASED MODEL FOR PHARMACO-KINETIC STUDIES 审中-公开
标题翻译：基于INSECT的药物动力学研究模型
公开(公告)号：US20120119081A1
公开(公告)日：2012-05-17
申请号：US13387098
申请日：2010-08-10
申请人： Peter Aadal Nielsen , Gunnar Andersson , Olga Andersson
发明人： Peter Aadal Nielsen , Gunnar Andersson , Olga Andersson
IPC分类号： H01J49/26 , G01N33/50
CPC分类号： G01N33/5085
摘要： There is provided a new methodology for initial assessment of compound PK. The invention is generally particular useful for efficient screening of and assessment of PK profiles of newly synthesized compounds in the early phase of drug discovery.
摘要翻译：为化合物PK的初步评估提供了新的方法。本发明通常特别适用于药物发现早期新合成化合物的PK谱的有效筛选和评估。

33. 发明申请

US20110093216A1 METHOD AND DEVICE FOR DETERMINING THE RELATIVE HUMIDITY OF AN INSULATING LIQUID FILLED ELECTRIC APPARATUS 有权
标题翻译：用于确定绝缘液体充填电器的相对湿度的方法和装置
公开(公告)号：US20110093216A1
公开(公告)日：2011-04-21
申请号：US12914718
申请日：2010-10-28
申请人： Gunnar Andersson , Bengt-Olof Stenestam
发明人： Gunnar Andersson , Bengt-Olof Stenestam
IPC分类号： G06F19/00 , G01N19/10
CPC分类号： H01F27/14 , G01N33/0031 , G01N33/2847 , H01F27/402 , H01F2027/404
摘要： A method for determining the relative humidity of an insulating liquid filled electric apparatus including a container containing insulating liquid and gas, a communication unit providing communication between the gas of the container and gas of an external environment, and providing dehydration of gas passing through the communication unit, wherein the method includes: continuously measuring and storing the relative humidity of the gas in the container, calculating an average value of the relative humidity in the gas based on the stored humidity measurements during a certain time period, and determining the relative humidity of the insulating liquid based on the average value of the relative humidity in the gas and a relationship between the relative humidity of the gas and the relative humidity of the insulating liquid at equilibrium.
摘要翻译：一种用于确定包括容纳绝缘液体和气体的容器的绝缘液体填充电气设备的相对湿度的方法，提供容器的气体与外部环境的气体之间的连通并提供通过通信的气体的脱水的通信单元单元，其中所述方法包括：连续地测量和存储所述容器中的气体的相对湿度，基于在一定时间段内存储的湿度测量值来计算气体中的相对湿度的平均值，并且确定相对湿度绝缘液体基于气体中的相对湿度的平均值以及气体的相对湿度与绝缘液体在平衡时的相对湿度之间的关系。

34. 发明授权

US07145760B2 Tap changer monitoring 有权
标题翻译：分接开关监控
公开(公告)号：US07145760B2
公开(公告)日：2006-12-05
申请号：US10450579
申请日：2001-12-14
申请人： Bengt-Olof Stenestam , Gunnar Andersson
发明人： Bengt-Olof Stenestam , Gunnar Andersson
IPC分类号： H01H47/00
CPC分类号： G01R31/3274 , G01R31/333 , H01F29/04 , H01H2009/0061
摘要： A method and means for diagnosing transformer tap changers is provided. Pressure is monitored in an insulating liquid of a tap changer for a period of time in which switching of the tap changer is carried through. Switching-related information is extracted from the pressure diagram. Quantities from pressure peaks are related to specific arcings of the switching sequence. Early error detection is achieved, whereby transformed failures may be avoided. Repeated measurements may be followed by trend evaluation. If a trend indicating tap changer problems is detected, an alarm signal is triggered. The transformer may be switched off if the pressure exceeds a predetermined emergency value. Information of the base pressure in the tap changer may be extracted and converting it to level of insulating liquid.
摘要翻译：提供了用于诊断变压器抽头变换器的方法和装置。在分接开关的绝缘液体中监测压力，持续一段时间，分接开关切换进行。从压力图提取开关相关信息。压力峰值的数量与切换序列的特定弧线有关。实现早期错误检测，从而可以避免变形的故障。重复测量可以跟随趋势评估。如果检测到指示分接开关故障的趋势，则触发报警信号。如果压力超过预定的紧急值，变压器可能会关闭。可以提取分接开关中的基础压力的信息，并将其转换成绝缘液体的水平。

