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31. 发明授权

US07854730B2 Catheter for uniform delivery of medication 有权
标题翻译：导管统一服药
公开(公告)号：US07854730B2
公开(公告)日：2010-12-21
申请号：US12272748
申请日：2008-11-17
申请人： James Dal Porto , Jose Castillo Deniega , Roger Massengale , Kenneth W. Rake
发明人： James Dal Porto , Jose Castillo Deniega , Roger Massengale , Kenneth W. Rake
IPC分类号： A61M25/00
CPC分类号： A61M25/0043 , A61M25/00 , A61M25/0023 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M25/0074 , A61M25/10 , A61M29/00 , A61M2025/0057 , A61M2025/0073
摘要： A catheter is provided for uniform distribution of fluid medication within an anatomical region. One embodiment of the catheter is compromised of an elongated, proximal tube defining a lumen and an elongated, distal tube having a closed end. The distal tube is constructed from a bio-absorbable material and also defines a lumen, which communicates with the lumen of the proximal tube. In one embodiment, at least a portion of the distal tube defines a porous side wall that permits fluid within the lumen to pass through the portion of the distal tube. In another embodiment, the proximal tube and the distal tube overlap one another and are secured to one another at the overlapping surfaces.
摘要翻译：提供导管用于在解剖区域内均匀分布流体药物。导管的一个实施例受限于限定内腔的细长近端管和具有闭合端的细长管远端管。远侧管由生物吸收材料构成，并且还限定了与近端管的内腔连通的内腔。在一个实施例中，远侧管的至少一部分限定允许内腔内的流体穿过远端管的一部分的多孔侧壁。在另一个实施例中，近端管和远端管彼此重叠并且在重叠表面处彼此固定。

32. 发明授权

US07771413B2 Fluid medication delivery device 有权
标题翻译：流体药物输送装置
公开(公告)号：US07771413B2
公开(公告)日：2010-08-10
申请号：US10942735
申请日：2004-09-16
申请人： Roger Massengale , Kevin M. Forrest , Bill Porter , Donald M. Earhart , Alan Dine
发明人： Roger Massengale , Kevin M. Forrest , Bill Porter , Donald M. Earhart , Alan Dine
IPC分类号： A61K9/22
CPC分类号： A61M35/00 , A61F2013/00651 , A61L15/22 , A61L15/42
摘要： A fluid delivery device for transdermal delivery of a fluid to a patient. The device comprises an envelope that may be applied to a patient's skin. The envelope comprises at least one diffusion layer coupled to at least one impermeable layer such that at least a chamber is defined therebetween. Other embodiments include internal diffusion layers, and thus possess additional chambers, as well. In one arrangement, an adhesive boundary layer permits the device to be removably secured to a patient and inhibits radial migration of fluid beyond the periphery of the device. In another arrangement, preferably, an anti-microbial layer is provided to inhibit the growth of microorganisms.
摘要翻译：用于将流体透皮递送至患者的流体递送装置。该装置包括可应用于患者皮肤的信封。该包络线包括至少一个与至少一个不可渗透层相连的扩散层，使得至少一个室被限定在其间。其他实施方案也包括内部扩散层，因此也具有另外的室。在一种布置中，粘合剂边界层允许该装置可移除地固定到患者身上并且抑制流体径向迁移超出该装置的周边。在另一种布置中，优选地，提供抗微生物层以抑制微生物的生长。

33. 发明申请

US20090182304A1 CATHETER FOR UNIFORM DELIVERY OF MEDICATION 有权
标题翻译：用于统一运送药物的导管
公开(公告)号：US20090182304A1
公开(公告)日：2009-07-16
申请号：US12414529
申请日：2009-03-30
申请人： Jose Castillo Deniega , Roger Massengale , Kenneth W. Rake
发明人： Jose Castillo Deniega , Roger Massengale , Kenneth W. Rake
IPC分类号： A61M5/14 , A61L17/06
CPC分类号： A61M25/0043 , A61M25/00 , A61M25/0023 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M25/0074 , A61M25/10 , A61M29/00 , A61M2025/0057 , A61M2025/0073
摘要： A catheter is provided for uniform distribution of fluid medication within an anatomical region. One embodiment of the catheter is comprised of an elongate tubular catheter body defining a lumen. A distal end of the lumen is closed and a portion of the catheter body includes a plurality of openings thereby defining an infusion section of the catheter. A tubular sheath is constructed from a porous material and is positioned over the infusion section. The tubular sheath extends at least a length of the infusion section. The tubular sheath and the catheter body are configured such that fluid within the lumen must pass through the tubular sheath to exit the catheter. In at least one embodiment, a pore size of the porous material is less than about 0.5 microns.
摘要翻译：提供导管用于在解剖区域内均匀分布流体药物。导管的一个实施例由限定内腔的细长管状导管主体组成。管腔的远端封闭，导管主体的一部分包括多个开口，从而限定导管的输注部分。管状护套由多孔材料构成并位于输注部分之上。管状护套延伸至少一段输注部分。管状护套和导管主体被构造成使得腔内的流体必须通过管状护套以离开导管。在至少一个实施方案中，多孔材料的孔径小于约0.5微米。

