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31. 发明申请

US20180177623A1 OBESITY TREATMENT DEVICES, SYSTEMS, AND METHODS 审中-公开
公开(公告)号：US20180177623A1
公开(公告)日：2018-06-28
申请号：US15853793
申请日：2017-12-23
申请人： Alexander S. Ganz , Robert A. Ganz
发明人： Alexander S. Ganz , Robert A. Ganz
IPC分类号： A61F5/00
摘要： Various devices, systems, and methods that can be used in the treatment of obesity and related illnesses are disclosed. In some instances, a portion of the bowel of an obese patient is distended for a therapeutically effective period. The distention may be achieved by introduction of an object that is of foreign origin relative to the body of the patient into the bowel of the patient. In some instances, the distention is achieved by a medical device that transitions from an undeployed state, in which the medical device is introduced into the bowel of the patient, to an expanded state in which the medical device distends the bowel by an amount sufficient to trigger an intestinal-gastric brake in the patient.

32. 发明申请

US20080275445A1 METHOD AND APPARATUS FOR GASTROINTESTINAL TRACT ABLATION FOR TREATMENT OF OBESITY 有权
标题翻译：用于治疗肥胖的胃肠道牵引治疗的方法和装置
公开(公告)号：US20080275445A1
公开(公告)日：2008-11-06
申请号：US12114628
申请日：2008-05-02
申请人： Douglas Kelly , David S. Utley , Robert A. Ganz , Michael P. Wallace , Nathan Every
发明人： Douglas Kelly , David S. Utley , Robert A. Ganz , Michael P. Wallace , Nathan Every
IPC分类号： A61B18/18
CPC分类号： A61B18/04 , A61B18/1492 , A61B18/18 , A61B2018/0022 , A61B2018/0212 , A61B2018/1467
摘要： Devices and methods for ablating tissue in the wall of various organs of the gastrointestinal tract of a patient in order to cure or ameliorate metabolic pathophysiological conditions such as obesity, insulin resistance, or type 2 diabetes mellitus are provided. Ablational treatment of target areas may be fractional or partial, rendering a post-treatment portion of target tissue ablated and another portion that is substantially intact. Fractional ablation is achieved by controlling the delivery of ablational energy across the surface area being treated, and controlling the depth of energy penetration into tissue. Surface area control of energy delivery may controlled by the spatial pattern of distributed ablation elements or by the selective activation of a subset of a dense pattern of ablation elements. Embodiments of the device include an ablational electrode array that spans 360 degrees and an array that spans an arc of less than 360 degrees.
摘要翻译：提供了用于消除患者胃肠道的各种器官的壁中的组织以便治愈或改善代谢病理生理条件如肥胖，胰岛素抵抗或2型糖尿病的装置和方法。目标区域的消融治疗可能是部分或部分，使目标组织的后处理部分消融，另一部分基本上完好无损。通过控制穿过所治疗的表面区域的消融能量的传递并控制能量渗入组织的深度来实现分数消融。能量输送的表面积控制可以由分布式消融元件的空间模式控制，或者通过选择性地激活消融元件的密集图案的子集。该装置的实施例包括跨越360度的消融电极阵列和跨越小于360度的弧的阵列。

33. 发明申请

US20220226016A1 MATERIAL REMOVAL FROM WITHIN A PATIENT 有权
公开(公告)号：US20220226016A1
公开(公告)日：2022-07-21
申请号：US17702427
申请日：2022-03-23
申请人： Robert A. Ganz , Mark Anders Rydell , Travis Sessions , Steven Berhow , Doug Wahnschaffe , Michael W. Augustine
发明人： Robert A. Ganz , Mark Anders Rydell , Travis Sessions , Steven Berhow , Doug Wahnschaffe , Michael W. Augustine
IPC分类号： A61B17/3207 , A61B1/00 , A61B1/018 , A61B1/267 , A61B1/273 , A61B1/31
摘要： A system can include an elongated member that includes a proximal portion and a distal portion that includes an agitator. The elongated member can extend through a working channel of an endoscope placed within a patient such that the agitator extends past a distal end of the endoscope into a target region within the patient. The agitator can include a plurality of disruption elements that can be in a low-profile state when within the working channel of the endoscope and can transition to an expanded state when advanced past the distal end of the endoscope. The plurality of disruption elements can define an empty cage configuration when in the expanded state. The system can include a driver coupled to the proximal portion of the elongated member. The driver can rotate the elongated member about a longitudinal axis of the elongated member.

