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31. 发明申请

US20110257907A1 PRESSURE-BASED TEMPERATURE ESTIMATION FOR IMPLANTABLE FLUID DELIVERY DEVICES 审中-公开
标题翻译：基于压力的温度估计可植入流体装置
公开(公告)号：US20110257907A1
公开(公告)日：2011-10-20
申请号：US12762121
申请日：2010-04-16
申请人： Scott L. Kalpin
发明人： Scott L. Kalpin
IPC分类号： G06F19/00 , G01K13/00 , G01L7/00 , A61M5/00
CPC分类号： A61M5/14276 , A61M2205/33 , A61M2205/3331 , A61M2205/3368 , A61M2205/3379 , G06F19/3468
摘要： A number of parameters related to the operation of a fluid delivery device are determined based on a pressure within the device sensed using a pressure sensor. In one example, the volume of therapeutic fluid added to or removed from a reservoir of a fluid delivery device is determined based on a sensed pressure of the reservoir. In another example, the volume of therapeutic fluid added to or removed from the reservoir is determined based on a sensed pressure of a refill port assembly of the device. In another example, an initial temperature of the reservoir as a therapeutic fluid is removed from the reservoir is estimated based on a sensed pressure within the device. In another example, a temperature of a therapeutic fluid added to the reservoir is estimated based on a sensed pressure within the device.
摘要翻译：基于使用压力传感器感测的装置内的压力来确定与流体输送装置的操作相关的许多参数。在一个示例中，基于感测到的储存器的压力来确定添加到流体输送装置的储存器中或从流体输送装置的储存器移除的治疗流体的体积。在另一个实例中，基于装置的再充填端口组件的检测到的压力来确定添加到储存器中或从储存器移除的治疗流体的体积。在另一个实例中，基于所检测到的装置内的压力来估计储存器作为治疗流体的初始温度从储存器中移出。在另一个实例中，基于装置内感测到的压力来估计添加到储存器中的治疗流体的温度。

32. 发明申请

US20110257593A1 DEVICES AND METHODS FOR DETECTING CATHETER COMPLICATIONS 有权
标题翻译：用于检测导管连接的装置和方法
公开(公告)号：US20110257593A1
公开(公告)日：2011-10-20
申请号：US13169092
申请日：2011-06-27
申请人： Scott L. Kalpin , Lucien Bell Solefack , Keith A. Miesel
发明人： Scott L. Kalpin , Lucien Bell Solefack , Keith A. Miesel
IPC分类号： A61M25/00
CPC分类号： A61M5/14276 , A61M5/16854 , A61M5/16859 , A61M5/1723 , A61M27/006 , A61M2005/1726 , A61M2025/0003 , A61M2202/0464 , A61M2205/3331 , A61M2205/3344 , A61M2205/3355 , A61M2210/0693 , A61M2230/005 , A61M2230/04 , A61M2230/06 , A61M2230/40 , A61M2230/42 , A61M2230/63
摘要： A method for determining status of an implanted catheter includes acquiring raw pressure data from a pressure sensor of in an implantable infusion device. The pressure sensor is in communication with a lumen of the catheter operably coupled to the infusion device. The catheter has a delivery region, in communication with the lumen, intended to be positioned in a fluid-filled target location of a patient. The method further includes filtering the raw pressure data to remove the DC component, leaving the AC component within a relevant physiological frequency range; rectifying the AC component to produce a rectified pressure signal; calculating a mean magnitude of the rectified signal; and determining whether the mean magnitude is below a predetermined threshold. If the mean magnitude is below the threshold, the catheter is determined to be in a state other than a normal state.
摘要翻译：用于确定植入导管的状态的方法包括从可植入输注装置中的压力传感器获取原始压力数据。压力传感器与可操作地连接到输注装置的导管的内腔连通。导管具有与内腔连通的输送区域，用于定位在患者的流体填充的目标位置。该方法还包括过滤原始压力数据以去除DC分量，将AC分量留在相关的生理频率范围内; 整流交流分量以产生整流压力信号; 计算整流信号的平均幅度; 以及确定平均幅度是否低于预定阈值。如果平均值低于阈值，则确定导管处于正常状态以外的状态。

