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    • 31. 发明授权
    • Gaming industry risk management clearinghouse
    • 游戏行业风险管理交换所
    • US08843411B2
    • 2014-09-23
    • US13343100
    • 2012-01-04
    • David Lawrence
    • David Lawrence
    • G06Q40/00
    • G06Q10/0635G06Q30/02G06Q40/00G06Q40/025G06Q40/08G06Q50/34G07F17/3234
    • Systems, methods, apparatus, computer program code and means for gathering, organizing and presenting on a real time basis information pertinent to Risks associated with subjects related to the Gaming Industry. Risks associated with the Gaming Industry can be managed by gathering data relevant to the Gaming Industry from multiple sources and aggregating the gathered data according to one or more risk variables. An inquiry relating to a risk subject can be received and portions of the aggregated data can be associated with the risk subject. The associated portions of the aggregated data can be transmitted to an entity placing the inquiry or other designated destination.
    • 系统,方法,设备,计算机程序代码和用于实时收集,组织和呈现与与博彩业相关的主题相关的风险的信息的手段。 可以通过从多个来源收集与游戏行业相关的数据,并根据一个或多个风险变量聚合收集的数据来管理与游戏行业相关的风险。 可以接收与风险主题有关的查询,并且可以将部分汇总数据与风险对象相关联。 聚合数据的相关部分可以被发送到放置查询或其他指定目的地的实体。
    • 34. 发明授权
    • Construction industry risk management clearinghouse
    • 建筑行业风险管理交换所
    • US08285615B2
    • 2012-10-09
    • US12464083
    • 2009-05-11
    • David Lawrence
    • David Lawrence
    • G06Q40/00
    • G06Q40/08G06Q30/018G06Q30/02
    • Systems, methods, apparatus, computer program code and means for gathering, organizing and presenting on a real time basis information pertinent to Risks associated with subjects related to the Construction Industry. Risks associated with the Construction Industry can be managed by gathering data relevant to the Construction Industry from multiple sources and aggregating the gathered data according to one or more Risk variables. An inquiry relating to a Risk subject can be received and portions of the aggregated data can be associated with the Risk subject. The associated portions of the aggregated data can be transmitted to an entity placing the inquiry or other designated destination.
    • 系统,方法,设备,计算机程序代码和用于实时收集,组织和呈现与建筑业有关的风险相关的信息的信息的手段。 可以通过从多个来源收集与建筑业相关的数据,并根据一个或多个风险变量汇总收集的数据来管理与建筑行业相关的风险。 可以接收与风险主题相关的查询,并且可以将部分汇总数据与风险主题相关联。 聚合数据的相关部分可以被发送到放置查询或其他指定目的地的实体。
    • 35. 发明授权
    • Link analysis mapping program risk management
    • 链接分析绘图程序风险管理
    • US08086617B2
    • 2011-12-27
    • US12785387
    • 2010-05-21
    • J. Gilmore ChildersDavid Lawrence
    • J. Gilmore ChildersDavid Lawrence
    • G06F17/30
    • G06Q40/08G06Q10/10G06Q40/06G06Q50/01
    • A method and system for managing risk by indicating links between one or more persons or entities which can include a process that gathers information about individuals and organizations into a computerized system where it can be analyzed to associate one or more individuals or organizations with links to other individuals or organizations. A user can designate a person or entity and the system will provide an indication of linkages associated with the designated person. Some embodiments can include a user specifying a particular type of link or limit links to a specified degree of separation between the designated person and any other person or entity.
    • 通过指示一个或多个个人或实体之间的链接来管理风险的方法和系统,其可以包括将个人和组织的信息收集到计算机化系统中的过程,其中可以对其进行分析,以将一个或多个个人或组织链接到其他 个人或组织。 用户可以指定个人或实体,并且系统将提供与指定的人相关联的链接的指示。 一些实施例可以包括指定特定类型的链接或限制链接到指定的人与任何其他个人或实体之间的特定分离程度的用户。
    • 36. 发明授权
    • Ecology valve fuel return system for gas turbine engine
    • 燃气轮机的生态阀燃油返回系统
    • US08046983B2
    • 2011-11-01
    • US12265468
    • 2008-11-05
    • David LawrencePaul Futa
    • David LawrencePaul Futa
    • F02G3/00
    • F02C7/232
    • An ecology valve (EV) fuel return system is provided. In one embodiment, the EV fuel return system includes a housing assembly having a fuel return outlet and a first manifold inlet. The fuel return outlet is fluidly coupled to a fuel supply system, and the first manifold inlet is fluidly coupled to a first manifold of a gas turbine engine (GTE). An ecology valve is disposed in the housing assembly and fluidly coupled to the fuel return outlet and to the first manifold inlet. A fuel routing assembly is fluidly coupled between the first manifold inlet, the fuel return outlet, and the ecology valve. The fuel routing assembly routes fuel: (i) from the first manifold inlet to the ecology valve when the GTE is in a shut-down mode, and (ii) from the ecology valve to the fuel return outlet when the GTE is in an engine start mode.
