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31. 发明授权

US6051710A Process for pyrimidinone compounds 失效
公开(公告)号：US6051710A
公开(公告)日：2000-04-18
申请号：US207892
申请日：1998-12-08
申请人： Ping Zhou , Edward Curtis Taylor , Colin Michael Tice
发明人： Ping Zhou , Edward Curtis Taylor , Colin Michael Tice
IPC分类号： B01J31/24 , C07B61/00 , C07D239/36 , C07D239/52 , C07D239/60 , C07D401/04 , C07F7/08
CPC分类号： C07D239/36 , C07D239/52 , C07D239/60 , C07D401/04 , C07F7/0812 , C07F7/0827 , C07F7/083
摘要： This invention relates to a process for the preparation of pyrimidinone compounds of the formula ##STR1## wherein Ar is an optionally substituted aryl or heteroaromatic moiety,R.sup.3 is an optionally substituted alkyl, alkenyl or alkynyl,R.sup.5 is a hydrogen atom, halo, cyano or an optionally substituted alkyl, alkenyl, alkynyl, alkoxy or alkylthio, andR.sup.6 is a hydrogen atom, cyano, or an optionally substituted alkyl, cycloalkyl, alkenyl, alkynyl, aryl, aralkyl or heteroaryl.The process comprises reaction of an amidine and a malonic acid derivative to give a hydroxypyrimidinone followed by conversion of the resulting hydroxypyrimidinone to a sulfonyloxypyrimidinone followed by reaction of the resulting sulfonyloxypyrimidinone with an organometallic reagent to give the desired pyrimidinone. The hydroxypyrimidinones, wherein R.sup.6 is hydroxy and sulfonyloxypyrimidinones wherein R.sup.6 is a substituted sulfonyloxy moiety, are themselves new and useful intermediates in the preparation of the desired pyrimidinones.

32. 发明授权

US5889184A Process for pyrimidinone compounds 失效
标题翻译：嘧啶酮化合物的方法
公开(公告)号：US5889184A
公开(公告)日：1999-03-30
申请号：US831174
申请日：1997-04-02
申请人： Ping Zhou , Edward Curtis Taylor , Colin Michael Tice
发明人： Ping Zhou , Edward Curtis Taylor , Colin Michael Tice
IPC分类号： B01J31/24 , C07B61/00 , C07D239/36 , C07D239/52 , C07D239/60 , C07D401/04 , C07F7/08
CPC分类号： C07D239/36 , C07D239/52 , C07D239/60 , C07D401/04 , C07F7/0812 , C07F7/0827 , C07F7/083
摘要： This invention relates to a process for the preparation of pyrimidinone compounds of the formula ##STR1## wherein Ar is an optionally substituted aryl or heteroaromatic moiety,R.sup.3 is an optionally substituted alkyl, alkenyl or alkynyl,R.sup.5 is a hydrogen atom, halo, cyano or an optionally substituted alkyl, alkenyl, alkynyl, alkoxy or alkylthio, andR.sup.6 is a hydrogen atom, cyano, or an optionally substituted alkyl, cycloalkyl, alkenyl, alkynyl, aryl, aralkyl or heteroaryl.The process comprises reaction of an amidine and a malonic acid derivative to give a hydroxypyrimidinone followed by conversion of the resulting hydroxypyrimidinone to a sulfonyloxypyrimidinone followed by reaction of the resulting sulfonyloxypyrimidinone with an organometallic reagent to give the desired pyrimidinone. The hydroxypyrimidinones, wherein R.sup.6 is hydroxy and sulfonyloxypyrimidinones wherein R.sup.6 is a substituted sulfonyloxy moiety, are themselves new and useful intermediates in the preparation of the desired pyrimidinones.
摘要翻译：本发明涉及一种制备下式的嘧啶酮化合物的方法，其中Ar是任选取代的芳基或杂芳族部分，R 3是任选取代的烷基，烯基或炔基，R 5是氢原子，卤素，氰基或任选取代的烷基，烯基，炔基，烷氧基或烷硫基，R 6是氢原子，氰基或任选取代的烷基，环烷基，烯基，炔基，芳基，芳烷基或杂芳基。该方法包括脒和丙二酸衍生物的反应，得到羟基嘧啶酮，随后将所得羟基嘧啶酮转化为磺酰氧基嘧啶酮，随后将所得的磺酰氧基嘧啶酮与有机金属试剂反应，得到所需的嘧啶酮。其中R6是羟基的羟基嘧啶酮和其中R6是取代的磺酰氧基部分的磺酰氧基嘧啶酮本身是制备所需嘧啶酮的新的和有用的中间体。