33. 发明申请

US20090082782A1 NEEDLE TO PORT TRAJECTOR INDICATOR 有权
标题翻译：针对港口拖车指示器
公开(公告)号：US20090082782A1
公开(公告)日：2009-03-26
申请号：US12207093
申请日：2008-09-09
申请人： Scott L. Kalpin
发明人： Scott L. Kalpin
IPC分类号： A61B19/00
CPC分类号： G06T11/206 , A61B17/3403 , A61B90/37 , A61B90/98 , A61B2034/107 , A61B2034/2051 , A61M5/14276 , A61M5/427 , A61M2039/0238 , A61M2205/3523 , A61M2209/045
摘要： A system includes (i) a needle for insertion into a port of an implantable infusion device, and (ii) a receiver apparatus having a port location signal receiver module capable of receiving a signal from the implantable infusion device regarding spatial orientation of the port. The system further includes a processor operably coupled to the receiver apparatus and capable of determining the orientation of the needle relative to the port based on the received signal. The system also includes a display operably coupled to the processor. The processor is configured to cause the display to graphically render trajectory of the needle relative to the port. The port is graphically rendered as a target structure having a reference area. The needle is graphically rendered as an object moveable relative to the target structure. Occupation of the reference area by the object indicates trajectory alignment of the port and the needle.
摘要翻译：系统包括（i）用于插入可植入输注装置的端口的针，以及（ii）具有端口位置信号接收器模块的接收器装置，其能够接收来自可植入输注装置的关于端口的空间取向的信号。该系统还包括可操作地耦合到接收机装置并且能够基于接收到的信号确定针相对于端口的取向的处理器。该系统还包括可操作地耦合到处理器的显示器。处理器被配置为使显示器以图形方式显示针头相对于端口的轨迹。该端口以图形方式呈现为具有参考区域的目标结构。针以图形方式呈现为可相对于目标结构移动的对象。通过对象占用参考区域表示端口和针的轨迹对齐。

34. 发明申请

US20090082757A1 PRESSURE BASED REFILL STATUS MONITOR FOR IMPLANTABLE PUMPS 有权
标题翻译：基于压力的灌注状态监测器
公开(公告)号：US20090082757A1
公开(公告)日：2009-03-26
申请号：US12199536
申请日：2008-08-27
申请人： Charles Randall Rogers , Scott L. Kalpin , William J. Mitchell
发明人： Charles Randall Rogers , Scott L. Kalpin , William J. Mitchell
IPC分类号： A61M5/168
CPC分类号： A61M5/14276 , A61M5/16854 , A61M2205/3331 , A61M2205/3382 , A61M2205/3386 , A61M2209/045
摘要： The present invention includes systems and methods for detecting fluid flow into or out of a port chamber or a reservoir of an implantable medical device utilizing a pressure sensor. The system detects characteristic pressure profiles associated with fluid flowing into the medical device, out of the medical device, and also whether one or both of the port chamber or reservoir are substantially empty or substantially full. In addition, the present invention may generate a sensory cue to a clinician to indicate the fluid status.
摘要翻译：本发明包括用于检测流入或流出使用压力传感器的可植入医疗装置的端口室或储存器的流体的系统和方法。该系统检测与流入医疗装置的流体相关的特征压力分布，离开医疗装置，以及端口腔室或储存器中的一个或两个基本上是空的还是基本上满的。此外，本发明可以产生临床医生的感觉提示以指示流体状态。

35. 发明授权

US09044537B2 Devices and methods for detecting catheter complications 有权
标题翻译：用于检测导管并发症的装置和方法
公开(公告)号：US09044537B2
公开(公告)日：2015-06-02
申请号：US13169092
申请日：2011-06-27
申请人： Scott L. Kalpin , Lucien Bell Solefack , Keith A. Miesel
发明人： Scott L. Kalpin , Lucien Bell Solefack , Keith A. Miesel
IPC分类号： A61M25/00 , A61M5/142 , A61M5/168 , A61M5/172 , A61M27/00
CPC分类号： A61M5/14276 , A61M5/16854 , A61M5/16859 , A61M5/1723 , A61M27/006 , A61M2005/1726 , A61M2025/0003 , A61M2202/0464 , A61M2205/3331 , A61M2205/3344 , A61M2205/3355 , A61M2210/0693 , A61M2230/005 , A61M2230/04 , A61M2230/06 , A61M2230/40 , A61M2230/42 , A61M2230/63
摘要： A method for determining status of an implanted catheter includes acquiring raw pressure data from a pressure sensor of in an implantable infusion device. The pressure sensor is in communication with a lumen of the catheter operably coupled to the infusion device. The catheter has a delivery region, in communication with the lumen, intended to be positioned in a fluid-filled target location of a patient. The method further includes filtering the raw pressure data to remove the DC component, leaving the AC component within a relevant physiological frequency range; rectifying the AC component to produce a rectified pressure signal; calculating a mean magnitude of the rectified signal; and determining whether the mean magnitude is below a predetermined threshold. If the mean magnitude is below the threshold, the catheter is determined to be in a state other than a normal state.
摘要翻译：用于确定植入导管的状态的方法包括从可植入输注装置中的压力传感器获取原始压力数据。压力传感器与可操作地连接到输注装置的导管的内腔连通。导管具有与内腔连通的输送区域，用于定位在患者的流体填充的目标位置。该方法还包括过滤原始压力数据以去除DC分量，将AC分量留在相关的生理频率范围内; 整流交流分量以产生整流压力信号; 计算整流信号的平均幅度; 以及确定平均幅度是否低于预定阈值。如果平均值低于阈值，则确定导管处于正常状态以外的状态。

