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31. 发明授权

US5801164A Methods of treating osteoporosis prophylactically or therapeutically 失效
标题翻译：预防或治疗骨质疏松症的方法
公开(公告)号：US5801164A
公开(公告)日：1998-09-01
申请号：US480310
申请日：1995-06-07
申请人： Joyce C. Knutson , Charles W. Bishop , Robert M. Moriarty
发明人： Joyce C. Knutson , Charles W. Bishop , Robert M. Moriarty
IPC分类号： A61K8/60 , A61K8/67 , A61K31/59 , A61Q19/00 , C07C35/21 , C07C401/00
CPC分类号： A61K31/592 , A61K31/59 , A61K8/606 , A61K8/67 , A61Q19/00 , C07C35/21 , C07C401/00
摘要： Methods of treating osteoporosis prophylactically or therapeutically are disclosed. The method of treating osteoporosis includes administering to a patient suffering therefrom an effective amount to treat the osteoporosis of novel 1.alpha.-hydroxyvitamin D.sub.4 and novel analogues 1,25-dihydroxyvitamin D.sub.4 and 1,24-dihydroxyvitamin D.sub.4, the aforementioned compounds having lower toxicity as measured by an LD.sub.50 test in rats when compared to a corresponding vitamin D.sub.3 compound. The method of administering the compound is substantially without occurrence of hypercalcemia.
摘要翻译：公开了预防或治疗骨质疏松症的方法。治疗骨质疏松症的方法包括向患有其的患者施用有效量的治疗新型1α-羟基维生素D4和新型类似物1,25-二羟基维生素D4和1,24-二羟基维生素D4的骨质疏松症，上述具有较低毒性的化合物与相应的维生素D3化合物相比，通过LD50测试在大鼠中测量。施用化合物的方法基本上不发生高钙血症。

32. 发明授权

US5763428A Methods of treating skin disorders with novel 1a-hydroxy vitamin D.sub.4 compounds and derivatives thereof 失效
标题翻译：用新型1a-羟基维生素D4化合物及其衍生物治疗皮肤病症的方法
公开(公告)号：US5763428A
公开(公告)日：1998-06-09
申请号：US484342
申请日：1995-06-07
申请人： Joyce C. Knutson , Charles W. Bishop
发明人： Joyce C. Knutson , Charles W. Bishop
IPC分类号： A61K31/59 , A61K8/60 , A61K8/67 , A61P17/00 , A61P35/00 , A61Q19/00 , C07C35/21 , C07C401/00 , C07J9/00
CPC分类号： A61K8/606 , A61K31/59 , A61K31/592 , A61K8/67 , A61Q19/00 , C07C35/21 , C07C401/00 , C07J9/00
摘要： The disclosure is of methods of treating various skin disorders, including skin cancer, with compounds of novel 1.alpha.-hydroxy vitamin D.sub.4 and novel analogues, thereof, including 1,25 dihydroxy vitamin D.sub.4 and 1,24 dihydroxy vitamin D.sub.4. Novel 1.alpha.-hydroxy vitamin D.sub.4 compounds and compounds of novel analogues suitable for use in the treatment of such disorders are also disclosed herein.
摘要翻译：本公开是用新的1α-羟基维生素D4及其新型类似物，包括1,25二羟基维生素D4和1,24二羟基维生素D4的化合物治疗各种皮肤疾病（包括皮肤癌）的方法。本文还公开了新的1α-羟基维生素D 4化合物和适合用于治疗这种病症的新型类似物的化合物。

