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31. 发明授权

US6034694A Method and apparatus for pixel composition 失效
公开(公告)号：US6034694A
公开(公告)日：2000-03-07
申请号：US884843
申请日：1997-06-30
申请人： Jerald Evans , James Graham , Thanh Nguyen
发明人： Jerald Evans , James Graham , Thanh Nguyen
IPC分类号： G06T3/00 , G06T15/50
CPC分类号： G06T15/503
摘要： The present invention provides a method and apparatus that permits the introduction of customized compositing techniques into an application by a developer. A Composite interface and a CompositeContext interface are defined. Custom compositing operations can be defined by implementing these interfaces. A Composite object provides a CompositeContext object that holds the state and performs the compositing work. Multiple CompositeContext objects can be created from one Composite object to maintain separate states in a multi-threaded environment. An object implementing the Composite interface can be set as rendering state on a graphics object that provides rendering methods. This allows arbitrary compositing rules to be used by a developer. In one implementation of the Composite and CompositeContext interfaces, an AlphaComposite class is defined. The AlphaComposite class implements common compositing rules, such as defined by Porter and Duff, for combining source and destination pixels to achieve blending and transparency effects with graphics and images.

32. 发明授权

US5981482A Interleukin-1 receptor intracellular ligand proteins 失效
标题翻译：白细胞介素-1受体细胞内配体蛋白
公开(公告)号：US5981482A
公开(公告)日：1999-11-09
申请号：US726036
申请日：1996-10-07
申请人： Lih-Ling Lin , James Graham
发明人： Lih-Ling Lin , James Graham
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C12N15/63
CPC分类号： C07K14/47 , A61K38/00
摘要： Novel IL-1-R intracellular ligand proteins are disclosed. Polynucleotides encoding the IL-1-R intracellular ligand protein are also disclosed, along with vectors, host cells, and methods of making the IL-1-R intracellular ligand protein. Pharmaceutical compositions containing the IL-1-R intracellular ligand protein, methods of treating inflammatory conditions, and methods of inhibiting IL-1-R intracellular domain binding are also disclosed. Methods of identifying inhibitors of IL-1-R intracellular domain binding and inhibitors identified by such methods are also disclosed.
摘要翻译：公开了新的IL-1-R细胞内配体蛋白。还公开了编码IL-1-R细胞内配体蛋白的多核苷酸以及载体，宿主细胞和制备IL-1-R细胞内配体蛋白的方法。还公开了含有IL-1-R细胞内配体蛋白的药物组合物，治疗炎性病症的方法和抑制IL-1-R细胞内结构域结合的方法。还公开了鉴定IL-1-R细胞内结构域结合抑制剂的方法和通过这些方法鉴定的抑制剂。

33. 发明授权

US5891675A TNF receptor death domain ligand proteins 失效
标题翻译： TNF受体死亡域配体蛋白
公开(公告)号：US5891675A
公开(公告)日：1999-04-06
申请号：US839032
申请日：1997-04-23
申请人： Lih-Ling Lin , Jennifer Chen , Andrea R. Schievella , James Graham
发明人： Lih-Ling Lin , Jennifer Chen , Andrea R. Schievella , James Graham
IPC分类号： A61K38/00 , C07K14/47 , C07K16/24 , C12N15/12 , C07K14/705
CPC分类号： C07K14/4743 , C07K14/47 , C07K16/24 , A61K38/00 , C07K2317/34
摘要： Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
摘要翻译：公开了新型TNF受体死亡结构域（“TNF-R1-DD”）配体蛋白。还公开了编码TNF-R1-DD配体蛋白的多核苷酸以及载体，宿主细胞和制备TNF-R1-DD配体蛋白的方法。还公开了含有TNF-R1-DD配体蛋白质的药物组合物，治疗炎性病症的方法和抑制TNF-R死亡结构域结合的方法。还公开了鉴定TNF-R死亡结构域结合抑制剂的方法和通过这些方法鉴定的抑制剂。

34. 发明授权

US09358441B2 Portable speed bag retention mechanism 有权
标题翻译：便携式速度袋保持机构
公开(公告)号：US09358441B2
公开(公告)日：2016-06-07
申请号：US14556076
申请日：2014-11-28
申请人： Christopher Rea , James Wickstead , James Graham
发明人： Christopher Rea , James Wickstead , James Graham
IPC分类号： A63B69/20
CPC分类号： A63B69/205 , A63B69/201 , A63B2225/09
摘要： A portable exercise apparatus retention mechanism with a base platform, an exercise apparatus retainer, and at least one extendible and retractable retaining structure fixed to the base platform with first and second end portions for engaging first and second opposed surfaces when at least one of the end portions is extended. A sub-panel can be secured to the base structure with a central portion of the retaining structure disposed therebetween. The retention mechanism can retain an exercise apparatus, such as a speed bag. The end portions can have contoured flanges. A supplementary engaging mechanism with extended and retracted positions can project laterally from the base platform. The supplementary engaging mechanism could comprise first and second members pivotally coupled to the base platform.
摘要翻译：一种便携式运动装置保持机构，其具有基座，运动装置保持器和至少一个可延伸和可缩回的保持结构，所述保持结构固定到所述基座平台，所述第一和第二端部用于当所述端部中的至少一个端部部分扩展。子板可以固定到基部结构，其中保持结构的中心部分设置在它们之间。保持机构可以保持诸如速度袋的运动装置。端部可以具有轮廓的凸缘。具有延伸和缩回位置的补充接合机构可从基座平台侧向突出。辅助接合机构可以包括枢转地联接到基座的第一和第二构件。