34. 发明授权

US06890346B2 Apparatus and method for debilitating or killing microorganisms within the body 失效
标题翻译：用于使身体内的微生物衰弱或杀死的装置和方法
公开(公告)号：US06890346B2
公开(公告)日：2005-05-10
申请号：US10119976
申请日：2002-04-09
申请人： Robert A. Ganz , Hans L. Melgaard
发明人： Robert A. Ganz , Hans L. Melgaard
IPC分类号： A61L2/12 , A61B17/22 , A61B18/00 , A61B18/22 , A61B18/24 , A61M36/04 , A61N5/04 , A61N5/06 , A61N5/10 , H01J35/32 , A61N5/00
CPC分类号： A61N5/0601 , A61B18/24 , A61B2017/22051 , A61B2018/00982 , A61B2018/2261 , A61N5/1001 , A61N2005/0609 , A61N2005/0651 , A61N2005/0654 , A61N2005/0661 , H01J35/32 , H01J2235/164
摘要： A surgical apparatus has a body portion that includes a shaft terminating in a distal head or tip for directing light radiation from the apparatus onto the lining of a body cavity for treating an ailment in a body cavity of a patient as for example a gastrointestinal ailment of a patient such as gastritis, gastric ulcer, duodenal ulcer, gastric cancer, gastric lymphoma, ulcerative colitis, or Crohn's disease as well as for treating diseases of the circulatory system, urogenital systems and other body cavities. During use, the shaft of the apparatus is inserted into a body cavity, e.g., stomach or colon, of the patient to place the distal tip of the shaft in the desired position. The body cavity of the patient is then irradiated with light radiation so as to kill or debilitate microorganisms lining the body cavity without serious destruction of the body tissue of the patient to thereby improve or alleviate one or more of the symptoms of the ailment. A probiotic comprising innocuous bacteria can be administered to the patient to reestablish the growth of normal microbial flora when treating the gastrointestinal tract.
摘要翻译：手术装置具有主体部分，该主体部分包括终止于远侧头部或尖端的轴，用于将来自该装置的光辐射引导到体腔的衬里上，用于治疗患者的体腔中的疾病，例如胃肠道疾病诸如胃炎，胃溃疡，十二指肠溃疡，胃癌，胃淋巴瘤，溃疡性结肠炎或克罗恩病的患者，以及用于治疗循环系统，泌尿生殖系统和其他体腔的疾病。在使用期间，将装置的轴插入到患者的体腔（例如胃或结肠）中，以将轴的远侧末端放置在期望的位置。然后用光辐射照射患者的体腔，以便杀死或破坏体腔内的微生物，而不会严重破坏患者的身体组织，从而改善或减轻疾病的一种或多种症状。可以向患者施用包含无害细菌的益生菌以在治疗胃肠道时重新建立正常微生物菌群的生长。