33. 发明授权

US5614513A Oral 1.alpha.-hydroxyprevitamin D 失效
标题翻译：口服1α-羟维生素D
公开(公告)号：US5614513A
公开(公告)日：1997-03-25
申请号：US485354
申请日：1995-06-07
申请人： Joyce C. Knutson , Charles W. Bishop , Charles R. Valliere
发明人： Joyce C. Knutson , Charles W. Bishop , Charles R. Valliere
IPC分类号： A61K9/20 , A61K9/28 , A61K9/50 , A61K31/59 , A61K31/593 , A61K31/66 , A61K33/24 , A61K38/23 , A61K47/38 , A61P3/00 , A61P3/14 , A61P17/06 , A61P19/08 , A61P43/00 , A01N45/00
CPC分类号： A61K31/593 , A61K31/59 , A61K31/592 , A61K31/66 , A61K31/70 , A61K33/24 , A61K38/23 , A61K9/5078
摘要： Method of increasing activated vitamin D blood level by administering orally a 1.alpha.-hydroxyprevitamin D or a delayed and sustained release formulation of activated vitamin D or a combination thereof. Both the previtamin D form and the delayed and sustained release activated vitamin D formulation increase vitamin D blood level without significant risk of hypercalcemia associated with other oral dosing of vitamin D forms.
摘要翻译：通过口服1α-羟基维生素D或活化的维生素D的延迟和持续释放制剂或其组合来增加活化的维生素D血液水平的方法。维生素D组合物和延迟释放激活的维生素D制剂都能增加维生素D血浆水平，而与其他口服维生素D形式相关的高钙血症并不具有显着的风险。

34. 发明授权

US5488120A 1.alpha.-hydroxy vitamin D.sub.4 and novel intermediates and analogues 失效
标题翻译： 1α-羟基维生素D4和新型中间体和类似物
公开(公告)号：US5488120A
公开(公告)日：1996-01-30
申请号：US296084
申请日：1994-08-24
申请人： Joyce C. Knutson , Charles W. Bishop , Robert M. Moriarty
发明人： Joyce C. Knutson , Charles W. Bishop , Robert M. Moriarty
IPC分类号： A61K31/59 , C07C35/21 , C07C401/00
CPC分类号： A61K31/592 , C07C35/21 , C07C401/00
摘要： Novel 1.alpha.-hydroxy Vitamin D.sub.4 and novel analogues, 1,25 dihydroxy Vitamin D.sub.4 and 1,24 dihydroxy Vitamin D.sub.4 which are useful for the treatment of disorders of calcium metabolism. Preparation of the novel 1.alpha.-hydroxy Vitamin D.sub.4 starts from ergosterol which is converted in six steps to 22,23-dihydroergosterol. 22,23-dihydroergosterol was irradiated to yield Vitamin D.sub.4 which was converted in four steps to 1.alpha.-hydroxy Vitamin D.sub.4 using a cyclovitamin procedure which produced the novel intermediates, Vitamin D.sub.4 tosylate, 3,5 cyclovitamin D.sub.4 and 1.alpha.-hydroxy cyclovitamin D.sub.4. 1,25 dihydroxy Vitamin D.sub.4 and 1,24 dihydroxy Vitamin D.sub.4 are isolated as biological products of the metabolism of novel 1.alpha.-hydroxy Vitamin D.sub.4 using cultured human liver cells.
摘要翻译：新型1α-羟基维生素D4和新型类似物，1,25二羟基维生素D4和1,24二羟基维生素D4，其可用于治疗钙代谢紊乱。新型1α-羟基维生素D4的制备从麦角甾醇开始，其以六步转化为22,23-二氢麦角甾醇。 22,23-二氢麦角甾醇被照射以产生维生素D4，其使用产生新的中间体维生素D4甲苯磺酸盐，3,5环维生素D4和1α-羟基环维生素D4的环维生素程序将其四步转化为1α-羟基维生素D4 。使用培养的人肝细胞，分离出1,25二羟基维生素D4和1,24二羟基维生素D4作为新型1α-羟基维生素D4代谢的生物学产物。