36. 发明授权

US08622998B2 Automated catheter length determination for implantable fluid delivery device 有权
标题翻译：可植入流体输送装置的自动导管长度测定
公开(公告)号：US08622998B2
公开(公告)日：2014-01-07
申请号：US13426826
申请日：2012-03-22
申请人： Scott L. Kalpin
发明人： Scott L. Kalpin
IPC分类号： A61K9/22 , A61M31/00 , A61M1/00
CPC分类号： A61M5/14276 , A61M5/16854 , A61M5/16859 , A61M2005/1402 , A61M2005/1405 , A61M2205/3344
摘要： Disclosed are methods and systems for automatically estimating the length of an implantable catheter by measuring the pressure decay response to pumping fluid through the catheter. The decay time for a unit fluid pressure pulse generated within the catheter is proportional to the catheter length, i.e. as the catheter length increases so does the decay time. The catheter length can therefore be estimated based on, e.g., the decay time of the pressure pulse. The estimated catheter length can also be analyzed to determine if it is representative of the actual catheter length, or, e.g., is affected by one or more catheter malfunctions including cuts and occlusions. Systems for automatically estimating the catheter length include an implantable catheter, a pumping mechanism, a pressure sensor configured to measure pressure within the catheter, and a processor that calculates the catheter length from a pressure pulse measured while delivering fluid through the catheter.
摘要翻译：公开了用于通过测量通过导管泵送流体的压力衰减响应来自动估计可植入导管的长度的方法和系统。在导管内产生的单位流体压力脉冲的衰减时间与导管长度成比例，即当导管长度增加时衰减时间也是如此。因此，可以基于例如压力脉冲的衰减时间来估计导管长度。还可以分析估计的导管长度以确定其是否代表实际的导管长度，或者例如受一种或多种导管功能的影响，包括切口和闭塞。用于自动估计导管长度的系统包括可植入导管，泵送机构，被配置为测量导管内的压力的压力传感器，以及处理器，其从输送流体通过导管时测量的压力脉冲计算导管长度。

37. 发明授权

US08512286B2 Detecting a full reservoir of an implantable infusion device 有权
标题翻译：检测植入式输液装置的完整容器
公开(公告)号：US08512286B2
公开(公告)日：2013-08-20
申请号：US13088619
申请日：2011-04-18
申请人： Scott L. Kalpin , James M. Haase
发明人： Scott L. Kalpin , James M. Haase
IPC分类号： A61M37/00
CPC分类号： A61M5/14276 , A61M5/1684 , A61M2205/3523 , A61M2209/045
摘要： An implantable infusion device includes a housing and a collapsible member and an interference member disposed within the housing. The collapsible member defines a reservoir for containing fluid and has an outer surface that moves between an empty position and a full position in response to a change in volume of fluid contained in the reservoir. The interference member is configured to engage the outer surface of the collapsible member as the reservoir approaches the full position and to cause pressure in the reservoir to increase following engagement with the surface of the collapsible member and concomitant fluid introduction into the reservoir. The infusion device further includes a pressure sensor in communication with the reservoir, which can be used to determine whether the reservoir is full by measuring characteristic pressures associated with the interference member engaging the outer surface of the collapsible member and concomitant fluid introduction into the reservoir.
摘要翻译：植入式输注装置包括壳体和可折叠构件以及设置在壳体内的干涉构件。可折叠构件限定用于容纳流体的储存器，并且具有响应于容纳在容器中的流体的体积变化而在空位置和满位置之间移动的外表面。干涉构件构造成当储存器接近整个位置时接合可收缩构件的外表面，并且使储存器中的压力随着与可折叠构件的表面的接合以及伴随的流体引入储存器而增加。输液装置还包括与储存器连通的压力传感器，其可用于通过测量与可收缩构件的外表面接合的干涉构件和伴随的流体引入储存器的特征压力来确定储存器是否满。

