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31. 发明申请

US20070299063A1 N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS 有权
标题翻译： N3烷基苯并咪唑衍生物作为MEK抑制剂
公开(公告)号：US20070299063A1
公开(公告)日：2007-12-27
申请号：US11762897
申请日：2007-06-14
申请人： Eli Wallace , Joseph Lyssikatos , Allison Marlow , T. Hurley , Kevin Koch
发明人： Eli Wallace , Joseph Lyssikatos , Allison Marlow , T. Hurley , Kevin Koch
IPC分类号： A61K31/54 , A61P29/00 , A61P35/00 , C07D211/32 , C07D235/04 , C07D401/02 , C07D403/02 , C07D413/02 , C07D417/02
CPC分类号： C07D235/06 , C04B35/632 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/04 , C07D413/06 , C07D417/06 , C07D417/12 , C07F9/65068 , C07F9/65586
摘要： Disclosed are amino acid prodrugs of compounds of the formula I and pharmaceutically acceptable salts thereof, wherein W, R1, R2, R7, R8, R9 and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative disease in mammals, and pharmaceutical compositions containing such compounds.
摘要翻译：公开了式I化合物及其药学上可接受的盐的氨基酸前药，其中W 1，R 2，R 2，R 7， R 8，R 9和R 10如说明书中所定义。这些化合物是MEK抑制剂，可用于治疗哺乳动物中的过度增生性疾病，例如癌症和炎症。还公开了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法，以及含有这些化合物的药物组合物。

32. 发明申请

US20070102595A1 Shelter Mast Support System 有权
标题翻译：住房支架系统
公开(公告)号：US20070102595A1
公开(公告)日：2007-05-10
申请号：US11164032
申请日：2005-11-08
申请人： Craig Hartzell , Kevin Koch , Aaron King
发明人： Craig Hartzell , Kevin Koch , Aaron King
IPC分类号： F16L3/00
CPC分类号： E04H12/2253 , Y10T24/28
摘要： A mast support system for use with a container (e.g., a Connex container) to hold a light fixture, security camera and other accessories that may be desirable to mount above or from the roof of the container, generally comprising a support structure for purposes of supporting the accessories, and means to affix the support structure to the container. Embodiments of the mast support system disclosed include one or more posts removably attached to a base, which is engaged with the corner of a container. Attached to the posts are accessory support systems, extending therefrom for positioning and angling the accessories.
摘要翻译：用于与容器（例如，Connex容器）一起使用的桅杆支撑系统，用于容纳灯具，安全摄像机和可能需要安装在容器顶部上方或从顶部顶部的其它附件，通常包括用于支持附件，以及将支撑结构固定到容器的手段。公开的桅杆支撑系统的实施例包括一个或多个可移除地附接到基座的柱，其与容器的角部接合。附件支撑系统是从附件支撑系统延伸，用于定位和垂直配件。

33. 发明申请

US20050159407A1 Carboxylic acid substituted heterocycles, derivatives thereof and methods of use 失效
标题翻译：羧酸取代的杂环，其衍生物和使用方法
公开(公告)号：US20050159407A1
公开(公告)日：2005-07-21
申请号：US11020751
申请日：2004-12-23
申请人： Kevin Koch , Andreas Temin , John Josey
发明人： Kevin Koch , Andreas Temin , John Josey
IPC分类号： A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/55 , A61P1/02 , A61P1/04 , A61P9/10 , A61P11/00 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/10 , A61P27/02 , A61P27/06 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D211/96 , C07D223/12 , C07D401/12 , C07D409/12 , C07D43/02
CPC分类号： C07D223/12
摘要： Selected novel carboxylic acid substituted heterocycle compounds are effective for prophylaxis and treatment of inflammation, tissue degradation, cancer, fibrosis and related diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of inflamation, tissue degradation and related diseases. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：选择的新型羧酸取代的杂环化合物对预防和治疗炎症，组织降解，癌症，纤维化和相关疾病是有效的。本发明包括新型化合物，类似物，前药和其药学上可接受的盐，用于预防和治疗炎症，组织降解和相关疾病的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