35. 发明授权

US5403831A Method of treating and preventing loss of bone mass using 1.alpha.-hydroxy-vitamin D.sub.2 失效
标题翻译：使用1α-羟基 - 维生素D2治疗和预防骨质量损失的方法
公开(公告)号：US5403831A
公开(公告)日：1995-04-04
申请号：US119895
申请日：1993-09-10
申请人： Hector F. DeLuca , Charles W. Bishop , Richard B. Mazess , John C. Gallagher
发明人： Hector F. DeLuca , Charles W. Bishop , Richard B. Mazess , John C. Gallagher
IPC分类号： A61K31/59 , A61K33/16 , A61K31/595
CPC分类号： A61K31/59 , A61K33/16
摘要： A method for reversing loss of bone mass or bone mineral content in a human being suffering from osteoporosis is disclosed which comprises administering to the human being a daily dosage of at least 2.0 micrograms/day of 1-alpha-hydroxy-Vitamin D.sub.2.
摘要翻译：公开了一种用于逆转患有骨质疏松症的人的骨质量或骨矿物质含量的损失的方法，其包括向人施用至少2.0微克/天的1-α-羟基维生素D2的日剂量。

36. 发明申请

US20100204189A1 Methods and Compounds for Vitamin D Therapy 有权
标题翻译：维生素D治疗方法与化合物
公开(公告)号：US20100204189A1
公开(公告)日：2010-08-12
申请号：US12597224
申请日：2008-04-25
申请人： P. Martin Petkovich , Charles W. Bishop , Eric J. Messner , Keith H. Crawford
发明人： P. Martin Petkovich , Charles W. Bishop , Eric J. Messner , Keith H. Crawford
IPC分类号： A61K31/592 , A61P5/18
CPC分类号： A61K31/592 , A61K9/0019 , A61K9/0053 , A61K47/14 , A61K47/44
摘要： Methods and compositions comprising 1,25-dihydroxyvitamin D2 are disclosed. A method for lowering or maintaining lowered serum parathyroid hormone in human patients including administering to said patients an effective amount of 1,25-dihydroxyvitamin D2 to lower or maintain lowered serum parathyroid hormone levels is disclosed. Dosage forms and dosing regimens are also disclosed.
摘要翻译：公开了包含1,25-二羟基维生素D2的方法和组合物。一种用于降低或维持人类患者血清甲状旁腺激素降低或降低的方法，包括向所述患者施用有效量的1,25-二羟维生素D 2以降低或维持血清甲状旁腺激素水平的降低。还公开了剂量形式和给药方案。

37. 发明申请

US20100144684A1 Method of Safely and Effectively Treating and Preventing Secondary Hyperparathyroidism in Chronic Kidney Disease 审中-公开
标题翻译：安全有效地治疗和预防慢性肾脏疾病中继发性甲状旁腺功能亢进的方法
公开(公告)号：US20100144684A1
公开(公告)日：2010-06-10
申请号：US12597234
申请日：2008-04-25
申请人： Charles W. Bishop
发明人： Charles W. Bishop
IPC分类号： A61K31/593 , A61K31/592 , A61P5/20 , A61P5/18 , A61P13/12
CPC分类号： A61K31/593 , A61K31/59 , A61K31/592 , A61K45/06 , A61K2300/00
摘要： A method of treating and preventing secondary hyperparathyroidism in CKD by increasing or maintaining blood concentrations of both 25-hydroxyvitamin D and 1,25-dihydroxyvitamin Din a patient by administering 25-hydroxyvitamin D3 with or without 25-hydroxyvitamin D2 and, as necessary, 1,25-dihydroxyvitamin D2 as a Vitamin D hormone replacement therapy.
摘要翻译：通过施用25-羟基维生素D 3与25-羟基维生素D 2和必要时，通过增加或维持25-羟基维生素D和1,25-二羟基维生素二者的血液浓度来治疗和预防CKD中继发性甲状旁腺功能亢进的方法，25-二羟基维生素D2作为维生素D激素替代疗法。