    • 提供生态阀(EV)燃油返回系统。 在一个实施例中,EV燃料返回系统包括具有燃料返回出口和第一歧管入口的壳体组件。 燃料回流出口流体地联接到燃料供应系统,并且第一歧管入口流体地联接到燃气涡轮发动机(GTE)的第一歧管。 生态阀设置在壳体组件中并且流体地联接到燃料返回出口和第一歧管入口。 燃料路由组件流体地联接在第一歧管入口,燃料返回出口和生态阀之间。 当GTE处于关闭模式时,燃料路由组件将燃料(i)从第一歧管入口流向生态阀,以及(ii)当GTE处于发动机时,从生态阀到燃料回流出口 启动模式。
    • 38. 发明申请
    • FLOW EQUALIZING OVERRIDE ASSEMBLY FOR FUEL DIVIDER SYSTEM
    • 用于燃油分流器系统的流量均衡化组装
    • US20100050593A1
    • 2010-03-04
    • US12199328
    • 2008-08-27
    • Paul FutaDavid TuttleDavid Lawrence
    • Paul FutaDavid TuttleDavid Lawrence
    • F02C9/28F02C7/228
    • F02C7/228F02C7/232F02C9/34
    • A flow equalizing override assembly is provided for use in conjunction with a gas turbine engine (GTE) and a fuel divider system. In one embodiment, the flow equalizing override assembly includes a housing assembly, a fuel divider (FD) valve, a remotely-actuatable valve, and a controller. The FD valve includes: (i) a piston slidably disposed within the housing assembly and movable between a default position and a flow equalizing position, and (ii) a control chamber defined by the piston and the housing assembly. The remotely-actuatable valve is fluidly coupled to the control chamber and is configured to selectively adjust the fuel pressure therein. The controller is configured to command the remotely-actuatable valve to adjust the pressure within the control chamber such that the piston moves from the default position to the flow equalizing position after ignition of the GTE.
    • 提供了一种与燃气涡轮发动机(GTE)和燃料分配器系统结合使用的均流超控组件。 在一个实施例中,流量均衡超控组件包括壳体组件,燃料分配器(FD)阀,可远程致动的阀和控制器。 FD阀包括:(i)可滑动地设置在壳体组件内并可在默认位置和流动平衡位置之间移动的活塞,以及(ii)由活塞和壳体组件限定的控制室。 可远程致动的阀流体地联接到控制室,并被构造成选择性地调节其中的燃料压力。 控制器被配置为命令可远程致动的阀来调节控制室内的压力,使得活塞在GTE点火之后从默认位置移动到流动平衡位置。
    • 39. 发明授权
    • Bond issue risk management
    • 债券发行风险管理
    • US07529702B2
    • 2009-05-05
    • US10730224
    • 2003-12-08
    • David Lawrence
    • David Lawrence
    • G06Q40/00
    • G06Q30/08G06Q40/00G06Q40/02G06Q40/04G06Q40/06G06Q50/188
    • The present invention provides an auction system that allows bond issue sales to be offered in an open and transparent manner, wherein, a certain percentage (up to 100%) of bonds in a bond issue can be offered to qualified bidders at a “buy now” pre-auction price, set by an issuer and/or lead manager. Investors can be allowed to “bid some bonds out of the auction process” and thus guarantee their allocation and also allow bidders to participate in an open auction for other bonds. Bonds to be offered in a bond issue can include a subset of pre-auction price bonds and a subset of auction price bonds. The pre-auction price bonds are offered to pre-auction bidders at a pre-auction price, and auction bonds are generally sold to the highest bidder. Pre-auction sales can serve as a catalyst for generating enthusiasm for an associated bond issue auction.
    • 本发明提供了一种允许以公开和透明的方式提供债券发行销售的拍卖系统,其中可以以“立即购买”的方式向合格的投标人提供债券发行中的一定百分比(高达100%)的债券 “拍卖前价格由发行人和/或主管经理设定。 投资者可以“投标拍卖过程中的一些债券”,从而保证其分配,并允许投标人参与其他债券的公开拍卖。 在债券发行中提供的债券可以包括拍卖前价格债券的一部分和拍卖价格债券的子集。 预拍卖价格债券以拍卖前价格提供给拍卖前投标人,拍卖债券通常以最高出价者出售。 拍卖前拍卖可以作为促成相关债券拍卖的热情的催化剂。
    • 40. 发明申请
    • POLYPEPTIDES SHARING SEQUENCE IDENTITY WITH A FIBROBLAST GROWTH FACTOR POLYPEPTIDE AND NUCLEIC ACIDS ENCODING THE SAME
    • 多肽与纤维蛋白原生长因子多肽和核酸共编序列序列识别
    • US20070077626A1
    • 2007-04-05
    • US11611037
    • 2006-12-14
    • David BotsteinAudrey GoddardAustin GurneyKenneth HillanDavid LawrenceMargaret Roy
    • David BotsteinAudrey GoddardAustin GurneyKenneth HillanDavid LawrenceMargaret Roy
    • C07K14/50C07H21/04C12P21/06
    • C07K14/50C07K2317/24C07K2319/00
    • The present invention is directed to novel polypeptides having homology to the PRO533 protein and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the polypeptides of the present invention. The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis and/or autocrine signaling. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act of predictors of the prognosis of tumor treatment. Furthermore, the compounds, compositions including antagonists and methods of the present invention are further expected to have therapeutic effect upon conditions characterized by FgF-19 modulation.
    • 本发明涉及与PRO533蛋白质和编码这些多肽的核酸分子具有同源性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞,包含与异源多肽序列融合的本发明多肽的嵌合多肽分子,与本发明的多肽结合的抗体,以及本发明多肽的制备方法 发明。 本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。 本发明基于在肿瘤细胞基因组中扩增的基因的鉴定。 预期这种基因扩增与基因产物的过度表达有关,并且有助于肿瘤发生和/或自分泌信号传导。 因此,由扩增的基因编码的蛋白质被认为是某些癌症的诊断和/或治疗(包括预防)的有用靶标,并且可以作为肿瘤治疗预后的预测因子。 此外,进一步预期本发明的化合物,包括拮抗剂和方法的组合物对于以FgF-19调节为特征的病症具有治疗作用。