38. 发明申请

US20120265144A1 ESTIMATING THE VOLUME OF FLUID IN THERAPEUTIC FLUID DELIVERY DEVICE RESERVOIR 有权
标题翻译：估计治疗流体装置储存中的液体体积
公开(公告)号：US20120265144A1
公开(公告)日：2012-10-18
申请号：US13438112
申请日：2012-04-03
申请人： Scott L. Kalpin , Michael D. Baudino
发明人： Scott L. Kalpin , Michael D. Baudino
IPC分类号： A61M5/00
CPC分类号： A61M5/14276 , A61M5/152 , A61M2005/14204 , A61M2205/3334
摘要： A number of parameters related to the operation of a fluid delivery device are determined based on pressures within the device sensed using multiple pressure sensors. In one example, the volume of therapeutic fluid within a reservoir of a fluid delivery device is estimated based on a measured pressure differential. In another example, the rate at which a therapeutic fluid is added to or removed from the reservoir is estimated based on the measured pressure differential.
摘要翻译：基于使用多个压力传感器感测的装置内的压力来确定与流体输送装置的操作有关的许多参数。在一个示例中，基于测量的压力差估计流体输送装置的储存器内的治疗流体的体积。在另一个实例中，基于所测量的压力差来估计加入到储存器中或从贮存器移除的治疗流体的速率。

39. 发明申请

US20120238949A1 AUTOMATED CATHETER LENGTH DETERMINATION FOR IMPLANTABLE FLUID DELIVERY DEVICE 有权
标题翻译：用于可植入流体输送设备的自动导管长度测定
公开(公告)号：US20120238949A1
公开(公告)日：2012-09-20
申请号：US13426826
申请日：2012-03-22
申请人： Scott L. Kalpin
发明人： Scott L. Kalpin
IPC分类号： A61M5/168
CPC分类号： A61M5/14276 , A61M5/16854 , A61M5/16859 , A61M2005/1402 , A61M2005/1405 , A61M2205/3344
摘要： Disclosed are methods and systems for automatically estimating the length of an implantable catheter by measuring the pressure decay response to pumping fluid through the catheter. The decay time for a unit fluid pressure pulse generated within the catheter is proportional to the catheter length, i.e. as the catheter length increases so does the decay time. The catheter length can therefore be estimated based on, e.g., the decay time of the pressure pulse. The estimated catheter length can also be analyzed to determine if it is representative of the actual catheter length, or, e.g., is affected by one or more catheter malfunctions including cuts and occlusions. Systems for automatically estimating the catheter length include an implantable catheter, a pumping mechanism, a pressure sensor configured to measure pressure within the catheter, and a processor that calculates the catheter length from a pressure pulse measured while delivering fluid through the catheter.
摘要翻译：公开了用于通过测量通过导管泵送流体的压力衰减响应来自动估计可植入导管的长度的方法和系统。在导管内产生的单位流体压力脉冲的衰减时间与导管长度成比例，即当导管长度增加时衰减时间也是如此。因此，可以基于例如压力脉冲的衰减时间来估计导管长度。还可以分析估计的导管长度以确定其是否代表实际的导管长度，或者例如受一种或多种导管功能的影响，包括切口和闭塞。用于自动估计导管长度的系统包括可植入导管，泵送机构，被配置为测量导管内的压力的压力传感器，以及处理器，其从输送流体通过导管时测量的压力脉冲计算导管长度。

40. 发明申请

US20110254686A1 RESERVOIR MONITORING FOR IMPLANTABLE FLUID DELIVERY DEVICES 有权
标题翻译：用于可植入流体输送装置的储存监测
公开(公告)号：US20110254686A1
公开(公告)日：2011-10-20
申请号：US12762108
申请日：2010-04-16
申请人： Scott L. Kalpin
发明人： Scott L. Kalpin
IPC分类号： G08B21/00 , G01F23/00 , G06F19/00 , A61M5/00
CPC分类号： A61M5/14276 , A61M5/1684 , A61M2205/3331 , A61M2205/3368 , A61M2205/3372
摘要： A number of parameters related to the operation of a fluid delivery device are determined based on a pressure within the device sensed using a pressure sensor. In one example, the volume of therapeutic fluid added to or removed from a reservoir of a fluid delivery device is determined based on a sensed pressure of the reservoir. In another example, the volume of therapeutic fluid added to or removed from the reservoir is determined based on a sensed pressure of a refill port assembly of the device. In another example, an initial temperature of the reservoir as a therapeutic fluid is removed from the reservoir is estimated based on a sensed pressure within the device. In another example, a temperature of a therapeutic fluid added to the reservoir is estimated based on a sensed pressure within the device.
摘要翻译：基于使用压力传感器感测的装置内的压力来确定与流体输送装置的操作相关的许多参数。在一个示例中，基于感测到的储存器的压力来确定添加到流体输送装置的储存器中或从流体输送装置的储存器移除的治疗流体的体积。在另一个实例中，基于装置的再充填端口组件的检测到的压力来确定添加到储存器中或从储存器移除的治疗流体的体积。在另一个实例中，基于所检测到的装置内的压力来估计储存器作为治疗流体的初始温度从储存器中移出。在另一个实例中，基于装置内感测到的压力来估计添加到储存器中的治疗流体的温度。

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