34. 发明申请

US20090105667A1 FLUID MEDICATION DELIVERY DEVICE 有权
标题翻译：流体药物递送装置
公开(公告)号：US20090105667A1
公开(公告)日：2009-04-23
申请号：US12343397
申请日：2008-12-23
申请人： Roger Massengale , Kevin M. Forrest , Bill Porter , Donald M. Earhart , Alan Dine
发明人： Roger Massengale , Kevin M. Forrest , Bill Porter , Donald M. Earhart , Alan Dine
IPC分类号： A61M5/00
CPC分类号： A61M35/00 , A61F2013/00651 , A61L15/22 , A61L15/42
摘要： A fluid delivery device is provided for transdermal delivery of fluid medications to patients. The device can comprise a thin envelope which is applied to a patient's skin. The envelope can comprise at least one diffusion layer coupled to at least one impermeable layer such that at least one chamber can exist therebetween. Other embodiments can include internal diffusion layers, and thus can possess additional chambers, as well. The impermeable layer can comprise a top surface of the device. A valve positioned in the impermeable layer can facilitate filling the device with fluid, as well as connection of the device to external fluid sources such as an intravenous bag, pump, or other external fluid delivery system. The diffusion layer can comprise a coiled wire member to control the rate of fluid flow from the device to the patient's skin.
摘要翻译：提供流体递送装置用于向患者透皮递送流体药物。该装置可以包括施加到患者皮肤的薄的信封。信封可以包括耦合到至少一个不可渗透层的至少一个扩散层，使得其间可以存在至少一个室。其他实施例可以包括内部扩散层，并且因此也可以具有附加的室。不透水层可以包括该装置的顶表面。定位在不渗透层中的阀可以有助于用流体填充装置，以及将装置连接到诸如静脉内袋，泵或其它外部流体输送系统的外部流体源。扩散层可以包括螺旋线构件，以控制从装置到患者皮肤的流体流速。

35. 发明申请

US20070289644A1 PRESSURE REGULATOR 有权
标题翻译：压力调节器
公开(公告)号：US20070289644A1
公开(公告)日：2007-12-20
申请号：US11849571
申请日：2007-09-04
申请人： Roger Massengale , Stanley Fry , Charles McPhee
发明人： Roger Massengale , Stanley Fry , Charles McPhee
IPC分类号： F16K37/00
CPC分类号： G05D16/0647 , Y10S137/903 , Y10T137/0379 , Y10T137/0396 , Y10T137/0497 , Y10T137/7825 , Y10T137/7871 , Y10T137/7922 , Y10T137/8225 , Y10T137/8326
摘要： A variable pressure regulator control device comprising a valve body having a fluid inlet, a fluid outlet, a fluid pressure-sensing chamber, and a valve seat in fluid communication with said inlet and defining an opening into said chamber, a resilient member having an outer edge and a self-restoring wall of the chamber which is responsive to pressure in said chamber, a valve stem extending through said chamber towards the valve seat, a valve element cooperating with said valve seat, said valve element being located between the valve seat and said fluid inlet, an adjuster mounted to said valve body in a position to deflect said resilient member, thereby moving the valve element away from the valve seat while said member flexes in response to pressure changes within said chamber to control the position of the valve element with respect to the valve seat, wherein said valve body includes a base incorporating said inlet, said outlet, and said valve seat, a retainer mounted atop said base, said retainer having an aperture for receiving said adjuster, and a cover fixing said adjuster for rotation therewith such that deflection of said resilient member is capable of being adjusted by rotation of said cover.
摘要翻译：一种可变压力调节器控制装置，包括具有流体入口，流体出口，流体压力感测室和与所述入口流体连通并限定到所述室中的开口的阀座的阀体，弹性构件具有外部边缘和腔室的自恢复壁，其响应于所述腔室中的压力，阀杆，其通过所述腔室朝向阀座延伸;阀元件，与所述阀座配合，所述阀体元件位于阀座和所述流体入口，安装到所述阀体上的调节器，以使所述弹性构件偏转的位置，从而使所述阀元件远离所述阀座移动，同时所述构件响应于所述腔室内的压力变化而弯曲以控制所述阀元件的位置相对于阀座，其中所述阀体包括包括所述入口，所述出口和所述阀座的基座，安装在所述基座顶部的保持器，所述保持器具有用于接收所述调节器的孔，以及固定所述调节器以使其旋转的盖，使得所述弹性构件的偏转能够通过所述盖的旋转来调节。