35. 发明授权

US06491618B1 Apparatus and method for debilitating or killing microorganisms within the body 失效
标题翻译：用于使身体内的微生物衰弱或杀死的装置和方法
公开(公告)号：US06491618B1
公开(公告)日：2002-12-10
申请号：US09598653
申请日：2000-06-22
申请人： Robert A. Ganz
发明人： Robert A. Ganz
IPC分类号： A61N500
CPC分类号： A61N5/0601 , A61B18/24 , A61B2017/22051 , A61B2018/00982 , A61B2018/2261 , A61N5/1001 , A61N2005/0609 , A61N2005/0651 , A61N2005/0654 , A61N2005/0661 , H01J35/32 , H01J2235/164
摘要： A surgical apparatus has a body portion that includes a shaft terminating in a distal head or tip and a means for directing light radiation from the apparatus onto the lining of a body cavity for treating a gastrointestinal ailment of a patient including gastritis, gastric ulcer, duodenal ulcer, gastric cancer, gastric lymphoma, ulcerative colitis, or Crohn's disease. The method of use of the apparatus comprises inserting the shaft of the apparatus into a body cavity, e.g., stomach or colon, of the patient to place the distal tip of the shaft in the desired position. The body cavity of the patient is then irradiated with ultraviolet light radiation in a preferred range of about 250 nm to 270 nm so as to kill or debilitate microorganisms lining the body cavity without serious destruction of the body tissue of the patient to thereby improve or alleviate one or more of the symptoms of the gastrointestinal ailment. A probiotic comprising innocuous bacteria can then be administered to the patient to reestablish the growth of normal microbial flora.
摘要翻译：手术装置具有主体部分，其包括终止于远侧头部或尖端的轴，以及用于将来自该装置的光辐射引导到体腔内衬上的装置，用于治疗患者的胃肠道疾病，包括胃炎，胃溃疡，十二指肠溃疡，胃癌，胃淋巴瘤，溃疡性结肠炎或克罗恩病。使用该装置的方法包括将装置的轴插入患者的体腔（例如胃或结肠）中，以将轴的远侧末端放置在期望的位置。然后在约250nm至270nm的优选范围内用紫外光辐射照射患者的体腔，以便杀死或使在体腔内的微生物丧失，而不会严重破坏患者的身体组织，从而改善或减轻一种或多种胃肠道疾病的症状。然后将包含无害细菌的益生菌施用于患者以重新建立正常微生物菌群的生长。

36. 发明授权

US06464625B2 Therapeutic method and apparatus for debilitating or killing microorganisms within the body 失效
标题翻译：用于使身体内的微生物衰弱或杀死的治疗方法和装置
公开(公告)号：US06464625B2
公开(公告)日：2002-10-15
申请号：US09338687
申请日：1999-06-23
申请人： Robert A. Ganz
发明人： Robert A. Ganz
IPC分类号： A61N500
CPC分类号： A61N5/0601 , A61B18/24 , A61B2017/22051 , A61B2018/00982 , A61B2018/2261 , A61N5/1001 , A61N2005/0609 , A61N2005/0651 , A61N2005/0654 , A61N2005/0661 , H01J35/32 , H01J2235/164
摘要： A treatment method and apparatus for debilitating or killing Helicobacter pylori or other microorganisms within the body of a patient is especially suited for treating stomach or duodenal ulcers. The present therapeutic method involves the use of ionizing radiation for eliminating pathogenic microorganisms within or supported upon the lining of a body cavity of a patient, e.g., the stomach. An elongated flexible shaft is provided for insertion into the body in any of various ways selected by the surgeon. It can be placed endoscopically, e.g., through the esophagus, placed surgically, placed laparoscopically or by CAT scan-guided percutaneous insertion. A radiant energy distribution head is provided at the end of the flexible shaft to transmit ionizing radiation for destroying microorganisms within the body. Radiant energy, e.g., x-ray, ultraviolet light, beta radiation, gamma radiation, radio waves, microwaves, or infrared energy, is then transferred from the head of the instrument to the epithelium around the head of the instrument in an amount sufficient to debilitate or kill the Helicobacter pylori or other microorganisms in the lining of the body cavity.
摘要翻译：幽门螺杆菌或患者体内幽门螺杆菌或其他微生物衰弱或杀伤的治疗方法和装置特别适用于治疗胃或十二指肠溃疡。本治疗方法包括使用电离辐射来消除病人微生物内部或支撑在患者体腔（例如胃）的衬里内。提供细长的柔性轴以用外科医生选择的各种方式插入体内。它可以内窥镜放置，例如通过食道放置，手术放置，腹腔镜放置或通过CAT扫描引导经皮插入。辐射能量分布头设置在柔性轴的端部以传输用于破坏身体内的微生物的电离辐射。然后将辐射能量，例如x射线，紫外线，β辐射，γ辐射，无线电波，微波或红外能量从仪器的头部转移到仪器头部周围的上皮，其量足以使幽门螺杆菌或身体内衬中的其他微生物衰弱或死亡。

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