33. 发明申请

US20130136766A1 EFFECTIVE FRACTION FROM THE FRUITING BODIES OF GANODERMA LUCIDUM, EXTRACTION METHOD, USE AND PREPARATION THEREOF 审中-公开
标题翻译：来自甘蔗叶片水果体的有效分离，提取方法，使用及其制备
公开(公告)号：US20130136766A1
公开(公告)日：2013-05-30
申请号：US13814739
申请日：2011-05-30
申请人： Ping Zhou , Hongjie Yang , Baosong Teng , Chendong Wang
发明人： Ping Zhou , Hongjie Yang , Baosong Teng , Chendong Wang
IPC分类号： A61K36/074
CPC分类号： A61K36/074
摘要： An effective fraction from the fruiting bodies of Ganoderma lucidum, extraction method, use and preparation thereof are provided. The effective fraction is prepared from the defatted fruiting bodies of Ganoderma lucidum by extracting with alkali, dialyzing and drying. The effective fraction has effect of significantly lowering blood sugar.
摘要翻译：提供灵芝子实体的有效成分，提取方法，用途及制备方法。有效成分由灵芝脱脂子实体制成，用碱提取，透析，干燥。有效部分具有显着降低血糖的作用。

34. 发明申请

US20130080669A1 Dynamically Determining A Primary Or Slave Assignment Based On An Order Of Cable Connection Between Two Devices 有权
标题翻译：基于两个设备之间的电缆连接顺序动态确定主或从设备
公开(公告)号：US20130080669A1
公开(公告)日：2013-03-28
申请号：US13246312
申请日：2011-09-27
申请人： Charles A. Cole , Phillip D. Jones , Adrian X. Rodriguez , Jared T. Siirila , Ping Zhou
发明人： Charles A. Cole , Phillip D. Jones , Adrian X. Rodriguez , Jared T. Siirila , Ping Zhou
IPC分类号： G06F13/00
CPC分类号： G06F13/426 , G06F13/364
摘要： Methods, apparatuses, and computer program products for dynamically determining a primary or slave assignment based on an order of cable connection between two devices are provided. Embodiments include detecting, by a first device, insertion of one end of a cable into a port of the first device; determining, by the first device, whether a power signal is received from the cable at the port of the first device; if the power signal is received, performing, by the first device, a data transfer operation over the cable as a slave device to a second device that is coupled to the other end of the cable; and if the power signal is not received, performing, by the first device, a data transfer operation over the cable as a primary device to the second device that is coupled to the other end of the cable.
摘要翻译：提供了用于基于两个设备之间的电缆连接的顺序动态地确定主或从属分配的方法，设备和计算机程序产品。实施例包括通过第一设备检测电缆的一端插入到第一设备的端口中; 由所述第一设备确定在所述第一设备的端口处是否从所述电缆接收电力信号; 如果接收到功率信号，则由第一设备执行通过电缆作为从设备的数据传输操作到耦合到电缆的另一端的第二设备; 并且如果未接收到电力信号，则由第一设备执行通过电缆作为主要设备的数据传输操作到耦合到电缆的另一端的第二设备。