34. 发明申请

US20050120217A1 Apparatus, System, and Method for Electronically Signing Electronic Transcripts 审中-公开
标题翻译：电子签名的装置，系统和方法
公开(公告)号：US20050120217A1
公开(公告)日：2005-06-02
申请号：US10711551
申请日：2004-09-24
申请人： Davin Fifield , Kevin Koch
发明人： Davin Fifield , Kevin Koch
IPC分类号： H04L9/32 , H04L29/06 , H04L9/00
CPC分类号： H04L9/3297 , G06F21/645 , H04L9/3247 , H04L63/12 , H04L63/126 , H04L2209/56 , H04L2209/60
摘要： A method for electronically signing an electronic transcript. The method includes obtaining an image of a court reporter's signature which may be incorporated into an electronic transcript. A hash operation performed on the electronic transcript to generate a representation of the contents of the electronic transcript. The representation of the contents of the electronic transcript is recorded/time stamped by a digital notary service, from which a notary record of the time stamping is obtained from the digital notary service. The notary record is digitally signed, and an electronically signed electronic transcript is formed by bundling the digitally signed notary record with the electronic transcript and with the data identifying the user. In this manner, an electronic transcript with an electronic signature is created. The electronic transcript may be viewed, with the image displayed in the viewer having an image of the court reporter's signature.
摘要翻译：一种用于电子签名电子抄本的方法。该方法包括获得可并入电子抄本中的法庭记者签名的图像。对电子抄本执行的哈希操作以产生电子抄本的内容的表示。电子誊本的内容的表示由数字公证人员记录/时间戳，从数字公证服务获得时间戳的公证记录。公证记录经数字签名，电子签名的电子记录是通过将数字签名的公证记录与电子抄本和识别用户的数据进行捆绑形成的。以这种方式，创建具有电子签名的电子抄本。可以看到电子抄本，其中在观看者中显示的图像具有法院记者的签名的图像。

35. 发明授权

US6051601A Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene B4 (LTB4) antagonists 失效
标题翻译：苯并吡喃和苯并稠合的化合物，它们的制备及其作为白三烯B4（LTB4）拮抗剂的用途
公开(公告)号：US6051601A
公开(公告)日：2000-04-18
申请号：US809728
申请日：1997-04-09
申请人： Mark Anthony Dombroski , Kevin Koch , Anthony Daniel Piscopio
发明人： Mark Anthony Dombroski , Kevin Koch , Anthony Daniel Piscopio
IPC分类号： C07D263/14 , A61K31/00 , A61K31/35 , A61K31/352 , A61K31/353 , A61P11/00 , A61P11/06 , A61P29/00 , A61P37/00 , A61P37/06 , C07C35/23 , C07C35/52 , C07C39/14 , C07C39/17 , C07C39/38 , C07C65/17 , C07C65/26 , C07C65/36 , C07D311/04 , C07D311/22 , C07D311/24 , C07D311/48 , C07D311/58 , C07D413/04 , C07D311/56
CPC分类号： C07D311/22 , C07D311/58
摘要： This invention relates to novel benzopyran and other benzo-fused leukotriene B.sub.4 (LTB.sub.4) antagonists and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing such compounds or a pharmaceutically acceptable salt thereof, and to methods of using such compounds as LTB.sub.4 antagonists. The compounds and the pharmaceutically acceptable salts of this invention inhibit the action of LTB.sub.4 and are therefore useful in the treatment of LTB.sub.4 induced illnesses such as inflammatory disorders including rheumatoid arthritis, osteoarthritis, inflammatory bowel disease, psoriasis and other skin disorders such as eczema, erythema, pruritus and acne, stroke and other forms of reperfuslon injury, graft rejection, autoimmune diseases, asthma, and other conditions where marked neutrophil infiltration occurs.
摘要翻译： PCT No.PCT / IB95 / 00401 Sec。 371日期1997年04月9日 102（e）日期1997年4月9日PCT提交1995年5月26日PCT公布。出版物WO96 / 11920 日本特开1996年4月25日本发明涉及含有这些化合物或其药学上可接受的盐的药物组合物的新型苯并吡喃和其它苯并稠合白三烯B4（LTB4）拮抗剂及其药学上可接受的盐，以及使用 LTB4拮抗剂。本发明的化合物和药学上可接受的盐抑制LTB4的作用，因此可用于治疗LTB4诱导的疾病，例如炎症性疾病，包括类风湿性关节炎，骨关节炎，炎性肠病，牛皮癣和其它皮肤疾病如湿疹，红斑，瘙痒和痤疮，中风和其他形式的再灌注损伤，移植排斥反应，自身免疫性疾病，哮喘和其他出现明显中性粒细胞浸润的病症。