35. 发明授权

US07074831B2 Compounds, methods for their preparation and use thereof 失效
标题翻译：化合物，其制备方法和用途
公开(公告)号：US07074831B2
公开(公告)日：2006-07-11
申请号：US11050430
申请日：2005-02-04
申请人： Stig Jönsson , Gunnar Andersson , Ulf Wellmar , Ingela Fritzson
发明人： Stig Jönsson , Gunnar Andersson , Ulf Wellmar , Ingela Fritzson
IPC分类号： A61K31/192 , C07C65/105
CPC分类号： C07C233/54 , C07C233/63 , C07C233/75 , C07C235/56 , C07C275/36 , C07C323/59 , C07C323/63 , C07C2601/02 , C07D207/06 , C07D211/14 , C07D295/096 , C07D295/155
摘要： Compounds of formula (I) for clinical treatment of autoimmune diseases, inflammatory diseases, organ transplant rejection and malignant neoplasia. A pharmaceutical composition comprising a compound of formula (I) in an amount giving a daily dosage of from 0.005 mg/kg to 10 mg/kg body weight, in particular from 0.025 mg/kg to 2 mg/kg body weight.
摘要翻译：用于临床治疗自身免疫疾病，炎性疾病，器官移植排斥和恶性肿瘤的式（I）化合物。一种药物组合物，其包含给予每日剂量为0.005mg / kg至10mg / kg体重，特别是0.025mg / kg至2mg / kg体重的式（I）化合物。

36. 发明授权

US06796971B2 Container for intravenous administration 有权
标题翻译：容器用于静脉给药
公开(公告)号：US06796971B2
公开(公告)日：2004-09-28
申请号：US09812866
申请日：2001-03-21
申请人： Gunnar Andersson , Bert Petterson
发明人： Gunnar Andersson , Bert Petterson
IPC分类号： A61M500
CPC分类号： B65D47/24 , A61J1/1425 , A61J1/1468 , A61J1/1481 , A61J1/1487 , A61J1/18 , A61J1/201 , A61J1/2096 , Y10S604/905
摘要： A device for storing and administering a medical fluid comprising a sealed flexible formed container with an opening part in its front end in which an insert is positioned. Over the insert, the container extends into a removable sealing cap. After removal of the sealing cap an injection means is attached to the insert and fluid administration through the insert is admitted in one direction by squeezing the container.
摘要翻译：一种用于储存和施用医用流体的装置，包括密封的柔性成形容器，其前端具有开口部分，插入件位于该容器的前端。在插入物上，容器延伸到可移除的密封盖中。在移除密封帽之后，将注入装置附接到插入件，并且通过挤压容器通过插入件的流体施加沿一个方向进入。

37. 发明授权

US06713137B1 Medical containers 失效
标题翻译：医疗容器
公开(公告)号：US06713137B1
公开(公告)日：2004-03-30
申请号：US09448922
申请日：1999-11-23
申请人： Gunnar Andersson , Vittorio Sala
发明人： Gunnar Andersson , Vittorio Sala
IPC分类号： B32B2732
CPC分类号： B32B27/32 , Y10T428/1334 , Y10T428/1352 , Y10T428/2495 , Y10T428/2826 , Y10T428/31913
摘要： The present invention relates to a flexible polyolefin multilayered film for preparation of medical containers by self sealing, comprising at least a first outer layer and a second layer, each of the layers consisting essentially only of one or more polypropylene based polymers selected from the group consisting of polypropylene homopolymers, polypropylene copolymers having randomly distribute ethylene units and mixtures of said homopolymers and said copolymers, wherein said second layer has a melting point in the range between 120° C. and 150°, said first outer layer has a lower flexibility and a higher melting point than said second layer, and said second comprises a polypropylene polyethylene copolymer with a higher amount of ethylene units than said outer layer. The present invention also relates to medical containers made of or comprising the above film.
摘要翻译：本发明涉及一种用于通过自密封制备医疗容器的柔性聚烯烃多层膜，其包括至少第一外层和第二层，每个层基本上仅由一种或多种聚丙烯基聚合物组成，所述聚丙烯基聚合物选自的聚丙烯均聚物，具有随机分布乙烯单元的聚丙烯共聚物和所述均聚物和所述共聚物的混合物，其中所述第二层的熔点在120℃至150℃的范围内，所述第一外层具有较低的柔性和比所述第二层高的熔点，而所述第二层包括具有比所述外层更高量的乙烯单元的聚丙烯聚乙烯共聚物。本发明还涉及由上述膜制成或包含上述膜的医疗容器。

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