35. 发明申请

US20110026409A1 Method, Devices and System for Local Collision Avoidance for Random Access in Relay Networks 有权
标题翻译：中继网络随机接入本地冲突避免的方法，设备和系统
公开(公告)号：US20110026409A1
公开(公告)日：2011-02-03
申请号：US12922515
申请日：2008-03-14
申请人： Honglin Hu , Haifeng Wang , Ping Zhou
发明人： Honglin Hu , Haifeng Wang , Ping Zhou
IPC分类号： H04L12/413 , H04L12/26
CPC分类号： H04W74/0841 , H04L1/1867 , H04W88/04
摘要： An apparatus such as a user equipment is in an embodiment of the invention configured to broadcast an access request to at least one neighboring node, the access request containing signature information indicating a user identifier, to check whether a collision indicator is received from a relay node, and to send another access request depending on a received collision indicator. The collision indicator may e.g. be a signature collision indicator, received from the node in case of colliding users, or a collision indicator of transmission received when transmissions of access requests are colliding at the node. A relay node may be configured to receive an access request from a user equipment, to detect a collision, and to inform the user equipment on a detected collision, indicating a type of collision.
摘要翻译：诸如用户设备的装置在本发明的实施例中被配置为向至少一个相邻节点广播访问请求，所述访问请求包含指示用户标识符的签名信息，以检查是否从中继节点接收到冲突指示符并且根据接收到的冲突指示符发送另一访问请求。碰撞指示器可以例如作为在碰撞用户的情况下从节点接收到的签名冲突指示符，或者当接入请求的传输在节点处碰撞时接收的传输的冲突指示符。中继节点可以被配置为从用户设备接收访问请求，以检测冲突，并且在检测到的冲突时通知用户设备，指示冲突的类型。

36. 发明授权

US07680556B2 Method for data collection during manufacturing processes 失效
标题翻译：制造过程中数据采集的方法
公开(公告)号：US07680556B2
公开(公告)日：2010-03-16
申请号：US10988805
申请日：2004-11-15
申请人： Boon Hong Sim , Ping Zhou
发明人： Boon Hong Sim , Ping Zhou
IPC分类号： G05B23/02 , G05B15/00 , G05B11/01 , G06F19/00 , G06F11/00 , H04Q5/22 , H04J3/16 , H04J3/22
CPC分类号： G05B19/41865 , Y02P90/20
摘要： The present invention discloses a new data collection method employed by a middle layer between the host and the equipment, which improves the speed and consistency of data collection. The middle layer incorporated with the proposed data collection method functions as a data format converter as well as a data processor/classifier, which helps to filter and format messages before delivering data to the host or equipment. The proposed data collection method enables the middle layer to perform local reply, local data sampling, and group data polling, thus relieving processing resources of both the equipment and the host. This allows implementation of APC on older wafer fabrication processes using old equipment.
摘要翻译：本发明公开了一种由主机与设备之间的中间层采用的新数据采集方式，提高了数据采集的速度和一致性。与提出的数据收集方法结合的中间层作为数据格式转换器以及数据处理器/分类器起作用，其在向主机或设备传送数据之前有助于过滤和格式化消息。所提出的数据采集方法使得中间层能够执行本地应答，本地数据采样和组数据轮询，从而减轻了设备和主机的处理资源。这允许使用旧设备在旧的晶圆制造工艺上实现APC。

37. 发明授权

US07541358B2 1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands 失效
标题翻译： 1-芳基或1-烷基磺酰基唑衍生物作为5-羟基色胺-6配体
公开(公告)号：US07541358B2
公开(公告)日：2009-06-02
申请号：US11891961
申请日：2007-08-14
申请人： Ping Zhou , Michael Gerard Kelly
发明人： Ping Zhou , Michael Gerard Kelly
IPC分类号： A61K31/5355 , A61K31/404 , A61P25/16 , C07D209/04 , C07D231/56 , C07D401/12
CPC分类号： C07D401/12 , C07D209/08 , C07D231/56 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
摘要翻译：本发明提供式I化合物及其用于治疗与5-HT 6受体有关或受其影响的病症的用途。

