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    • 32. 发明授权
    • Pseudoceramides, and dermatologic external preparations containing the same
    • 假甲酰胺和含有它们的皮肤外用制剂
    • US06221371B1
    • 2001-04-24
    • US09308031
    • 1999-05-10
    • In-sub BaikJong-gi LeeByeong-deog ParkYoon KimMyung-jin Lee
    • In-sub BaikJong-gi LeeByeong-deog ParkYoon KimMyung-jin Lee
    • A61K600
    • A61Q19/00A61K8/68A61Q5/00A61Q5/02A61Q17/00A61Q19/08C07C235/08C07C235/74C07H15/12
    • The present invention relates to pseudoceramide derivatives represented by formula(I) or (II): R1—COCHR2CONR3R4  (I) R1—CH(OH)CHR2CONR3R4  (II) wherein, each of R1 and R2 represents linear or branched alkyl group or alkenyl group having 6˜22 carbon atoms; each of R3 and R4 represents hydrogen, methyl, ethyl, propyl, or linear or branched C2˜C6 alkyl group having one or more hydroxyl group(s), or monosaccharide, a process for preparing the same, and dermatologic external preparations containing the same. When the pseudoceramide derivatives according to the present invention are applied in an dermatologic external preparations the moisture-retaining property and resilience of skin and hair is enhanced such so that the derivatives are useful in protection of skin-aging. In addition, the derivatives are useful for inducing the formation of lipid layer on damaged skin and for preventing the inhibition of lipid synthesis.
    • 本发明涉及由式(I)或(II)表示的假花生酰胺衍生物:其中,R1和R2各自表示具有6〜22个碳原子的直链或支链烷基或烯基; R 3和R 4各自表示氢,甲基,乙基,丙基或具有一个或多个羟基或单糖的直链或支链C 2 -C 6烷基,其制备方法和含有该羟基的皮肤外用制剂 。 当根据本发明的假心外酰胺衍生物应用于皮肤外用制剂时,皮肤和毛发的保湿性和弹性得到增强,使得衍生物可用于保护皮肤老化。 此外,该衍生物可用于诱导损伤皮肤上形成脂质层并防止脂质合成的抑制。