36. 发明授权

US07264018B2 Pressure regulator 有权
标题翻译：压力调节器
公开(公告)号：US07264018B2
公开(公告)日：2007-09-04
申请号：US11527848
申请日：2006-09-27
申请人： Roger Massengale , Stanley E. Fry , Charles J. McPhee
发明人： Roger Massengale , Stanley E. Fry , Charles J. McPhee
IPC分类号： F16K37/00
CPC分类号： G05D16/0647 , Y10S137/903 , Y10T137/0379 , Y10T137/0396 , Y10T137/0497 , Y10T137/7825 , Y10T137/7871 , Y10T137/7922 , Y10T137/8225 , Y10T137/8326
摘要： A variable device for regulating the outlet pressure of a fluid from a valve body, includes a pressure-sensing chamber having a wall formed by a resilient self-restoring diaphragm which is responsive to pressure in the chamber. A valve element connected to the diaphragm controls flow into the chamber. Increased pressure in the chamber decreases the flow into the chamber and decreasing pressure increases flow whereby fluid flow out from the chamber is maintained at a desired pressure. The outlet pressure is adjusted by deflecting the diaphragm in a direction to open the valve while permitting a section of the diaphragm connected to the valve member to remain responsive to the pressure in the chamber. An adjustment cover is provided to adjustably deflect the diaphragm and includes a catch mechanism to allow adjustment of the fluid outlet pressures and also retain the device at a desired value. An indicator arrangement may be provided to visually indicate the fluid outlet pressure.
摘要翻译：用于调节来自阀体的流体的出口压力的可变装置包括压力感测室，该压力感测室具有由响应腔室中的压力的弹性自恢复隔膜形成的壁。连接到隔膜的阀元件控制流入腔室。室中增加的压力降低了进入室的流量，并且减小的压力增加了流量，从而从腔室流出的流体保持在期望的压力。出口压力通过使膜片沿打开阀的方向偏转来调节，同时允许连接到阀构件的隔膜的一部分保持对腔室中的压力的响应。提供调节盖以可调节地偏转隔膜并且包括捕获机构以允许调节流体出口压力并且还将装置保持在期望值。可以提供指示器布置以在视觉上指示流体出口压力。

37. 发明授权

US08323266B2 Fluid medication delivery device 有权
公开(公告)号：US08323266B2
公开(公告)日：2012-12-04
申请号：US12853774
申请日：2010-08-10
申请人： Roger Massengale , Kevin M. Forrest , Bill Porter , Donald M. Earhart , Alan Dine
发明人： Roger Massengale , Kevin M. Forrest , Bill Porter , Donald M. Earhart , Alan Dine
IPC分类号： A61K9/00
CPC分类号： A61M35/00 , A61F2013/00651 , A61L15/22 , A61L15/42
摘要： A fluid delivery device for transdermal delivery of a fluid to a patient. The device comprises an envelope that may be applied to a patient's skin. The envelope comprises at least one diffusion layer coupled to at least one impermeable layer such that at least a chamber is defined therebetween. Other embodiments include internal diffusion layers, and thus possess additional chambers, as well. In one arrangement, an adhesive boundary layer permits the device to be removably secured to a patient and inhibits radial migration of fluid beyond the periphery of the device. In another arrangement, preferably, an anti-microbial layer is provided to inhibit the growth of microorganisms.

38. 发明授权

US08052651B2 Apparatus and method for securing a catheter within an anatomy 有权
标题翻译：用于将导管固定在解剖结构内的装置和方法
公开(公告)号：US08052651B2
公开(公告)日：2011-11-08
申请号：US12113858
申请日：2008-05-01
申请人： Roger Massengale
发明人： Roger Massengale
IPC分类号： A61M5/32
CPC分类号： A61M25/02 , A61B17/04 , A61B2017/00004 , A61B2017/3488 , A61M2025/0037 , A61M2025/0286 , A61M2025/0293
摘要： An apparatus and method for securing a catheter within a target area of the anatomy are disclosed. The catheter includes a passage or opening through which a suture filament may be routed. The suture filament can be secured relative to anatomical tissue to retain the catheter within a desired region. After the catheter has been used to complete the desired medical procedure, the suture filament may be released, permitting the catheter to be easily withdrawn from the anatomy. The catheter may include a biodegradable tip, which when absorbed by the body would enable the catheter to be removed. Biodegradable suture filaments and other components may also be used to facilitate the release of the catheter from the anatomy.
摘要翻译：公开了一种用于将导管固定在解剖结构的目标区域内的装置和方法。导管包括通道或开口，缝合线丝可穿过该通道或开口。缝合线丝可以相对于解剖组织固定，以将导管保持在期望的区域内。在使用导管完成所需的医疗程序之后，可以释放缝合线，允许导管容易地从解剖结构中撤出。导管可以包括可生物降解的尖端，当被身体吸收时，可以使导管去除。也可以使用可生物降解的缝线细丝和其它组分来促进导管从解剖结构的释放。