38. 发明授权

US07488832B2 Azolylacylguanidines as β-secretase inhibitors 失效
标题翻译：作为β-分泌酶抑制剂的烟酰酰基胍
公开(公告)号：US07488832B2
公开(公告)日：2009-02-10
申请号：US11352820
申请日：2006-02-13
申请人： Derek Cecil Cole , Eric Steven Manas , Lee Dalton Jennings , Frank Eldridge Lovering , Joseph Raymond Stock , William Jay Moore , John Watson Ellingboe , Jeffrey Scott Condon , Mohani Nirmala Sukhdeo , Ping Zhou , Junjun Wu , Koi Michele Morris
发明人： Derek Cecil Cole , Eric Steven Manas , Lee Dalton Jennings , Frank Eldridge Lovering , Joseph Raymond Stock , William Jay Moore , John Watson Ellingboe , Jeffrey Scott Condon , Mohani Nirmala Sukhdeo , Ping Zhou , Junjun Wu , Koi Michele Morris
IPC分类号： C07D207/325 , A61K31/4025
CPC分类号： C07D207/327 , C07D207/33 , C07D207/333 , C07D207/335 , C07D207/337 , C07D207/36 , C07D401/10 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/10 , C07D417/12
摘要： The present invention provides an azolylacylquanidine compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译：本发明提供了式I的吡唑基酰基喹啉化合物。本发明还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样沉积物和神经原纤维缠结的方法。

39. 发明申请

US20080287424A1 AZOLYLACYLGUANIDINES AS beta-SECRETASE INHIBITORS 审中-公开
标题翻译： AZOLYLACYLGUANIDINES作为β-分泌酶抑制剂
公开(公告)号：US20080287424A1
公开(公告)日：2008-11-20
申请号：US12173303
申请日：2008-07-15
申请人： Derek Cecil Cole , Eric Steven Manas , Lee Dalton Jennings , Frank Eldridge Lovering , Joseph Raymond Stock , William Jay Moore , John Watson Ellingboe , Jeffrey Scott Condon , Mohani Nirmala Sukhdeo , Ping Zhou , Junjun Wu , Koi Michele Morris
发明人： Derek Cecil Cole , Eric Steven Manas , Lee Dalton Jennings , Frank Eldridge Lovering , Joseph Raymond Stock , William Jay Moore , John Watson Ellingboe , Jeffrey Scott Condon , Mohani Nirmala Sukhdeo , Ping Zhou , Junjun Wu , Koi Michele Morris
IPC分类号： A61K31/541 , A61K31/40 , C07D207/327 , C07D401/10 , A61P25/28 , C12N9/99 , A61K31/454 , C07D417/10
CPC分类号： C07D207/327 , C07D207/33 , C07D207/333 , C07D207/335 , C07D207/337 , C07D207/36 , C07D401/10 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/10 , C07D417/12
摘要： The present invention provides an azolylacylquanidine compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译：本发明提供了式I的吡唑基酰基喹啉化合物。本发明还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样沉积物和神经原纤维缠结的方法。

40. 发明授权

US07417047B2 Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for β-secretase modulation 失效
标题翻译：氨基-5-（5元）杂芳基咪唑酮化合物及其用于β-分泌酶调节的用途
公开(公告)号：US07417047B2
公开(公告)日：2008-08-26
申请号：US11478122
申请日：2006-06-29
申请人： Michael Sotirios Malamas , Ping Zhou , William Floyd Fobare , William Ronald Solvibile , Iwan Suwandi Gunawan , James Joseph Erdei , Yinfa Yan , Patrick Michael Andrae , Dominick Anthony Quagliato
发明人： Michael Sotirios Malamas , Ping Zhou , William Floyd Fobare , William Ronald Solvibile , Iwan Suwandi Gunawan , James Joseph Erdei , Yinfa Yan , Patrick Michael Andrae , Dominick Anthony Quagliato
IPC分类号： A61K31/4178 , A61K31/4439 , A61K31/506 , C07D403/04 , C07D401/14
CPC分类号： C07D417/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/14
摘要： The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译：本发明提供式I的2-氨基-5-杂芳基-5-苯基咪唑酮化合物本发明还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样沉积物和神经原纤维缠结的方法。

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