35. 发明授权

US08853216B2 Hydroxylated pyrimidyl cyclopentane as AKT protein kinase inhibitor 有权
标题翻译：羟基化嘧啶环戊烷作为AKT蛋白激酶抑制剂
公开(公告)号：US08853216B2
公开(公告)日：2014-10-07
申请号：US12811983
申请日：2009-01-09
申请人： Josef Bencsik , James F. Blake , Nicholas C. Kallan , Ian S. Mitchell , Keith L. Spencer , Dengming Xiao , Rui Xu , Christine Chabot , Steven Do , Jun Liang , Brian Safina , Birong Zhang , James Graham
发明人： Josef Bencsik , James F. Blake , Nicholas C. Kallan , Ian S. Mitchell , Keith L. Spencer , Dengming Xiao , Rui Xu , Christine Chabot , Steven Do , Jun Liang , Brian Safina , Birong Zhang , James Graham
IPC分类号： C07D239/70 , A61K31/517 , A61P35/00 , A61P29/00 , A61P25/00 , A61P9/00 , A61P15/02 , A61P17/00
CPC分类号： C07D239/70
摘要： The present invention provides a compound and pharmaceutically acceptable salts thereof, comprising the Formula I. Also provided are methods of using the compound of this invention as an AKT protein kinase inhibitor and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译：本发明提供了包含式I的化合物及其药学上可接受的盐。还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。

36. 发明申请

US20120171935A1 CMP PAD Conditioning Tool 审中-公开
标题翻译： CMP PAD调节工具
公开(公告)号：US20120171935A1
公开(公告)日：2012-07-05
申请号：US13326464
申请日：2011-12-15
申请人： Gary Ruland , Mark Schweizer , Charles Rarey , Thomas Easley , James Graham
发明人： Gary Ruland , Mark Schweizer , Charles Rarey , Thomas Easley , James Graham
IPC分类号： B24B53/017 , B24B1/00
CPC分类号： B24D18/0009 , B24B53/017 , B24D3/06 , B24D3/34 , B24D7/02 , B24D18/0027 , B24D18/0054
摘要： The present disclosure provides a CMP pad conditioning tool with at least one integral abrasive protrusion. The present disclosure further provides a method for preparing this CMP pad conditioning tool, along with a method for using said tool to condition a CMP pad.
摘要翻译：本公开提供了具有至少一个整体研磨突起的CMP垫调节工具。本公开还提供了一种用于制备该CMP垫调节工具的方法，以及使用该工具来调节CMP垫的方法。

37. 发明申请

US20090175874A1 NOVEL INTERLEUKIN-1 RECEPTOR INTRACELLULAR LIGAND PROTEINS AND INHIBITORS OF LIGAND BINDING 审中-公开
标题翻译：新一代白细胞介素-1受体细胞内配子蛋白及其配体抑制剂
公开(公告)号：US20090175874A1
公开(公告)日：2009-07-09
申请号：US12172798
申请日：2008-07-14
申请人： Lih-Ling Lin , James Graham
发明人： Lih-Ling Lin , James Graham
IPC分类号： A61K39/395 , A61P29/00
CPC分类号： C07K14/47 , A61K38/00
摘要： Novel IL-1-R intracellular ligand proteins are disclosed. Polynucleotides encoding the IL-1-R intracellular ligand protein are also disclosed, along with vectors, host cells, and methods of making the IL-1-R intracellular ligand protein. Pharmaceutical compositions containing the IL-1-R intracellular ligand protein, methods of treating inflammatory conditions, and methods of inhibiting IL-1-R intracellular domain binding are also disclosed. Methods of identifying inhibitors of IL-1-R intracellular domain binding and inhibitors identified by such methods are also disclosed.
摘要翻译：公开了新的IL-1-R细胞内配体蛋白。还公开了编码IL-1-R细胞内配体蛋白的多核苷酸以及载体，宿主细胞和制备IL-1-R细胞内配体蛋白的方法。还公开了含有IL-1-R细胞内配体蛋白的药物组合物，治疗炎性病症的方法和抑制IL-1-R细胞内结构域结合的方法。还公开了鉴定IL-1-R细胞内结构域结合抑制剂的方法和通过这些方法鉴定的抑制剂。