39. 发明授权

US08048057B2 Catheter for uniform delivery of medication 有权
标题翻译：导管统一服药
公开(公告)号：US08048057B2
公开(公告)日：2011-11-01
申请号：US12414529
申请日：2009-03-30
申请人： Jose Castillo Deniega , Roger Massengale , Kenneth W. Rake
发明人： Jose Castillo Deniega , Roger Massengale , Kenneth W. Rake
IPC分类号： A61M25/00 , A61M31/00 , A61B17/04 , A61L17/00
CPC分类号： A61M25/0043 , A61M25/00 , A61M25/0023 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M25/0074 , A61M25/10 , A61M29/00 , A61M2025/0057 , A61M2025/0073
摘要： A catheter is provided for uniform distribution of fluid medication within an anatomical region. One embodiment of the catheter is comprised of an elongate tubular catheter body defining a lumen. A distal end of the lumen is closed and a portion of the catheter body includes a plurality of openings thereby defining an infusion section of the catheter. A tubular sheath is constructed from a porous material and is positioned over the infusion section. The tubular sheath extends at least a length of the infusion section. The tubular sheath and the catheter body are configured such that fluid within the lumen must pass through the tubular sheath to exit the catheter. In at least one embodiment, a pore size of the porous material is less than about 0.5 microns.
摘要翻译：提供导管用于在解剖区域内均匀分布流体药物。导管的一个实施例由限定内腔的细长管状导管主体组成。管腔的远端封闭，导管主体的一部分包括多个开口，从而限定导管的输注部分。管状护套由多孔材料构成并位于输注部分之上。管状护套延伸至少一段输注部分。管状护套和导管主体被构造成使得腔内的流体必须通过管状护套以离开导管。在至少一个实施方案中，多孔材料的孔径小于约0.5微米。

40. 发明授权

US08043465B2 Catheter for uniform delivery of medication 有权
标题翻译：导管统一服药
公开(公告)号：US08043465B2
公开(公告)日：2011-10-25
申请号：US10420133
申请日：2003-04-18
申请人： Jose Castillo Deniega , Roger Massengale , Kenneth W. Rake
发明人： Jose Castillo Deniega , Roger Massengale , Kenneth W. Rake
IPC分类号： B29C65/00 , A61M25/00
CPC分类号： A61M25/0074 , A61M25/00 , A61M25/0023 , A61M25/0043 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M2025/0037 , A61M2025/0039 , A61M2025/0057 , A61M2025/0073
摘要： The present invention provides a catheter for the delivery of fluid medication across an anatomical region. In accordance with some embodiments, the catheter includes an elongated tubular member made of a porous membrane. The porous membrane is configured so that a fluid introduced into an open end of the tubular member will flow through side walls of the tubular member at a substantially uniform rate along a length of the tubular member. In accordance with other embodiments, the catheter includes an elongated “weeping” tubular coil spring attached to an end of, or enclosed within, a tube. Fluid within the spring and greater than or equal to a threshold pressure advantageously flows radially outward between the spring coils. Advantageously, the fluid is dispensed substantially uniformly throughout a length of the spring. In accordance with other embodiments, the catheter includes a tube having a plurality of exit holes in a side wall of the tube. The exit holes combine to form a flow-restricting orifice of the catheter. Advantageously, fluid within the catheter flows through all of the exit holes, resulting in uniform distribution of fluid within an anatomical region.
摘要翻译：本发明提供一种用于在解剖区域上输送流体药物的导管。根据一些实施例，导管包括由多孔膜制成的细长管状构件。多孔膜被构造成使得引入到管状构件的开口端的流体将沿着管状构件的长度以基本均匀的速率流过管状构件的侧壁。根据其他实施例，导管包括连接到管的端部或封闭在管内的细长的“哭泣”管状螺旋弹簧。弹簧内的流体大于或等于阈值压力有利地在弹簧圈之间径向向外流动。有利地，流体在弹簧的整个长度上基本均匀地分配。根据其他实施例，导管包括管，其在管的侧壁中具有多个出口孔。出口孔结合形成导管的限流孔。有利地，导管内的流体流过所有出口孔，导致流体在解剖区域内的均匀分布。

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