36. 发明授权

US08035387B2 Methods and apparatus for compensating field inhomogeneities in magnetic resonance studies 有权
标题翻译：用于补偿磁共振研究中的磁场不均匀性的方法和装置
公开(公告)号：US08035387B2
公开(公告)日：2011-10-11
申请号：US12087616
申请日：2007-01-12
申请人： Robin De Graaf , Kevin Koch
发明人： Robin De Graaf , Kevin Koch
IPC分类号： G01V3/00
CPC分类号： G01R33/3873
摘要： One aspect of the present disclosure relates to a method or determining location(s) at which at least one magnetic article is to be positioned during a magnetic resonance imaging procedure of at least one subject. A magnetic field Bo is applied to a region that includes the at least one subject and does not include the at least one magnetic article. First magnetic resonance information about the region in response to the applied magnetic field BO is received. The first magnetic resonance information relates at least in part to one or more magnetic field inhomogeneities in the region. Based at least in part on the first magnetic resonance information, at least one first location proximate the at least one subject at which at least one paramagnetic article and/or diamagnetic article is to be positioned is determined, so as to at least partially compensate for the one or more magnetic field inhomogeneities.
摘要翻译：本公开的一个方面涉及在至少一个对象的磁共振成像过程期间至少一个磁性制品将要被定位的方法或确定位置。将磁场Bo施加到包括至少一个对象的区域，并且不包括至少一个磁性制品。接收关于响应于所施加的磁场BO的区域的第一磁共振信息。第一磁共振信息至少部分地涉及该区域中的一个或多个磁场不均匀性。至少部分地基于第一磁共振信息确定至少一个邻近至少一个对象的至少一个对象的至少一个第一位置，在该位置处至少一个顺磁性物品和/或抗磁性物品将被定位，以便至少部分地补偿一个或多个磁场不均匀性。

37. 发明申请

US20060234618A1 Gambrel systems 审中-公开
标题翻译： Gambrel系统
公开(公告)号：US20060234618A1
公开(公告)日：2006-10-19
申请号：US11110479
申请日：2005-04-20
申请人： Kevin Koch , Laverne Maxwell
发明人： Kevin Koch , Laverne Maxwell
IPC分类号： A22B7/00
CPC分类号： A22B5/06 , A22B7/002
摘要： Gambrel systems are provided for hanging and transporting animal carcasses. For example, a gambrel includes an elongated member having a retaining portion, e.g., a notch or other means, adjacent each end of the elongated member to prevent a leg of the carcass from slipping off of the end when the gambrel is tilted from the horizontal.
摘要翻译： Gambrel系统用于悬挂和运输动物尸体。例如，赌徒包括细长构件，该细长构件具有与细长构件的每个端部相邻的保持部分，例如凹口或其它装置，以防止当游离体从水平面倾斜时胎体的腿部从端部滑出。

38. 发明申请

US20060030610A1 Method of treating inflammatory diseases 失效
公开(公告)号：US20060030610A1
公开(公告)日：2006-02-09
申请号：US11208442
申请日：2005-08-19
申请人： Kevin Koch , T. Hurley , Hong Yang , Joseph Lyssikatos , James Blake , Allison Marlow , Eli Wallace
发明人： Kevin Koch , T. Hurley , Hong Yang , Joseph Lyssikatos , James Blake , Allison Marlow , Eli Wallace
IPC分类号： A61K31/42 , C07D261/20
CPC分类号： C07D261/20 , A61K31/42 , C07D417/06 , C07D471/04
摘要： Disclosed are methods of treating inflammatory diseases and disorders, such as arthritis and inflammatory bowel disease, in mammals.