38. 发明申请

US20080053869A1 VPS tar separation 有权
标题翻译： VPS焦油分离
公开(公告)号：US20080053869A1
公开(公告)日：2008-03-06
申请号：US11880983
申请日：2007-07-25
申请人： James McCoy , Paul Keusenkothen , Alok Srivastava , James Graham
发明人： James McCoy , Paul Keusenkothen , Alok Srivastava , James Graham
IPC分类号： C10C1/04
CPC分类号： C10G7/06
摘要： A process is described for producing deasphalted steam cracker tar comprising feeding steam cracker tar to a vacuum pipestill (VPS) including a flash zone separated from a zone comprising trays by at least one annular entrainment ring and obtaining as an overheads a deasphalted tar product and as a bottoms an asphaltenic heavy tar product. Also according to the invention, there is a system for the upgrading of tar comprising said VPS with at least one annular entrainment ring.
摘要翻译：描述了一种用于生产脱沥青蒸汽裂化器焦油的方法，其包括将蒸气裂解焦油加入到真空管道（VPS）中，所述真空管道（VPS）包括通过至少一个环形夹带环从包含塔板的区域分离的闪蒸区域，并获得脱沥青焦油产物和作为塔顶馏出物一种沥青质焦油产品的底部。同样根据本发明，存在一种用于使包含所述VPS的焦油升级至少一个环形夹带环的系统。

39. 发明申请

US20070233610A1 AN IMPROVED INSTITUTIONAL ELECTRONIC MESSAGING SYSTEM 失效
标题翻译：改进的机构电子消声系统
公开(公告)号：US20070233610A1
公开(公告)日：2007-10-04
申请号：US11308505
申请日：2006-03-30
申请人： Joel Gyllenskog , Larry Larsen , Randall Barber , Albert Pittman , James Graham
发明人： Joel Gyllenskog , Larry Larsen , Randall Barber , Albert Pittman , James Graham
IPC分类号： G06Q99/00
CPC分类号： G06Q10/107 , G06Q20/382 , Y10S707/99939
摘要： An electronic messaging system for both participating institutions and nonparticpating institutions and their populations. When an institution is participating in the system of the present invention, both message senders and recipients are authenticated and known and verified before any communication can take place. Messages for institutions not currently participating in the system are converted to printed mail for delivery to the non-participating institution using traditional postal systems. The present invention also teaches novel message processing techniques that take advantage of the electronic format of the messages to provide automated security and translation and/or transliteration services and further teaches the novel feature of marking incoming messages with a code to assist in accurately and secure delivery of reply messages to the appropriate party.
摘要翻译：为参与机构和非专业机构及其人员提供电子信息系统。当机构参与本发明的系统时，在发生任何通信之前，两个消息发送者和接收者都被认证和已知和验证。目前未参与系统的机构的消息将转换为印刷邮件，以便使用传统的邮政系统交付给非参与机构。本发明还教导了利用消息的电子格式来提供自动安全性和翻译和/或音译服务的新颖的消息处理技术，并且进一步教导了用代码标记传入消息的新颖特征，以帮助准确和安全地传递的回复信息给对方。

40. 发明申请

US20070066860A1 Steam cracking of high tan crudes 有权
标题翻译：蒸汽裂纹高棕褐色原油
公开(公告)号：US20070066860A1
公开(公告)日：2007-03-22
申请号：US11231490
申请日：2005-09-20
申请人： John Buchanan , Paul Keusenkothen , Stephen Brown , Julian Wolfenbarger , James Graham , James McCoy
发明人： John Buchanan , Paul Keusenkothen , Stephen Brown , Julian Wolfenbarger , James Graham , James McCoy
IPC分类号： C07C4/02
CPC分类号： C10G9/00 , C10G2300/1033 , C10G2300/1055 , C10G2300/1059 , C10G2300/107 , C10G2300/1074 , C10G2300/1077 , C10G2300/203 , C10G2300/206 , C10G2300/807 , C10G2400/20 , Y02P30/40
摘要： The invention is directed to a process comprising feeding high TAN feedstreams to a steam cracker, whereby naphthenic acids in the feedstreams are substantially converted to CO, CO2, and low amounts of smaller acids (e.g., formic, acetic, propionic, and butyric acids). The feedstream is preferably a high TAN feedstream comprising crude or high TAN feedstream which has previously been subjected to a refinery process to remove resid.
摘要翻译：本发明涉及一种方法，其包括将高TAN进料流供给蒸汽裂化器，由此进料流中的环烷酸基本上转化为CO，CO 2 CO 2和少量较小的酸（例如甲酸，乙酸，丙酸和丁酸）。进料流优选是高TAN进料流，其包含先前经过炼油方法以除去渣油的粗TAN进料流或高TAN进料流。

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