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    • 35. 发明授权
    • Mass spectrometer
    • 质谱仪
    • US06884995B2
    • 2005-04-26
    • US10610677
    • 2003-07-02
    • Robert Harold BatemanKevin GilesJohn Brian HoyesSteve Pringle
    • Robert Harold BatemanKevin GilesJohn Brian HoyesSteve Pringle
    • H01J49/02H01J49/26
    • H01J49/005H01J49/062
    • A mass spectrometer is disclosed comprising a collision cell wherein ions having substantially different mass to charge ratios are arranged to be transmitted through at least a portion of the collision cell at substantially the same time and with substantially the same velocity preferably by means of one or more transient DC voltages or one or more transient DC voltage waveforms which are applied to the electrodes forming the collision cell so that ions are urged through the collision cell at a constant controlled velocity. By appropriate setting of the velocity of the DC voltage or DC voltage waveform passing along the length of the collision cell an efficient collision cell is provided which is able to fragment ions having considerably different mass to charge ratio at substantially the same time in an optimal manner.
    • 公开了一种质谱仪,其包括碰撞池,其中具有基本上不同的质荷比的离子被布置成在基本相同的时间和基本上相同的速度下通过至少一部分的碰撞池传播通过一个或多个 瞬态DC电压或一个或多个瞬态DC电压波形,其被施加到形成碰撞电池的电极,使得离子以恒定的受控速度被迫穿过碰撞池。 通过适当设定沿着碰撞电池的长度通过的直流电压或直流电压波形的速度,提供了一种有效的碰撞电池,其能够以最佳方式在基本上相同的时间将具有相当不同质荷比的离子分解 。
    • 36. 发明授权
    • Methods and apparatus for mass spectrometry
    • 质谱方法和仪器
    • US06717130B2
    • 2004-04-06
    • US09876122
    • 2001-06-08
    • Robert Harold BatemanJohn Brian HoyesEdward James Clayton
    • Robert Harold BatemanJohn Brian HoyesEdward James Clayton
    • B01D5944
    • H01J49/0045
    • A method is disclosed of identifying parent ions by matching daughter ions found to be produced at substantially the same time that the parent ions elute from a mixture. Ions emitted from an ion source are incident upon a collision cell which alternately and repeatedly switches between a first mode wherein the ions are substantially fragmented to produce daughter ions and a second mode wherein the ions are not substantially fragmented. Mass spectra are taken in both modes, and at the end of an experimental run parent and daughter ions are recognized by comparing the mass spectra obtained in the two different modes. Daughter ions are matched to particular parent ions on the basis of the closeness of fit of their elution times, and this enables parent ions to then be identified.
    • 公开了一种通过匹配发现在母体离子从混合物中洗脱出的基本上同时产生的子离子来鉴定亲本离子的方法。 从离子源发射的离子入射到碰撞单元上,该碰撞单元在离子基本上分裂以产生子离子的第一模式之间交替重复地切换,而第二模式其中离子基本上不分段。 在两种模式下都采用质谱,在实验运行结束时,通过比较两种不同模式中获得的质谱来识别母体和子离子。 基于其洗脱时间的拟合程度,子离子与特定的母体离子相匹配,这使母体离子能够被识别。
    • 39. 发明授权
    • Methods and apparatus for mass spectrometry
    • 质谱方法和仪器
    • US06586727B2
    • 2003-07-01
    • US09796544
    • 2001-03-02
    • Robert Harold BatemanJohn Brian Hoyes
    • Robert Harold BatemanJohn Brian Hoyes
    • H01J4940
    • H01J49/0045H01J49/4215
    • An improved method of parent ion scanning is disclosed. In one embodiment a quadrupole mass filter 3 upstream of a collision cell 4 is arranged to operate in a highpass mode. Parent ions transmitted by the mass filter 3 are fragmented in the collision cell 4 and detected by an orthogonal time of flight analyser 5 which obtains a daughter ion mass spectrum. Ions having a mass to charge ratio below the cutoff of the mass filter 3 are identified as daughter ions, and candidate parent ions may then be discovered and their identity confirmed by obtaining corresponding daughter ion spectra. In a second embodiment, the collision cell 4 alternates between high and low fragmentation and candidate parent ions can additionally be identified on the basis of the loss of a predetermined ion or neutral particle.
    • 公开了改进的亲离子扫描方法。 在一个实施例中,碰撞单元4上游的四极质量过滤器3布置成以高通模式操作。 由质量过滤器3传递的亲本离子在碰撞池4中被分段,并且通过获得子离子质谱的飞行分析仪5的正交时间检测。 具有低于质量过滤器3的截止值的质荷比的离子被鉴定为子离子,然后可以通过获得相应的子离子光谱来发现候选母体离子并且确定它们的身份。 在第二实施例中,碰撞单元4在高和低碎片之间交替,并且候选母离子可以另外根据预定离子或中性粒子的损失来识别。
    • 40. 发明授权
    • Methods and apparatus for tandem mass spectrometry
    • 串联质谱法的方法和装置
    • US6107623A
    • 2000-08-22
    • US138152
    • 1998-08-21
    • Robert Harold BatemanJohn Brian Hoyes
    • Robert Harold BatemanJohn Brian Hoyes
    • H01J49/26H01J49/40H01J49/42B01D59/44
    • H01J49/004H01J49/4215
    • The invention provides methods and apparatus for tandem mass spectrometry (MS/MS) in which parent ions generated from a sample are passed through a mass filter (2) and are fragmented into daughter ions in fragmentation means (3), the daughter ions being passed through a discontinuous output mass analyser, such as a time-of-flight analyzer (16) or an ion storage device (29). The range of possible parent mass-to-charge ratios is split into a plurality of smaller ranges, and the mass filter (2) is set to pass ions of each smaller range in turn. A flag is set for each smaller range which produces daughter ions of interest, and the mass filter (2) is set to pass each mass-to-charge ratio of the flagged ranges so that the mass-to-charge ratios of the fragmented ions produced for each of the mass-to-charge ratios passed may be determined using the discontinuous analyser (16, 29). The flagged ranges may be themselves split into a plurality of still smaller ranges, which are correspondingly flagged.
    • 本发明提供串联质谱法(MS / MS)的方法和装置,其中从样品产生的亲本离子通过质量过滤器(2),并在碎片装置(3)中碎裂成子离子,子离子通过 通过不连续输出质量分析器,例如飞行时间分析器(16)或离子存储装置(29)。 可能的母体质荷比的范围被分成多个较小的范围,并且质量过滤器(2)被设置为依次通过每个较小范围的离子。 对于产生感兴趣的子离子的每个较小的范围设置标志,并且质量过滤器(2)被设置为通过标记范围的每个质荷比,使得碎裂离子的质荷比 可以使用不连续分析仪(16,29)来确定通过的每个质荷比。 标记的范围本身可以分成多个相应标记的较小范围。