38. 发明申请

US20090311316A1 TREATING VITAMIN D INSUFFICIENCY AND DEFICIENCY WITH 25-HYDROXYVITAMIN D2 AND 25-HYDROXYVITAMIN D3 有权
标题翻译：用25羟维生素D2和25-羟维生素D3处理维生素D缺乏症和缺乏症
公开(公告)号：US20090311316A1
公开(公告)日：2009-12-17
申请号：US12278053
申请日：2007-02-02
申请人： Charles W. Bishop , Keith H. Crawford , Eric J. Messner
发明人： Charles W. Bishop , Keith H. Crawford , Eric J. Messner
IPC分类号： A61K31/59 , A61K9/52
CPC分类号： A61K31/593 , A61K9/00 , A61K9/0019 , A61K9/16 , A61K9/48 , A61K9/4808 , A61K9/4858 , A61K9/4866 , A61K9/4875 , A61K31/592 , A61K47/26
摘要： Methods and compositions for treating 25-hydroxyvitamin D insufficiency and deficiency in a patient are described herein. The method includes orally administering to the patient a delayed, sustained release formulation including a first ingredient selected from the group consisting of 25-hydroxyvitamin D2, 25-hydroxyvitamin D3, or a combination of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3, or it includes gradually administering to the patient a sterile intravenous formulation including a first ingredient selected from the group consisting of 25-hydroxyvitamin D2, 25-hydroxyvitamin D3, or a combination of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3.
摘要翻译：本文描述了用于治疗患者的25-羟基维生素D不足和缺乏症的方法和组合物。该方法包括向患者口服给予延迟的持续释放制剂，其包括选自由25-羟基维生素D2,25-羟基维生素D3或25-羟基维生素D 2和25-羟基维生素D 3组合组成的组的第一成分，或其包括向患者逐渐施用无菌静脉内制剂，其包含选自由25-羟基维生素D2,25-羟基维生素D3或25-羟基维生素D 2和25-羟基维生素D3的组合组成的组的第一成分。

39. 发明授权

US07122530B2 24-hydroxyvitamin D, analogs and uses thereof 有权
标题翻译： 24-羟基维生素D，类似物及其用途
公开(公告)号：US07122530B2
公开(公告)日：2006-10-17
申请号：US09753697
申请日：2001-01-03
申请人： Charles W. Bishop , Joyce C. Knutson , Stephen Strugnell
发明人： Charles W. Bishop , Joyce C. Knutson , Stephen Strugnell
IPC分类号： A01N45/00 , A61K31/59
CPC分类号： A61K31/59 , A61K31/592 , C07C401/00
摘要： The invention provides 24-hydroxyvitamin D compounds and methods for their use in the treatment and prophylaxis of hyperparathyroidism and hyperproliferative diseases, and in the modulation of the immune and inflammatory responses as well as the treatment of bone depletive disorders.
摘要翻译：本发明提供了24羟基维生素D化合物及其用于治疗和预防甲状旁腺功能亢进和过度增生性疾病以及调节免疫和炎症反应以及治疗骨缺失性疾病的方法。

40. 发明授权

US06537982B1 Method of treating prostatic diseases using active vitamin D analogues 失效
标题翻译：使用活性维生素D类似物治疗前列腺疾病的方法
公开(公告)号：US06537982B1
公开(公告)日：2003-03-25
申请号：US09596149
申请日：1998-02-23
申请人： Charles W. Bishop , Joyce C. Knutson , Richard B. Mazess
发明人： Charles W. Bishop , Joyce C. Knutson , Richard B. Mazess
IPC分类号： A61K3159
CPC分类号： A61K31/592 , A61K31/59 , A61K31/593 , A61K31/66 , A61K31/714 , A61K33/00 , A61K33/06 , A61K33/16 , A61K33/22 , A61K38/23 , A61K2300/00
摘要： The invention provides therapeutic methods for inhibiting, ameliorating or alleviating the hyperproliferative cellular activity of diseases of the prostate, e.g., prostatic cancer and prostatic hyperplasia, which includes administering to a patient in need thereof an active vitamin D analogue. Cell differentiation is promoted, induced or enhanced without causing to the patient dose-limiting hypercalcemia and hypercalciuria.
摘要翻译：本发明提供了用于抑制，改善或减轻前列腺疾病的过度增殖细胞活性的治疗方法，例如前列腺癌和前列腺增生，其包括向有需要的患者施用活性维生素D类似物。促进，诱导或增强细胞分化，而不会导致患者剂量限制性高钙血症和高钙尿症。

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