39. 发明申请

US20050086596A1 Electronic document with selectively editable fields and methods for same 有权
标题翻译：具有选择性可编辑字段和方法的电子文档
公开(公告)号：US20050086596A1
公开(公告)日：2005-04-21
申请号：US10948889
申请日：2004-09-23
申请人： Kevin Koch , Grover Mundell
发明人： Kevin Koch , Grover Mundell
IPC分类号： G06F15/00 , G06F17/22 , G06F17/24 , G06F21/00
CPC分类号： G06F21/6218 , G06F17/2247 , G06F17/243
摘要： An electronic file such as an HTML web page accessible via a browser by a user. The electronic file may include one or more textual field descriptors for display within the browser; one or more editable data fields associated with the textual field descriptors, the editable data fields for receiving data for the user of the browser; and a module having a view mode and an edit mode, the view mode for displaying the textual field descriptors, the edit mode for permitting the user to enter data in the editable data fields. In one example, the view mode may be invoked when the electronic file is open in the browser. The edit mode may be invoked only if the browser contains a control for activating the edit mode. In this way, the user is able to edit the data in the document and retransmit the document to other users who can only view the data as read-only data.
摘要翻译：诸如HTML网页之类的电子文件可由用户通过浏览器访问。电子文件可以包括用于在浏览器内显示的一个或多个文本字段描述符; 与文本字段描述符相关联的一个或多个可编辑数据字段，用于为浏览器的用户接收数据的可编辑数据字段; 以及具有视图模式和编辑模式的模块，用于显示文本字段描述符的视图模式，允许用户在可编辑数据字段中输入数据的编辑模式。在一个示例中，当电子文件在浏览器中打开时，可以调用视图模式。仅当浏览器包含用于激活编辑模式的控件时才可以调用编辑模式。以这种方式，用户能够编辑文档中的数据，并将文档重新发送给只能以只读数据查看数据的其他用户。

40. 发明申请

US20050033697A1 Method and apparatus for permitting access to, tracking, and reporting real time transcriptions 有权
标题翻译：允许访问，跟踪和报告实时转录的方法和设备
公开(公告)号：US20050033697A1
公开(公告)日：2005-02-10
申请号：US10637260
申请日：2003-08-09
申请人： Grover Mundell , Kevin Koch
发明人： Grover Mundell , Kevin Koch
IPC分类号： G06Q20/00 , G06Q30/00 , G07F17/16 , G06F17/60
CPC分类号： G06Q20/28 , G06Q20/06 , G06Q20/123 , G06Q20/1235 , G06Q30/0283 , G06Q30/04 , G06Q30/06
摘要： A device and method for permitting access to a real time data stream through prepayments or other payment arrangements and/or calculating a fee corresponding to usage of a real time data stream, wherein the real time data stream includes transcript data from a court transcription. In one example, a device may include a data collection device for receiving prepayment data, such as a code, key, token, pass that may contain purchase units therein; and a counter. In one embodiment, if the counter contains a value representing unused real time connections, then the data collection device permits the computing device to access to the real time data stream. In one example, the prepayment data includes a code containing a number representing a quantity of connections that may be made to the real time data stream. In another example, a method may include receiving the real time data stream; extracting one or more billing data elements from the real time data stream; storing said one or more billing data elements for processing; and calculating the fee based on at least one of the one or more billing data elements. In this way, charges may be calculated and levied or itemized according to the usage of such a real time service during a court proceeding such as a deposition.
摘要翻译：一种用于允许通过预付款或其他支付安排访问实时数据流和/或计算与实时数据流的使用相对应的费用的装置和方法，其中所述实时数据流包括来自法庭转录的转录数据。在一个示例中，设备可以包括用于接收预付费数据的数据收集设备，诸如可以在其中包含购买单元的代码，密钥，令牌，通行证; 和柜台。在一个实施例中，如果计数器包含表示未使用的实时连接的值，则数据收集装置允许计算设备访问实时数据流。在一个示例中，预付费数据包括包含表示可以对实时数据流进行连接的数量的数字的代码。在另一示例中，方法可以包括接收实时数据流; 从所述实时数据流中提取一个或多个计费数据元素; 存储所述一个或多个计费数据元素以进行处理; 以及基于所述一个或多个计费数据元素中的至少一个来计算所述费用。以这种方式，可以在诸如沉积的法庭诉讼期间根据这种实时服务的使用来计算和分类收费。

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